DK0839154T3 - Biologiske aktive peptider og præparater samt anvendelse deraf - Google Patents

Biologiske aktive peptider og præparater samt anvendelse deraf

Info

Publication number: DK0839154T3
Authority: DK; Denmark
Prior art keywords: preparations; biologically active; active peptides; derivatives; geodiamolide
Prior art date: 1995-04-20

Application number

DK96910116T

Other languages

English (en)

Inventor

Raymond Andersen

John Coleman

Silva Dilip De

Fangming Kong

Edward Piers

Debra Wallace

Michel Roberge

Theresa Allen

Original Assignee

Univ British Columbia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-20

Filing date

1996-04-22

Publication date

2004-04-19

1996-04-22 Application filed by Univ British Columbia filed Critical Univ British Columbia

2004-04-19 Application granted granted Critical

2004-04-19 Publication of DK0839154T3 publication Critical patent/DK0839154T3/da

Links

238000002360 preparation method Methods 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
JGALXBSQYGEYPE-BFGKGAQZSA-N (3s,6r,9s,12s,16r,18s)-6-[(4-hydroxy-3-iodophenyl)methyl]-3,7,9,12,16,18-hexamethyl-14-methylidene-1-oxa-4,7,10-triazacyclooctadecane-2,5,8,11,15-pentone Chemical compound O=C1N[C@@H](C)C(=O)O[C@@H](C)C[C@@H](C)C(=O)C(=C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@@H]1CC1=CC=C(O)C(I)=C1 JGALXBSQYGEYPE-BFGKGAQZSA-N 0.000 abstract 1
KQODQNJLJQHFQV-MKWZWQCGSA-N (e,4s)-4-[[(2s)-3,3-dimethyl-2-[[(2s)-3-methyl-2-(methylamino)-3-(1-methylindol-3-yl)butanoyl]amino]butanoyl]-methylamino]-2,5-dimethylhex-2-enoic acid Chemical class C1=CC=C2C(C(C)(C)[C@@H](C(=O)N[C@H](C(=O)N(C)[C@H](\C=C(/C)C(O)=O)C(C)C)C(C)(C)C)NC)=CN(C)C2=C1 KQODQNJLJQHFQV-MKWZWQCGSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
230000002927 anti-mitotic effect Effects 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
JGALXBSQYGEYPE-UHFFFAOYSA-N geodiamolide G Natural products O=C1NC(C)C(=O)OC(C)CC(C)C(=O)C(=C)CC(C)C(=O)NC(C)C(=O)N(C)C1CC1=CC=C(O)C(I)=C1 JGALXBSQYGEYPE-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Crystallography & Structural Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK96910116T 1995-04-20 1996-04-22 Biologiske aktive peptider og præparater samt anvendelse deraf DK0839154T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9508195.6A GB9508195D0 (en)	1995-04-20	1995-04-20	Novel biologically active compounds and compositions,their use and derivation
PCT/GB1996/000942 WO1996033211A1 (en)	1995-04-20	1996-04-22	Biologically active peptides and compositions, their use

Publications (1)

Publication Number	Publication Date
DK0839154T3 true DK0839154T3 (da)	2004-04-19

Family

ID=10773352

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96910116T DK0839154T3 (da)	1995-04-20	1996-04-22	Biologiske aktive peptider og præparater samt anvendelse deraf

Country Status (12)

Country	Link
US (4)	US6153590A (da)
EP (1)	EP0839154B1 (da)
JP (2)	JP4008493B2 (da)
AT (1)	ATE256698T1 (da)
AU (1)	AU5341696A (da)
CA (1)	CA2220021C (da)
DE (1)	DE69631141T2 (da)
DK (1)	DK0839154T3 (da)
ES (1)	ES2213173T3 (da)
GB (1)	GB9508195D0 (da)
PT (1)	PT839154E (da)
WO (1)	WO1996033211A1 (da)

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RU2005111753A (ru)	2002-09-20	2005-11-20	Уайт Холдингз Корпорейшн (Us)	Способ получения промежуточных соединений, используемых в синтезе ингибиторов тубулина
US20040121965A1 (en) *	2002-09-20	2004-06-24	Wyeth Holdings Corporation	Method of treating resistant tumors
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AU2005288696A1 (en) *	2004-09-28	2006-04-06	Pharma Mar S.A., Sociedad Unipersonal	Ecteinascidin compounds as anti -inflammatory agents
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RS50510B (sr)	2004-10-29	2010-03-02	Pharma Mar S.A., Sociedad Unipersonal	Formulacije koje sadrže ekteinascidin i disaharid
US20060148014A1 (en) *	2004-12-09	2006-07-06	Sergei Agoulnik	Tubulin isotype screening in cancer therapy using hemiasterlin analogs
AU2006244450A1 (en) *	2005-05-05	2006-11-16	Eisai Co., Ltd.	Unsolvated and host-guest solvated crystalline forms of (2E,4S)-4-[(N-{[(2R)-1-isopropylpiperidin-2-yl]-carbonyl}-3-methyl-L-valyl)(methyl)amino)-2,5-dimethylhex-2-enoic acid and their pharmaceutical uses
GB0522082D0 (en) *	2005-10-31	2005-12-07	Pharma Mar Sa	Formulations
US8106154B2 (en) *	2007-01-31	2012-01-31	Affymax, Inc.	Nitrogen-based linkers for attaching modifying groups to polypeptides and other macromolecules
JP2011500046A (ja) *	2007-10-19	2011-01-06	ファルマ・マール・ソシエダード・アノニマ	Ｅｔ−７４３治療のための予後分子マーカー
US8716308B2 (en)	2008-01-11	2014-05-06	Albany Molecular Research, Inc.	(1-azinone)-substituted pyridoindoles
WO2011003012A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
US8637501B2 (en)	2009-07-01	2014-01-28	Albany Molecular Research, Inc.	Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine MCH-1 antagonists, methods of making, and use thereof
US9073925B2 (en)	2009-07-01	2015-07-07	Albany Molecular Research, Inc.	Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
US8629158B2 (en)	2009-07-01	2014-01-14	Albany Molecular Research, Inc.	Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
US8993765B2 (en)	2010-12-21	2015-03-31	Albany Molecular Research, Inc.	Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
WO2012088038A2 (en)	2010-12-21	2012-06-28	Albany Molecular Research, Inc.	Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
CN103570603A (zh) *	2012-07-19	2014-02-12	杭州中肽生化有限公司	哈米特林的一种合成新方法
PL2968440T3 (pl)	2013-03-15	2019-12-31	Zymeworks Inc.	Związki cytotoksyczne i antymitotyczne oraz sposoby ich stosowania
RU2729194C2 (ru)	2013-12-27	2020-08-05	Займворкс Инк.	Сульфонамидсодержащие связывающие системы для лекарственных конъюгатов
AU2014373640B2 (en)	2013-12-27	2018-08-30	Var2 Pharmaceuticals Aps	VAR2CSA-drug conjugates
AU2015318556C1 (en)	2014-09-17	2021-01-07	Zymeworks Bc Inc.	Cytotoxic and anti-mitotic compounds, and methods of using the same
MX391259B (es)	2015-10-14	2025-03-21	X Therma Inc	Composiciones y métodos para reducir la formación de cristales de hielo.
US10517958B2 (en)	2016-10-04	2019-12-31	Zymeworks Inc.	Compositions and methods for the treatment of platinum-drug resistant cancer
TWI799438B (zh) *	2017-08-10	2023-04-21	日商住友製藥股份有限公司	半星芒體衍生物及此等之抗體藥物複合體
ES2974288T3 (es) *	2017-08-10	2024-06-26	Sumitomo Pharma Co Ltd	Conjugados de anticuerpo-fármaco que incluyen un derivado de hemiasterlina
JP7560255B2 (ja) *	2019-02-13	2024-10-02	住友ファーマ株式会社	ヘミアスタリン誘導体を含む抗体薬物複合体を含有する医薬
US12178879B2 (en)	2019-02-13	2024-12-31	Sumitomo Pharma Co., Ltd.	Hemiasterlin derivative and antibody-drug conjugate thereof
US12312419B2 (en)	2019-02-13	2025-05-27	Sumitomo Pharma Co., Ltd.	Hemiasterlin derivative having cysteine residue
JP7437328B2 (ja) *	2019-02-13	2024-02-22	住友ファーマ株式会社	多能性幹細胞の除去剤

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1995
- 1995-04-20 GB GBGB9508195.6A patent/GB9508195D0/en active Pending
1996
- 1996-04-22 EP EP96910116A patent/EP0839154B1/en not_active Expired - Lifetime
- 1996-04-22 DE DE69631141T patent/DE69631141T2/de not_active Expired - Lifetime
- 1996-04-22 ES ES96910116T patent/ES2213173T3/es not_active Expired - Lifetime
- 1996-04-22 AT AT96910116T patent/ATE256698T1/de not_active IP Right Cessation
- 1996-04-22 WO PCT/GB1996/000942 patent/WO1996033211A1/en not_active Ceased
- 1996-04-22 AU AU53416/96A patent/AU5341696A/en not_active Abandoned
- 1996-04-22 DK DK96910116T patent/DK0839154T3/da active
- 1996-04-22 CA CA2220021A patent/CA2220021C/en not_active Expired - Lifetime
- 1996-04-22 JP JP53156496A patent/JP4008493B2/ja not_active Expired - Lifetime
- 1996-04-22 PT PT96910116T patent/PT839154E/pt unknown
- 1996-04-22 US US08/930,584 patent/US6153590A/en not_active Expired - Lifetime
2000
- 2000-06-14 US US09/593,417 patent/US6870028B1/en not_active Expired - Fee Related
2005
- 2005-01-14 US US11/034,922 patent/US7410951B2/en not_active Expired - Fee Related
2006
- 2006-08-14 JP JP2006221150A patent/JP4006466B2/ja not_active Expired - Lifetime
2008
- 2008-07-21 US US12/176,716 patent/US7772397B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0839154B1 (en)	2003-12-17
US7410951B2 (en)	2008-08-12
DE69631141T2 (de)	2004-09-30
DE69631141D1 (de)	2004-01-29
CA2220021A1 (en)	1996-10-24
ES2213173T3 (es)	2004-08-16
JP2007031441A (ja)	2007-02-08
ATE256698T1 (de)	2004-01-15
PT839154E (pt)	2004-05-31
WO1996033211A1 (en)	1996-10-24
JP4008493B2 (ja)	2007-11-14
US6870028B1 (en)	2005-03-22
JPH11505211A (ja)	1999-05-18
CA2220021C (en)	2012-06-26
EP0839154A1 (en)	1998-05-06
JP4006466B2 (ja)	2007-11-14
US6153590A (en)	2000-11-28
US20090088573A1 (en)	2009-04-02
AU5341696A (en)	1996-11-07
US7772397B2 (en)	2010-08-10
GB9508195D0 (en)	1995-06-07
US20050171137A1 (en)	2005-08-04

Publication	Publication Date	Title
DK0839154T3 (da)	2004-04-19	Biologiske aktive peptider og præparater samt anvendelse deraf
DE59914996D1 (en)	2009-05-14	Heterocyclisch substituierte amide als calpainhemmer
CY1107628T1 (el)	2013-04-18	Ανθρωπινα ctla-4 αντισωματα και χρησεις αυτων
ES2133807T3 (es)	1999-09-16	Compuestos de peptidilo y su uso terapeutico como inhibidores de metaloproteasas.
FI970810A0 (fi)	1997-02-26	Ionipolymeerejä sisältäviä biologisesti aktiivisia anioneja
DK1039912T3 (da)	2002-10-28	Angiostatiske midler og præparater til behandling af GLC1A-glaukom
AR010062A1 (es)	2000-05-17	Nuevos benzamidaldehidos y su utilizacion
TR199800012T1 (xx)	1998-04-21	Piroloprimidinler ve preparasyon i�in tatbikler.
NO304884B1 (no)	1999-03-01	9-[(substituerte glycyl)amido]-6-demetyl-6-deoksotetracykliner, og medisinske preparater derav
CY2431B1 (en)	2004-11-12	Novel phenanthridines substituted in the 6 position.
ATE404667T1 (de)	2008-08-15	Chromatin-regulatorgene
ATE255632T1 (de)	2003-12-15	Immortalisierung bzw. desimmortalisierung von zellen
HUP9800731A2 (hu)	1998-07-28	Eljárás ivarsejt osztódás stimulálására
AR021695A1 (es)	2002-07-31	4,5-pirazinoxindoles, composicion farmaceutica y uso
ATE190352T1 (de)	2000-03-15	Dorsalgewebe beeinflussender faktor und zusammensetzungen
ATE196083T1 (de)	2000-09-15	Verwendung von ferrioxamin-b zur behandlung septischen schocks
AR020563A1 (es)	2002-05-15	Compuestos (poli)tia-alquinoicos y sus derivados, composiciones que los incluyen y su utilizacion
TR200001102T2 (tr)	2000-08-21	İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
ATE199641T1 (de)	2001-03-15	Terpenderivate (sarcodictyine) als antikrebsmittel
DE69835828D1 (de)	2006-10-19	Muc-1 derivate und deren verwendung zur behandlung von krebsassoziierter muc-1 mucin induzierter immunosuppression
NZ504614A (en)	2002-12-20	Echinocandin derivatives and application as anti-fungal agents
ATE165594T1 (de)	1998-05-15	Triarylethylenderivate zur therapeutischen verwendung
BR0008791A (pt)	2005-04-05	Derivados anticonvulsivos, úteis no tratamento de tremor essencial
MX9800053A (es)	1998-03-29	Herbicidas de cis-2,3-expoxicicloalcanol bencilado.
TR200101476T2 (tr)	2001-10-22	N-ikameli azabisikloaklan türevlerinin merkezi sinir sistemi bozukluklarının tedavisinde kullanılması