ATE258175T1 - 3-thiazol-4-yl-pyrrolidinderivate als amp- spezifische phosphodiesterase-inhibitoren - Google Patents

3-thiazol-4-yl-pyrrolidinderivate als amp- spezifische phosphodiesterase-inhibitoren

Info

Publication number: ATE258175T1
Authority: AT; Austria
Prior art keywords: thiazole; phosphodiesterase inhibitors; pyrrolidine derivatives; specific phosphodiesterase; disclosed
Prior art date: 1999-12-23

Application number

AT00992525T

Other languages

English (en)

Inventor

Kerry W Fowler

Joshua Odingo

Original Assignee

Icos Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-23

Filing date

2000-11-28

Publication date

2004-02-15

2000-11-28 Application filed by Icos Corp filed Critical Icos Corp

2004-02-15 Application granted granted Critical

2004-02-15 Publication of ATE258175T1 publication Critical patent/ATE258175T1/de

Links

RWTPTYUXLDJACB-UHFFFAOYSA-N 4-pyrrolidin-3-yl-1,3-thiazole Chemical class C1NCCC1C1=CSC=N1 RWTPTYUXLDJACB-UHFFFAOYSA-N 0.000 title 1
229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 title 1
239000002571 phosphodiesterase inhibitor Substances 0.000 title 1
210000003169 central nervous system Anatomy 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
102000004127 Cytokines Human genes 0.000 abstract 1
108090000695 Cytokines Proteins 0.000 abstract 1
101100296720 Dictyostelium discoideum Pde4 gene Proteins 0.000 abstract 1
101100082610 Plasmodium falciparum (isolate 3D7) PDEdelta gene Proteins 0.000 abstract 1
229940124639 Selective inhibitor Drugs 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
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- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Oncology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Tropical Medicine & Parasitology (AREA)
Communicable Diseases (AREA)
Hospice & Palliative Care (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Otolaryngology (AREA)
Ophthalmology & Optometry (AREA)
Psychology (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)

AT00992525T 1999-12-23 2000-11-28 3-thiazol-4-yl-pyrrolidinderivate als amp- spezifische phosphodiesterase-inhibitoren ATE258175T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US17195099P	1999-12-23	1999-12-23
PCT/US2000/042293 WO2001046184A1 (en)	1999-12-23	2000-11-28	3-thiazol-4-yl-pyprolidine derivatives as amp-specific phosphodiesterase inhibitors

Publications (1)

Publication Number	Publication Date
ATE258175T1 true ATE258175T1 (de)	2004-02-15

Family

ID=22625761

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00992525T ATE258175T1 (de)	1999-12-23	2000-11-28	3-thiazol-4-yl-pyrrolidinderivate als amp- spezifische phosphodiesterase-inhibitoren

Country Status (12)

Country	Link
US (2)	US6313156B1 (de)
EP (1)	EP1242415B1 (de)
JP (1)	JP2003518116A (de)
CN (1)	CN1222523C (de)
AT (1)	ATE258175T1 (de)
AU (1)	AU778593B2 (de)
CA (1)	CA2395114C (de)
DE (1)	DE60007897T2 (de)
DK (1)	DK1242415T3 (de)
ES (1)	ES2215093T3 (de)
PT (1)	PT1242415E (de)
WO (1)	WO2001046184A1 (de)

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US7897609B2 (en)	2004-06-18	2011-03-01	3M Innovative Properties Company	Aryl substituted imidazonaphthyridines
US8026366B2 (en)	2004-06-18	2011-09-27	3M Innovative Properties Company	Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
WO2006065280A2 (en)	2004-06-18	2006-06-22	3M Innovative Properties Company	Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
ES2392648T3 (es)	2004-12-30	2012-12-12	3M Innovative Properties Company	Compuestos quirales sustituidos que contienen un núcleo 1,2-imidazo-4,5-c condensado
JP5543068B2 (ja)	2004-12-30	2014-07-09	スリーエムイノベイティブプロパティズカンパニー	キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
CA2597092A1 (en)	2005-02-04	2006-08-10	Coley Pharmaceutical Group, Inc.	Aqueous gel formulations containing immune reponse modifiers
CA2597587A1 (en)	2005-02-11	2006-08-17	Coley Pharmaceutical Group, Inc.	Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
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JP2008538550A (ja)	2005-04-01	2008-10-30	コーリーファーマシューティカルグループ，インコーポレイテッド	ウイルス感染および腫瘍性疾患を処置するためのサイトカイン生合成の調節因子としての１−置換ピラゾロ（３，４−ｃ）環状化合物
EP2258359A3 (de)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin
JP2009506069A (ja)	2005-08-26	2009-02-12	ブレインセルス，インコーポレイティド	ムスカリン性受容体調節による神経発生
JP2009512711A (ja)	2005-10-21	2009-03-26	ブレインセルス，インコーポレイティド	Ｐｄｅ阻害による神経新生の調節
EP2314289A1 (de)	2005-10-31	2011-04-27	Braincells, Inc.	Gaba-rezeptor-vermittelte modulation von neurogenese
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en)	2006-05-09	2007-11-22	Braincells, Inc.	Neurogenesis by modulating angiotensin
CA2651862A1 (en)	2006-05-09	2007-11-22	Braincells, Inc.	5 ht receptor mediated neurogenesis
WO2008008432A2 (en)	2006-07-12	2008-01-17	Coley Pharmaceutical Group, Inc.	Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods
WO2008030651A1 (en) *	2006-09-08	2008-03-13	Braincells, Inc.	Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
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EP2226323A1 (de)	2009-02-27	2010-09-08	Almirall, S.A.	Neuartige Tetrahydropyrazol[3,4-c]isochinolin-5-amin-Derivate
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2000
- 2000-11-27 US US09/723,091 patent/US6313156B1/en not_active Expired - Fee Related
- 2000-11-28 DE DE60007897T patent/DE60007897T2/de not_active Expired - Fee Related
- 2000-11-28 WO PCT/US2000/042293 patent/WO2001046184A1/en not_active Ceased
- 2000-11-28 DK DK00992525T patent/DK1242415T3/da active
- 2000-11-28 CN CNB008191212A patent/CN1222523C/zh not_active Expired - Fee Related
- 2000-11-28 PT PT00992525T patent/PT1242415E/pt unknown
- 2000-11-28 CA CA002395114A patent/CA2395114C/en not_active Expired - Fee Related
- 2000-11-28 AU AU45077/01A patent/AU778593B2/en not_active Ceased
- 2000-11-28 EP EP00992525A patent/EP1242415B1/de not_active Expired - Lifetime
- 2000-11-28 AT AT00992525T patent/ATE258175T1/de not_active IP Right Cessation
- 2000-11-28 JP JP2001547094A patent/JP2003518116A/ja active Pending
- 2000-11-28 ES ES00992525T patent/ES2215093T3/es not_active Expired - Lifetime
2001
- 2001-09-18 US US09/954,934 patent/US6486186B2/en not_active Expired - Fee Related

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Publication number	Publication date
US6486186B2 (en)	2002-11-26
PT1242415E (pt)	2004-05-31
US6313156B1 (en)	2001-11-06
JP2003518116A (ja)	2003-06-03
ES2215093T3 (es)	2004-10-01
EP1242415B1 (de)	2004-01-21
CA2395114C (en)	2006-07-11
CN1222523C (zh)	2005-10-12
DK1242415T3 (da)	2004-06-01
DE60007897T2 (de)	2004-11-04
AU4507701A (en)	2001-07-03
DE60007897D1 (de)	2004-02-26
CN1434823A (zh)	2003-08-06
AU778593B2 (en)	2004-12-09
WO2001046184A1 (en)	2001-06-28
EP1242415A1 (de)	2002-09-25
CA2395114A1 (en)	2001-06-28
US20020042435A1 (en)	2002-04-11

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