ATE257407T1 - Herstellung von peptidhältigen, biologisch abbaubaren mikrokügelchen durch ein schmelzverfahren - Google Patents

Herstellung von peptidhältigen, biologisch abbaubaren mikrokügelchen durch ein schmelzverfahren

Info

Publication number
ATE257407T1
ATE257407T1 AT96937031T AT96937031T ATE257407T1 AT E257407 T1 ATE257407 T1 AT E257407T1 AT 96937031 T AT96937031 T AT 96937031T AT 96937031 T AT96937031 T AT 96937031T AT E257407 T1 ATE257407 T1 AT E257407T1
Authority
AT
Austria
Prior art keywords
microspheres
biodegradable
prepared
drug delivery
microdroplets
Prior art date
Application number
AT96937031T
Other languages
English (en)
Inventor
Younsik Cha
Young Kweon Choi
Chaul Min Pai
Original Assignee
Macromed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macromed Inc filed Critical Macromed Inc
Application granted granted Critical
Publication of ATE257407T1 publication Critical patent/ATE257407T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D7/00—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Diabetes (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Peptides Or Proteins (AREA)
AT96937031T 1995-10-25 1996-10-25 Herstellung von peptidhältigen, biologisch abbaubaren mikrokügelchen durch ein schmelzverfahren ATE257407T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/547,962 US5665428A (en) 1995-10-25 1995-10-25 Preparation of peptide containing biodegradable microspheres by melt process
PCT/US1996/017237 WO1997015389A1 (en) 1995-10-25 1996-10-25 Preparation of peptide containing biodegradable microspheres by melt process

Publications (1)

Publication Number Publication Date
ATE257407T1 true ATE257407T1 (de) 2004-01-15

Family

ID=24186865

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96937031T ATE257407T1 (de) 1995-10-25 1996-10-25 Herstellung von peptidhältigen, biologisch abbaubaren mikrokügelchen durch ein schmelzverfahren

Country Status (9)

Country Link
US (1) US5665428A (de)
EP (1) EP0857081B1 (de)
JP (1) JPH11515016A (de)
KR (1) KR100422391B1 (de)
AT (1) ATE257407T1 (de)
AU (1) AU7479796A (de)
CA (1) CA2235602A1 (de)
DE (1) DE69631290D1 (de)
WO (1) WO1997015389A1 (de)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
IL110787A0 (en) * 1993-08-27 1994-11-11 Sandoz Ag Biodegradable polymer, its preparation and pharmaceutical composition containing it
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
DE19715504C2 (de) * 1997-04-14 2000-10-26 Max Planck Gesellschaft PMMA-Membranen mit Polyethylenglykol-gekoppelten Wirksubstanzen
US6342250B1 (en) 1997-09-25 2002-01-29 Gel-Del Technologies, Inc. Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices
EP1034207B1 (de) * 1997-10-03 2005-03-02 Macromed Inc. Biologisch abbaubare triblock-poly(lactide-co-glycolide)-polyethylenglycol-copolymere mit umgekehrter thermischer gelierung
US6201072B1 (en) * 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
KR20010015856A (ko) * 1997-12-12 2001-02-26 마크로메드 인코퍼레이션 단백질 변성용으로 헤테로 작용기를 가진 별 모양의폴리(에틸렌글리콜)
ATE235231T1 (de) * 1998-01-21 2003-04-15 Takeda Chemical Industries Ltd Verfahren zur gerfriertrocknung von präparaten mit verzörgerter wirkstoffabgabe
GB9808052D0 (en) 1998-04-17 1998-06-17 Secr Defence Implants for administering substances and methods of producing implants
JP2002513045A (ja) 1998-04-27 2002-05-08 ザ ダウ ケミカル カンパニー カプセル化された活性物質
US20050147690A1 (en) * 1998-09-25 2005-07-07 Masters David B. Biocompatible protein particles, particle devices and methods thereof
US7662409B2 (en) * 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
US20030007991A1 (en) * 1998-09-25 2003-01-09 Masters David B. Devices including protein matrix materials and methods of making and using thereof
KR100274842B1 (ko) * 1998-10-01 2001-03-02 김효근 미립구를 이용한 레티노익산의 서방형 약물방출 시스템
GB9905136D0 (en) * 1999-03-06 1999-04-28 Danbiosyst Uk Surface modification of lamellar particles
JP2002539172A (ja) 1999-03-17 2002-11-19 ノバルティス アクチエンゲゼルシャフト Ｔｇｆ−ベータを含む医薬組成物
US20040110722A1 (en) * 1999-05-27 2004-06-10 Ornberg Richard L. Modified hyaluronic acid polymers
AU5048400A (en) * 1999-05-27 2000-12-18 Monsanto Company Biomaterials modified with superoxide dismutase mimics
US6521431B1 (en) * 1999-06-22 2003-02-18 Access Pharmaceuticals, Inc. Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments
KR100360827B1 (ko) * 1999-08-14 2002-11-18 주식회사 삼양사 난용성 약물을 가용화하기 위한 고분자 조성물 및 그의 제조방법
US6589549B2 (en) 2000-04-27 2003-07-08 Macromed, Incorporated Bioactive agent delivering system comprised of microparticles within a biodegradable to improve release profiles
FR2809112B1 (fr) * 2000-05-16 2004-05-07 Centre Nat Rech Scient Materiaux a base de polymeres biodegradables et son procede de preparation
US7217770B2 (en) * 2000-05-17 2007-05-15 Samyang Corporation Stable polymeric micelle-type drug composition and method for the preparation thereof
US7666445B2 (en) * 2000-10-20 2010-02-23 The Trustees Of The University Of Pennsylvania Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use
MXPA03004112A (es) * 2000-11-09 2003-08-19 Astrazeneca Ab Composicion farmaceutica oral que contiene un copolimero de bloque.
IT1319655B1 (it) 2000-11-15 2003-10-23 Eurand Int Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
WO2003000156A1 (en) 2001-06-22 2003-01-03 Southern Biosystems, Inc. Zero-order prolonged release coaxial implants
CN1194688C (zh) * 2001-07-03 2005-03-30 山东绿叶制药股份有限公司 石杉碱甲及其衍生物或其盐的注射用缓释微球及其制备方法
US8778322B2 (en) * 2001-10-18 2014-07-15 Samyang Biopharmaceuticals Corporation pH responsive biodegradable polylactic acid derivatives forming polymeric micelles and uses thereof for poorly water soluble drug delivery
CA2483778A1 (en) * 2002-04-29 2003-11-13 Gel-Del Technologies, Inc. Biomatrix structural containment and fixation systems and methods of use thereof
US8465537B2 (en) * 2003-06-17 2013-06-18 Gel-Del Technologies, Inc. Encapsulated or coated stent systems
US20050142205A1 (en) * 2003-07-18 2005-06-30 Julia Rashba-Step Methods for encapsulating small spherical particles prepared by controlled phase separation
BRPI0412735A (pt) * 2003-07-18 2006-09-26 Baxter Int métodos para a fabricação, uso e composição de partìculas esféricas pequenas preparadas mediante a separação de fase controlada
JP2007508240A (ja) * 2003-07-22 2007-04-05 バクスター・インターナショナル・インコーポレイテッド 低分子量有機分子の小球状粒子ならびにその調製方法および使用方法
WO2005034852A2 (en) 2003-08-26 2005-04-21 Gel-Del Technologies, Inc. Protein biomaterials and biocoacervates and methods of making and using thereof
US9066912B2 (en) * 2003-11-17 2015-06-30 Ethicon, Inc. Drug-enhanced adhesion prevention
WO2005055945A2 (en) * 2003-12-08 2005-06-23 Gel-Del Technologies, Inc. Mucoadhesive drug delivery devices and methods of making and using thereof
CA2553254C (en) * 2004-01-12 2013-12-17 The Trustees Of The University Of Pennsylvania Long-term delivery formulations and methods of use thereof
US8329203B2 (en) * 2004-01-12 2012-12-11 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
US8221778B2 (en) 2005-01-12 2012-07-17 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
US8277831B2 (en) * 2004-02-17 2012-10-02 Advanced Technologies And Regenerative Medicine, Llc. Drug-enhanced adhesion prevention
PT1718258E (pt) 2004-02-23 2009-06-16 Euro Celtique Sa Dispositivo de administração transdérmica de opióides com resistência ao abuso
MXPA06012992A (es) * 2004-05-12 2007-02-12 Baxter Int Microesferas que comprenden proteina y que muestran inyectabilidad en altas concentraciones de este agente.
CA2566199C (en) * 2004-05-12 2013-10-22 Baxter International Inc. Delivery of as-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes
EP1765294B1 (de) * 2004-05-12 2008-09-24 Baxter International Inc. Nukleinsäure-mikrokügelchen, ihre herstellung und abgabe
US8728525B2 (en) 2004-05-12 2014-05-20 Baxter International Inc. Protein microspheres retaining pharmacokinetic and pharmacodynamic properties
US8980300B2 (en) 2004-08-05 2015-03-17 Advanced Cardiovascular Systems, Inc. Plasticizers for coating compositions
BRPI0515191A (pt) * 2004-08-13 2008-07-08 Angiotech Internac Ag composição farmacêutica, método para aumentar osso ou substituir perda óssea, método para reduzir a dor associada com cicatriz pós-cirúrgica, método para prevenir aderência cirúrgicas, método para aumento ou reparo de pele ou tecido, método para manter volume em fluido ocular durante cirurgia ocular, método para reduzir a dor associada com osteoartrite, método para tratar doença de refluxo gastroesofágico, método para tratar ou prevenir incontinência urinária, método para tratar ou prevenir incontinência fecal, implante método e dispositivo médico
US20080095822A1 (en) * 2004-11-16 2008-04-24 Universite De Liege Active Substance Delivery System Comprising A Hydrogel Atrix And Microcarriers
US20060224095A1 (en) * 2005-04-05 2006-10-05 University Of New Hampshire Biocompatible polymeric vesicles self assembled from triblock copolymers
EP1885335A1 (de) * 2005-04-27 2008-02-13 BAXTER INTERNATIONAL INC. (a Delaware corporation) Oberflächenmodifizierte mikroteilchen und verfahren zu ihrer bildung und verwendung
US7261529B2 (en) * 2005-09-07 2007-08-28 Southwest Research Institute Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents
US7758778B2 (en) 2005-09-07 2010-07-20 Southwest Research Institute Methods for preparing biodegradable microparticle formulations containing pharmaceutically active agents
US9693967B2 (en) * 2005-09-07 2017-07-04 Southwest Research Institute Biodegradable microparticle pharmaceutical formulations exhibiting improved released rates
BRPI0615563A2 (pt) * 2005-09-07 2011-05-24 Southwest Res Inst formulações farmacêuticas em micropartìcula biodegradável exibindo taxas de liberação aperfeiçoadas
EP1937252B1 (de) 2005-09-19 2017-10-25 Neuronascent, Inc. Zusammensetzungen zur stimulierung der neurogenese und hemmung der neuronalen degeneration
DE102006040123A1 (de) * 2006-08-26 2008-03-20 Evonik Degussa Gmbh Verfahren zur Herstellung von Mikropartikeln
US7669732B2 (en) * 2005-10-25 2010-03-02 Imi Cornelius Inc. Cup lid dispenser
US20070281031A1 (en) * 2006-06-01 2007-12-06 Guohan Yang Microparticles and methods for production thereof
US9028859B2 (en) * 2006-07-07 2015-05-12 Advanced Cardiovascular Systems, Inc. Phase-separated block copolymer coatings for implantable medical devices
US7846361B2 (en) 2006-07-20 2010-12-07 Orbusneich Medical, Inc. Bioabsorbable polymeric composition for a medical device
CN101500616A (zh) 2006-08-04 2009-08-05 巴克斯特国际公司 预防和/或逆转新发作自身免疫糖尿病的基于微球的组合物
WO2008060786A2 (en) * 2006-10-06 2008-05-22 Baxter International Inc. Microencapsules containing surface-modified microparticles and methods of forming and using the same
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
EP2073754A4 (de) 2006-10-20 2012-09-26 Orbusneich Medical Inc Bioresorbierbare polymerzusammensetzung und hintergrund für eine medizinische vorrichtung
US8246950B2 (en) 2007-02-20 2012-08-21 Aptalis Pharma Limited Stable digestive enzyme compositions
CN101686939B (zh) * 2007-04-17 2013-03-27 巴克斯特国际公司 用于肺部投送的核酸微粒
PL2170340T3 (pl) 2007-06-21 2016-06-30 Neuronascent Inc Sposoby i kompozycje stymulacji neurogenezy i hamowania degeneracji neuronów z wykorzystaniem izotiazolopirymidonów
US20090004243A1 (en) 2007-06-29 2009-01-01 Pacetti Stephen D Biodegradable triblock copolymers for implantable devices
CA2711001A1 (en) * 2007-12-26 2009-07-09 Gel-Del Technologies, Inc. Biocompatible protein-based particles and methods thereof
US20090202642A1 (en) * 2008-02-08 2009-08-13 Xiao Huang Drug Delivery System Comprising Microparticles and Gelation System
WO2009109856A2 (en) 2008-03-07 2009-09-11 Axcan Pharma Inc. Method for detecting infectious parvovirus in pharmaceutical preparations
GB0810990D0 (en) 2008-06-16 2008-07-23 Q Chip Ltd Device and method of making solid beads
US8323685B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing compositions containing microparticles
US8367427B2 (en) 2008-08-20 2013-02-05 Baxter International Inc. Methods of processing compositions containing microparticles
US20100047292A1 (en) * 2008-08-20 2010-02-25 Baxter International Inc. Methods of processing microparticles and compositions produced thereby
US8323615B2 (en) 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing multi-phasic dispersions
US20100050462A1 (en) * 2008-08-29 2010-03-04 Joseph Francis Attonito Body exsiccation chamber
US10016534B2 (en) 2008-11-17 2018-07-10 Gel-Del Technologies, Inc. Protein biomaterial and biocoacervate vessel graft systems and methods of making and using thereof
US20130268062A1 (en) 2012-04-05 2013-10-10 Zeus Industrial Products, Inc. Composite prosthetic devices
JP5300987B2 (ja) 2009-01-16 2013-09-25 ゼウス インダストリアル プロダクツ， インコーポレイテッド 高粘度材料を含むｐｔｆｅのエレクトロスピニング
WO2010129545A2 (en) * 2009-05-04 2010-11-11 Psivida Us, Inc. Porous silicon drug-eluting particles
JP5456892B2 (ja) 2009-08-07 2014-04-02 ゼウス インダストリアル プロダクツ インコーポレイテッド 多層複合体
US9074095B2 (en) 2010-06-03 2015-07-07 Technology Innovation Momentum Fund (Israel) Limited Partnership Malleable hydrogel hybrids made of self-assembled peptides and biocompatible polymers and uses thereof
UA111726C2 (uk) 2010-10-01 2016-06-10 Апталіс Фарма Лімітед Препарат панкреліпази низької сили з кишковорозчинним покриттям
CN102782196A (zh) 2010-10-14 2012-11-14 宙斯工业产品股份有限公司 抗微生物基材
EP2635255B1 (de) 2010-11-01 2019-08-21 EyePoint Pharmaceuticals US, Inc. Biologisch abbaubare vorrichtungen auf siliciumbasis zur abgabe therapeutischer mittel
US9149045B2 (en) 2010-12-07 2015-10-06 Kimberly-Clark Worldwide, Inc. Wipe coated with a botanical emulsion having antimicrobial properties
US8445032B2 (en) 2010-12-07 2013-05-21 Kimberly-Clark Worldwide, Inc. Melt-blended protein composition
US8524264B2 (en) 2010-12-07 2013-09-03 Kimberly-Clark Worldwide, Inc. Protein stabilized antimicrobial composition formed by melt processing
US9832993B2 (en) 2010-12-07 2017-12-05 Kimberly-Clark Worldwide, Inc. Melt processed antimicrobial composition
US10821085B2 (en) 2010-12-07 2020-11-03 Kimberly-Clark Worldwide, Inc. Wipe coated with a botanical composition having antimicrobial properties
US9648874B2 (en) 2010-12-07 2017-05-16 Kimberly-Clark Worldwide, Inc. Natural, multiple use and re-use, user saturated wipes
CN103561682A (zh) 2011-01-28 2014-02-05 梅瑞特医药体系股份有限公司 静电纺丝ptfe涂层支架及其使用方法
CA2843556A1 (en) 2011-08-08 2013-02-14 Aptalis Pharma Ltd. Method for dissolution testing of solid compositions containing digestive enzymes
US8574628B2 (en) 2011-12-19 2013-11-05 Kimberly-Clark Worldwide, Inc. Natural, multiple release and re-use compositions
KR102037543B1 (ko) 2012-01-16 2019-10-28 메리트 메디컬 시스템즈, 인크. 회전 방사 재료로 커버링된 의료 기구 및 제조 방법
US11541154B2 (en) 2012-09-19 2023-01-03 Merit Medical Systems, Inc. Electrospun material covered medical appliances and methods of manufacture
US9198999B2 (en) 2012-09-21 2015-12-01 Merit Medical Systems, Inc. Drug-eluting rotational spun coatings and methods of use
US9827703B2 (en) 2013-03-13 2017-11-28 Merit Medical Systems, Inc. Methods, systems, and apparatuses for manufacturing rotational spun appliances
WO2014159710A1 (en) 2013-03-13 2014-10-02 Merit Medical Systems, Inc. Serially deposited fiber materials and associated devices and methods
JP6649246B2 (ja) * 2013-03-14 2020-02-19 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ タンパク質の徐放性送達の組成物及び製造プロセス中のタンパク質の安定化方法
EP2968571A4 (de) 2013-03-15 2016-09-07 Psivida Inc Biologisch abbaubare zusammensetzungen auf siliciumbasis zur abgabe therapeutischer mittel
MX2016001593A (es) 2013-08-09 2016-09-29 Allergan Pharmaceuticals Int Ltd Composicion de enzima digestiva adecuada para administracion enterica.
WO2015054662A1 (en) 2013-10-10 2015-04-16 Eastern Virginia Medical School 4-((2-hydroxy-3-methoxybenzyl)amino) benzenesulfonamide derivatives as 12-lipoxygenase inhibitors
JP2017519490A (ja) 2014-06-19 2017-07-20 アプタリス ファルマ リミテッド 膵臓抽出物からのウイルス汚染の除去方法
CN118634202A (zh) * 2016-08-05 2024-09-13 帕克治疗公司 室温稳定的口服降钙素制剂
US9987369B2 (en) 2016-11-01 2018-06-05 International Business Machines Corporation Vitamin functionalized gel-forming block copolymers for biomedical applications
US11534375B2 (en) * 2017-03-28 2022-12-27 Agency For Science, Technology And Research Solvent-free method of encapsulating a hydrophobic active
KR101969723B1 (ko) * 2017-10-26 2019-04-17 충남대학교산학협력단 용융 전기분사 공정에 의한 생분해성 마이크로비드의 제조방법
JP7094524B2 (ja) 2018-01-24 2022-07-04 思納福（北京）医療科技有限公司 デジタルｐｃｒ検出器、デジタルｐｃｒ定量検出方法、異なる体積のデジタルｐｃｒの定量解析方法、デジタルｐｃｒ検出方法、核酸検出微小球、核酸検出微小球製造方法、核酸検出微小球試薬キット及びハイスループット核酸検出方法
CN111206081B (zh) * 2018-11-21 2023-06-30 思纳福(苏州)生命科技有限公司 核酸检测微球、制备方法、试剂盒及高通量核酸检测方法
WO2020071912A1 (en) * 2018-10-02 2020-04-09 Innocore Technologies B.V. Extended release formulations of human chorionic gonadotropin (hcg)
EP3901216B1 (de) 2018-12-20 2024-04-17 LG Chem, Ltd. Polyalkylencarbonat-polymilchsäureverbund, verfahren zu seiner herstellung und damit hergestellter formkörper
CN113651950B (zh) * 2021-08-23 2023-12-22 陈强 一种可生物降解高分子微球及其制备方法
WO2023056368A1 (en) 2021-09-30 2023-04-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cyclic peptides as non-hormonal male contraceptive agents and methods of use thereof
CN116159035A (zh) * 2022-10-14 2023-05-26 上海威高医疗技术发展有限公司 一种低熔点疏水性聚合物微球及其制备方法
CN115536872A (zh) * 2022-10-19 2022-12-30 上海威高医疗技术发展有限公司 一种含聚合物微球的交联凝胶材料及其制备方法
CN116262157B (zh) * 2022-12-29 2024-05-10 高颜苑科技(深圳)有限责任公司 一种基于生发的多肽缓释微针制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0092918B1 (de) * 1982-04-22 1988-10-19 Imperial Chemical Industries Plc Mittel mit verzögerter Freigabe
US4438253A (en) * 1982-11-12 1984-03-20 American Cyanamid Company Poly(glycolic acid)/poly(alkylene glycol) block copolymers and method of manufacturing the same
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
GB8416234D0 (en) * 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
ES2058081T3 (es) * 1986-09-05 1994-11-01 American Cyanamid Co Poliesteres que contienen bloques de oxido de alquileno como sistemas de administracion de medicamentos.
JP2670680B2 (ja) * 1988-02-24 1997-10-29 株式会社ビーエムジー 生理活性物質含有ポリ乳酸系微小球およびその製造法
JPH064540B2 (ja) * 1988-09-14 1994-01-19 多木化学株式会社 医用組成物
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5324519A (en) * 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5418010A (en) * 1990-10-05 1995-05-23 Griffith Laboratories Worldwide, Inc. Microencapsulation process
US5330768A (en) * 1991-07-05 1994-07-19 Massachusetts Institute Of Technology Controlled drug delivery using polymer/pluronic blends
GB9211268D0 (en) * 1992-05-28 1992-07-15 Ici Plc Salts of basic peptides with carboxyterminated polyesters

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DE69631290D1 (de) 2004-02-12
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EP0857081A4 (de) 1999-03-17
KR19990067014A (ko) 1999-08-16
US5665428A (en) 1997-09-09
JPH11515016A (ja) 1999-12-21
CA2235602A1 (en) 1997-05-01
EP0857081A1 (de) 1998-08-12
EP0857081B1 (de) 2004-01-07
KR100422391B1 (ko) 2004-06-12

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