ATE256498T1 - Reaktionen mit organischen verbindungen - Google Patents
Reaktionen mit organischen verbindungenInfo
- Publication number
- ATE256498T1 ATE256498T1 AT98954569T AT98954569T ATE256498T1 AT E256498 T1 ATE256498 T1 AT E256498T1 AT 98954569 T AT98954569 T AT 98954569T AT 98954569 T AT98954569 T AT 98954569T AT E256498 T1 ATE256498 T1 AT E256498T1
- Authority
- AT
- Austria
- Prior art keywords
- reaction
- aromatic compound
- phases
- reacting
- phase
- Prior art date
Links
- 238000006243 chemical reaction Methods 0.000 title abstract 6
- 150000002894 organic compounds Chemical class 0.000 title 1
- 150000001491 aromatic compounds Chemical class 0.000 abstract 5
- 239000012071 phase Substances 0.000 abstract 5
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 239000008346 aqueous phase Substances 0.000 abstract 2
- 239000000376 reactant Substances 0.000 abstract 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 238000011109 contamination Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000802 nitrating effect Effects 0.000 abstract 1
- 238000006396 nitration reaction Methods 0.000 abstract 1
- 239000012074 organic phase Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
- 239000001117 sulphuric acid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
- C07C303/04—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by substitution of hydrogen atoms by sulfo or halosulfonyl groups
- C07C303/06—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by substitution of hydrogen atoms by sulfo or halosulfonyl groups by reaction with sulfuric acid or sulfur trioxide
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/08—Preparation of nitro compounds by substitution of hydrogen atoms by nitro groups
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00819—Materials of construction
- B01J2219/00822—Metal
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00819—Materials of construction
- B01J2219/00831—Glass
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00819—Materials of construction
- B01J2219/00833—Plastic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9723262.3A GB9723262D0 (en) | 1997-11-05 | 1997-11-05 | Reactions of aromatic compounds |
| PCT/GB1998/003288 WO1999022858A1 (en) | 1997-11-05 | 1998-11-05 | Reactions of aromatic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE256498T1 true ATE256498T1 (de) | 2004-01-15 |
Family
ID=10821546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98954569T ATE256498T1 (de) | 1997-11-05 | 1998-11-05 | Reaktionen mit organischen verbindungen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6515189B1 (de) |
| EP (1) | EP1028802B1 (de) |
| JP (1) | JP2001521913A (de) |
| AT (1) | ATE256498T1 (de) |
| AU (1) | AU1163199A (de) |
| DE (1) | DE69820673T2 (de) |
| ES (1) | ES2212369T3 (de) |
| GB (1) | GB9723262D0 (de) |
| WO (1) | WO1999022858A1 (de) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19935692A1 (de) | 1999-07-29 | 2001-02-01 | Merck Patent Gmbh | Nitrierung in einem statischen Mikromischer |
| WO2001009318A1 (fr) * | 1999-07-29 | 2001-02-08 | Helix Research Institute | Genes associes au cancer du foie |
| JP4733331B2 (ja) * | 2000-03-14 | 2011-07-27 | マイクロニックス、インコーポレーテッド | マイクロ流動体分析用デバイス |
| DE10026646A1 (de) * | 2000-05-29 | 2001-12-06 | Merck Patent Gmbh | Verfahren zur Herstellung von Indolen |
| DE10031381A1 (de) * | 2000-06-28 | 2002-01-10 | Merck Patent Gmbh | Verfahren zur Kupplung von organischen Verbindungen |
| JP2003028836A (ja) * | 2001-07-11 | 2003-01-29 | Kanagawa Acad Of Sci & Technol | マイクロチャンネル立体交差構造体と立体交差多層流の形成方法 |
| DE10250406B4 (de) | 2001-10-30 | 2007-10-25 | Hitachi, Ltd. | Reaktionsvorrichtung und Mischsystem |
| EP1380337B1 (de) * | 2002-07-12 | 2012-11-14 | Tosoh Corporation | Vorrichtung mit feinen Kanälen und chemisches Verfahren zur Verwendung dieser Vorrichtung für Fluide |
| US7118920B2 (en) * | 2002-10-22 | 2006-10-10 | Battelle Memorial Institute | Multiphasic microchannel reactions |
| WO2004040645A1 (en) * | 2002-10-31 | 2004-05-13 | Stichting Voor De Technische Wetenschappen | Microfluidic heat exchanger for locatized temperature control |
| JP2004181298A (ja) * | 2002-11-29 | 2004-07-02 | National Institute Of Advanced Industrial & Technology | マイクロリアクターとそれによる反応方法 |
| GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
| GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
| US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
| US7470308B2 (en) | 2004-02-10 | 2008-12-30 | Fujifilm Corporation | Method of producing magnetic particles and reaction method using microreactor and microreactor |
| US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
| US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
| DE102004049730B4 (de) * | 2004-10-11 | 2007-05-03 | Technische Universität Darmstadt | Mikrokapillarreaktor und Verfahren zum kontrollierten Vermengen von nicht homogen mischbaren Fluiden unter Verwendung dieses Mikrokapillarreaktors |
| JP4776246B2 (ja) * | 2005-02-08 | 2011-09-21 | 三菱瓦斯化学株式会社 | 過カルボン酸を含む溶液の製造方法 |
| WO2007081385A2 (en) | 2006-01-11 | 2007-07-19 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
| US20100298567A1 (en) * | 2006-01-12 | 2010-11-25 | Lonza Ag | Nitration of activated aromatics in microreactors |
| EP2530167A1 (de) | 2006-05-11 | 2012-12-05 | Raindance Technologies, Inc. | Mikrofluidische Vorrichtungen |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| EP2077912B1 (de) | 2006-08-07 | 2019-03-27 | The President and Fellows of Harvard College | Fluorkohlenstoffemulsionsstabilisierende tenside |
| WO2008097559A2 (en) | 2007-02-06 | 2008-08-14 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
| US20080235122A1 (en) * | 2007-03-22 | 2008-09-25 | First Data Corporation | Master gift card, systems and methods |
| US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| JP2009062341A (ja) * | 2007-09-07 | 2009-03-26 | National Institute Of Advanced Industrial & Technology | 脱酸素した高温高圧水環境におけるニトロ化反応方法とその装置 |
| JP5494904B2 (ja) * | 2008-07-03 | 2014-05-21 | 独立行政法人産業技術総合研究所 | モノニトロ化法とその製造反応装置 |
| US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| EP4047367A1 (de) | 2008-07-18 | 2022-08-24 | Bio-Rad Laboratories, Inc. | Verfahren zum nachweis von zielanalyten unter verwendung von tropfenbibliotheken |
| US8318439B2 (en) | 2008-10-03 | 2012-11-27 | Micronics, Inc. | Microfluidic apparatus and methods for performing blood typing and crossmatching |
| WO2010111231A1 (en) | 2009-03-23 | 2010-09-30 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
| US10520500B2 (en) | 2009-10-09 | 2019-12-31 | Abdeslam El Harrak | Labelled silica-based nanomaterial with enhanced properties and uses thereof |
| US10837883B2 (en) | 2009-12-23 | 2020-11-17 | Bio-Rad Laboratories, Inc. | Microfluidic systems and methods for reducing the exchange of molecules between droplets |
| US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
| US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
| EP4484577A3 (de) | 2010-02-12 | 2025-03-26 | Bio-Rad Laboratories, Inc. | Digitale analytanalyse |
| US9562897B2 (en) | 2010-09-30 | 2017-02-07 | Raindance Technologies, Inc. | Sandwich assays in droplets |
| EP2457886B1 (de) * | 2010-11-29 | 2014-04-02 | Corning Incorporated | Sulfonierung in Mikroreaktoren mit kontinuierlichem Fluss |
| EP3412778A1 (de) | 2011-02-11 | 2018-12-12 | Raindance Technologies, Inc. | Verfahren zur bildung gemischter tröpfchen |
| WO2012112804A1 (en) | 2011-02-18 | 2012-08-23 | Raindance Technoligies, Inc. | Compositions and methods for molecular labeling |
| EP3216872B1 (de) | 2011-06-02 | 2020-04-01 | Bio-Rad Laboratories, Inc. | Enzymquantifizierung |
| US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
| US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
| CN103113232A (zh) * | 2013-01-22 | 2013-05-22 | 南京理工大学 | 一种在微反应器中催化硝化甲苯的方法 |
| WO2014182844A1 (en) | 2013-05-07 | 2014-11-13 | Micronics, Inc. | Microfluidic devices and methods for performing serum separation and blood cross-matching |
| US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
| US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
| WO2015103367A1 (en) | 2013-12-31 | 2015-07-09 | Raindance Technologies, Inc. | System and method for detection of rna species |
| US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
| CN107890843B (zh) * | 2017-11-16 | 2020-04-07 | 南京工业大学 | 一种微反应器装置及其在制备苯系物的磺化产物中的应用 |
| CN110683956B (zh) * | 2018-08-16 | 2021-02-12 | 中国科学院大连化学物理研究所 | 一种超声微反应器内连续合成单硝基甲苯的系统及方法 |
| CN115260036A (zh) * | 2022-07-15 | 2022-11-01 | 鄂尔多斯市瀚博科技有限公司 | 一种硝基苯的生产工艺 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3976704A (en) * | 1975-01-06 | 1976-08-24 | Varen Technology | Nitration process |
| US4308215A (en) * | 1978-06-15 | 1981-12-29 | Varen Technology | Sulfonation process |
| US5811062A (en) | 1994-07-29 | 1998-09-22 | Battelle Memorial Institute | Microcomponent chemical process sheet architecture |
| ATE235292T1 (de) * | 1994-10-22 | 2003-04-15 | Central Research Lab Ltd | Verfahren und vorichtung fur diffusionsaustausch zwischen nicht mischbare flüssigkeiten |
| CA2203283A1 (en) | 1994-10-22 | 1996-05-02 | British Nuclear Fuels Plc | Method and apparatus for diffusive transfer between immiscible fluids |
| US5932100A (en) * | 1995-06-16 | 1999-08-03 | University Of Washington | Microfabricated differential extraction device and method |
-
1997
- 1997-11-05 GB GBGB9723262.3A patent/GB9723262D0/en not_active Ceased
-
1998
- 1998-11-05 ES ES98954569T patent/ES2212369T3/es not_active Expired - Lifetime
- 1998-11-05 AT AT98954569T patent/ATE256498T1/de not_active IP Right Cessation
- 1998-11-05 US US09/554,692 patent/US6515189B1/en not_active Expired - Fee Related
- 1998-11-05 EP EP98954569A patent/EP1028802B1/de not_active Expired - Lifetime
- 1998-11-05 JP JP2000518779A patent/JP2001521913A/ja active Pending
- 1998-11-05 DE DE69820673T patent/DE69820673T2/de not_active Expired - Fee Related
- 1998-11-05 WO PCT/GB1998/003288 patent/WO1999022858A1/en not_active Ceased
- 1998-11-05 AU AU11631/99A patent/AU1163199A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US6515189B1 (en) | 2003-02-04 |
| WO1999022858A1 (en) | 1999-05-14 |
| EP1028802A1 (de) | 2000-08-23 |
| JP2001521913A (ja) | 2001-11-13 |
| AU1163199A (en) | 1999-05-24 |
| EP1028802B1 (de) | 2003-12-17 |
| ES2212369T3 (es) | 2004-07-16 |
| DE69820673T2 (de) | 2004-10-21 |
| GB9723262D0 (en) | 1998-01-07 |
| DE69820673D1 (de) | 2004-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |