DK0765389T3 - Cellesystemer havende specifik interaktion på peptide bindingspar - Google Patents

Cellesystemer havende specifik interaktion på peptide bindingspar

Info

Publication number
DK0765389T3
DK0765389T3 DK95920689T DK95920689T DK0765389T3 DK 0765389 T3 DK0765389 T3 DK 0765389T3 DK 95920689 T DK95920689 T DK 95920689T DK 95920689 T DK95920689 T DK 95920689T DK 0765389 T3 DK0765389 T3 DK 0765389T3
Authority
DK
Denmark
Prior art keywords
peptide
transcriptional activation
fusion protein
protein
host cell
Prior art date
Application number
DK95920689T
Other languages
English (en)
Inventor
Kathleen H Young
Bradley A Ozenberger
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of DK0765389T3 publication Critical patent/DK0765389T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Mobile Radio Communication Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK95920689T 1994-06-14 1995-05-31 Cellesystemer havende specifik interaktion på peptide bindingspar DK0765389T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/259,609 US5989808A (en) 1994-06-14 1994-06-14 Identification of compounds affecting specific interaction of peptide binding pairs
PCT/US1995/006895 WO1995034646A1 (en) 1994-06-14 1995-05-31 Novel cell systems having specific interaction of peptide binding pairs

Publications (1)

Publication Number Publication Date
DK0765389T3 true DK0765389T3 (da) 2003-10-27

Family

ID=22985626

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95920689T DK0765389T3 (da) 1994-06-14 1995-05-31 Cellesystemer havende specifik interaktion på peptide bindingspar

Country Status (18)

Country Link
US (3) US5989808A (da)
EP (1) EP0765389B1 (da)
AT (1) ATE245189T1 (da)
AU (1) AU706173B2 (da)
CA (1) CA2195083A1 (da)
DE (1) DE69531302T2 (da)
DK (1) DK0765389T3 (da)
ES (1) ES2202366T3 (da)
GE (1) GEP20022619B (da)
IL (1) IL114118A0 (da)
LT (1) LT4230B (da)
LV (1) LV11906B (da)
NZ (1) NZ287372A (da)
PT (1) PT765389E (da)
RU (1) RU2208646C2 (da)
SI (1) SI9520073B (da)
WO (1) WO1995034646A1 (da)
ZA (1) ZA954892B (da)

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US7226761B2 (en) * 1992-11-05 2007-06-05 Danisco Sweeteners Oy Manufacture of five-carbon sugars and sugar alcohols
US6891021B2 (en) 1993-02-12 2005-05-10 Board Of Trustees Of The Leland Stanford Junior University Regulated apoptosis
US6972193B1 (en) * 1993-02-12 2005-12-06 Board Of Trustees Of Leland Stanford Junior University Regulated transcription of targeted genes and other biological events
US6770446B1 (en) * 1994-06-14 2004-08-03 Wyeth Cell systems having specific interaction of peptide binding pairs
US5610015A (en) * 1995-03-23 1997-03-11 Wisconsin Alumni Research Foundation System to detect protein-RNA interactions
NZ502795A (en) * 1995-04-11 2001-09-28 Gen Hospital Corp Method of identifying molecular interactions employing counterselection and at least two hybrid molecules or two hybrid systems
US6171800B1 (en) 1995-06-07 2001-01-09 Biogen, Inc. Method of making and binding CAIP polypeptides
US5837844A (en) * 1995-06-07 1998-11-17 Biogen, Inc. CAIP-like gene family
US6423824B1 (en) 1995-06-07 2002-07-23 Biogen, Inc. CAIP-like gene family
EP1241265A3 (en) * 1996-04-26 2004-02-18 Massachusetts Institute Of Technology Screening assay for small ligands
WO1997041255A1 (en) * 1996-04-26 1997-11-06 Massachusetts Institute Of Technology Three-hybrid screening assay
US6696251B1 (en) 1996-05-31 2004-02-24 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
WO1997049808A1 (en) * 1996-06-27 1997-12-31 Biogen, Inc. The caip-like gene family
FR2761697B1 (fr) * 1997-04-03 1999-05-28 Inst Nat Sante Rech Med Methodes de detection d'interactions entre plusieurs proteines
DE19715683C2 (de) * 1997-04-15 1999-11-11 Max Planck Gesellschaft Neue Reportervektoren für One-Hybrid und Two-Hybrid Systeme
US7005295B1 (en) 1997-04-16 2006-02-28 Wyeth β-amyloid peptide-binding proteins and polynucleotides encoding the same
US6787319B2 (en) 1997-04-16 2004-09-07 American Home Products Corp. β-amyloid peptide-binding proteins and polynucleotides encoding the same
ES2181197T3 (es) 1997-04-25 2003-02-16 Wyeth Corp Isoformas de mort1 neuronal.
US6479653B1 (en) 1997-08-26 2002-11-12 Ariad Gene Therapeutics, Inc. Compositions and method for regulation of transcription
JP4296608B2 (ja) * 1997-08-27 2009-07-15 田辺三菱製薬株式会社 Ｐｐａｒのアゴニスト及びアンタゴニストのスクリーニング方法
EP1149920A1 (en) * 1997-10-15 2001-10-31 Diversa, Inc. Screening for novel compounds which regulate biological interactions
AU1094699A (en) * 1997-10-15 1999-05-03 Diversa Corporation Screening for novel compounds which regulate biological interactions
US6261842B1 (en) 1997-10-23 2001-07-17 Wisconsin Alumni Research Foundation Microorganism genomics, compositions and methods related thereto
JP2002502585A (ja) * 1997-11-14 2002-01-29 ロシュ ダイアグノスティックス コーポレイション 抗原存在下においてエフェクター複合体を形成する可変領域融合ペプチド
DE69935313T2 (de) 1998-01-09 2007-11-15 Phylogica Ltd., Northbridge Nachweisverfahren für peptide
EP0974649A1 (en) * 1998-06-22 2000-01-26 Universität Zürich Screening system
US7166475B2 (en) 1999-02-26 2007-01-23 Cyclacel Ltd. Compositions and methods for monitoring the modification state of a pair of polypeptides
GB9907687D0 (en) * 1999-04-01 1999-05-26 Kudos Pharm Ltd Assays methods and means
EP1194756A4 (en) 1999-04-21 2004-12-29 Wyeth Corp METHODS OF IDENTIFYING N-TYPE ION CHANNEL INACTIVATION MODULATORS
MXPA02010446A (es) * 2000-04-24 2003-04-25 Wyeth Corp Sistemas celulares novedosos, con interaccion especifica de los pares que se unen a los peptidos.
CA2420325A1 (en) 2000-08-25 2002-02-28 Basf Plant Science Gmbh Plant polynucleotides encoding novel prenyl proteases
WO2002046400A2 (en) * 2000-12-08 2002-06-13 The Board Of Trustees Of The University Of Illinois Mutated class ii major histocompatibility proteins
ES2338111T3 (es) 2002-08-21 2010-05-04 Revivicor, Inc. Animales porcinos que carecen de cualquier expresion de alfa 1,3 galactosiltransferasa funcional.
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
ATE472556T1 (de) 2002-12-02 2010-07-15 Amgen Fremont Inc Gegen den tumor nekrose faktor gerichtete antikörper und deren verwendungen
US20070298414A1 (en) * 2003-11-17 2007-12-27 Doyle Donald F Engineering Enzymes Through Genetic Selection
EP1544307A1 (en) * 2003-12-18 2005-06-22 AXXAM S.r.l. LAC9 chimeric receptor and uses thereof
EP1774017B1 (en) 2004-07-26 2013-05-15 Pfenex Inc. Process for improved protein expression by strain engineering
US20090186097A1 (en) 2005-08-09 2009-07-23 David Lee Ayares Transgenic Ungulates Expressing CTLA4-IG and Uses Thereof
BRPI0707514A2 (pt) * 2006-02-07 2011-05-10 Wyeth Corp mÉtodo de identificaÇço de um agente que module ossos ou um lipÍdio; mÉtodo de identificaÇço de um agente que module a atividade de norrin-frizzled4; kit para identificar um agente que module a atividade de lrp5-norrin-frizzled4; cÉlula ou linhagem celular desprovida de norrin nativo e que expresse uma lrp5 nço nativa e uma frizzled4 nço nativa
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
US9394571B2 (en) 2007-04-27 2016-07-19 Pfenex Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
CN101131363B (zh) * 2007-09-30 2010-12-01 南京大学 一种基于酵母三杂交的小分子化合物检测方法
US10603174B2 (en) 2015-03-24 2020-03-31 Osiris Therapeutics, Inc. Compositions comprising meniscal tissues and uses thereof

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Publication number Priority date Publication date Assignee Title
US5283173A (en) * 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
US5322801A (en) * 1990-04-19 1994-06-21 The General Hospital Corporation Protein partner screening assays and uses thereof
CA2148252C (en) * 1992-10-30 2007-06-12 Roger Brent Interaction trap system for isolating novel proteins
US5512473A (en) * 1993-01-29 1996-04-30 Brent; Roger Max-interacting proteins and related molecules and methods
US5582995A (en) * 1993-06-11 1996-12-10 The General Hospital Corporation Methods of screening for compounds which inhibit the direct binding of Ras to Raf
JPH09504111A (ja) * 1993-12-30 1997-04-22 ザ ソールク インスチチュート フォア バイオロジカル スタディズ Ｇａｌ４−受容体構築体の新規な使用
ES2146749T3 (es) * 1994-01-21 2000-08-16 Icos Corp Materiales y metodos en relacion con proteinas que interaccionan con la caseina quinasa i.
US5525490A (en) * 1994-03-29 1996-06-11 Onyx Pharmaceuticals, Inc. Reverse two-hybrid method
US5691147A (en) * 1994-06-02 1997-11-25 Mitotix, Inc. CDK4 binding assay

Also Published As

Publication number Publication date
WO1995034646A1 (en) 1995-12-21
LT97004A (en) 1997-07-25
ATE245189T1 (de) 2003-08-15
RU2208646C2 (ru) 2003-07-20
AU706173B2 (en) 1999-06-10
LV11906A (lv) 1997-12-20
SI9520073B (sl) 2004-06-30
LT4230B (en) 1997-10-27
ZA954892B (en) 1996-01-30
IL114118A0 (en) 1995-10-31
ES2202366T3 (es) 2004-04-01
US5989808A (en) 1999-11-23
EP0765389B1 (en) 2003-07-16
GEP20022619B (en) 2002-01-25
DE69531302T2 (de) 2004-04-22
US6251602B1 (en) 2001-06-26
LV11906B (en) 1998-06-20
SI9520073A (sl) 1998-02-28
US6284519B1 (en) 2001-09-04
PT765389E (pt) 2003-11-28
AU2606695A (en) 1996-01-05
DE69531302D1 (de) 2003-08-21
NZ287372A (en) 1997-11-24
EP0765389A1 (en) 1997-04-02
CA2195083A1 (en) 1995-12-21

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