ATE259363T1 - Piperazinderivate als 5-ht1b antagonisten - Google Patents
Piperazinderivate als 5-ht1b antagonistenInfo
- Publication number
- ATE259363T1 ATE259363T1 AT00967803T AT00967803T ATE259363T1 AT E259363 T1 ATE259363 T1 AT E259363T1 AT 00967803 T AT00967803 T AT 00967803T AT 00967803 T AT00967803 T AT 00967803T AT E259363 T1 ATE259363 T1 AT E259363T1
- Authority
- AT
- Austria
- Prior art keywords
- piperazine derivatives
- ht1b antagonists
- ht1b
- antagonists
- piperazine
- Prior art date
Links
- 102100027499 5-hydroxytryptamine receptor 1B Human genes 0.000 title 1
- 101710138639 5-hydroxytryptamine receptor 1B Proteins 0.000 title 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9922831.4A GB9922831D0 (en) | 1999-09-25 | 1999-09-25 | Novel compounds |
| GB0001936A GB0001936D0 (en) | 2000-01-27 | 2000-01-27 | Novel compounds |
| GB0013873A GB0013873D0 (en) | 2000-06-07 | 2000-06-07 | Novel compounds |
| PCT/EP2000/009442 WO2001023374A1 (en) | 1999-09-25 | 2000-09-21 | Piperazine derivatives as 5-ht1b antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE259363T1 true ATE259363T1 (de) | 2004-02-15 |
Family
ID=27255501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00967803T ATE259363T1 (de) | 1999-09-25 | 2000-09-21 | Piperazinderivate als 5-ht1b antagonisten |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US6747030B1 (de) |
| EP (1) | EP1216239B1 (de) |
| JP (1) | JP2003510317A (de) |
| KR (1) | KR20020030126A (de) |
| CN (1) | CN1190432C (de) |
| AR (1) | AR029454A1 (de) |
| AT (1) | ATE259363T1 (de) |
| AU (1) | AU765020B2 (de) |
| BR (1) | BR0014279A (de) |
| CA (1) | CA2385737A1 (de) |
| CO (1) | CO5200839A1 (de) |
| CZ (1) | CZ20021038A3 (de) |
| DE (1) | DE60008262T2 (de) |
| DK (1) | DK1216239T3 (de) |
| ES (1) | ES2211624T3 (de) |
| HK (1) | HK1046909B (de) |
| HU (1) | HUP0202787A3 (de) |
| IL (1) | IL148818A0 (de) |
| MX (1) | MXPA02003175A (de) |
| MY (1) | MY122391A (de) |
| NO (1) | NO20021459L (de) |
| NZ (1) | NZ517865A (de) |
| PE (1) | PE20010641A1 (de) |
| PL (1) | PL362900A1 (de) |
| PT (1) | PT1216239E (de) |
| TR (1) | TR200200795T2 (de) |
| WO (1) | WO2001023374A1 (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1216239B1 (de) * | 1999-09-25 | 2004-02-11 | SmithKline Beecham plc | Piperazinderivate als 5-ht1b antagonisten |
| US6906192B2 (en) | 2000-11-07 | 2005-06-14 | Bristol Myers Squibb Company | Processes for the preparation of acid derivatives useful as serine protease inhibitors |
| HUP0400651A2 (hu) | 2000-11-07 | 2004-06-28 | Bristol-Myers Squibb Company | Szerin proteáz inhibitorokként alkalmazható savszármazékok és ezeket tartalmazó gyógyszerkészítmények |
| GB0106419D0 (en) | 2001-03-15 | 2001-05-02 | Smithkline Beecham Plc | Novel compounds |
| GB0106586D0 (en) * | 2001-03-16 | 2001-05-09 | Smithkline Beecham Plc | Novel compounds |
| GB0224557D0 (en) * | 2002-10-22 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| BRPI0410561A (pt) | 2003-06-18 | 2006-06-20 | Pfizer Prod Inc | lactamas de piperazinileteroarilóxi-n-arill e de piperazinilarilóxi |
| RU2007107349A (ru) | 2004-07-28 | 2008-09-10 | Глэксо Груп Лимитед (GB) | Пиперазиновые производные, применение для лечения желудочно-кишечных расстройств |
| ATE535525T1 (de) | 2006-03-31 | 2011-12-15 | Wako Pure Chem Ind Ltd | Cyaninfarbstoff vom pyrazoltyp |
| PE20080176A1 (es) | 2006-03-31 | 2008-04-25 | Glaxo Group Ltd | Compuestos de arilpiperazina sulfonamida como agonista de los receptores de secretagogos de la hormona de crecimiento (ghs) |
