ATE259640T1 - Verwendung von matrix-metalloproteinase inhibitoren zur förderung der wundheilung - Google Patents

Verwendung von matrix-metalloproteinase inhibitoren zur förderung der wundheilung

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Publication number
ATE259640T1
ATE259640T1 AT97949584T AT97949584T ATE259640T1 AT E259640 T1 ATE259640 T1 AT E259640T1 AT 97949584 T AT97949584 T AT 97949584T AT 97949584 T AT97949584 T AT 97949584T AT E259640 T1 ATE259640 T1 AT E259640T1
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AT
Austria
Prior art keywords
wound healing
matrix metalloproteinase
metalloproteinase inhibitors
promote wound
alzheimer
Prior art date
Application number
AT97949584T
Other languages
English (en)
Inventor
Thomas Michael Andrew Bocan
Peter Alan Boxer
Joseph Thomas Peterson Jr
Denis Schrier
Andrew David White
Original Assignee
Warner Lambert Co
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Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE259640T1 publication Critical patent/ATE259640T1/de

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
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    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/404—Indoles, e.g. pindolol
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    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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    • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
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    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants

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AT97949584T 1996-12-17 1997-11-21 Verwendung von matrix-metalloproteinase inhibitoren zur förderung der wundheilung ATE259640T1 (de)

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US3275396P 1996-12-17 1996-12-17
PCT/US1997/021532 WO1998026773A1 (en) 1996-12-17 1997-11-21 Use of matrix metalloproteinase inhibitors for treating neurological disorders and promoting wound healing

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US6410580B1 (en) 1998-02-04 2002-06-25 Novartis Ag Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases
EP1053226A1 (de) 1998-02-04 2000-11-22 Novartis AG Sulfonylaminoderivate, die metalloproteinasen hemmen
AU6229699A (en) * 1998-10-26 2000-05-15 Sumitomo Pharmaceuticals Company, Limited Beta-amyloid formation inhibitors
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JP4074043B2 (ja) 2000-03-27 2008-04-09 株式会社資生堂 皮膚基底膜形成促進剤、人工皮膚形成促進剤及び人工皮膚の製造方法
US6376524B1 (en) 2000-06-21 2002-04-23 Sunesis Pharmaceuticals, Inc. Triphenyl compounds as interleukin-4 antagonists
WO2002006227A1 (en) * 2000-07-18 2002-01-24 Chugai Seiyaku Kabushiki Kaisha Matrix metalloprotease inhibitors
WO2002026696A1 (en) 2000-09-29 2002-04-04 Prolifix Limited Carbamic acid compounds comprising an amide linkage as hdac inhibitors
ATE298565T1 (de) * 2000-11-23 2005-07-15 Vernalis Oxford Ltd N-formyl hydroxylamine derivate als inhibitoren der bakteriellen polypeptid deformylase zur behandlung von mikrobiellen infektionen
WO2003006006A1 (en) * 2001-07-09 2003-01-23 The Regents Of The University Of California Use of matrix metalloproteinase inhibitors to mitigate nerve damage
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US7250514B1 (en) 2002-10-21 2007-07-31 Takeda San Diego, Inc. Histone deacetylase inhibitors
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MX2007001337A (es) * 2004-08-02 2008-03-13 Genmedica Therapeutics Sl Compuestos para inhibir amina-oxidasas que contienen cobre y usos de los mismos.
GB0708507D0 (en) 2007-05-02 2007-06-13 Queen Mary & Westfield College Substituted phosphonates and their use
US20090136718A1 (en) * 2007-11-28 2009-05-28 Paul Dacey Reinforced Bonded Constructs
WO2010011302A1 (en) * 2008-07-22 2010-01-28 Chdi, Inc. Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
BR112014004741B1 (pt) 2011-08-30 2021-10-13 Chdi Foundation, Inc Entidade química, seu uso e composição farmacêutica compreendendo a mesma
AU2012300246A1 (en) 2011-08-30 2014-03-06 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
AU2015289492B2 (en) 2014-07-17 2020-02-20 Chdi Foundation, Inc. Methods and compositions for treating HIV-related disorders
CN111249281B (zh) * 2020-03-26 2020-11-24 徐州医科大学 Trpml1特异性小分子抑制剂ml-si3的新用途
CN116209439A (zh) 2020-09-23 2023-06-02 圣裘德儿童研究医院有限公司 作为cereblon蛋白调节剂的取代的N-(2-(2,6-二氧代哌啶-3-基)-1,3-二氧代异吲哚啉-5-基)芳基磺酰胺类似物
KR102612229B1 (ko) * 2021-05-21 2023-12-08 가천대학교 산학협력단 N-[(4'-브로모[1,1'-바이페닐]-4-일)설포닐]-l-발린 또는 이의 약제학적으로 허용 가능한 염을 포함하는 아밀로이드 베타의 올리고머화 및 피브릴화 억제용 조성물

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ZA9711279B (en) 1998-06-23
EP0946166B1 (de) 2004-02-18
WO1998026773A1 (en) 1998-06-25
AU737117B2 (en) 2001-08-09
EP0946166A1 (de) 1999-10-06
BR9714142A (pt) 2000-02-29
DK0946166T3 (da) 2004-05-03
DE69727695T2 (de) 2005-02-10
US6340709B1 (en) 2002-01-22
AU7735398A (en) 1998-07-15
NZ334925A (en) 2001-06-29
ES2212142T3 (es) 2004-07-16
PT946166E (pt) 2004-06-30
DE69727695D1 (de) 2004-03-25
CA2264692A1 (en) 1998-06-25

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