ATE258686T1 - Nachweis, quantifizierung und klassifizierung von ras-proteinen in körperflüssigkeiten und geweben - Google Patents

Nachweis, quantifizierung und klassifizierung von ras-proteinen in körperflüssigkeiten und geweben

Info

Publication number
ATE258686T1
ATE258686T1 AT96118598T AT96118598T ATE258686T1 AT E258686 T1 ATE258686 T1 AT E258686T1 AT 96118598 T AT96118598 T AT 96118598T AT 96118598 T AT96118598 T AT 96118598T AT E258686 T1 ATE258686 T1 AT E258686T1
Authority
AT
Austria
Prior art keywords
tissues
detection
ras
quantification
classification
Prior art date
Application number
AT96118598T
Other languages
English (en)
Inventor
Walter Patrick Carney
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of ATE258686T1 publication Critical patent/ATE258686T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57585—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds identifiable in body fluids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57575—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
AT96118598T 1988-04-22 1989-04-20 Nachweis, quantifizierung und klassifizierung von ras-proteinen in körperflüssigkeiten und geweben ATE258686T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18558288A 1988-04-22 1988-04-22
US33482389A 1989-04-11 1989-04-11

Publications (1)

Publication Number Publication Date
ATE258686T1 true ATE258686T1 (de) 2004-02-15

Family

ID=26881267

Family Applications (2)

Application Number Title Priority Date Filing Date
AT96118598T ATE258686T1 (de) 1988-04-22 1989-04-20 Nachweis, quantifizierung und klassifizierung von ras-proteinen in körperflüssigkeiten und geweben
AT89904962T ATE154134T1 (de) 1988-04-22 1989-04-20 Nachweis, quantifizierung und klassifizierung von ras-proteinen in körperflüssigkeiten und geweben

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT89904962T ATE154134T1 (de) 1988-04-22 1989-04-20 Nachweis, quantifizierung und klassifizierung von ras-proteinen in körperflüssigkeiten und geweben

Country Status (9)

Country Link
EP (2) EP0411018B1 (de)
JP (1) JPH0816679B2 (de)
AT (2) ATE258686T1 (de)
AU (1) AU634961B2 (de)
CA (1) CA1340368C (de)
DE (2) DE68929511T2 (de)
DK (1) DK254390A (de)
FI (1) FI905189A0 (de)
WO (1) WO1989010565A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028527A (en) * 1988-02-22 1991-07-02 Applied Bio Technology Monoclonal antibodies against activated ras proteins with amino acid mutations at position 13 of the protein
GB9103974D0 (en) * 1991-02-26 1991-04-10 Norsk Hydro As Therapeutically useful peptides or peptide fragments
US6087188A (en) * 1992-11-13 2000-07-11 Alk A/S Two-site immunoassay for an antibody with chemiluminescent label and biotin bound ligand
WO1998021585A1 (en) * 1996-11-15 1998-05-22 Cornell Research Foundation, Inc. Activated ras interaction assay
CA2612693C (en) * 2005-06-23 2012-05-08 Bayer Healthcare Llc Quantitative assays for ras p21 in body fluids
US20100255514A1 (en) 2007-08-16 2010-10-07 The Royal Institution For The Advancement Of Learning/Mcgill University Tumor cell-derived microvesicles
CA2733672C (en) * 2007-08-16 2018-09-11 The Royal Institution For The Advancement Of Learning/Mcgill University Tumor cell-derived microvesicles

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4228237A (en) * 1978-09-21 1980-10-14 Calbiochem-Behring Corp. Methods for the detection and determination of ligands
JPS5837713B2 (ja) 1978-12-01 1983-08-18 富士通株式会社 半導体レ−ザ−装置の製造方法
SE447028B (sv) * 1980-06-30 1986-10-20 Erik Audunn Cerven Bestemning av endstaende sackaridgrupper i glykoprotein
US4535058A (en) * 1982-10-01 1985-08-13 Massachusetts Institute Of Technology Characterization of oncogenes and assays based thereon
US4504585A (en) * 1982-04-05 1985-03-12 Aalto Scientific, Ltd. Affinity immunoassay system
US4699877A (en) * 1982-11-04 1987-10-13 The Regents Of The University Of California Methods and compositions for detecting human tumors
CA1219232A (en) * 1983-08-17 1987-03-17 Richard A. Lerner Polypeptide-induced monoclonal receptors to protein ligands
US4725550A (en) * 1984-01-19 1988-02-16 Research Foundation Of State University Of New York Novel mutation of the c-K-ras oncogene activated in a human lung carcinoma
JPS6185327A (ja) * 1984-09-19 1986-04-30 シタス　コーポレイシヨン 発癌遺伝子生成物に対する抗体
US4762706A (en) * 1984-10-17 1988-08-09 Cetus Corporation Peptide antibodies and their use in detecting oncogene products
US4798787A (en) * 1984-09-19 1989-01-17 Cetus Corporation Peptide antibodies and their use in detecting oncogene products
GB8501563D0 (en) * 1985-01-22 1985-02-20 Kodak Ltd Uv-absorbing polymers
CA1296660C (en) * 1985-01-29 1992-03-03 Walter P. Carney Monoclonal antibody against a ras oncogene p21 related dodecapeptide
US5028527A (en) * 1988-02-22 1991-07-02 Applied Bio Technology Monoclonal antibodies against activated ras proteins with amino acid mutations at position 13 of the protein
AU3533089A (en) * 1988-04-22 1989-11-24 E.I. Du Pont De Nemours And Company Monoclonal antibodies specific for the harvey, kirsten, and n ras proteins and their use as diagnostic reagents
TWI228804B (en) 2003-07-02 2005-03-01 Lite On Semiconductor Corp Chip package substrate having flexible printed circuit board and method for fabricating the same

Also Published As

Publication number Publication date
EP0767381A1 (de) 1997-04-09
JPH03505250A (ja) 1991-11-14
JPH0816679B2 (ja) 1996-02-21
AU634961B2 (en) 1993-03-11
WO1989010565A1 (en) 1989-11-02
AU3447989A (en) 1989-11-24
EP0767381B1 (de) 2004-01-28
EP0411018A1 (de) 1991-02-06
DE68929511D1 (de) 2004-03-04
DE68929511T2 (de) 2004-11-18
ATE154134T1 (de) 1997-06-15
DE68928106T2 (de) 1997-12-04
DK254390D0 (da) 1990-10-22
FI905189A7 (fi) 1990-10-22
DK254390A (da) 1990-12-21
EP0411018B1 (de) 1997-06-04
DE68928106D1 (de) 1997-07-10
CA1340368C (en) 1999-02-02
FI905189A0 (fi) 1990-10-22
EP0411018A4 (en) 1991-08-21

Similar Documents

Publication Publication Date Title
CY1115366T1 (el) Δεικτες ογκου
CA2072314A1 (en) Methods for detection of carcinoma metastases by nucleic acid amplification
EP1364063A4 (de) Nachweis von herpex-simplex-virus
ATE361025T1 (de) Analytisches messgerät mit stechhilfe
WO1995016919A3 (en) Methods and compositions for the detection of colon cancers
ATE191567T1 (de) Bestimmung von nukleären matrixproteinen in flüssigkeiten
CY1108182T1 (el) Μεσα εντοπισμου του παθολογικου μετασχηματισμου της πρωτεϊνης app και εφαρμογες τους
ATE258686T1 (de) Nachweis, quantifizierung und klassifizierung von ras-proteinen in körperflüssigkeiten und geweben
EP1537415A4 (de) VERFAHREN ZUR DIAGNOSE VON GEBûRMUTTERHALSKREBS
ATE163676T1 (de) Molekulare klone von hiv-1 und deren verwendung
ATE166157T1 (de) Nachweis des syndecangehalts in biologischen materialien, wie geweben und körperflüssigkeiten, zur anzeige der bösartigen umwandlung von zellen
BR9914873A (pt) Sensor capaz de detectar seletivamente apresença de material fecal e artigo higiênico
EA199900138A1 (ru) Обнаружение активности гепараназы млекопитающих и очистка гепараназы млекопитающих
ATE229571T1 (de) Nachweis und identifizierung von nicht-polio enteroviren
CY1106349T1 (el) Συστηματα ανιχνευσης ανοσοπροσδιορισμου ιικου αντιγονου ηπατιτιδας c
WO2000026251A3 (en) A COMPLEX OF A CHAPERONE WITH ss-AMYLOID AND METHODS EMPLOYING THIS COMPLEX
ATE323176T1 (de) Nachweis von brusttumorvirus-artigen sequenzen in brustkrebs bei menschen
EP0563244A4 (en) Human phospholipase activating protein and methods for diagnosis of rheumatoid arthritis
ITRM920603A1 (it) La sequenza dell'inserto cprl3, parte del gene della proteina della oociste di cryptosporidium (cowp), e derivati utili per la diagnosi dell'infezione da cryptosporidium
RU95118039A (ru) Способ определения функционального состояния биологически активных точек тела человека
EP1398378A4 (de) In neuroblastom isolierte nukleinsäuren
NO904548L (no) Paavisning, kvantifisering og klassifikasjon av ras-proteiner i kroppsfluider og -vev.
DE69915437D1 (de) Plasmasammlungen von mehr als 200 gesunden Patienten und davon abgeleiteter Kalibrierstandard
WO2024192027A8 (en) Kidney cancer detection proteins and methods of use thereof
FR2790958B1 (fr) Detection dans un echantillon biologique de la proteine hsi, cette proteine etant associee a un cancer mammaire

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0767381

Country of ref document: EP

EELA Cancelled due to lapse of time