IL67445A - Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids - Google Patents

Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids

Info

Publication number
IL67445A
IL67445A IL67445A IL6744582A IL67445A IL 67445 A IL67445 A IL 67445A IL 67445 A IL67445 A IL 67445A IL 6744582 A IL6744582 A IL 6744582A IL 67445 A IL67445 A IL 67445A
Authority
IL
Israel
Prior art keywords
steroidal anti
carboxylic acids
ethyl esters
esters
inflammatory carboxylic
Prior art date
Application number
IL67445A
Other languages
English (en)
Other versions
IL67445A0 (en
Inventor
Ladkani David
Weiner Ben-Zion
Yellin Haim
Avnir David
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Priority to IL67445A priority Critical patent/IL67445A/xx
Publication of IL67445A0 publication Critical patent/IL67445A0/xx
Priority to AU21056/83A priority patent/AU563459B2/en
Priority to ZA838591A priority patent/ZA838591B/xx
Priority to DE8383307490T priority patent/DE3369972D1/de
Priority to JP58230741A priority patent/JPS59112944A/ja
Priority to AT83307490T priority patent/ATE25665T1/de
Priority to EP83307490A priority patent/EP0112130B1/de
Publication of IL67445A publication Critical patent/IL67445A/xx
Priority to US06/810,393 priority patent/US4851426A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00—Preparation of esters of carbonic or haloformic acids
    • C07C68/06—Preparation of esters of carbonic or haloformic acids from organic carbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/56—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position
    • C07C229/58—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position having the nitrogen atom of at least one of the amino groups further bound to a carbon atom of a six-membered aromatic ring, e.g. N-phenyl-anthranilic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/96—Esters of carbonic or haloformic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
IL67445A 1982-12-09 1982-12-09 Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids IL67445A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IL67445A IL67445A (en) 1982-12-09 1982-12-09 Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids
AU21056/83A AU563459B2 (en) 1982-12-09 1983-11-08 Ethoxycarbonyloxy ethyl esters
ZA838591A ZA838591B (en) 1982-12-09 1983-11-17 Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids
DE8383307490T DE3369972D1 (en) 1982-12-09 1983-12-08 Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids, their preparation and use
JP58230741A JPS59112944A (ja) 1982-12-09 1983-12-08 非ステロイド抗炎症カルボン酸のエトキシカルボニルオキシエチルエステル、その製造方法および該エトキシカルボニルオキシエチルエステルを有効成分とする医薬組成物
AT83307490T ATE25665T1 (de) 1982-12-09 1983-12-08 Aethoxycarbonyloxyaethylester von nichtsteroiden entzuendungshemmenden carbonsaeuren, ihre herstellung und anwendung.
EP83307490A EP0112130B1 (de) 1982-12-09 1983-12-08 Äthoxycarbonyloxyäthylester von nichtsteroiden entzündungshemmenden Carbonsäuren, ihre Herstellung und Anwendung
US06/810,393 US4851426A (en) 1982-12-09 1986-02-12 Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids and pharmaceutical compositions thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL67445A IL67445A (en) 1982-12-09 1982-12-09 Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids

Publications (2)

Publication Number Publication Date
IL67445A0 IL67445A0 (en) 1983-05-15
IL67445A true IL67445A (en) 1985-11-29

Family

ID=11053929

Family Applications (1)

Application Number Title Priority Date Filing Date
IL67445A IL67445A (en) 1982-12-09 1982-12-09 Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids

Country Status (8)

Country Link
US (1) US4851426A (de)
EP (1) EP0112130B1 (de)
JP (1) JPS59112944A (de)
AT (1) ATE25665T1 (de)
AU (1) AU563459B2 (de)
DE (1) DE3369972D1 (de)
IL (1) IL67445A (de)
ZA (1) ZA838591B (de)

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IL67623A (en) * 1983-01-05 1984-09-30 Teva Pharma 1'-ethoxycarbonyloxyethyl ester of valproic acid,its preparation and pharmaceutical compositions containing it
US4916230A (en) * 1984-07-02 1990-04-10 Merck & Co., Inc. Process for preparing novel N-(acyloxy-alkoxy)carbonyl derivatives useful as bioreversible prodrug moieties for primary and secondary amine functions in drugs
DK8502611A (de) * 1985-08-08 1986-12-12
ES8605220A1 (es) * 1985-10-25 1986-03-16 Espanola Prod Quimicos Procedimiento de preparacion de esteres del dietilenglicol
US4912248A (en) * 1987-05-18 1990-03-27 The Procter & Gamble Company Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation
AU655762B2 (en) * 1989-12-26 1995-01-12 Nova Pharmaceutical Corporation Prodrug anhydrides of asprin, indomethacin and ibuprofen, their preparation, compositions, and anti-inflammatory method of use
GB9001405D0 (en) * 1990-01-22 1990-03-21 Leo Pharm Prod Ltd New intermediates,their production and use
WO1992017185A1 (en) * 1991-03-29 1992-10-15 University Of Florida Targeted drug delivery via mixed phosphate derivatives
AU2259692A (en) * 1991-07-03 1993-02-11 Sano Corporation Composition and method for transdermal delivery of diclofenac
ATE214608T1 (de) * 1992-06-30 2002-04-15 Howard K Shapiro Verwendung einer kombination bestehend aus einem aminderivat oder aminverwandten derivat der benzoesäure und einem amino-polysaccharide zur herstellung eines medikaments fuer die behandlung von entzündlichen erkrankungen
IT1274175B (it) * 1994-11-22 1997-07-15 Lab Alchemia Srl Procedimento per la preparazione di una combinazione chimica farmacologicamente attiva
DK0823897T3 (da) * 1995-05-01 2004-12-06 Scarista Ltd Nicotinsyreestere og farmaceutiske præparater indeholdende disse
USRE40546E1 (en) * 1996-05-01 2008-10-21 Scarista, Ltd. 1,3-Propane diol esters and ethers and methods for their use in drug delivery
MY118354A (en) * 1995-05-01 2004-10-30 Scarista Ltd 1,3-propane diol derivatives as bioactive compounds
US7109326B2 (en) * 1997-04-15 2006-09-19 Genentech, Inc. Halo-alkoxycarbonyl prodrugs
US6207700B1 (en) 1999-01-07 2001-03-27 Vanderbilt University Amide derivatives for antiangiogenic and/or antitumorigenic use
US6762182B1 (en) 1999-01-07 2004-07-13 Vanderbilt University Converting cox inhibition compounds that are not COX-2 selective inhibitors to derivatives that are COX-2 selective inhibitors
US6306890B1 (en) 1999-08-30 2001-10-23 Vanderbilt University Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors
US6552078B2 (en) 1999-10-27 2003-04-22 Nobex Corp 6-methoxy-2-naphthylacetic acid prodrugs
TWI262791B (en) * 1999-10-27 2006-10-01 Nobex Corp 6-methoxy-2-naphthylacetic acid prodrugs
US6436990B1 (en) 1999-10-27 2002-08-20 Nobex Corporation 6-methoxy-2-naphthylacetic acid prodrugs
US6927239B1 (en) * 2000-08-02 2005-08-09 Pharmanutrients Methods and compositions for the attenuation and/or prevention of stress/catabolic responses
US6683112B2 (en) * 2000-10-24 2004-01-27 Andrx Corporation Gabapentin prodrugs and formulations
US20030060465A1 (en) * 2000-12-19 2003-03-27 Jilani Jamal A. Prodrugs of non-steroidal anti-inflammatory and carboxylic acid containing compounds
PL348487A1 (en) * 2001-07-06 2003-01-13 Pan New esters of the acetylisalicylic acid with oligomers of the 3-hydrobutyric acid, method of their manufacture and preparations containing these esters
WO2005002293A2 (en) * 2003-06-25 2005-01-06 Vanderbilt University Cox-2-targeted imaging agents
CA2562783A1 (en) * 2004-04-26 2005-12-01 Vanderbilt University Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity
US20070053984A1 (en) * 2005-03-03 2007-03-08 Monique Spann-Wade Topical gels compositions
US7351740B2 (en) 2005-06-20 2008-04-01 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use
WO2007149456A2 (en) * 2006-06-19 2007-12-27 Vanderbilt University Methods and compositions for diagnostic and therapeutic targeting of cox-2
US20080317684A1 (en) * 2006-09-06 2008-12-25 Isw Group, Inc. Topical Compositions
ES2589915T3 (es) * 2008-10-08 2016-11-17 Xgene Pharmaceutical Inc Conjugados de GABA y métodos de utilización de los mismos
US20100120727A1 (en) * 2008-11-12 2010-05-13 Kyphia Pharmaceuticals, Inc. Eflornithine Prodrugs, Conjugates and Salts, and Methods of Use Thereof
WO2011028234A1 (en) * 2009-09-04 2011-03-10 Xenoport, Inc. Uses of acyloxyalkyl carbamate prodrugs of tranexamic acid
WO2013059245A1 (en) 2011-10-17 2013-04-25 Vanderbilt University Indomethacin analogs for the treatment of castrate-resistant prostate cancer
KR102670655B1 (ko) * 2020-08-13 2024-05-29 난징 헤론 파마슈티컬 사이언스 앤 테크놀로지 컴퍼니 리미티드 이부프로펜 에스테르계 전구약물, 약학적 조성물 및 제조방법과 응용
CN114728882B (zh) * 2021-06-29 2024-08-23 南京海融医药科技股份有限公司 一种布洛芬酯衍生物及其乳状制剂
TWI874828B (zh) * 2022-05-11 2025-03-01 陳建文 在關節腔中長期緩釋放的雙氯芬酸前驅藥、其製備方法及使用方法

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US4412994A (en) * 1980-04-24 1983-11-01 Interx Research Corporation Mannich-base hydroxamic acid prodrugs, compositions and use
EP0079872B1 (de) * 1981-11-17 1985-03-20 KabiVitrum AB Verbindungen mit antifibrinolytischer Wirksamkeit
US4542158A (en) * 1981-12-21 1985-09-17 Merck & Co., Inc. Prodrug esters of diflunisal and related compounds
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US4426391A (en) * 1982-09-15 1984-01-17 Merck & Co., Inc. [(Alkoxycarbonyl)oxy]alkyl esters of methyldopa

Also Published As

Publication number Publication date
JPS59112944A (ja) 1984-06-29
ZA838591B (en) 1984-07-25
EP0112130A1 (de) 1984-06-27
US4851426A (en) 1989-07-25
DE3369972D1 (en) 1987-04-09
EP0112130B1 (de) 1987-03-04
AU2105683A (en) 1984-06-14
IL67445A0 (en) 1983-05-15
AU563459B2 (en) 1987-07-09
ATE25665T1 (de) 1987-03-15

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