ATE256112T1 - Verfahren zur herstellung von 1-(6-methylpyridin- 3-yl)-2-((4-(methylsulfonyl)phenyl) ethanon - Google Patents
Verfahren zur herstellung von 1-(6-methylpyridin- 3-yl)-2-((4-(methylsulfonyl)phenyl) ethanonInfo
- Publication number
- ATE256112T1 ATE256112T1 AT00951393T AT00951393T ATE256112T1 AT E256112 T1 ATE256112 T1 AT E256112T1 AT 00951393 T AT00951393 T AT 00951393T AT 00951393 T AT00951393 T AT 00951393T AT E256112 T1 ATE256112 T1 AT E256112T1
- Authority
- AT
- Austria
- Prior art keywords
- methylthio
- phenyl
- pyridine
- methyl
- give
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- BSKHPKMHTQYZBB-UHFFFAOYSA-N 2-methylpyridine Chemical compound CC1=CC=CC=N1 BSKHPKMHTQYZBB-UHFFFAOYSA-N 0.000 abstract 3
- VWVZFHRDLPHBEG-UHFFFAOYSA-N 1-(chloromethyl)-4-methylsulfanylbenzene Chemical compound CSC1=CC=C(CCl)C=C1 VWVZFHRDLPHBEG-UHFFFAOYSA-N 0.000 abstract 2
- BBPATOFBGJZMJM-UHFFFAOYSA-N 2-(4-methylsulfanylphenyl)acetonitrile Chemical compound CSC1=CC=C(CC#N)C=C1 BBPATOFBGJZMJM-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- MTXQKSQYMREAGJ-UHFFFAOYSA-N (4-methylsulfanylphenyl)methanol Chemical compound CSC1=CC=C(CO)C=C1 MTXQKSQYMREAGJ-UHFFFAOYSA-N 0.000 abstract 1
- QCTITLPDUACHDS-UHFFFAOYSA-N 1-(6-methylpyridin-3-yl)-2-(4-methylsulfanylphenyl)ethanone Chemical compound C1=CC(SC)=CC=C1CC(=O)C1=CC=C(C)N=C1 QCTITLPDUACHDS-UHFFFAOYSA-N 0.000 abstract 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal cyanide Chemical class 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 229940111134 coxibs Drugs 0.000 abstract 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99114667 | 1999-07-27 | ||
| US18668000P | 2000-03-03 | 2000-03-03 | |
| PCT/EP2000/006825 WO2001007410A1 (en) | 1999-07-27 | 2000-07-17 | Process for preparing 1-(6-methylpyridin-3-yl)-2-[(4-(methylsulphonyl) phenyl] ethanone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE256112T1 true ATE256112T1 (de) | 2003-12-15 |
Family
ID=44693678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00951393T ATE256112T1 (de) | 1999-07-27 | 2000-07-17 | Verfahren zur herstellung von 1-(6-methylpyridin- 3-yl)-2-((4-(methylsulfonyl)phenyl) ethanon |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1198455B1 (de) |
| JP (1) | JP4773013B2 (de) |
| AT (1) | ATE256112T1 (de) |
| AU (1) | AU6435000A (de) |
| DE (1) | DE60007133T2 (de) |
| DK (1) | DK1198455T3 (de) |
| ES (1) | ES2207536T3 (de) |
| WO (1) | WO2001007410A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1315244B1 (it) * | 1999-10-15 | 2003-02-03 | Zambon Spa | Processo per la preparazione di intermedi utili nella sintesi didiarilpiridine |
| CN100402503C (zh) | 2003-03-28 | 2008-07-16 | 日产化学工业株式会社 | 丙烯腈化合物的制造方法 |
| ITMI20110362A1 (it) * | 2011-03-09 | 2012-09-10 | F I S Fabbrica Italiana Sint P A | Procedimento per la preparazione di 1-(6-metilpiridin-3-il)-2-[4-(metilsolfonil)fenil]etanone, un intermedio dell'etoricoxib. |
| ITMI20111455A1 (it) | 2011-07-29 | 2013-01-30 | Italiana Sint Spa | Nuovo procedimento per la preparazione di 1-(6-metilpiridin-3-il)-2-[4-(metilsolfonil)fenil]etanone, un intermedio dell'etoricoxib. |
| ITMI20120394A1 (it) | 2012-03-14 | 2013-09-15 | Zach System Spa | Processo di sintesi di un chetosolfone derivato |
| ITMI20121947A1 (it) * | 2012-11-15 | 2014-05-16 | Erregierre Spa | Processo di sintesi di un intermedio nella produzione di etoricoxib |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3717647A (en) * | 1971-04-09 | 1973-02-20 | Schering Corp | Alpha-nicotinoyl phenylacetonitriles |
| SE7600674L (sv) * | 1975-02-05 | 1976-08-06 | Rohm & Haas | Fungicider |
| US4115578A (en) * | 1975-12-18 | 1978-09-19 | Rohm And Haas Company | 1-Substituted aralkyl imidazoles |
| ZA821968B (en) * | 1981-03-30 | 1983-01-26 | Hoffmann La Roche | Pyridine derivatives |
| EP0062238B1 (de) * | 1981-03-30 | 1985-01-30 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | 1,3-Dioxolan-Derivate, Herstellung dieser Verbindungen, fungizide Mittel, die diese Verbindungen als Wirkstoffe enthalten sowie Verwendung solcher Verbindungen bzw. Mittel zur Bekämpfung von Fungi in der Landwirtschaft und im Gartenbau |
| TW492959B (en) * | 1997-04-18 | 2002-07-01 | Merck & Co Inc | Process for making 2-aryl-3-aryl-5-halo pyridines useful as cox-2 inhibitors |
| AR015938A1 (es) * | 1997-09-25 | 2001-05-30 | Merck Sharp & Dohme | Procedimiento para preparar diaril piridinas utiles como inhibidores cox-2 y compuesto intermediario |
-
2000
- 2000-07-17 ES ES00951393T patent/ES2207536T3/es not_active Expired - Lifetime
- 2000-07-17 AT AT00951393T patent/ATE256112T1/de active
- 2000-07-17 AU AU64350/00A patent/AU6435000A/en not_active Abandoned
- 2000-07-17 WO PCT/EP2000/006825 patent/WO2001007410A1/en not_active Ceased
- 2000-07-17 JP JP2001512497A patent/JP4773013B2/ja not_active Expired - Fee Related
- 2000-07-17 DE DE60007133T patent/DE60007133T2/de not_active Expired - Lifetime
- 2000-07-17 DK DK00951393T patent/DK1198455T3/da active
- 2000-07-17 EP EP00951393A patent/EP1198455B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60007133D1 (de) | 2004-01-22 |
| EP1198455A1 (de) | 2002-04-24 |
| AU6435000A (en) | 2001-02-13 |
| JP4773013B2 (ja) | 2011-09-14 |
| DE60007133T2 (de) | 2004-09-09 |
| EP1198455B1 (de) | 2003-12-10 |
| WO2001007410A1 (en) | 2001-02-01 |
| DK1198455T3 (da) | 2004-04-05 |
| JP2003505449A (ja) | 2003-02-12 |
| ES2207536T3 (es) | 2004-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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