ATE253899T1 - Intraoral löslicher formpressling und verfahren zu seiner herstellung - Google Patents
Intraoral löslicher formpressling und verfahren zu seiner herstellungInfo
- Publication number
- ATE253899T1 ATE253899T1 AT95906533T AT95906533T ATE253899T1 AT E253899 T1 ATE253899 T1 AT E253899T1 AT 95906533 T AT95906533 T AT 95906533T AT 95906533 T AT95906533 T AT 95906533T AT E253899 T1 ATE253899 T1 AT E253899T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- soluble molding
- intraorally
- intraorally soluble
- molding
- Prior art date
Links
- 238000000465 moulding Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 2
- 238000004090 dissolution Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Cosmetics (AREA)
- Detergent Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Dental Preparations (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1011294 | 1994-01-31 | ||
| JP8665294 | 1994-04-25 | ||
| PCT/JP1995/000102 WO1995020380A1 (en) | 1994-01-31 | 1995-01-27 | Intraorally soluble compressed molding and process for producing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE253899T1 true ATE253899T1 (de) | 2003-11-15 |
Family
ID=26345308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95906533T ATE253899T1 (de) | 1994-01-31 | 1995-01-27 | Intraoral löslicher formpressling und verfahren zu seiner herstellung |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0745382B1 (de) |
| JP (1) | JP3122141B2 (de) |
| KR (1) | KR100386391B1 (de) |
| CN (1) | CN1182838C (de) |
| AT (1) | ATE253899T1 (de) |
| AU (1) | AU699715B2 (de) |
| CA (1) | CA2179382C (de) |
| DE (1) | DE69532110T2 (de) |
| DK (1) | DK0745382T3 (de) |
| ES (1) | ES2210280T3 (de) |
| FI (1) | FI120817B (de) |
| HU (1) | HUT74908A (de) |
| MX (1) | MX9603035A (de) |
| NO (1) | NO316662B1 (de) |
| NZ (1) | NZ278678A (de) |
| PH (1) | PH31467A (de) |
| PL (1) | PL187160B1 (de) |
| PT (1) | PT745382E (de) |
| RU (1) | RU2147227C1 (de) |
| TW (1) | TW391880B (de) |
| WO (1) | WO1995020380A1 (de) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69738829D1 (de) * | 1996-07-12 | 2008-08-21 | Daiichi Seiyaku Co | Schnell zerfallende, druckgeformte Materialien sowie Prozess zu deren Herstellung |
| EP0839526A3 (de) * | 1996-10-31 | 1999-01-07 | Takeda Chemical Industries, Ltd. | Festes pharmazeutisches Präparat mit schneller Auflösungs- oder Disintegrationeigenschaften |
| US6024981A (en) * | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
| TW580397B (en) * | 1997-05-27 | 2004-03-21 | Takeda Chemical Industries Ltd | Solid preparation |
| FR2766089B1 (fr) * | 1997-07-21 | 2000-06-02 | Prographarm Lab | Comprime multiparticulaire perfectionne a delitement rapide |
| KR100655627B1 (ko) * | 1998-03-16 | 2006-12-12 | 아스텔라스세이야쿠 가부시키가이샤 | 구강 내에서 급속히 붕괴되는 정제 |
| US6465009B1 (en) | 1998-03-18 | 2002-10-15 | Yamanouchi Pharmaceutical Co., Ltd. | Water soluble polymer-based rapidly dissolving tablets and production processes thereof |
| DE69934505T2 (de) | 1998-05-18 | 2007-10-04 | Takeda Pharmaceutical Co. Ltd. | Im munde zerfallende tablette enthaltend ein benzimidazole |
| CA2337015C (en) | 1998-07-15 | 2004-09-07 | Asahi Kasei Kogyo Kabushiki Kaisha | Excipient |
| TW585786B (en) | 1998-07-28 | 2004-05-01 | Takeda Chemical Industries Ltd | Lansoprazole-containing rapidly disintegrable solid pharmaceutical composition |