| KR102205755B1 (ko) | 2010-08-10 | 2021-01-22 | 렘펙스 파머수티클스 인코퍼레이티드 | 고리형 보론산 에스터 유도체의 결정 형태 |
| WO2013033461A1 (en) | 2011-08-31 | 2013-03-07 | Rempex Pharmaceuticals, Inc. | Heterocyclic boronic acid ester derivatives and therapeutic uses thereof |
| US9156858B2 (en) | 2012-05-23 | 2015-10-13 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US10561675B2 (en) | 2012-06-06 | 2020-02-18 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
| CN102766139B (zh) * | 2012-08-14 | 2014-09-17 | 江苏先声药物研究有限公司 | 阿齐沙坦的多晶型物及其制备方法 |
| JP2016509594A (ja) | 2013-01-04 | 2016-03-31 | レンペックス・ファーマシューティカルズ・インコーポレイテッド | ボロン酸誘導体及びその治療的使用 |
| US9241947B2 (en) | 2013-01-04 | 2016-01-26 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US9101638B2 (en) | 2013-01-04 | 2015-08-11 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| JP6324409B2 (ja) | 2013-01-04 | 2018-05-16 | レンペックス・ファーマシューティカルズ・インコーポレイテッド | ボロン酸誘導体及びその治療的使用 |
| FI3604316T3 (fi) | 2014-05-05 | 2024-02-29 | Melinta Therapeutics Inc | Boronaattisuolojen synteesi |
| US9687497B1 (en) | 2014-05-05 | 2017-06-27 | Rempex Pharmaceuticals, Inc. | Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof |
| AU2015264418A1 (en) | 2014-05-19 | 2016-11-10 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| EA201692301A1 (ru) | 2014-07-01 | 2017-06-30 | Ремпекс Фармасьютикалз, Инк. | Производные бороновой кислоты и их терапевтическое применение |
| WO2016081297A1 (en) | 2014-11-18 | 2016-05-26 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
| GB2532990A (en) | 2014-12-05 | 2016-06-08 | Schlumberger Holdings | Corrosion inhibition |
| US20180051041A1 (en) | 2015-03-17 | 2018-02-22 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| GB2543498A (en) * | 2015-10-19 | 2017-04-26 | Schlumberger Holdings | Corrosion inhibition |
| UA124464C2 (uk) | 2016-06-30 | 2021-09-22 | Кьюпекс Біофарма, Інк. | Похідні боронової кислоти та їх терапевтичні застосування |
| EP3694864B1 (de) | 2017-10-11 | 2025-03-05 | Qpex Biopharma, Inc. | Boronsäurederivate und ihre synthese |
| WO2019204419A1 (en) | 2018-04-20 | 2019-10-24 | The Medicines Company (San Diego), Llc | Boronic acid derivatives and therapeutic uses thereof |
| WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
| AU2021266715A1 (en) | 2020-05-05 | 2022-11-17 | Qpex Biopharma, Inc. | Boronic acid derivatives and synthesis, polymorphic forms, and therapeutic uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2162792T3 (es) * | 1991-09-18 | 2002-01-16 | Glaxo Group Ltd | Derivados de benzanilida como antagonistas de 5-ht1d. |
| JP3328936B2 (ja) * | 1993-09-03 | 2002-09-30 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ５ｈｔ１ｄレセプター拮抗薬用インドールおよびインドリン誘導体 |
| JP2001506995A (ja) * | 1996-12-19 | 2001-05-29 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | Ｎ−ピペラジン−１−イルフェニル−ベンズアミド誘導体 |
| US6159979A (en) * | 1997-04-18 | 2000-12-12 | Smithkline Beecham P.L.C. | Bicyclic aryl or a bicyclic heterocyclic ring containing compounds having a combined 5HT1A, 5HT1B and 5HT1D receptor antagonistic activity |
| AU732863B2 (en) * | 1997-04-18 | 2001-05-03 | Smithkline Beecham Plc | Indole derivatives having combined 5HT1A, 5HT1B and 5HT1D receptor antagonist activity |
| GB9725931D0 (en) * | 1997-12-05 | 1998-02-04 | Smithkline Beecham Plc | Novel compounds |
| EP1216239B1 (de) * | 1999-09-25 | 2004-02-11 | SmithKline Beecham plc | Piperazinderivate als 5-ht1b antagonisten |
-
2000
- 2000-09-21 EP EP00967803A patent/EP1216239B1/de not_active Expired - Lifetime
- 2000-09-21 TR TR2002/00795T patent/TR200200795T2/xx unknown
- 2000-09-21 WO PCT/EP2000/009442 patent/WO2001023374A1/en not_active Ceased
- 2000-09-21 CA CA002385737A patent/CA2385737A1/en not_active Abandoned
- 2000-09-21 MX MXPA02003175A patent/MXPA02003175A/es active IP Right Grant
- 2000-09-21 HU HU0202787A patent/HUP0202787A3/hu unknown
- 2000-09-21 CZ CZ20021038A patent/CZ20021038A3/cs unknown
- 2000-09-21 DK DK00967803T patent/DK1216239T3/da active
- 2000-09-21 PT PT00967803T patent/PT1216239E/pt unknown
- 2000-09-21 AT AT00967803T patent/ATE259363T1/de not_active IP Right Cessation
- 2000-09-21 AU AU77836/00A patent/AU765020B2/en not_active Ceased
- 2000-09-21 BR BR0014279-4A patent/BR0014279A/pt not_active IP Right Cessation
- 2000-09-21 CN CNB008162697A patent/CN1190432C/zh not_active Expired - Fee Related
- 2000-09-21 JP JP2001526526A patent/JP2003510317A/ja active Pending
- 2000-09-21 NZ NZ517865A patent/NZ517865A/en unknown
- 2000-09-21 IL IL14881800A patent/IL148818A0/xx unknown
- 2000-09-21 DE DE60008262T patent/DE60008262T2/de not_active Expired - Fee Related
- 2000-09-21 PL PL00362900A patent/PL362900A1/xx not_active Application Discontinuation
- 2000-09-21 KR KR1020027003825A patent/KR20020030126A/ko not_active Ceased
- 2000-09-21 US US10/089,013 patent/US6747030B1/en not_active Expired - Fee Related
- 2000-09-21 ES ES00967803T patent/ES2211624T3/es not_active Expired - Lifetime
- 2000-09-21 HK HK02108463.9A patent/HK1046909B/en not_active IP Right Cessation
- 2000-09-22 PE PE2000000989A patent/PE20010641A1/es not_active Application Discontinuation
- 2000-09-22 AR ARP000104983A patent/AR029454A1/es not_active Application Discontinuation
- 2000-09-22 MY MYPI20004437A patent/MY122391A/en unknown
- 2000-09-22 CO CO00072095A patent/CO5200839A1/es not_active Application Discontinuation
-
2002
- 2002-03-22 NO NO20021459A patent/NO20021459L/no not_active Application Discontinuation
-
2004
- 2004-03-17 US US10/802,236 patent/US20040176388A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NO20021459D0 (no) | 2002-03-22 |
| US6747030B1 (en) | 2004-06-08 |
| CO5200839A1 (es) | 2002-09-27 |
| CZ20021038A3 (cs) | 2002-08-14 |
| NZ517865A (en) | 2003-11-28 |
| PE20010641A1 (es) | 2001-07-14 |
| MY122391A (en) | 2006-04-29 |
| HK1046909A1 (en) | 2003-01-30 |
| JP2003510317A (ja) | 2003-03-18 |
| AU765020B2 (en) | 2003-09-04 |
| CN1399635A (zh) | 2003-02-26 |
| US20040176388A1 (en) | 2004-09-09 |
| HK1046909B (en) | 2004-12-03 |
| CA2385737A1 (en) | 2001-04-05 |
| TR200200795T2 (tr) | 2002-07-22 |
| HUP0202787A3 (en) | 2003-12-29 |
| ES2211624T3 (es) | 2004-07-16 |
| CN1190432C (zh) | 2005-02-23 |
| AR029454A1 (es) | 2003-07-02 |
| KR20020030126A (ko) | 2002-04-22 |
| DE60008262D1 (de) | 2004-03-18 |
| IL148818A0 (en) | 2002-09-12 |
| PT1216239E (pt) | 2004-05-31 |
| HUP0202787A2 (hu) | 2002-12-28 |
| EP1216239B1 (de) | 2004-02-11 |
| MXPA02003175A (es) | 2002-09-30 |
| NO20021459L (no) | 2002-03-22 |
| EP1216239A1 (de) | 2002-06-26 |
| WO2001023374A1 (en) | 2001-04-05 |
| BR0014279A (pt) | 2002-05-21 |
| DK1216239T3 (da) | 2004-06-14 |
| PL362900A1 (en) | 2004-11-02 |
| DE60008262T2 (de) | 2004-12-16 |
| AU7783600A (en) | 2001-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1216239 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |