ATE256148T1 - Menschliche monoklonale antikörper gegen das hepatitis b oberflächenantigen - Google Patents

Menschliche monoklonale antikörper gegen das hepatitis b oberflächenantigen

Info

Publication number
ATE256148T1
ATE256148T1 AT97924227T AT97924227T ATE256148T1 AT E256148 T1 ATE256148 T1 AT E256148T1 AT 97924227 T AT97924227 T AT 97924227T AT 97924227 T AT97924227 T AT 97924227T AT E256148 T1 ATE256148 T1 AT E256148T1
Authority
AT
Austria
Prior art keywords
hbvsag
antibodies
cell lines
surface antigen
mice
Prior art date
Application number
AT97924227T
Other languages
English (en)
Inventor
Yair Reisner
Shlomo Dagan
Original Assignee
Yeda Res & Dev
Xtl Biopharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev, Xtl Biopharmaceuticals Ltd filed Critical Yeda Res & Dev
Application granted granted Critical
Publication of ATE256148T1 publication Critical patent/ATE256148T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/46—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—DNA viruses
    • C07K16/082—Hepadnaviridae (F), e.g. hepatitis B virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Environmental Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT97924227T 1996-06-11 1997-06-10 Menschliche monoklonale antikörper gegen das hepatitis b oberflächenantigen ATE256148T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL11862596A IL118625A0 (en) 1996-06-11 1996-06-11 Anti HBV antibodies
PCT/IL1997/000184 WO1997047654A1 (en) 1996-06-11 1997-06-10 Human monoclonal antibodies to the hepatitis b surface antigen

Publications (1)

Publication Number Publication Date
ATE256148T1 true ATE256148T1 (de) 2003-12-15

Family

ID=11068955

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97924227T ATE256148T1 (de) 1996-06-11 1997-06-10 Menschliche monoklonale antikörper gegen das hepatitis b oberflächenantigen

Country Status (11)

Country Link
US (2) US6254867B1 (de)
EP (1) EP0912611B9 (de)
JP (1) JP3672933B2 (de)
AT (1) ATE256148T1 (de)
AU (1) AU2975697A (de)
DE (1) DE69726734T2 (de)
DK (1) DK0912611T3 (de)
ES (1) ES2210527T3 (de)
IL (1) IL118625A0 (de)
PT (1) PT912611E (de)
WO (1) WO1997047654A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL118626A0 (en) * 1996-06-11 1996-10-16 Xtl Biopharmaceuticals Limited Anti HBV antibody
DE19726597C1 (de) * 1997-06-23 1998-11-19 Wengler Georg S Verfahren zur Herstellung von monoklonalen Antikörper
EP1322761A4 (de) * 2000-10-02 2005-03-23 Korea Res Inst Of Bioscience HUMANISIERTER ANTIKöRPER GEGEN DAS OBERFLäCHENANTIGEN S DES HEPATITIS B VIRUS UND HERSTELLUNGSVERFAHREN
SG153666A1 (en) * 2001-10-04 2009-07-29 Yeda Res & Dev Treatment of hepatitis b virus infection with human monoclonal antibodies
CN1558763A (zh) * 2001-10-04 2004-12-29 XTL������ҩ���޹�˾ 用人单克隆抗体治疗乙型肝炎病毒感染
KR100467706B1 (ko) * 2002-01-15 2005-01-24 주식회사 녹십자홀딩스 Ｂ형 간염 바이러스의 표면 항원에 대한 인간항체
EP1474682A4 (de) * 2002-02-11 2005-10-12 Alexion Pharma Inc Produktion von menschlichen antikörpern in immundefizienten, nicht-menschlichen säugerwirten
CN1305905C (zh) 2002-03-22 2007-03-21 Aprogen株式会社 人源化抗体及其制备方法
EP1532279B1 (de) * 2002-05-31 2011-02-16 Children's Hospital Medical Center Verfahren, zusammensetzung und kit für die antigenbindung von norwalk-ähnlichen viren
US7977098B2 (en) 2002-05-31 2011-07-12 Children's Hospital Medical Center Antigenic binding patterns of norovirus to human histo-blood group antigens
EP1848740A1 (de) * 2005-01-14 2007-10-31 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, the Department of Health and Human Services, An hepatitis-b-virus bindende oder dieses neutralisierende monoklonale antikörper
CN101166763B (zh) 2005-04-18 2012-09-19 伊达研究和发展有限公司 稳定的抗乙肝病毒(hbv)抗体配制剂
US20110152263A1 (en) * 2006-11-16 2011-06-23 Xi Jiang Composition and method for inhibiting norovirus infection
US20100150942A1 (en) * 2008-12-03 2010-06-17 Cantor Thomas L Affinity purified human polyclonal antibodies and methods of making and using them
US8486421B2 (en) 2009-06-09 2013-07-16 Children's Hospital Medical Center Antigen-norovirus P-domain monomers and dimers, antigen-norovirus P-particle molecules, and methods for their making and use
NZ705730A (en) * 2012-08-30 2016-06-24 Replicor Inc Methods for the treatment of hepatitis b and hepatitis d infections
US9512201B2 (en) 2012-09-27 2016-12-06 Janssen Vaccines & Prevention B.V. Human binding molecules capable of binding to and neutralizing hepatitis B viruses and uses thereof
EP2920300B1 (de) * 2012-11-13 2018-09-12 F.Hoffmann-La Roche Ag Anreicherung von antigenspezifischen plasmablasten
US9321803B2 (en) 2013-07-12 2016-04-26 Children's Hospital Medical Center Compositions and methods for inhibiting norovirus infection
CA3038552A1 (en) * 2016-09-30 2018-04-05 Baylor College Of Medicine Antibody based gene therapy with tissue-directed expression
JP7641695B2 (ja) 2017-03-28 2025-03-07 チルドレンズ ホスピタル メディカル センター ノロウイルスｓ粒子ベースのワクチンならびにその作製および使用方法
WO2025240246A1 (en) 2024-05-13 2025-11-20 Gilead Sciences, Inc. Combination therapies with ribavirin

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61104796A (ja) 1984-10-26 1986-05-23 Chemo Sero Therapeut Res Inst モノクロ−ナル抗体の製造方法
US5849288A (en) 1990-01-15 1998-12-15 Yeda Research And Development Co. Ltd. Method for production of monoclonal antibodies in chimeric mice or rats having xenogeneic antibody-producing cells
US5652373A (en) 1990-01-15 1997-07-29 Yeda Research And Development Co. Ltd. Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems
DK0438053T3 (da) 1990-01-15 1999-11-22 Yeda Res & Dev Varig transplantation og udvikling af humane hæmopoietiske cellelinjer i normale pattedyr
US5849987A (en) 1992-06-02 1998-12-15 Yeda Research And Development Co. Ltd. Animal model for hepatitis virus infection
US5804160A (en) 1991-06-04 1998-09-08 Yeda Research And Development Co. Ltd Animal model for hepatitis virus infection
US5858328A (en) 1991-06-04 1999-01-12 Yeda Research And Development Co. Ltd. Animal model for hepatitis virus infection
US5866757A (en) 1992-06-02 1999-02-02 Yeda Research And Development Co. Ltd. Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems
WO1994011495A1 (en) 1992-11-06 1994-05-26 Sandoz, Ltd. Production of human monoclonal antibodies active against hepatitis b surface antigen
EP0698042A1 (de) 1993-05-10 1996-02-28 Stichting Centraal Laboratorium van de Bloedtransfusiedienst van het Nederlandse Rode Kruis Antikoerperzusammensetzung gegen hepatitis-b-virus oberflaechenantigen

Also Published As

Publication number Publication date
JP2000513215A (ja) 2000-10-10
IL118625A0 (en) 1996-10-16
US6254867B1 (en) 2001-07-03
EP0912611B1 (de) 2003-12-10
DE69726734D1 (de) 2004-01-22
JP3672933B2 (ja) 2005-07-20
WO1997047654A1 (en) 1997-12-18
USRE40831E1 (en) 2009-07-07
EP0912611A1 (de) 1999-05-06
AU2975697A (en) 1998-01-07
EP0912611B9 (de) 2004-12-01
PT912611E (pt) 2004-04-30
DE69726734T2 (de) 2004-09-30
DK0912611T3 (da) 2004-03-29
ES2210527T3 (es) 2004-07-01

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