| FR2785538B1 (fr) * | 1998-11-06 | 2004-04-09 | Prographarm Laboratoires | Comprime a delitement rapide perfectionne |
| WO2000048575A1 (fr) * | 1999-02-17 | 2000-08-24 | Kyowa Hakko Kogyo Co., Ltd. | Comprimes et procede de production de comprimes |
| FR2790387B1 (fr) * | 1999-03-01 | 2001-05-18 | Prographarm Laboratoires | Comprime orodispersible presentant une faible friabilite et son procede de preparation |
| GB9910505D0 (en) * | 1999-05-06 | 1999-07-07 | Electrosols Ltd | A method and apparatus for manufacturing consumable tablets |
| WO2002002083A1 (en) | 2000-06-30 | 2002-01-10 | Yamanouchi Pharmaceutical Co., Ltd. | Tablet rapidly disintegrating in mouth and process for producing the same |
| US6656492B2 (en) | 2000-06-30 | 2003-12-02 | Yamanouchi Pharmaceutical Co., Ltd. | Quick disintegrating tablet in buccal cavity and manufacturing method thereof |
| CN1638739A (zh) * | 2000-08-18 | 2005-07-13 | 法玛西雅厄普约翰美国公司 | 治疗成瘾性障碍的化合物 |
| JP2002087965A (ja) * | 2000-09-14 | 2002-03-27 | Lion Corp | 口中崩壊性アスピリン含有錠剤 |
| US7147869B2 (en) * | 2000-12-07 | 2006-12-12 | Altana Pharma Ag | Rapidly disintegrating tablet comprising an acid-labile active ingredient |
| US6998139B2 (en) * | 2001-03-15 | 2006-02-14 | Astellas Pharma Inc. | Bitterness-reduced intrabuccally quick disintegrating tablets and method for reducing bitterness |
| US6872405B2 (en) | 2001-05-10 | 2005-03-29 | Yamanouchi Pharmaceutical Co., Ltd. | Quick-disintegrating tablet in buccal cavity and manufacturing method thereof |
| JP4019374B2 (ja) | 2001-07-27 | 2007-12-12 | アステラス製薬株式会社 | 口腔内速崩壊錠用徐放性微粒子含有組成物およびその製造法 |
| JPWO2003028706A1 (ja) * | 2001-09-28 | 2005-01-13 | 株式会社三和化学研究所 | 有核型速溶崩壊性成型品 |
| RU2187307C1 (ru) * | 2001-10-15 | 2002-08-20 | Сыров Кирилл Константинович | Твердые стабильные лекарственные формы преднизолона |
| RU2210381C2 (ru) * | 2001-10-25 | 2003-08-20 | Кобатов Алексей Иванович | Пептидсодержащий препарат и способ его получения |
| RU2192848C1 (ru) * | 2001-10-30 | 2002-11-20 | Закрытое акционерное общество "ВЕРОФАРМ" | Противорвотное средство |
| FR2831820B1 (fr) * | 2001-11-05 | 2004-08-20 | Ethypharm Sa | Comprime orodispersible presentant une grande homogeneite et son procede de preparation |
| WO2003039472A2 (en) * | 2001-11-07 | 2003-05-15 | Pharmacia Corporation | Intraorally disintegrating valdecoxib compositions prepared by fluid bed granulation process |
| FR2834894B1 (fr) * | 2002-01-21 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible de piribedil |
| FR2834891B1 (fr) * | 2002-01-23 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible de 2-({2-methoxy-2-[3(trifluoromethyl)phenyl]ethyl}amino)ethyl4 -(2-(9h-fluoren-9-yl)acetyl]amino}ethyl)benzoate |
| FR2834897B1 (fr) * | 2002-01-23 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible de testosterone |
| FR2834893B1 (fr) * | 2002-01-23 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible de perindopril |
| FR2834892B1 (fr) * | 2002-01-23 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible de mitiglinide |
| FR2834896B1 (fr) * | 2002-01-23 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible d'ivabradine |
| FR2834890B1 (fr) * | 2002-01-23 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible d'agomelatine |
| RU2207129C1 (ru) * | 2002-05-07 | 2003-06-27 | Закрытое акционерное общество "Брынцалов-А" | Средство, обладающее нейролептическим действием |
| AU2003259336A1 (en) * | 2002-08-21 | 2004-03-11 | Phoqus Pharmaceuticals Limited | Use of an aqueous solution of citric acid and a water-soluble sugar like lactitol as granulation liquid in the manufacture of tablets |
| MXPA05009095A (es) * | 2003-01-27 | 2006-05-19 | Astellas Pharma Inc | Particulas finas entericas de liberacion sostenida de tamsulosin o su sal y metodo de fabricacion de las mismas. |
| RU2234316C1 (ru) * | 2003-04-16 | 2004-08-20 | Тимофеева Татьяна Всеволодовна | Фармацевтическая композиция для получения таблеток нитроглицерина |
| EP1473029B1 (de) * | 2003-04-30 | 2005-03-23 | Ferring B.V. | Feste Dosierungsform mit Desmopressin |
| JP4739217B2 (ja) * | 2003-05-07 | 2011-08-03 | サムヤン コーポレイション | 速く溶ける錠剤を製造するための高可塑性顆粒 |
| US8647668B2 (en) | 2003-10-15 | 2014-02-11 | Fuji Chemical Industry Co., Ltd. | Tablet quickly disintegrating in oral cavity |
| US8349361B2 (en) | 2003-10-15 | 2013-01-08 | Fuji Chemical Industry Co., Ltd. | Composition for rapid disintegrating tablet in oral cavity |
| JP3841804B2 (ja) | 2003-10-15 | 2006-11-08 | 富士化学工業株式会社 | 口腔内速崩壊性錠剤用の組成物 |
| CA2490601C (en) * | 2003-12-29 | 2006-05-02 | Ferring B.V. | Method for preparing solid dosage form of desmopressin |
| US7670624B2 (en) | 2004-01-29 | 2010-03-02 | Astella Pharma Inc. | Gastrointestinal-specific multiple drug release system |
| RU2252759C1 (ru) * | 2004-02-17 | 2005-05-27 | ООО "Инполимед АО" | Средство для купирования и лечения ишемической болезни сердца и способ его производства |
| SE0401031D0 (sv) * | 2004-04-22 | 2004-04-22 | Duocort Ab | A new glucocorticoid replacement therapy |
| JP2007533697A (ja) | 2004-04-22 | 2007-11-22 | デュオコート エービー | グルココルチコイド救急治療用の医薬組成物 |
| US7723306B2 (en) | 2004-05-10 | 2010-05-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation |
| US7727962B2 (en) | 2004-05-10 | 2010-06-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Powder comprising new compositions of oligosaccharides and methods for their preparation |
| DE102004022928A1 (de) * | 2004-05-10 | 2005-12-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulver enthaltend neuartige Oligosacharidgemische und Verfahren zu deren Herstellung |
| US7611709B2 (en) | 2004-05-10 | 2009-11-03 | Boehringer Ingelheim Pharma Gmbh And Co. Kg | 1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives |
| DE102004022926A1 (de) * | 2004-05-10 | 2005-12-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Sprühgetrocknete Pulver enthaltend zumindest ein 1,4 O-verknüpftes Saccharose-Derivat und Verfahren zu deren Herstellung |
| TWI354559B (en) * | 2004-12-27 | 2011-12-21 | Yaizu Suisankagaku Ind Co Ltd | Oral disintegrative n-acetylglucosamine tablet and |
| RU2278681C1 (ru) * | 2005-01-24 | 2006-06-27 | Открытое акционерное общество "Нижегородский химико-фармацевтический завод" | Средство для лечения заболеваний предстательной железы |
| WO2006080498A1 (ja) * | 2005-01-31 | 2006-08-03 | Kyowa Hakko Kogyo Co., Ltd. | オルニチン塩酸塩を含有する錠剤 |
| WO2006085497A1 (ja) * | 2005-02-09 | 2006-08-17 | Kissei Pharmaceutical Co., Ltd. | 口腔内崩壊錠 |
| CN1839847B (zh) * | 2005-03-31 | 2012-07-11 | 成都科瑞德医药投资有限责任公司 | 盐酸替扎尼定口腔崩解片及其制备方法 |
| RU2370268C2 (ru) * | 2005-05-25 | 2009-10-20 | Лабораториос Баго С.А. | Способ получения фармацевтической композиции для орального введения, обладающей улучшенной биодоступностью биологически активного действующего лекарственного вещества, и фармацевтическая композиция, полученная этим способом |
| US20090306227A1 (en) * | 2005-08-31 | 2009-12-10 | Toshiyuki Ioka | Tablet for removing tongue coating |
| JP5215172B2 (ja) * | 2006-04-13 | 2013-06-19 | 東亜薬品株式会社 | 乾式直打速崩壊性錠剤 |
| EP2062599A4 (de) | 2006-09-14 | 2013-03-27 | Astellas Pharma Inc | Oral zerfallende tablette und verfahren zu ihrer herstellung |
| WO2008081829A1 (ja) | 2006-12-27 | 2008-07-10 | Astellas Pharma Inc. | 難水溶性薬物の溶解性維持用アミノアルキルメタアクリレートコポリマーe |
| US9314454B2 (en) | 2007-12-28 | 2016-04-19 | Sawai Pharmaceutical Co., Ltd. | Oral cavity disintegrating tablet and method of producing the same |
| JP5515074B2 (ja) * | 2008-12-08 | 2014-06-11 | 杏林製薬株式会社 | 口腔内速崩壊性錠剤 |
| TWI429401B (zh) | 2010-06-13 | 2014-03-11 | Meiji Co Ltd | 固形乳及其製造方法 |
| US9861577B2 (en) | 2010-08-31 | 2018-01-09 | Kyowa Hakko Kirin Co., Ltd. | Orally disintegrating tablet |
| WO2013098268A2 (en) | 2011-12-26 | 2013-07-04 | Novartis Ag | Tablets and dry-coated agents |
| JP6040218B2 (ja) * | 2012-02-23 | 2016-12-07 | フロイント産業株式会社 | 口腔内崩壊錠用直打賦形剤及びその製造方法、並びに口腔内崩壊錠 |
| TWI612975B (zh) | 2012-03-02 | 2018-02-01 | 安斯泰來製藥股份有限公司 | 速崩散性錠劑 |
| BR112014026292B1 (pt) * | 2012-04-24 | 2022-09-27 | Daiichi Sankyo Company, Limited | Comprimido oralmente desintegrável, e, processo para a produção de um comprimido oralmente desintegrável |
| CN102784117A (zh) * | 2012-08-23 | 2012-11-21 | 海南卫康制药(潜山)有限公司 | 硫酸庆大霉素组合物冻干口腔崩解片及其制备方法 |
| KR101352689B1 (ko) * | 2012-12-31 | 2014-01-17 | (주) 에프엔지리서치 | 불연속상과 연속상으로 이루어지는 응집단위를 포함하는 마이크로그래뉼 제형 |
| WO2014119667A1 (ja) * | 2013-01-30 | 2014-08-07 | 沢井製薬株式会社 | カンデサルタンシレキセチル含有医薬組成物 |
| CN103202817B (zh) * | 2013-04-28 | 2014-10-08 | 山东天力药业有限公司 | 一种可直压性甘露醇颗粒的制备方法 |
| WO2017217494A1 (ja) | 2016-06-16 | 2017-12-21 | 東和薬品株式会社 | 口腔内崩壊錠 |
| ES2902123T3 (es) | 2017-03-31 | 2022-03-25 | Toray Industries | Composición medicinal en tabletas que comprende nalfurafina |
| CA3097953C (en) * | 2018-05-17 | 2023-09-12 | Fertin Pharma A/S | A tableted chewing gum suitable for active pharmaceutical ingredients |
| JP2023125300A (ja) * | 2022-02-28 | 2023-09-07 | アルフレッサファーマ株式会社 | 湿製錠剤及び湿製錠剤の製造方法 |
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|---|---|---|---|---|
| DE1617638A1 (de) * | 1967-05-24 | 1971-05-13 | Miles Lab | Tablettenbindemittel |
| US3619292A (en) * | 1968-07-15 | 1971-11-09 | Penick & Ford Ltd | Tablets and method of forming |
| US3627583A (en) * | 1969-04-29 | 1971-12-14 | Sucrest Corp | Direct compression vehicles |
| US3873694A (en) * | 1973-09-27 | 1975-03-25 | Cpc International Inc | Direct compression tabletting composition and pharmaceutical tablets produced therefrom |
| CA1080024A (en) * | 1975-12-24 | 1980-06-24 | Leonard Spooner | Confection containing xylitol |
| US4698101A (en) * | 1982-08-30 | 1987-10-06 | Suomen Sokeri Oy (Finnish Sugar Company Ltd.) | Binder-diluent composition and method |
| US5073374A (en) * | 1988-11-30 | 1991-12-17 | Schering Corporation | Fast dissolving buccal tablet |
| SU1680182A1 (ru) * | 1989-06-23 | 1991-09-30 | Щелковский Витаминный Завод | Способ получени таблеток фенасала |
| JPH0669948B2 (ja) * | 1989-07-21 | 1994-09-07 | エスエス製薬株式会社 | トローチ剤 |
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| US5204115A (en) * | 1990-12-12 | 1993-04-20 | Suomen Xyrofin Oy | Directly compressible xylitol and method |
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| US5837285A (en) * | 1992-02-18 | 1998-11-17 | Nakamichi; Kouichi | Fast soluble tablet |
| JPH05310558A (ja) * | 1992-05-07 | 1993-11-22 | Lion Corp | 固形製剤組成物 |
-
1995
- 1995-01-27 AT AT95906533T patent/ATE253899T1/de active
- 1995-01-27 CN CNB951914081A patent/CN1182838C/zh not_active Expired - Lifetime
- 1995-01-27 EP EP95906533A patent/EP0745382B1/de not_active Expired - Lifetime
- 1995-01-27 DE DE69532110T patent/DE69532110T2/de not_active Expired - Lifetime
- 1995-01-27 HU HU9602083A patent/HUT74908A/hu not_active Application Discontinuation
- 1995-01-27 WO PCT/JP1995/000102 patent/WO1995020380A1/ja not_active Ceased
- 1995-01-27 JP JP07519980A patent/JP3122141B2/ja not_active Expired - Lifetime
- 1995-01-27 ES ES95906533T patent/ES2210280T3/es not_active Expired - Lifetime
- 1995-01-27 PH PH49851A patent/PH31467A/en unknown
- 1995-01-27 AU AU14671/95A patent/AU699715B2/en not_active Ceased
- 1995-01-27 NZ NZ278678A patent/NZ278678A/en not_active IP Right Cessation
- 1995-01-27 RU RU96117252/14A patent/RU2147227C1/ru not_active IP Right Cessation
- 1995-01-27 TW TW084100735A patent/TW391880B/zh not_active IP Right Cessation
- 1995-01-27 MX MX9603035A patent/MX9603035A/es unknown
- 1995-01-27 PL PL95315552A patent/PL187160B1/pl not_active IP Right Cessation
- 1995-01-27 PT PT95906533T patent/PT745382E/pt unknown
- 1995-01-27 KR KR1019960704132A patent/KR100386391B1/ko not_active Expired - Lifetime
- 1995-01-27 DK DK95906533T patent/DK0745382T3/da active
- 1995-01-27 CA CA002179382A patent/CA2179382C/en not_active Expired - Fee Related
-
1996
- 1996-07-30 NO NO19963180A patent/NO316662B1/no not_active IP Right Cessation
- 1996-07-31 FI FI963022A patent/FI120817B/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PL315552A1 (en) | 1996-11-12 |
| WO1995020380A1 (en) | 1995-08-03 |
| FI963022A0 (fi) | 1996-07-31 |
| CN1139878A (zh) | 1997-01-08 |
| AU699715B2 (en) | 1998-12-10 |
| EP0745382B1 (de) | 2003-11-12 |
| KR100386391B1 (ko) | 2003-08-30 |
| FI120817B (fi) | 2010-03-31 |
| JP3122141B2 (ja) | 2001-01-09 |
| AU1467195A (en) | 1995-08-15 |
| EP0745382A1 (de) | 1996-12-04 |
| CA2179382C (en) | 2009-11-10 |
| CA2179382A1 (en) | 1995-08-03 |
| TW391880B (en) | 2000-06-01 |
| DK0745382T3 (da) | 2004-03-22 |
| PL187160B1 (pl) | 2004-05-31 |
| CN1182838C (zh) | 2005-01-05 |
| NO963180D0 (no) | 1996-07-30 |
| PH31467A (en) | 1998-11-03 |
| HUT74908A (en) | 1997-03-28 |
| EP0745382A4 (de) | 1997-10-29 |
| NZ278678A (en) | 1998-03-25 |
| FI963022L (fi) | 1996-07-31 |
| HU9602083D0 (en) | 1996-09-30 |
| PT745382E (pt) | 2004-04-30 |
| ES2210280T3 (es) | 2004-07-01 |
| MX9603035A (es) | 1997-05-31 |
| RU2147227C1 (ru) | 2000-04-10 |
| NO316662B1 (no) | 2004-03-22 |
| DE69532110T2 (de) | 2004-09-09 |
| DE69532110D1 (de) | 2003-12-18 |
| NO963180L (no) | 1996-09-30 |
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