DK1258490T3 - Fremgangsmåde til fremstilling af indolopyrrolocarbazol, mellemprodukter dertil og fremgangsmåde til fremstillingen af mellemprodukterne - Google Patents

Fremgangsmåde til fremstilling af indolopyrrolocarbazol, mellemprodukter dertil og fremgangsmåde til fremstillingen af mellemprodukterne

Info

Publication number
DK1258490T3
DK1258490T3 DK01906200T DK01906200T DK1258490T3 DK 1258490 T3 DK1258490 T3 DK 1258490T3 DK 01906200 T DK01906200 T DK 01906200T DK 01906200 T DK01906200 T DK 01906200T DK 1258490 T3 DK1258490 T3 DK 1258490T3
Authority
DK
Denmark
Prior art keywords
compound
preparation
group
äivü
äiiü
Prior art date
Application number
DK01906200T
Other languages
English (en)
Inventor
Shouichi Hiraga
Masashi Kawasaki
Atsushi Akao
Asayuki Kamatani
Masayuki Hagiwara
Fumio Nakano
Toshiaki Mase
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Application granted granted Critical
Publication of DK1258490T3 publication Critical patent/DK1258490T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK01906200T 2000-02-24 2001-02-22 Fremgangsmåde til fremstilling af indolopyrrolocarbazol, mellemprodukter dertil og fremgangsmåde til fremstillingen af mellemprodukterne DK1258490T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000048140 2000-02-24
PCT/JP2001/001289 WO2001062769A1 (fr) 2000-02-24 2001-02-22 Procede de preparation de derives d'indolopyrrolocarbazole, leurs intermediaires, et procede de preparation des intermediaires

Publications (1)

Publication Number Publication Date
DK1258490T3 true DK1258490T3 (da) 2004-04-05

Family

ID=18570268

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01906200T DK1258490T3 (da) 2000-02-24 2001-02-22 Fremgangsmåde til fremstilling af indolopyrrolocarbazol, mellemprodukter dertil og fremgangsmåde til fremstillingen af mellemprodukterne

Country Status (13)

Country Link
US (1) US6790836B2 (da)
EP (1) EP1258490B1 (da)
JP (1) JP3388489B2 (da)
CN (1) CN1185247C (da)
AT (1) ATE255122T1 (da)
AU (1) AU2001234119A1 (da)
CA (1) CA2399209C (da)
DE (1) DE60101312T2 (da)
DK (1) DK1258490T3 (da)
ES (1) ES2210127T3 (da)
PT (1) PT1258490E (da)
TR (1) TR200302314T4 (da)
WO (1) WO2001062769A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050058444A (ko) * 2002-08-23 2005-06-16 반유 세이야꾸 가부시끼가이샤 인돌로피롤로카르바졸 유도체의 제조법
AU2003248104A1 (en) * 2003-07-24 2005-02-14 Banyu Pharmaceutical Co., Ltd. Crystalline 6-n-pyridylmethylaminoindolocarbazoles
US20060189800A1 (en) * 2003-07-24 2006-08-24 Mitsuru Ohkubo Indolopyrrolocabazole derivative and antitumor agent
WO2005116044A1 (ja) * 2004-05-28 2005-12-08 Banyu Pharmaceutical Co.,Ltd インドロピロロカルバゾール誘導体の製造法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591842A (en) 1991-11-29 1997-01-07 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
US5668271A (en) 1991-11-29 1997-09-16 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
NZ245203A (en) 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
US5804564A (en) 1994-05-09 1998-09-08 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
WO1995030682A1 (en) 1994-05-09 1995-11-16 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyprolocarbazole derivative
US5922860A (en) 1994-05-09 1999-07-13 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
AU3086495A (en) * 1994-08-02 1996-03-04 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazoles
AU6836696A (en) 1995-09-05 1997-03-27 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
JP3536574B2 (ja) 1997-02-28 2004-06-14 萬有製薬株式会社 抗腫瘍性インドロピロロカルバゾール誘導体
ATE315335T1 (de) 2000-10-31 2006-02-15 Advanced Life Sciences Inc Indolocarbazol-antikrebsmittel und verfahren zu ihrer verwendung

Also Published As

Publication number Publication date
DE60101312D1 (de) 2004-01-08
EP1258490B1 (en) 2003-11-26
TR200302314T4 (tr) 2004-01-21
CN1185247C (zh) 2005-01-19
US20030060621A1 (en) 2003-03-27
AU2001234119A1 (en) 2001-09-03
DE60101312T2 (de) 2004-08-26
EP1258490A4 (en) 2003-04-02
PT1258490E (pt) 2004-04-30
ES2210127T3 (es) 2004-07-01
CA2399209C (en) 2009-07-28
US6790836B2 (en) 2004-09-14
JP3388489B2 (ja) 2003-03-24
ATE255122T1 (de) 2003-12-15
CA2399209A1 (en) 2001-08-30
EP1258490A1 (en) 2002-11-20
WO2001062769A1 (fr) 2001-08-30
CN1400976A (zh) 2003-03-05

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