ATE315565T1 - Prozess zur herstellung von 4- (8-chloro-5, 6- dihydro-11h-benzo-(5,6)-cyclohepta-(1,2-b)- pyridin-11-ylidene)-1- piperidinecarbonsäureethylester (loratadine) - Google Patents
Prozess zur herstellung von 4- (8-chloro-5, 6- dihydro-11h-benzo-(5,6)-cyclohepta-(1,2-b)- pyridin-11-ylidene)-1- piperidinecarbonsäureethylester (loratadine)Info
- Publication number
- ATE315565T1 ATE315565T1 AT02774756T AT02774756T ATE315565T1 AT E315565 T1 ATE315565 T1 AT E315565T1 AT 02774756 T AT02774756 T AT 02774756T AT 02774756 T AT02774756 T AT 02774756T AT E315565 T1 ATE315565 T1 AT E315565T1
- Authority
- AT
- Austria
- Prior art keywords
- chloro
- loratadine
- dihydro
- pyridine
- benzo
- Prior art date
Links
- JCCNYMKQOSZNPW-UHFFFAOYSA-N loratadine Chemical compound C1CN(C(=O)OCC)CCC1=C1C2=NC=CC=C2CCC2=CC(Cl)=CC=C21 JCCNYMKQOSZNPW-UHFFFAOYSA-N 0.000 title abstract 4
- 229960003088 loratadine Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical class CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- XCQHILUUHXSTOX-UHFFFAOYSA-N 4,4-dimethyl-2-(3-methylpyridin-2-yl)-5h-1,3-oxazole Chemical compound CC1=CC=CN=C1C1=NC(C)(C)CO1 XCQHILUUHXSTOX-UHFFFAOYSA-N 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- DDGRAFHHXYIQQR-UHFFFAOYSA-N 1-chloro-3-(chloromethyl)benzene Chemical compound ClCC1=CC=CC(Cl)=C1 DDGRAFHHXYIQQR-UHFFFAOYSA-N 0.000 abstract 1
- MYGXGCCFTPKWIH-UHFFFAOYSA-N 4-chloro-1-methylpiperidine Chemical compound CN1CCC(Cl)CC1 MYGXGCCFTPKWIH-UHFFFAOYSA-N 0.000 abstract 1
- 239000007818 Grignard reagent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000004795 grignard reagents Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001MI002308A ITMI20012308A1 (it) | 2001-11-05 | 2001-11-05 | Processo per la preparazione dell'estere etilico dell'acido 4-(8-cloro-5,6-diidro-11h-benzo-5,67-cicloepta-1,2-b-piridin-11-ilidene)-1-piper |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE315565T1 true ATE315565T1 (de) | 2006-02-15 |
Family
ID=11448567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02774756T ATE315565T1 (de) | 2001-11-05 | 2002-10-29 | Prozess zur herstellung von 4- (8-chloro-5, 6- dihydro-11h-benzo-(5,6)-cyclohepta-(1,2-b)- pyridin-11-ylidene)-1- piperidinecarbonsäureethylester (loratadine) |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7449583B2 (de) |
| EP (1) | EP1442035B1 (de) |
| JP (1) | JP4307262B2 (de) |
| CN (1) | CN100366620C (de) |
| AT (1) | ATE315565T1 (de) |
| AU (1) | AU2002340487B2 (de) |
| BR (1) | BR0213909A (de) |
| CA (1) | CA2465686C (de) |
| DE (1) | DE60208703T8 (de) |
| EA (1) | EA007740B1 (de) |
| ES (1) | ES2256543T3 (de) |
| HU (1) | HUP0402390A3 (de) |
| IL (1) | IL161734A0 (de) |
| IT (1) | ITMI20012308A1 (de) |
| MX (1) | MXPA04004255A (de) |
| NO (1) | NO326489B1 (de) |
| NZ (1) | NZ533287A (de) |
| WO (1) | WO2003040140A1 (de) |
| ZA (1) | ZA200404262B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20012308A1 (it) * | 2001-11-05 | 2003-05-05 | Zambon Spa | Processo per la preparazione dell'estere etilico dell'acido 4-(8-cloro-5,6-diidro-11h-benzo-5,67-cicloepta-1,2-b-piridin-11-ilidene)-1-piper |
| WO2015084693A2 (en) * | 2013-12-05 | 2015-06-11 | Merck Sharp & Dohme Corp. | New process for preparing loratadine from a ketone intermediate |
| CN109897027B (zh) * | 2019-04-28 | 2021-11-02 | 梯尔希（南京）药物研发有限公司 | 一种3-羟基地氯雷他定代谢物的合成方法 |
| CN113135893B (zh) * | 2021-06-21 | 2022-02-11 | 北京鑫开元医药科技有限公司 | 苯并环庚烷并吡啶化合物、其制备方法及其用途 |
| CN115778924A (zh) * | 2022-12-22 | 2023-03-14 | 河北三禾实创生物科技有限公司 | 一种氯雷他定制剂及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4731447A (en) * | 1985-05-13 | 1988-03-15 | Schering Corporation | Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof |
| WO1996006096A1 (en) * | 1994-08-23 | 1996-02-29 | Nissan Chemical Industries, Ltd. | Pyridine derivative |
| WO2000005215A1 (en) * | 1998-07-24 | 2000-02-03 | Russinsky Limited | A process for preparing benzocycloheptapyridin-11-ones |
| AR021715A1 (es) * | 1998-12-18 | 2002-07-31 | Schering Corp | Proceso para preparar compuestos triciclicos que tienen actividad antihistaminica e intermediarios. |
| ITMI20012308A1 (it) * | 2001-11-05 | 2003-05-05 | Zambon Spa | Processo per la preparazione dell'estere etilico dell'acido 4-(8-cloro-5,6-diidro-11h-benzo-5,67-cicloepta-1,2-b-piridin-11-ilidene)-1-piper |
-
2001
- 2001-11-05 IT IT2001MI002308A patent/ITMI20012308A1/it unknown
-
2002
- 2002-10-29 HU HU0402390A patent/HUP0402390A3/hu unknown
- 2002-10-29 EA EA200400642A patent/EA007740B1/ru not_active IP Right Cessation
- 2002-10-29 NZ NZ533287A patent/NZ533287A/en not_active IP Right Cessation
- 2002-10-29 MX MXPA04004255A patent/MXPA04004255A/es active IP Right Grant
- 2002-10-29 CA CA2465686A patent/CA2465686C/en not_active Expired - Fee Related
- 2002-10-29 CN CNB028243463A patent/CN100366620C/zh not_active Expired - Fee Related
- 2002-10-29 US US10/493,314 patent/US7449583B2/en not_active Expired - Fee Related
- 2002-10-29 IL IL16173402A patent/IL161734A0/xx not_active IP Right Cessation
- 2002-10-29 BR BR0213909-0A patent/BR0213909A/pt not_active Application Discontinuation
- 2002-10-29 AT AT02774756T patent/ATE315565T1/de not_active IP Right Cessation
- 2002-10-29 DE DE60208703T patent/DE60208703T8/de active Active
- 2002-10-29 EP EP02774756A patent/EP1442035B1/de not_active Expired - Lifetime
- 2002-10-29 AU AU2002340487A patent/AU2002340487B2/en not_active Ceased
- 2002-10-29 JP JP2003542186A patent/JP4307262B2/ja not_active Expired - Fee Related
- 2002-10-29 ES ES02774756T patent/ES2256543T3/es not_active Expired - Lifetime
- 2002-10-29 WO PCT/EP2002/012056 patent/WO2003040140A1/en not_active Ceased
-
2004
- 2004-05-31 ZA ZA200404262A patent/ZA200404262B/en unknown
- 2004-06-04 NO NO20042297A patent/NO326489B1/no not_active IP Right Cessation
-
2008
- 2008-09-09 US US12/207,170 patent/US20090005567A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200404262B (en) | 2005-08-11 |
| JP4307262B2 (ja) | 2009-08-05 |
| US7449583B2 (en) | 2008-11-11 |
| EP1442035B1 (de) | 2006-01-11 |
| DE60208703T2 (de) | 2006-10-19 |
| CA2465686A1 (en) | 2003-05-15 |
| HUP0402390A3 (en) | 2011-03-28 |
| DE60208703T8 (de) | 2007-05-03 |
| US20090005567A1 (en) | 2009-01-01 |
| EP1442035A1 (de) | 2004-08-04 |
| EA200400642A1 (ru) | 2004-12-30 |
| CN1599736A (zh) | 2005-03-23 |
| JP2005513005A (ja) | 2005-05-12 |
| BR0213909A (pt) | 2004-08-31 |
| IL161734A0 (en) | 2005-11-20 |
| EA007740B1 (ru) | 2006-12-29 |
| NO20042297L (no) | 2004-06-04 |
| ES2256543T3 (es) | 2006-07-16 |
| US20050171352A1 (en) | 2005-08-04 |
| CA2465686C (en) | 2010-03-23 |
| MXPA04004255A (es) | 2005-03-31 |
| AU2002340487B2 (en) | 2007-12-13 |
| HUP0402390A2 (en) | 2006-02-28 |
| CN100366620C (zh) | 2008-02-06 |
| NO326489B1 (no) | 2008-12-15 |
| WO2003040140A1 (en) | 2003-05-15 |
| NZ533287A (en) | 2005-08-26 |
| ITMI20012308A1 (it) | 2003-05-05 |
| DE60208703D1 (de) | 2006-04-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |