ATE255122T1 - Verfahren zur herstellung von indolopyrrolocarbazol-derivaten, deren zwischenprodukte sowie verfahren zur herstellung der zwischenprodukte - Google Patents

Verfahren zur herstellung von indolopyrrolocarbazol-derivaten, deren zwischenprodukte sowie verfahren zur herstellung der zwischenprodukte

Info

Publication number
ATE255122T1
ATE255122T1 AT01906200T AT01906200T ATE255122T1 AT E255122 T1 ATE255122 T1 AT E255122T1 AT 01906200 T AT01906200 T AT 01906200T AT 01906200 T AT01906200 T AT 01906200T AT E255122 T1 ATE255122 T1 AT E255122T1
Authority
AT
Austria
Prior art keywords
compound
group
producing
preparation
intermediate products
Prior art date
Application number
AT01906200T
Other languages
English (en)
Inventor
Shouichi Hiraga
Masashi Kawasaki
Atsushi Akao
Asayuki Kamatani
Masayuki Hagiwara
Fumio Nakano
Toshiaki Mase
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Application granted granted Critical
Publication of ATE255122T1 publication Critical patent/ATE255122T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT01906200T 2000-02-24 2001-02-22 Verfahren zur herstellung von indolopyrrolocarbazol-derivaten, deren zwischenprodukte sowie verfahren zur herstellung der zwischenprodukte ATE255122T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000048140 2000-02-24
PCT/JP2001/001289 WO2001062769A1 (fr) 2000-02-24 2001-02-22 Procede de preparation de derives d'indolopyrrolocarbazole, leurs intermediaires, et procede de preparation des intermediaires

Publications (1)

Publication Number Publication Date
ATE255122T1 true ATE255122T1 (de) 2003-12-15

Family

ID=18570268

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01906200T ATE255122T1 (de) 2000-02-24 2001-02-22 Verfahren zur herstellung von indolopyrrolocarbazol-derivaten, deren zwischenprodukte sowie verfahren zur herstellung der zwischenprodukte

Country Status (13)

Country Link
US (1) US6790836B2 (de)
EP (1) EP1258490B1 (de)
JP (1) JP3388489B2 (de)
CN (1) CN1185247C (de)
AT (1) ATE255122T1 (de)
AU (1) AU2001234119A1 (de)
CA (1) CA2399209C (de)
DE (1) DE60101312T2 (de)
DK (1) DK1258490T3 (de)
ES (1) ES2210127T3 (de)
PT (1) PT1258490E (de)
TR (1) TR200302314T4 (de)
WO (1) WO2001062769A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050058444A (ko) * 2002-08-23 2005-06-16 반유 세이야꾸 가부시끼가이샤 인돌로피롤로카르바졸 유도체의 제조법
AU2003248104A1 (en) * 2003-07-24 2005-02-14 Banyu Pharmaceutical Co., Ltd. Crystalline 6-n-pyridylmethylaminoindolocarbazoles
US20060189800A1 (en) * 2003-07-24 2006-08-24 Mitsuru Ohkubo Indolopyrrolocabazole derivative and antitumor agent
WO2005116044A1 (ja) * 2004-05-28 2005-12-08 Banyu Pharmaceutical Co.,Ltd インドロピロロカルバゾール誘導体の製造法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591842A (en) 1991-11-29 1997-01-07 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
US5668271A (en) 1991-11-29 1997-09-16 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
NZ245203A (en) 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
US5804564A (en) 1994-05-09 1998-09-08 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
WO1995030682A1 (en) 1994-05-09 1995-11-16 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyprolocarbazole derivative
US5922860A (en) 1994-05-09 1999-07-13 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
AU3086495A (en) * 1994-08-02 1996-03-04 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazoles
AU6836696A (en) 1995-09-05 1997-03-27 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
JP3536574B2 (ja) 1997-02-28 2004-06-14 萬有製薬株式会社 抗腫瘍性インドロピロロカルバゾール誘導体
ATE315335T1 (de) 2000-10-31 2006-02-15 Advanced Life Sciences Inc Indolocarbazol-antikrebsmittel und verfahren zu ihrer verwendung

Also Published As

Publication number Publication date
DE60101312D1 (de) 2004-01-08
DK1258490T3 (da) 2004-04-05
EP1258490B1 (de) 2003-11-26
TR200302314T4 (tr) 2004-01-21
CN1185247C (zh) 2005-01-19
US20030060621A1 (en) 2003-03-27
AU2001234119A1 (en) 2001-09-03
DE60101312T2 (de) 2004-08-26
EP1258490A4 (de) 2003-04-02
PT1258490E (pt) 2004-04-30
ES2210127T3 (es) 2004-07-01
CA2399209C (en) 2009-07-28
US6790836B2 (en) 2004-09-14
JP3388489B2 (ja) 2003-03-24
CA2399209A1 (en) 2001-08-30
EP1258490A1 (de) 2002-11-20
WO2001062769A1 (fr) 2001-08-30
CN1400976A (zh) 2003-03-05

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