ES2113879T3 - Analogos de glp-1 utiles para el tratamiento de diabetes. - Google Patents

Analogos de glp-1 utiles para el tratamiento de diabetes.

Info

Publication number
ES2113879T3
ES2113879T3 ES91903738T ES91903738T ES2113879T3 ES 2113879 T3 ES2113879 T3 ES 2113879T3 ES 91903738 T ES91903738 T ES 91903738T ES 91903738 T ES91903738 T ES 91903738T ES 2113879 T3 ES2113879 T3 ES 2113879T3
Authority
ES
Spain
Prior art keywords
analogs
glp
amino acid
acid substitutions
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91903738T
Other languages
English (en)
Inventor
Douglas I Buckley
Joel F Habener
Joanne B Mallory
Svetlana Mojsov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2113879T3 publication Critical patent/ES2113879T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

LA INVENCION SE REFIERE A ANALOGOS EFECTIVOS DE LOS PEPTIDOS ACTIVOS GLP EN UNAS CARACTERISTICAS MEJORADAS PARA EL TRATAMIENTO DE LA DIABETES DE TIPO II. ESTOS ANALOGOS TIENEN SUBSTITUCIONES DEL ACIDO AMINO EN LAS POSICIONES 7 TERMINAL C Y / O CONTIENEN VARIAS OTRAS SUBSTITUCIONES DEL ACIDO AMINO EN EL PEPTIDO BASICO. LOS ANALOGOS PUEDEN TENER TANTO UNA CAPACIDAD MEJORADA PARA ESTIMULAR LA PRODUCCION DE INSULINA EN COMPARACION CON EL GLUCAGON COMO PUEDEN EXHIBIR UNA ESTABILIDAD MEJORADA EN EL PLASMA EN COMPARACION CON EL GLP 37). NINGUNA DE ESAS PROPIEDADES MEJORARA LA POTENCIA DEL ANALOGO COMO TERAPEUTICO. LOS ANALOGOS QUE TIENEN SUBSTITUCIONES DEL ACIDO AMINO D EN LAS POSICIONES 7 Y 8 Y / O ACIDOS AMINO N TE RESISTENTES A LA DEGRADACION "IN VIVO".
ES91903738T 1990-01-24 1991-01-24 Analogos de glp-1 utiles para el tratamiento de diabetes. Expired - Lifetime ES2113879T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46873690A 1990-01-24 1990-01-24
PCT/US1991/000500 WO1991011457A1 (en) 1990-01-24 1991-01-24 Glp-1 analogs useful for diabetes treatment

Publications (1)

Publication Number Publication Date
ES2113879T3 true ES2113879T3 (es) 1998-05-16

Family

ID=23861028

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91903738T Expired - Lifetime ES2113879T3 (es) 1990-01-24 1991-01-24 Analogos de glp-1 utiles para el tratamiento de diabetes.

Country Status (8)

Country Link
EP (1) EP0512042B1 (es)
JP (5) JP3262329B2 (es)
AT (1) ATE164852T1 (es)
CA (1) CA2073856C (es)
DE (1) DE69129226T2 (es)
DK (1) DK0512042T3 (es)
ES (1) ES2113879T3 (es)
WO (1) WO1991011457A1 (es)

Families Citing this family (241)

* Cited by examiner, † Cited by third party
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