ATE256142T1 - Bibliotheken von unterschiedlich markierten oligomeren - Google Patents
Bibliotheken von unterschiedlich markierten oligomerenInfo
- Publication number
- ATE256142T1 ATE256142T1 AT99922334T AT99922334T ATE256142T1 AT E256142 T1 ATE256142 T1 AT E256142T1 AT 99922334 T AT99922334 T AT 99922334T AT 99922334 T AT99922334 T AT 99922334T AT E256142 T1 ATE256142 T1 AT E256142T1
- Authority
- AT
- Austria
- Prior art keywords
- support
- lot
- labels
- libraries
- lots
- Prior art date
Links
- 238000004458 analytical method Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000004949 mass spectrometry Methods 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- -1 trimethylphenyl Chemical group 0.000 abstract 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6872—Methods for sequencing involving mass spectrometry
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B20/00—Methods specially adapted for identifying library members
- C40B20/04—Identifying library members by means of a tag, label, or other readable or detectable entity associated with the library members, e.g. decoding processes
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
- C40B50/10—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support involving encoding steps
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
- C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/10—Apparatus specially adapted for use in combinatorial chemistry or with libraries for identifying library members
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/10—Methods of screening libraries by measuring physical properties, e.g. mass
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Structural Engineering (AREA)
- Zoology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98303873 | 1998-05-15 | ||
| PCT/GB1999/001561 WO1999060007A2 (en) | 1998-05-15 | 1999-05-17 | Libraries of oligomers labelled with different tags |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE256142T1 true ATE256142T1 (de) | 2003-12-15 |
Family
ID=8234828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99922334T ATE256142T1 (de) | 1998-05-15 | 1999-05-17 | Bibliotheken von unterschiedlich markierten oligomeren |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6780981B1 (de) |
| EP (2) | EP1068216B1 (de) |
| JP (1) | JP2002515588A (de) |
| AT (1) | ATE256142T1 (de) |
| AU (1) | AU3943799A (de) |
| CA (1) | CA2332862A1 (de) |
| DE (1) | DE69913509T2 (de) |
| DK (1) | DK1068216T3 (de) |
| WO (1) | WO1999060007A2 (de) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7211390B2 (en) | 1999-09-16 | 2007-05-01 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| US7244559B2 (en) | 1999-09-16 | 2007-07-17 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| US20020137053A1 (en) * | 2000-07-19 | 2002-09-26 | Dana Ault-Riche | Collections of binding proteins and tags and uses thereof for nested sorting and high throughput screening |
| EP1176151B1 (de) | 2000-07-28 | 2014-08-20 | Agilent Technologies, Inc. | Synthese von Polynukleotiden unter Gebrauch von kombinierter Oxidations- und Entschützungschemie |
| CA2418735A1 (en) * | 2000-08-14 | 2002-02-21 | Isis Innovation Limited | Mass spectrometry |
| WO2002027026A2 (en) * | 2000-09-28 | 2002-04-04 | Matrix Technologies Corporation | Improved support for solid phase hybridization assays |
| EP1401850A1 (de) * | 2001-06-20 | 2004-03-31 | Nuevolution A/S | Nukleosidderivate zur herstellung einer verbindungsbibliothek |
| GB0115581D0 (en) * | 2001-06-26 | 2001-08-15 | Glaxo Group Ltd | Method of mass spectometry |
| AU2002367839A1 (en) * | 2001-07-16 | 2003-11-17 | Hk Pharmaceuticals, Inc. | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions |
| DE10147074A1 (de) * | 2001-09-25 | 2003-05-08 | Beru Ag | Verfahren zum Betreiben einer aus mehreren Heizelementen bestehenden mehrstufigen elektrischen Heizung |
| US6902921B2 (en) | 2001-10-30 | 2005-06-07 | 454 Corporation | Sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
| US6956114B2 (en) | 2001-10-30 | 2005-10-18 | '454 Corporation | Sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
| IL163822A0 (en) * | 2002-03-15 | 2005-12-18 | Nuevolution As | An improved method for synthesising templated molecules |
| JP4606028B2 (ja) | 2002-04-04 | 2011-01-05 | エレクトロフォレティクス リミテッド | 被分析物の分析方法 |
| AU2003247266A1 (en) * | 2002-08-01 | 2004-02-23 | Nuevolution A/S | Multi-step synthesis of templated molecules |
| DE10240746A1 (de) * | 2002-09-01 | 2004-03-18 | Epigenomics Ag | Verfahren zum Nachweis von Nukleinsäuresequenzen mittels spaltbarer Sondenmoleküle |
| PT1558744E (pt) | 2002-10-30 | 2011-09-22 | Nuevolution As | Codificação enzimática |
| EP1564300A4 (de) * | 2002-11-13 | 2007-09-05 | Hitachi High Tech Corp | Verfahren zur nukleinsäureamplifikation und vorrichtung dafür |
| WO2004044242A1 (en) * | 2002-11-14 | 2004-05-27 | John Nicholas Housby | Polymorphism assay |
| WO2004056994A2 (en) * | 2002-12-19 | 2004-07-08 | Nuevolution A/S | Quasirandom structure and function guided synthesis methods |
| SG153699A1 (en) * | 2003-01-16 | 2009-07-29 | Caprotec Bioanalytics Gmbh | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions |
| AU2004209001B2 (en) | 2003-01-29 | 2007-10-11 | 454 Life Sciences Corporation | Bead emulsion nucleic acid amplification |
| US7575865B2 (en) | 2003-01-29 | 2009-08-18 | 454 Life Sciences Corporation | Methods of amplifying and sequencing nucleic acids |
| DE10304219B3 (de) * | 2003-01-30 | 2004-08-19 | Epigenomics Ag | Verfahren zum Nachweis von Cytosin-Methylierungsmustern mit hoher Sensitivität |
| EP1597395A2 (de) | 2003-02-21 | 2005-11-23 | Nuevolution A/S | Methode zur herstellung einer bibliothek der zweiten generation |
| GB0306756D0 (en) * | 2003-03-24 | 2003-04-30 | Xzillion Gmbh & Co Kg | Mass labels |
| WO2005003778A2 (en) * | 2003-07-02 | 2005-01-13 | Nuevolution A/S | A method for identifying a synthetic molecule having affinity towards a target |
| US7585970B2 (en) * | 2003-08-30 | 2009-09-08 | Agilent Technologies, Inc. | Method of polynucleotide synthesis using modified support |
| US7385050B2 (en) | 2003-08-30 | 2008-06-10 | Agilent Technologies, Inc. | Cleavable linker for polynucleotide synthesis |
| US7193077B2 (en) | 2003-08-30 | 2007-03-20 | Agilent Technologies, Inc. | Exocyclic amine triaryl methyl protecting groups in two-step polynucleotide synthesis |
| US7417139B2 (en) | 2003-08-30 | 2008-08-26 | Agilent Technologies, Inc. | Method for polynucleotide synthesis |
| US7427679B2 (en) | 2003-08-30 | 2008-09-23 | Agilent Technologies, Inc. | Precursors for two-step polynucleotide synthesis |
| DE602004023960D1 (de) | 2003-09-18 | 2009-12-17 | Nuevolution As | Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen |
| TW200533919A (en) * | 2003-12-08 | 2005-10-16 | Oxford Gene Tech Ip Ltd | Derivatived molecules for mass spectrometry |
| EP1506959A3 (de) * | 2004-09-22 | 2005-07-27 | Oxford Gene Technology Ip Limited | Derivatisierte Molekülen für Massenspektroskopie |
| EP1723255B1 (de) * | 2004-02-17 | 2010-12-29 | Nuevolution A/S | Anreicherungsverfahren mit eliminierung durch fehlpaarungshybridisierung |
| WO2005084210A2 (en) * | 2004-02-27 | 2005-09-15 | Hitachi Chemical Research Center, Inc. | Multiplex detection probes |
| US7622281B2 (en) * | 2004-05-20 | 2009-11-24 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for clonal amplification of nucleic acid |
| US8632970B2 (en) | 2005-05-09 | 2014-01-21 | Affymetrix, Inc. | Multiplex capture of nucleic acids |
| US9574189B2 (en) | 2005-12-01 | 2017-02-21 | Nuevolution A/S | Enzymatic encoding methods for efficient synthesis of large libraries |
| US20070224601A1 (en) * | 2006-03-24 | 2007-09-27 | Mccuen Heather B | Quantification of depurination through the use of two cleavage sites |
| US7960526B2 (en) * | 2009-03-30 | 2011-06-14 | Berry And Associates, Inc. | Colorimetric-oxycarbonyl protecting groups for use in organic syntheses |
| ES2713873T3 (es) | 2010-04-16 | 2019-05-24 | Nuevolution As | Complejos bifuncionales y métodos para hacer y utilizar tales complejos |
| ES2676183T3 (es) | 2010-07-02 | 2018-07-17 | Ventana Medical Systems, Inc. | Detección de dianas usando marcas de masa y espectrometría de masas |
| US11084037B2 (en) * | 2017-09-25 | 2021-08-10 | Plexium, Inc. | Oligonucleotide encoded chemical libraries |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5410068A (en) * | 1989-10-23 | 1995-04-25 | Perseptive Biosystems, Inc. | Succinimidyl trityl compounds and a process for preparing same |
| US5770358A (en) | 1991-09-18 | 1998-06-23 | Affymax Technologies N.V. | Tagged synthetic oligomer libraries |
| US5565324A (en) * | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| US5605798A (en) * | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| US6074823A (en) * | 1993-03-19 | 2000-06-13 | Sequenom, Inc. | DNA sequencing by mass spectrometry via exonuclease degradation |
| ATE220114T1 (de) | 1993-03-19 | 2002-07-15 | Sequenom Inc | Dns-sequenzbestimmung durch massenspektrometrie auf dem weg des abbaus mit exonuklease |
| GB9315847D0 (en) * | 1993-07-30 | 1993-09-15 | Isis Innovation | Tag reagent and assay method |
| US6075166A (en) | 1995-03-31 | 2000-06-13 | Smithkline Beecham Corporation | Photolytically cleavable encoding and linking agents for use in combinatorial chemistry |
| CN1163619C (zh) * | 1996-01-23 | 2004-08-25 | 佳根基因组学公司 | 测定核酸分子序列的方法和组合物 |
| EP1457496B1 (de) | 1996-11-06 | 2014-01-15 | Sequenom, Inc. | Immobilisierung mit hoher Dichte von Nukleinsäuren |
| DE19782097T1 (de) * | 1996-11-06 | 1999-10-14 | Sequenom Inc | Zusammensetzungen und Verfahren zur Immobilisierung von Nucleinsäuren an feste Träger |
| US6699668B1 (en) * | 1997-01-15 | 2004-03-02 | Xzillion Gmbh & Co. | Mass label linked hybridisation probes |
| ATE340869T1 (de) | 1997-01-15 | 2006-10-15 | Xzillion Gmbh & Co Kg | Massenmarkierte hybridisierungssonden |
-
1999
- 1999-05-17 WO PCT/GB1999/001561 patent/WO1999060007A2/en not_active Ceased
- 1999-05-17 AT AT99922334T patent/ATE256142T1/de not_active IP Right Cessation
- 1999-05-17 US US09/700,462 patent/US6780981B1/en not_active Expired - Fee Related
- 1999-05-17 AU AU39437/99A patent/AU3943799A/en not_active Abandoned
- 1999-05-17 EP EP99922334A patent/EP1068216B1/de not_active Expired - Lifetime
- 1999-05-17 CA CA002332862A patent/CA2332862A1/en not_active Abandoned
- 1999-05-17 EP EP03078845A patent/EP1428810A3/de not_active Withdrawn
- 1999-05-17 DK DK99922334T patent/DK1068216T3/da active
- 1999-05-17 DE DE69913509T patent/DE69913509T2/de not_active Expired - Fee Related
- 1999-05-17 JP JP2000549625A patent/JP2002515588A/ja active Pending
-
2004
- 2004-05-11 US US10/843,873 patent/US7399846B2/en not_active Expired - Fee Related
-
2007
- 2007-05-04 US US11/800,241 patent/US7741044B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999060007A2 (en) | 1999-11-25 |
| DE69913509T2 (de) | 2004-09-23 |
| JP2002515588A (ja) | 2002-05-28 |
| US20050003408A1 (en) | 2005-01-06 |
| DE69913509D1 (de) | 2004-01-22 |
| EP1068216B1 (de) | 2003-12-10 |
| CA2332862A1 (en) | 1999-11-25 |
| EP1428810A2 (de) | 2004-06-16 |
| EP1428810A3 (de) | 2004-07-14 |
| DK1068216T3 (da) | 2004-04-13 |
| AU3943799A (en) | 1999-12-06 |
| EP1068216A2 (de) | 2001-01-17 |
| US7399846B2 (en) | 2008-07-15 |
| US7741044B2 (en) | 2010-06-22 |
| WO1999060007A3 (en) | 2000-01-20 |
| US20090029866A1 (en) | 2009-01-29 |
| US6780981B1 (en) | 2004-08-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |