ATE252906T1 - Pharmazeutische formulierung, die ein beta- lactamase hemmendes penem in kombination mit einem beta-laktam-antibiotikum enthalten und ihre verwendung zur behandlung von bakteriellen infektionen - Google Patents

Pharmazeutische formulierung, die ein beta- lactamase hemmendes penem in kombination mit einem beta-laktam-antibiotikum enthalten und ihre verwendung zur behandlung von bakteriellen infektionen

Info

Publication number: ATE252906T1
Authority: AT; Austria
Prior art keywords: beta; penem; combination; pharmaceutical formulation; lactam antibiotic
Prior art date: 1994-04-25

Application number

AT95917949T

Other languages

English (en)

Inventor

K Coleman

J E Neale

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-04-25

Filing date

1995-04-22

Publication date

2003-11-15

1994-04-25 Priority claimed from GB9408164A external-priority patent/GB9408164D0/en

1994-04-25 Priority claimed from GB9408163A external-priority patent/GB9408163D0/en

1994-04-25 Priority claimed from GB9408162A external-priority patent/GB9408162D0/en

1994-04-25 Priority claimed from GB9408161A external-priority patent/GB9408161D0/en

1995-04-22 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2003-11-15 Application granted granted Critical

2003-11-15 Publication of ATE252906T1 publication Critical patent/ATE252906T1/de

Links

239000003782 beta lactam antibiotic agent Substances 0.000 title abstract 2
HHXMXAQDOUCLDN-RXMQYKEDSA-N penem Chemical compound S1C=CN2C(=O)C[C@H]21 HHXMXAQDOUCLDN-RXMQYKEDSA-N 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
239000002132 β-lactam antibiotic Substances 0.000 title abstract 2
229940124586 β-lactam antibiotics Drugs 0.000 title abstract 2
208000035143 Bacterial infection Diseases 0.000 title 1
108090000204 Dipeptidase 1 Proteins 0.000 title 1
208000022362 bacterial infectious disease Diseases 0.000 title 1
102000006635 beta-lactamase Human genes 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
125000001424 substituent group Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 abstract 1
229960003022 amoxicillin Drugs 0.000 abstract 1
125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
150000001768 cations Chemical class 0.000 abstract 1
GPRBEKHLDVQUJE-VINNURBNSA-N cefotaxime Chemical compound N([C@@H]1C(N2C(=C(COC(C)=O)CS[C@@H]21)C(O)=O)=O)C(=O)/C(=N/OC)C1=CSC(N)=N1 GPRBEKHLDVQUJE-VINNURBNSA-N 0.000 abstract 1
229960004261 cefotaxime Drugs 0.000 abstract 1
ORFOPKXBNMVMKC-DWVKKRMSSA-N ceftazidime Chemical compound S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC(C)(C)C(O)=O)C=2N=C(N)SC=2)CC=1C[N+]1=CC=CC=C1 ORFOPKXBNMVMKC-DWVKKRMSSA-N 0.000 abstract 1
229960000484 ceftazidime Drugs 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 abstract 1
IVBHGBMCVLDMKU-GXNBUGAJSA-N piperacillin Chemical compound O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 IVBHGBMCVLDMKU-GXNBUGAJSA-N 0.000 abstract 1
229960002292 piperacillin Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

AT95917949T 1994-04-25 1995-04-22 Pharmazeutische formulierung, die ein beta- lactamase hemmendes penem in kombination mit einem beta-laktam-antibiotikum enthalten und ihre verwendung zur behandlung von bakteriellen infektionen ATE252906T1 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GB9408164A GB9408164D0 (en)	1994-04-25	1994-04-25	Pharmaceutical formulations
GB9408163A GB9408163D0 (en)	1994-04-25	1994-04-25	Pharmaceutical formulations
GB9408162A GB9408162D0 (en)	1994-04-25	1994-04-25	Pharmaceutical formulations
GB9408161A GB9408161D0 (en)	1994-04-25	1994-04-25	Pharmaceutical formulations
PCT/EP1995/001546 WO1995028935A1 (en)	1994-04-25	1995-04-22	Pharmaceutical formulations containing a beta-lactamase inhibiting penem in combination with a beta-lactam antibiotic and their use in the treatment of bacterial infections

Publications (1)

Publication Number	Publication Date
ATE252906T1 true ATE252906T1 (de)	2003-11-15

Family

ID=27451150

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95917949T ATE252906T1 (de)	1994-04-25	1995-04-22	Pharmazeutische formulierung, die ein beta- lactamase hemmendes penem in kombination mit einem beta-laktam-antibiotikum enthalten und ihre verwendung zur behandlung von bakteriellen infektionen

Country Status (17)

Country	Link
US (3)	US5911985A (de)
EP (1)	EP0758240B1 (de)
JP (2)	JP3865770B2 (de)
KR (1)	KR100363604B1 (de)
CN (1)	CN1094353C (de)
AT (1)	ATE252906T1 (de)
AU (1)	AU690685B2 (de)
BR (1)	BR9507521A (de)
CZ (1)	CZ286898B6 (de)
DE (1)	DE69532032T2 (de)
ES (1)	ES2206502T3 (de)
HU (1)	HUT76340A (de)
MX (1)	MX9605149A (de)
NO (1)	NO964500L (de)
NZ (1)	NZ285085A (de)
PL (1)	PL179415B1 (de)
WO (1)	WO1995028935A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6472383B1 (en)	1994-04-25	2002-10-29	Smithkline Beecham P.L.C.	Pharmaceutical formulations
EP1199077A1 (de) *	2000-10-19	2002-04-24	Amura Limited	Stabilisierte Oxapenem-3-carbonsäure enthaltende Arzneimittel durch Gefriergetrocknen mit pharmazeutischen Trägern
US20040132708A1 (en) *	2002-05-01	2004-07-08	Wyeth	Process for preparing 6-alkylidene penem derivatives
AR039476A1 (es) *	2002-05-01	2005-02-23	Wyeth Corp	Proceso para preparar derivados de 6-alquiliden penem
AR039475A1 (es)	2002-05-01	2005-02-23	Wyeth Corp	6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
AR039774A1 (es)	2002-05-01	2005-03-02	Wyeth Corp	6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
TW200716102A (en) *	2005-06-01	2007-05-01	Wyeth Corp	Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200716104A (en) *	2005-06-01	2007-05-01	Wyeth Corp	Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200727897A (en) *	2005-07-27	2007-08-01	Wyeth Corp	Bicyclic 6-alkylidene-penem β-lactamase inhibitors and β-lactam antibiotic combination: a broad spectrum antibiotic
BRPI0613928A2 (pt) *	2005-07-27	2011-02-15	Wyeth Corp	método para o tratamento de uma infecção ou doença bacteriana; composição; produto; e uso de cefepima ou de um sal farmaceuticamente aceitável da mesma e um composto de fórmula i ou um sal farmaceuticamente aceitável ou éster hidrolisável in vivo do mesmo
GT200600380A (es) *	2005-08-24	2007-03-29		Proceso para la preparacion de inhibidores de beta-lactamasa

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR228726A1 (es) *	1978-05-26	1983-04-15	Glaxo Group Ltd	Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato
DE3062168D1 (en) *	1979-04-21	1983-04-07	Beecham Group Plc	Clavulanic acid derivatives, their preparation and use in pharmaceutical compositions
EP0041768B1 (de) *	1980-04-24	1987-11-11	Beecham Group Plc	Beta-Lactam-Verbindungen, ihre Herstellung und Verwendung
EP0120613A1 (de) *	1983-03-02	1984-10-03	Beecham Group Plc	Penem-Derivate und Vorstufenverbindungen
GB8518422D0 (en) *	1985-07-22	1985-08-29	Beecham Group Plc	Compounds
GB8518416D0 (en) *	1985-07-22	1985-08-29	Beecham Group Plc	Compounds
GB8518421D0 (en) *	1985-07-22	1985-08-29	Beecham Group Plc	Compounds
BR8603523A (pt) *	1985-07-27	1987-03-04	Sumitomo Metal Ind	Processo e aparelho para gaseificar um material carbonaceo solido em um banho de metal em fusao
GB9222700D0 (en) *	1992-10-29	1992-12-09	Smithkline Beecham Plc	Chemical compounds

1995
- 1995-04-22 AT AT95917949T patent/ATE252906T1/de not_active IP Right Cessation
- 1995-04-22 EP EP95917949A patent/EP0758240B1/de not_active Expired - Lifetime
- 1995-04-22 ES ES95917949T patent/ES2206502T3/es not_active Expired - Lifetime
- 1995-04-22 WO PCT/EP1995/001546 patent/WO1995028935A1/en not_active Ceased
- 1995-04-22 AU AU24073/95A patent/AU690685B2/en not_active Ceased
- 1995-04-22 JP JP52736295A patent/JP3865770B2/ja not_active Expired - Fee Related
- 1995-04-22 CN CN95193309A patent/CN1094353C/zh not_active Expired - Fee Related
- 1995-04-22 KR KR1019960706126A patent/KR100363604B1/ko not_active Expired - Fee Related
- 1995-04-22 US US08/732,379 patent/US5911985A/en not_active Expired - Fee Related
- 1995-04-22 DE DE69532032T patent/DE69532032T2/de not_active Expired - Fee Related
- 1995-04-22 HU HU9602928A patent/HUT76340A/hu unknown
- 1995-04-22 CZ CZ19963156A patent/CZ286898B6/cs not_active IP Right Cessation
- 1995-04-22 BR BR9507521A patent/BR9507521A/pt not_active Application Discontinuation
- 1995-04-22 MX MX9605149A patent/MX9605149A/es unknown
- 1995-04-22 NZ NZ285085A patent/NZ285085A/en not_active IP Right Cessation
- 1995-04-22 PL PL95317045A patent/PL179415B1/pl unknown
- 1995-06-01 US US08/457,562 patent/US5776455A/en not_active Expired - Fee Related
1996
- 1996-10-23 NO NO964500A patent/NO964500L/no unknown
1998
- 1998-01-26 US US09/013,140 patent/US5939066A/en not_active Expired - Fee Related
2005
- 2005-07-11 JP JP2005201459A patent/JP2005298525A/ja active Pending

Also Published As

Publication number	Publication date
BR9507521A (pt)	1997-09-16
AU2407395A (en)	1995-11-16
HUT76340A (en)	1997-08-28
AU690685B2 (en)	1998-04-30
PL317045A1 (en)	1997-03-03
NO964500L (no)	1996-11-26
WO1995028935A1 (en)	1995-11-02
KR970702723A (ko)	1997-06-10
CN1149254A (zh)	1997-05-07
CZ315696A3 (en)	1997-06-11
CN1094353C (zh)	2002-11-20
MX9605149A (es)	1997-12-31
CZ286898B6 (en)	2000-07-12
EP0758240A1 (de)	1997-02-19
ES2206502T3 (es)	2004-05-16
JP2005298525A (ja)	2005-10-27
JP3865770B2 (ja)	2007-01-10
EP0758240B1 (de)	2003-10-29
NO964500D0 (no)	1996-10-23
PL179415B1 (pl)	2000-09-29
US5776455A (en)	1998-07-07
KR100363604B1 (ko)	2003-04-11
HU9602928D0 (en)	1996-12-30
JPH09512260A (ja)	1997-12-09
DE69532032D1 (de)	2003-12-04
US5939066A (en)	1999-08-17
US5911985A (en)	1999-06-15
DE69532032T2 (de)	2004-07-22
NZ285085A (en)	1998-04-27

Legal Events

Date	Code	Title	Description
2004-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
MX9804107A (es)	1998-09-30	Derivados de quinolina.
AU584388B2 (en)	1989-05-25	Novel heterocyclic compounds
FR05C0045I2 (de)	2007-08-03
HK5684A (en)	1984-01-20	Penicillin derivatives
ATE252906T1 (de)	2003-11-15	Pharmazeutische formulierung, die ein beta- lactamase hemmendes penem in kombination mit einem beta-laktam-antibiotikum enthalten und ihre verwendung zur behandlung von bakteriellen infektionen
RU94030236A (ru)	1996-06-20	Производные 3 бета-алкенил-пенама, способ их получения, лекарственные средства и их применение для борьбы и предупреждения болезней
AU6389086A (en)	1987-04-16	A method for the treatment of atherosclerosis, thrombosis and peripheral vesseldisease
MY117265A (en)	2004-06-30	6-(substituted methylene) penems and intermediates
AU5819794A (en)	1994-08-15	Piperazine derivatives
GB1456144A (en)	1976-11-17	Ureido-aryl cephalosporin compounds
ES2001773A6 (es)	1988-06-16	Un procedimiento para preparar un compuesto de cefalosporina
AU6092090A (en)	1991-02-14	A method for the treatment of cardiac and of vascular hypertrophy and hyperplasia
CA2188695A1 (en)	1995-11-02	Pharmaceutical formulations containing a beta-lactamase inhibiting penem in combination with a beta-lactam antibiotic and their use in the treatment of bacterial infections
GB9326248D0 (en)	1994-02-23	Pharmaceutical formulations
ATE231510T1 (de)	2003-02-15	Penamsulfone als beta-laktamase inhibitoren
HUT61771A (en)	1993-03-01	Process for producing new cephalosporin derivatives and pharmaceutical compositions containing them as active components
KR900005050B1 (en)	1990-07-19	6-beta (substituted)-(s)-hydroxymethyl-penicillanic acids and derivatives thereof
TW371304B (en)	1999-10-01	Cephem compounds having antibacterial activity, their production and pharmaceutical composition
TW257758B (en)	1995-09-21	Piperazine derivatives (1)