ATE256698T1 - Biologisch aktive peptide und ihre zubereitungen und verwendungen - Google Patents

Biologisch aktive peptide und ihre zubereitungen und verwendungen

Info

Publication number: ATE256698T1
Authority: AT; Austria
Prior art keywords: preparations; biologically active; active peptides; derivatives; geodiamolide
Prior art date: 1995-04-20

Application number

AT96910116T

Other languages

English (en)

Inventor

Raymond Andersen

Chemistry

John Coleman

Silva Dilip De

Fangming Kong

Edward Piers

Debra Wallace

Michel Roberge

Biochemistry

Theresa Allen

Original Assignee

Univ British Columbia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-20

Filing date

1996-04-22

Publication date

2004-01-15

1996-04-22 Application filed by Univ British Columbia filed Critical Univ British Columbia

2004-01-15 Application granted granted Critical

2004-01-15 Publication of ATE256698T1 publication Critical patent/ATE256698T1/de

Links

238000002360 preparation method Methods 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
JGALXBSQYGEYPE-BFGKGAQZSA-N (3s,6r,9s,12s,16r,18s)-6-[(4-hydroxy-3-iodophenyl)methyl]-3,7,9,12,16,18-hexamethyl-14-methylidene-1-oxa-4,7,10-triazacyclooctadecane-2,5,8,11,15-pentone Chemical compound O=C1N[C@@H](C)C(=O)O[C@@H](C)C[C@@H](C)C(=O)C(=C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@@H]1CC1=CC=C(O)C(I)=C1 JGALXBSQYGEYPE-BFGKGAQZSA-N 0.000 abstract 1
KQODQNJLJQHFQV-MKWZWQCGSA-N (e,4s)-4-[[(2s)-3,3-dimethyl-2-[[(2s)-3-methyl-2-(methylamino)-3-(1-methylindol-3-yl)butanoyl]amino]butanoyl]-methylamino]-2,5-dimethylhex-2-enoic acid Chemical class C1=CC=C2C(C(C)(C)[C@@H](C(=O)N[C@H](C(=O)N(C)[C@H](\C=C(/C)C(O)=O)C(C)C)C(C)(C)C)NC)=CN(C)C2=C1 KQODQNJLJQHFQV-MKWZWQCGSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
230000002927 anti-mitotic effect Effects 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
JGALXBSQYGEYPE-UHFFFAOYSA-N geodiamolide G Natural products O=C1NC(C)C(=O)OC(C)CC(C)C(=O)C(=C)CC(C)C(=O)NC(C)C(=O)N(C)C1CC1=CC=C(O)C(I)=C1 JGALXBSQYGEYPE-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Crystallography & Structural Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Hematology (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT96910116T 1995-04-20 1996-04-22 Biologisch aktive peptide und ihre zubereitungen und verwendungen ATE256698T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9508195.6A GB9508195D0 (en)	1995-04-20	1995-04-20	Novel biologically active compounds and compositions,their use and derivation
PCT/GB1996/000942 WO1996033211A1 (en)	1995-04-20	1996-04-22	Biologically active peptides and compositions, their use

Publications (1)

Publication Number	Publication Date
ATE256698T1 true ATE256698T1 (de)	2004-01-15

Family

ID=10773352

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96910116T ATE256698T1 (de)	1995-04-20	1996-04-22	Biologisch aktive peptide und ihre zubereitungen und verwendungen

Country Status (12)

Country	Link
US (4)	US6153590A (de)
EP (1)	EP0839154B1 (de)
JP (2)	JP4008493B2 (de)
AT (1)	ATE256698T1 (de)
AU (1)	AU5341696A (de)
CA (1)	CA2220021C (de)
DE (1)	DE69631141T2 (de)
DK (1)	DK0839154T3 (de)
ES (1)	ES2213173T3 (de)
GB (1)	GB9508195D0 (de)
PT (1)	PT839154E (de)
WO (1)	WO1996033211A1 (de)

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US7064211B2 (en)	2002-03-22	2006-06-20	Eisai Co., Ltd.	Hemiasterlin derivatives and uses thereof
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JP2008522624A (ja) *	2004-12-09	2008-07-03	エーザイ・アール・アンド・ディー・マネジメント株式会社	ヘミアスタリン（ｈｅｍｉａｓｔｅｒｌｉｎ）アナログを使用する癌治療におけるチューブリンのアイソタイプのスクリーニング
AU2006244450A1 (en) *	2005-05-05	2006-11-16	Eisai Co., Ltd.	Unsolvated and host-guest solvated crystalline forms of (2E,4S)-4-[(N-{[(2R)-1-isopropylpiperidin-2-yl]-carbonyl}-3-methyl-L-valyl)(methyl)amino)-2,5-dimethylhex-2-enoic acid and their pharmaceutical uses
GB0522082D0 (en) *	2005-10-31	2005-12-07	Pharma Mar Sa	Formulations
US8106154B2 (en) *	2007-01-31	2012-01-31	Affymax, Inc.	Nitrogen-based linkers for attaching modifying groups to polypeptides and other macromolecules
WO2009050303A1 (en) *	2007-10-19	2009-04-23	Pharma Mar, S.A.	Prognostic molecular markers for et-743 treatment
CA2727055C (en)	2008-01-11	2016-12-20	Albany Molecular Research, Inc.	(1-azinone) -substituted pyridoindoles as mch antagonists
WO2011003005A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof
WO2011003021A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
WO2011003012A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
US8629158B2 (en)	2009-07-01	2014-01-14	Albany Molecular Research, Inc.	Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
US8697700B2 (en)	2010-12-21	2014-04-15	Albany Molecular Research, Inc.	Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof
WO2012088124A2 (en)	2010-12-21	2012-06-28	Albany Molecular Research, Inc.	Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof
CN103570603A (zh) *	2012-07-19	2014-02-12	杭州中肽生化有限公司	哈米特林的一种合成新方法
HK1220626A1 (zh)	2013-03-15	2017-05-12	The Centre For Drug Research And Development	具细胞毒性和抗有丝分裂的化合物以及其使用方法
KR102384740B1 (ko)	2013-12-27	2022-04-07	자임워크스 인코포레이티드	약물 접합체를 위한 설폰아마이드-함유 연결 시스템
MX2016008448A (es)	2013-12-27	2017-01-09	Zymeworks Inc	Conjugados de var2csa-farmaco.
ES2905569T3 (es)	2014-09-17	2022-04-11	Zymeworks Inc	Compuestos citotóxicos y antimitóticos y métodos para utilizarlos
WO2017066454A2 (en)	2015-10-14	2017-04-20	X-Therma, Inc.	Compositions and methods for reducing ice crystal formation
US10517958B2 (en)	2016-10-04	2019-12-31	Zymeworks Inc.	Compositions and methods for the treatment of platinum-drug resistant cancer
CN111051329B (zh) *	2017-08-10	2024-07-30	住友制药株式会社	哈米特林衍生物及它们的抗体药物复合物
CA3072153A1 (en) *	2017-08-10	2019-02-14	Sumitomo Dainippon Pharma Co., Ltd.	Antibody-drug conjugates including hemiasterlin derivative
CN113412271B (zh) *	2019-02-13	2024-10-22	住友制药株式会社	具有半胱氨酸残基的哈米特林衍生物
US20220202948A1 (en) *	2019-02-13	2022-06-30	Sumitomo Dainippon Pharma Co., Ltd.	Agent for Eliminating Pluripotent Stem Cells
US12178879B2 (en)	2019-02-13	2024-12-31	Sumitomo Pharma Co., Ltd.	Hemiasterlin derivative and antibody-drug conjugate thereof
JP7560255B2 (ja) *	2019-02-13	2024-10-02	住友ファーマ株式会社	ヘミアスタリン誘導体を含む抗体薬物複合体を含有する医薬

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1995
- 1995-04-20 GB GBGB9508195.6A patent/GB9508195D0/en active Pending
1996
- 1996-04-22 EP EP96910116A patent/EP0839154B1/de not_active Expired - Lifetime
- 1996-04-22 AU AU53416/96A patent/AU5341696A/en not_active Abandoned
- 1996-04-22 US US08/930,584 patent/US6153590A/en not_active Expired - Lifetime
- 1996-04-22 PT PT96910116T patent/PT839154E/pt unknown
- 1996-04-22 ES ES96910116T patent/ES2213173T3/es not_active Expired - Lifetime
- 1996-04-22 JP JP53156496A patent/JP4008493B2/ja not_active Expired - Lifetime
- 1996-04-22 DE DE69631141T patent/DE69631141T2/de not_active Expired - Lifetime
- 1996-04-22 AT AT96910116T patent/ATE256698T1/de not_active IP Right Cessation
- 1996-04-22 WO PCT/GB1996/000942 patent/WO1996033211A1/en not_active Ceased
- 1996-04-22 DK DK96910116T patent/DK0839154T3/da active
- 1996-04-22 CA CA2220021A patent/CA2220021C/en not_active Expired - Lifetime
2000
- 2000-06-14 US US09/593,417 patent/US6870028B1/en not_active Expired - Fee Related
2005
- 2005-01-14 US US11/034,922 patent/US7410951B2/en not_active Expired - Fee Related
2006
- 2006-08-14 JP JP2006221150A patent/JP4006466B2/ja not_active Expired - Lifetime
2008
- 2008-07-21 US US12/176,716 patent/US7772397B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US7772397B2 (en)	2010-08-10
CA2220021C (en)	2012-06-26
AU5341696A (en)	1996-11-07
JP2007031441A (ja)	2007-02-08
DK0839154T3 (da)	2004-04-19
US20050171137A1 (en)	2005-08-04
CA2220021A1 (en)	1996-10-24
DE69631141T2 (de)	2004-09-30
JP4008493B2 (ja)	2007-11-14
WO1996033211A1 (en)	1996-10-24
US7410951B2 (en)	2008-08-12
JPH11505211A (ja)	1999-05-18
JP4006466B2 (ja)	2007-11-14
US6870028B1 (en)	2005-03-22
DE69631141D1 (de)	2004-01-29
EP0839154A1 (de)	1998-05-06
PT839154E (pt)	2004-05-31
EP0839154B1 (de)	2003-12-17
GB9508195D0 (en)	1995-06-07
US6153590A (en)	2000-11-28
US20090088573A1 (en)	2009-04-02
ES2213173T3 (es)	2004-08-16

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2004-09-15

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