ATE25665T1 - Aethoxycarbonyloxyaethylester von nichtsteroiden entzuendungshemmenden carbonsaeuren, ihre herstellung und anwendung. - Google Patents
Aethoxycarbonyloxyaethylester von nichtsteroiden entzuendungshemmenden carbonsaeuren, ihre herstellung und anwendung.Info
- Publication number
- ATE25665T1 ATE25665T1 AT83307490T AT83307490T ATE25665T1 AT E25665 T1 ATE25665 T1 AT E25665T1 AT 83307490 T AT83307490 T AT 83307490T AT 83307490 T AT83307490 T AT 83307490T AT E25665 T1 ATE25665 T1 AT E25665T1
- Authority
- AT
- Austria
- Prior art keywords
- inflammatory
- aethoxycarbonyloxyaethylester
- preparation
- application
- steroid anti
- Prior art date
Links
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
- 150000001721 carbon Chemical class 0.000 title 1
- 150000002148 esters Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003637 steroidlike Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C68/00—Preparation of esters of carbonic or haloformic acids
- C07C68/06—Preparation of esters of carbonic or haloformic acids from organic carbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/56—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position
- C07C229/58—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position having the nitrogen atom of at least one of the amino groups further bound to a carbon atom of a six-membered aromatic ring, e.g. N-phenyl-anthranilic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/96—Esters of carbonic or haloformic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fats And Perfumes (AREA)
- Steroid Compounds (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL67445A IL67445A (en) | 1982-12-09 | 1982-12-09 | Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids |
| EP83307490A EP0112130B1 (de) | 1982-12-09 | 1983-12-08 | Äthoxycarbonyloxyäthylester von nichtsteroiden entzündungshemmenden Carbonsäuren, ihre Herstellung und Anwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE25665T1 true ATE25665T1 (de) | 1987-03-15 |
Family
ID=11053929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT83307490T ATE25665T1 (de) | 1982-12-09 | 1983-12-08 | Aethoxycarbonyloxyaethylester von nichtsteroiden entzuendungshemmenden carbonsaeuren, ihre herstellung und anwendung. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4851426A (de) |
| EP (1) | EP0112130B1 (de) |
| JP (1) | JPS59112944A (de) |
| AT (1) | ATE25665T1 (de) |
| AU (1) | AU563459B2 (de) |
| DE (1) | DE3369972D1 (de) |
| IL (1) | IL67445A (de) |
| ZA (1) | ZA838591B (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL67623A (en) * | 1983-01-05 | 1984-09-30 | Teva Pharma | 1'-ethoxycarbonyloxyethyl ester of valproic acid,its preparation and pharmaceutical compositions containing it |
| US4916230A (en) * | 1984-07-02 | 1990-04-10 | Merck & Co., Inc. | Process for preparing novel N-(acyloxy-alkoxy)carbonyl derivatives useful as bioreversible prodrug moieties for primary and secondary amine functions in drugs |
| DK8502611A (de) * | 1985-08-08 | 1986-12-12 | ||
| ES8605220A1 (es) * | 1985-10-25 | 1986-03-16 | Espanola Prod Quimicos | Procedimiento de preparacion de esteres del dietilenglicol |
| US4912248A (en) * | 1987-05-18 | 1990-03-27 | The Procter & Gamble Company | Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation |
| EP0510080A4 (en) * | 1989-12-26 | 1992-12-02 | Nova Pharmaceutical Corporation | Prodrug anhydrides of asprin, indomethacin and ibuprofen, their preparation, compositions, and anti-inflammatory method of use |
| GB9001405D0 (en) * | 1990-01-22 | 1990-03-21 | Leo Pharm Prod Ltd | New intermediates,their production and use |
| JPH06510020A (ja) * | 1991-03-29 | 1994-11-10 | ユニバーシティ・オブ・フロリダ | 混成リン酸エステル誘導体を経た標的への薬剤供給 |
| JPH06509099A (ja) * | 1991-07-03 | 1994-10-13 | サノ・コーポレーシヨン | ジクロフエナツクの経皮デリバリーに対する組成物及び方法 |
| CA2120367C (en) * | 1992-06-30 | 2004-05-11 | Howard K. Shapiro | Compositions and use of pharmaceutical compositions in the treatment of symptoms of disorders related to chronic inflammatory diseases and etiologically related symptomology |
| IT1274175B (it) * | 1994-11-22 | 1997-07-15 | Lab Alchemia Srl | Procedimento per la preparazione di una combinazione chimica farmacologicamente attiva |
| USRE40546E1 (en) * | 1996-05-01 | 2008-10-21 | Scarista, Ltd. | 1,3-Propane diol esters and ethers and methods for their use in drug delivery |
| CA2220091C (en) * | 1995-05-01 | 2011-01-04 | Scotia Holdings Plc | Nicotinic acid esters and pharmaceutical compositions containing them |
| MY118354A (en) * | 1995-05-01 | 2004-10-30 | Scarista Ltd | 1,3-propane diol derivatives as bioactive compounds |
| US7109326B2 (en) * | 1997-04-15 | 2006-09-19 | Genentech, Inc. | Halo-alkoxycarbonyl prodrugs |
| US6207700B1 (en) | 1999-01-07 | 2001-03-27 | Vanderbilt University | Amide derivatives for antiangiogenic and/or antitumorigenic use |
| US6762182B1 (en) | 1999-01-07 | 2004-07-13 | Vanderbilt University | Converting cox inhibition compounds that are not COX-2 selective inhibitors to derivatives that are COX-2 selective inhibitors |
| US6306890B1 (en) | 1999-08-30 | 2001-10-23 | Vanderbilt University | Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors |
| US6436990B1 (en) | 1999-10-27 | 2002-08-20 | Nobex Corporation | 6-methoxy-2-naphthylacetic acid prodrugs |
| TWI262791B (en) * | 1999-10-27 | 2006-10-01 | Nobex Corp | 6-methoxy-2-naphthylacetic acid prodrugs |
| US6552078B2 (en) | 1999-10-27 | 2003-04-22 | Nobex Corp | 6-methoxy-2-naphthylacetic acid prodrugs |
| US6927239B1 (en) * | 2000-08-02 | 2005-08-09 | Pharmanutrients | Methods and compositions for the attenuation and/or prevention of stress/catabolic responses |
| US6683112B2 (en) * | 2000-10-24 | 2004-01-27 | Andrx Corporation | Gabapentin prodrugs and formulations |
| US20030060465A1 (en) * | 2000-12-19 | 2003-03-27 | Jilani Jamal A. | Prodrugs of non-steroidal anti-inflammatory and carboxylic acid containing compounds |
| PL348487A1 (en) * | 2001-07-06 | 2003-01-13 | Pan | New esters of the acetylisalicylic acid with oligomers of the 3-hydrobutyric acid, method of their manufacture and preparations containing these esters |
| JP2007524630A (ja) * | 2003-06-25 | 2007-08-30 | バンダービルト・ユニバーシティ | Ｃｏｘ−２標的造影剤 |
| AU2005244770A1 (en) * | 2004-04-26 | 2005-12-01 | Vanderbilt University | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity |
| US20070053984A1 (en) * | 2005-03-03 | 2007-03-08 | Monique Spann-Wade | Topical gels compositions |
| EP1919859B1 (de) | 2005-06-20 | 2010-06-02 | Xenoport, Inc. | Acyloxyalkylcarbamat-prodrugs von tranexansäure und anwendung |
| CA2657691A1 (en) * | 2006-06-19 | 2007-12-27 | Vanderbilt University | Methods and compositions for diagnostic and therapeutic targeting of cox-2 |
| US20080317684A1 (en) * | 2006-09-06 | 2008-12-25 | Isw Group, Inc. | Topical Compositions |
| ES2589915T3 (es) | 2008-10-08 | 2016-11-17 | Xgene Pharmaceutical Inc | Conjugados de GABA y métodos de utilización de los mismos |
| US20100120727A1 (en) * | 2008-11-12 | 2010-05-13 | Kyphia Pharmaceuticals, Inc. | Eflornithine Prodrugs, Conjugates and Salts, and Methods of Use Thereof |
| WO2011028234A1 (en) * | 2009-09-04 | 2011-03-10 | Xenoport, Inc. | Uses of acyloxyalkyl carbamate prodrugs of tranexamic acid |
| US9346803B2 (en) | 2011-10-17 | 2016-05-24 | Vanderbilt University | Indomethacin analogs for the treatment of castrate-resistant prostate cancer |
| WO2022033202A1 (zh) * | 2020-08-13 | 2022-02-17 | 南京海融医药科技股份有限公司 | 布洛芬酯类前药、药物组合物以及制备方法和应用 |
| KR102669063B1 (ko) * | 2021-06-29 | 2024-05-23 | 난징 헤론 파마슈티컬 사이언스 앤 테크놀로지 컴퍼니 리미티드 | 이부프로펜 에스테르 유도체 및 그 에멀젼 제제 |
| TWI874828B (zh) * | 2022-05-11 | 2025-03-01 | 陳建文 | 在關節腔中長期緩釋放的雙氯芬酸前驅藥、其製備方法及使用方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3412131A (en) * | 1966-08-02 | 1968-11-19 | Smith Kline French Lab | Alkyl carbonates of salicylic acid |
| US3646201A (en) * | 1969-07-31 | 1972-02-29 | Liggett & Myers Inc | Salicylate carbonate compounds |
| US3873521A (en) * | 1970-09-17 | 1975-03-25 | Astra Laekemedel Ab | Esters of {60 -amino penicillins |
| JPS5562049A (en) * | 1978-10-31 | 1980-05-10 | Bago Sa Labor | Novel ester of phenyll and pyridinee33carboxylic acid and its manufacture |
| US4412994A (en) * | 1980-04-24 | 1983-11-01 | Interx Research Corporation | Mannich-base hydroxamic acid prodrugs, compositions and use |
| EP0079872B1 (de) * | 1981-11-17 | 1985-03-20 | KabiVitrum AB | Verbindungen mit antifibrinolytischer Wirksamkeit |
| US4542158A (en) * | 1981-12-21 | 1985-09-17 | Merck & Co., Inc. | Prodrug esters of diflunisal and related compounds |
| NZ202721A (en) * | 1981-12-21 | 1985-12-13 | Merck & Co Inc | Diflunisal derivatives and pharmaceutical compositions |
| US4426391A (en) * | 1982-09-15 | 1984-01-17 | Merck & Co., Inc. | [(Alkoxycarbonyl)oxy]alkyl esters of methyldopa |
-
1982
- 1982-12-09 IL IL67445A patent/IL67445A/xx unknown
-
1983
- 1983-11-08 AU AU21056/83A patent/AU563459B2/en not_active Ceased
- 1983-11-17 ZA ZA838591A patent/ZA838591B/xx unknown
- 1983-12-08 JP JP58230741A patent/JPS59112944A/ja active Pending
- 1983-12-08 AT AT83307490T patent/ATE25665T1/de not_active IP Right Cessation
- 1983-12-08 DE DE8383307490T patent/DE3369972D1/de not_active Expired
- 1983-12-08 EP EP83307490A patent/EP0112130B1/de not_active Expired
-
1986
- 1986-02-12 US US06/810,393 patent/US4851426A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0112130A1 (de) | 1984-06-27 |
| US4851426A (en) | 1989-07-25 |
| IL67445A0 (en) | 1983-05-15 |
| EP0112130B1 (de) | 1987-03-04 |
| ZA838591B (en) | 1984-07-25 |
| AU2105683A (en) | 1984-06-14 |
| DE3369972D1 (en) | 1987-04-09 |
| AU563459B2 (en) | 1987-07-09 |
| JPS59112944A (ja) | 1984-06-29 |
| IL67445A (en) | 1985-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |