ATE254136T1 - Interaktions-fullensysteme zum nachweis von protein-interaktionen - Google Patents

Interaktions-fullensysteme zum nachweis von protein-interaktionen

Info

Publication number
ATE254136T1
ATE254136T1 AT95928118T AT95928118T ATE254136T1 AT E254136 T1 ATE254136 T1 AT E254136T1 AT 95928118 T AT95928118 T AT 95928118T AT 95928118 T AT95928118 T AT 95928118T AT E254136 T1 ATE254136 T1 AT E254136T1
Authority
AT
Austria
Prior art keywords
protein
binding
interaction
gene
protein interactions
Prior art date
Application number
AT95928118T
Other languages
English (en)
Inventor
Roger Brent
John M Mccoy
Timm H Jessen
Chanxing Wilson Xu
Original Assignee
Gen Hospital Corp
Inst Genetics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp, Inst Genetics Llc filed Critical Gen Hospital Corp
Application granted granted Critical
Publication of ATE254136T1 publication Critical patent/ATE254136T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Vehicle Body Suspensions (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT95928118T 1994-07-20 1995-07-20 Interaktions-fullensysteme zum nachweis von protein-interaktionen ATE254136T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27808294A 1994-07-20 1994-07-20
PCT/US1995/009307 WO1996002561A1 (en) 1994-07-20 1995-07-20 Interaction trap systems for detecting protein interactions

Publications (1)

Publication Number Publication Date
ATE254136T1 true ATE254136T1 (de) 2003-11-15

Family

ID=23063609

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95928118T ATE254136T1 (de) 1994-07-20 1995-07-20 Interaktions-fullensysteme zum nachweis von protein-interaktionen

Country Status (8)

Country Link
US (3) US6004746A (de)
EP (2) EP0773952B1 (de)
JP (1) JP4064452B2 (de)
AT (1) ATE254136T1 (de)
DE (1) DE69532127T2 (de)
DK (1) DK0773952T3 (de)
ES (1) ES2210306T3 (de)
WO (1) WO1996002561A1 (de)

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Also Published As

Publication number Publication date
JP4064452B2 (ja) 2008-03-19
HK1012006A1 (en) 1999-07-23
EP0773952A4 (de) 2000-01-19
DK0773952T3 (da) 2004-03-22
US6242183B1 (en) 2001-06-05
ES2210306T3 (es) 2004-07-01
US6004746A (en) 1999-12-21
US20090130676A1 (en) 2009-05-21
DE69532127T2 (de) 2004-08-26
EP0773952A1 (de) 1997-05-21
DE69532127D1 (de) 2003-12-18
EP0773952B1 (de) 2003-11-12
JPH10504713A (ja) 1998-05-12
WO1996002561A1 (en) 1996-02-01
EP1405911A1 (de) 2004-04-07

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