DK0765389T3 - Cellesystemer havende specifik interaktion på peptide bindingspar - Google Patents

Cellesystemer havende specifik interaktion på peptide bindingspar

Info

Publication number
DK0765389T3
DK0765389T3 DK95920689T DK95920689T DK0765389T3 DK 0765389 T3 DK0765389 T3 DK 0765389T3 DK 95920689 T DK95920689 T DK 95920689T DK 95920689 T DK95920689 T DK 95920689T DK 0765389 T3 DK0765389 T3 DK 0765389T3
Authority
DK
Denmark
Prior art keywords
peptide
transcriptional activation
fusion protein
protein
host cell
Prior art date
Application number
DK95920689T
Other languages
English (en)
Inventor
Kathleen H Young
Bradley A Ozenberger
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of DK0765389T3 publication Critical patent/DK0765389T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Mobile Radio Communication Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK95920689T 1994-06-14 1995-05-31 Cellesystemer havende specifik interaktion på peptide bindingspar DK0765389T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/259,609 US5989808A (en) 1994-06-14 1994-06-14 Identification of compounds affecting specific interaction of peptide binding pairs
PCT/US1995/006895 WO1995034646A1 (en) 1994-06-14 1995-05-31 Novel cell systems having specific interaction of peptide binding pairs

Publications (1)

Publication Number Publication Date
DK0765389T3 true DK0765389T3 (da) 2003-10-27

Family

ID=22985626

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95920689T DK0765389T3 (da) 1994-06-14 1995-05-31 Cellesystemer havende specifik interaktion på peptide bindingspar

Country Status (18)

Country Link
US (3) US5989808A (da)
EP (1) EP0765389B1 (da)
AT (1) ATE245189T1 (da)
AU (1) AU706173B2 (da)
CA (1) CA2195083A1 (da)
DE (1) DE69531302T2 (da)
DK (1) DK0765389T3 (da)
ES (1) ES2202366T3 (da)
GE (1) GEP20022619B (da)
IL (1) IL114118A0 (da)
LT (1) LT4230B (da)
LV (1) LV11906B (da)
NZ (1) NZ287372A (da)
PT (1) PT765389E (da)
RU (1) RU2208646C2 (da)
SI (1) SI9520073B (da)
WO (1) WO1995034646A1 (da)
ZA (1) ZA954892B (da)

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US7226761B2 (en) * 1992-11-05 2007-06-05 Danisco Sweeteners Oy Manufacture of five-carbon sugars and sugar alcohols
US6891021B2 (en) 1993-02-12 2005-05-10 Board Of Trustees Of The Leland Stanford Junior University Regulated apoptosis
US6972193B1 (en) * 1993-02-12 2005-12-06 Board Of Trustees Of Leland Stanford Junior University Regulated transcription of targeted genes and other biological events
US6770446B1 (en) * 1994-06-14 2004-08-03 Wyeth Cell systems having specific interaction of peptide binding pairs
US5610015A (en) * 1995-03-23 1997-03-11 Wisconsin Alumni Research Foundation System to detect protein-RNA interactions
EP0830459B1 (en) * 1995-04-11 2007-01-24 The General Hospital Corporation Reverse two-hybrid systems
US5837844A (en) * 1995-06-07 1998-11-17 Biogen, Inc. CAIP-like gene family
US6171800B1 (en) 1995-06-07 2001-01-09 Biogen, Inc. Method of making and binding CAIP polypeptides
US6423824B1 (en) 1995-06-07 2002-07-23 Biogen, Inc. CAIP-like gene family
CA2252886C (en) * 1996-04-26 2008-02-12 Massachusetts Institute Of Technology Three-hybrid screening assay
EP1241265A3 (en) * 1996-04-26 2004-02-18 Massachusetts Institute Of Technology Screening assay for small ligands
US6696251B1 (en) 1996-05-31 2004-02-24 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
AU6342696A (en) * 1996-06-27 1998-01-14 Biogen, Inc. The caip-like gene family
FR2761697B1 (fr) * 1997-04-03 1999-05-28 Inst Nat Sante Rech Med Methodes de detection d'interactions entre plusieurs proteines
DE19715683C2 (de) * 1997-04-15 1999-11-11 Max Planck Gesellschaft Neue Reportervektoren für One-Hybrid und Two-Hybrid Systeme
US7005295B1 (en) 1997-04-16 2006-02-28 Wyeth β-amyloid peptide-binding proteins and polynucleotides encoding the same
US6787319B2 (en) 1997-04-16 2004-09-07 American Home Products Corp. β-amyloid peptide-binding proteins and polynucleotides encoding the same
DK0977846T3 (da) 1997-04-25 2002-10-14 Wyeth Corp Neuronale MORT1-isoformer
US6479653B1 (en) 1997-08-26 2002-11-12 Ariad Gene Therapeutics, Inc. Compositions and method for regulation of transcription
JP4296608B2 (ja) * 1997-08-27 2009-07-15 田辺三菱製薬株式会社 Ｐｐａｒのアゴニスト及びアンタゴニストのスクリーニング方法
US6846627B2 (en) 1997-10-15 2005-01-25 Diversa Corporation Screening for novel compounds which regulate biological interactions
EP1149920A1 (en) * 1997-10-15 2001-10-31 Diversa, Inc. Screening for novel compounds which regulate biological interactions
US6261842B1 (en) 1997-10-23 2001-07-17 Wisconsin Alumni Research Foundation Microorganism genomics, compositions and methods related thereto
JP2002502585A (ja) * 1997-11-14 2002-01-29 ロシュ ダイアグノスティックス コーポレイション 抗原存在下においてエフェクター複合体を形成する可変領域融合ペプチド
EP1053347B1 (en) 1998-01-09 2007-02-28 Phylogica Limited Peptide detection method
EP0974649A1 (en) * 1998-06-22 2000-01-26 Universität Zürich Screening system
US7166475B2 (en) 1999-02-26 2007-01-23 Cyclacel Ltd. Compositions and methods for monitoring the modification state of a pair of polypeptides
GB9907687D0 (en) * 1999-04-01 1999-05-26 Kudos Pharm Ltd Assays methods and means
NZ514710A (en) * 1999-04-21 2004-07-30 Wyeth Corp Methods of identifying compounds which affect binding between two key regulatory regions of voltage-gated sodium and potassium ion channels
JP2004527204A (ja) * 2000-04-24 2004-09-09 ワイエス ペプチド結合対の特異的相互作用を有する新規な細胞系
DE60143959D1 (de) 2000-08-25 2011-03-10 Basf Plant Science Gmbh En kodieren
US20020165149A1 (en) * 2000-12-08 2002-11-07 Kranz David M. Mutated class II major histocompatibility proteins
ES2609292T3 (es) 2002-08-21 2017-04-19 Revivicor, Inc. Animales porcinos que carecen de cualquier expresión de alfa 1,3 galactosiltransferasa funcional
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
JP4754219B2 (ja) 2002-12-02 2011-08-24 アムジエン・フレモント・インコーポレイテツド 腫瘍壊死因子を対象とする抗体、およびそれらの使用
US20070298414A1 (en) * 2003-11-17 2007-12-27 Doyle Donald F Engineering Enzymes Through Genetic Selection
EP1544307A1 (en) * 2003-12-18 2005-06-22 AXXAM S.r.l. LAC9 chimeric receptor and uses thereof
CN101031655A (zh) 2004-07-26 2007-09-05 陶氏环球技术公司 通过株工程改进蛋白表达的方法
AU2006292827B2 (en) 2005-08-09 2013-02-14 Revivicor, Inc. Transgenic ungulates expressing CTLA4-IG and uses thereof
CA2635906A1 (en) * 2006-02-07 2007-08-16 Wyeth Materials and methods for identifying agents that modulate norrin. norrin mimetics, and agents identified thereby
US9394571B2 (en) 2007-04-27 2016-07-19 Pfenex Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
CN101131363B (zh) * 2007-09-30 2010-12-01 南京大学 一种基于酵母三杂交的小分子化合物检测方法
WO2016154452A2 (en) 2015-03-24 2016-09-29 Osiris Therapeutics, Inc. Compositions comprising meniscal tissues and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283173A (en) * 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
US5322801A (en) * 1990-04-19 1994-06-21 The General Hospital Corporation Protein partner screening assays and uses thereof
JP3537141B2 (ja) * 1992-10-30 2004-06-14 ザ ゼネラル ホスピタル コーポレーション 新種蛋白質分離のための相互作用を用いる補捉システム
US5512473A (en) * 1993-01-29 1996-04-30 Brent; Roger Max-interacting proteins and related molecules and methods
US5582995A (en) * 1993-06-11 1996-12-10 The General Hospital Corporation Methods of screening for compounds which inhibit the direct binding of Ras to Raf
EP0737314A4 (en) * 1993-12-30 1999-11-03 Salk Inst For Biological Studi USES FOR GAL 4 RECEPTOR CONSTRUCTS
EP0690874B1 (en) * 1994-01-21 2000-03-22 Icos Corporation Materials and methods relating to proteins that interact with casein kinase i
US5525490A (en) * 1994-03-29 1996-06-11 Onyx Pharmaceuticals, Inc. Reverse two-hybrid method
US5691147A (en) * 1994-06-02 1997-11-25 Mitotix, Inc. CDK4 binding assay

Also Published As

Publication number Publication date
AU706173B2 (en) 1999-06-10
ATE245189T1 (de) 2003-08-15
PT765389E (pt) 2003-11-28
NZ287372A (en) 1997-11-24
LV11906B (en) 1998-06-20
GEP20022619B (en) 2002-01-25
AU2606695A (en) 1996-01-05
US5989808A (en) 1999-11-23
EP0765389A1 (en) 1997-04-02
ZA954892B (en) 1996-01-30
RU2208646C2 (ru) 2003-07-20
EP0765389B1 (en) 2003-07-16
DE69531302D1 (de) 2003-08-21
SI9520073A (sl) 1998-02-28
IL114118A0 (en) 1995-10-31
LT4230B (en) 1997-10-27
US6284519B1 (en) 2001-09-04
US6251602B1 (en) 2001-06-26
ES2202366T3 (es) 2004-04-01
WO1995034646A1 (en) 1995-12-21
DE69531302T2 (de) 2004-04-22
LT97004A (en) 1997-07-25
LV11906A (lv) 1997-12-20
CA2195083A1 (en) 1995-12-21
SI9520073B (sl) 2004-06-30

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