IS1664B - Ný aðferð við að framleiða útskipt 4-fenýl-4-píperídínkarboxamíð sem hefur bæði staðbundin deyfandiog kvalastillandi áhrif - Google Patents

Ný aðferð við að framleiða útskipt 4-fenýl-4-píperídínkarboxamíð sem hefur bæði staðbundin deyfandiog kvalastillandi áhrif

Info

Publication number: IS1664B
Authority: IS; Iceland
Prior art keywords: piperidinecarboxamide; phenyl; new method; local anesthetic; analgesic effect
Prior art date: 1989-12-21

Application number

IS3659A

Other languages

English (en)

Other versions

IS3659A7 (is

Inventor

Ask Anna-Lena

Verner Sandberg Rune

Original Assignee

Aktiebolaget Astra

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-21

Filing date

1990-12-17

Publication date

1997-07-04

1990-12-17 Application filed by Aktiebolaget Astra filed Critical Aktiebolaget Astra

1991-06-22 Publication of IS3659A7 publication Critical patent/IS3659A7/is

1997-07-04 Publication of IS1664B publication Critical patent/IS1664B/is

Links

238000000034 method Methods 0.000 title abstract 2
JPUKONSIEHCAQA-UHFFFAOYSA-N 4-phenylpiperidine-4-carboxamide Chemical class C=1C=CC=CC=1C1(C(=O)N)CCNCC1 JPUKONSIEHCAQA-UHFFFAOYSA-N 0.000 title 1
230000000202 analgesic effect Effects 0.000 title 1
239000003589 local anesthetic agent Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pain & Pain Management (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Cosmetics (AREA)

IS3659A 1989-12-21 1990-12-17 Ný aðferð við að framleiða útskipt 4-fenýl-4-píperídínkarboxamíð sem hefur bæði staðbundin deyfandiog kvalastillandi áhrif IS1664B (is)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE8904298A SE8904298D0 (sv)	1989-12-21	1989-12-21	New compounds

Publications (2)

Publication Number	Publication Date
IS3659A7 IS3659A7 (is)	1991-06-22
IS1664B true IS1664B (is)	1997-07-04

Family

ID=20377821

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS3659A IS1664B (is)	1989-12-21	1990-12-17	Ný aðferð við að framleiða útskipt 4-fenýl-4-píperídínkarboxamíð sem hefur bæði staðbundin deyfandiog kvalastillandi áhrif

Country Status (40)

Country	Link
US (2)	US5227389A (is)
EP (1)	EP0506778B1 (is)
JP (1)	JP2656152B2 (is)
KR (1)	KR0179382B1 (is)
CN (1)	CN1037841C (is)
AT (1)	ATE138650T1 (is)
AU (1)	AU647068B2 (is)
BG (1)	BG60912B1 (is)
BR (1)	BR1100379A (is)
CA (1)	CA2069608C (is)
CZ (1)	CZ278035B6 (is)
DE (1)	DE69027221T2 (is)
DK (1)	DK0506778T3 (is)
DZ (1)	DZ1468A1 (is)
EG (1)	EG19361A (is)
ES (1)	ES2087280T3 (is)
FI (1)	FI100881B (is)
HK (1)	HK22997A (is)
HR (1)	HRP920591B1 (is)
HU (1)	HU213110B (is)
IE (1)	IE74855B1 (is)
IL (1)	IL96636A (is)
IS (1)	IS1664B (is)
LT (1)	LT4005B (is)
LV (2)	LV10949B (is)
NO (1)	NO178858C (is)
NZ (1)	NZ236293A (is)
PL (1)	PL163591B1 (is)
PT (1)	PT96303B (is)
RO (1)	RO112864B1 (is)
RU (1)	RU2039043C1 (is)
SA (1)	SA91110209B1 (is)
SE (1)	SE8904298D0 (is)
SG (1)	SG46413A1 (is)
SI (1)	SI9012346B (is)
SK (1)	SK658190A3 (is)
UA (1)	UA26403A (is)
WO (1)	WO1991009845A1 (is)
YU (1)	YU48086B (is)
ZA (1)	ZA909903B (is)

Families Citing this family (25)

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Publication number	Priority date	Publication date	Assignee	Title
JP3916092B2 (ja) *	1993-09-17	2007-05-16	杏林製薬株式会社	イミダゾリジノン誘導体とその酸付加塩及び老年性痴呆症の治療薬
SE9400447D0 (sv) *	1994-02-11	1994-02-11	Astra Ab	New compounds
SE9404438D0 (sv) *	1994-12-21	1994-12-21	Astra Ab	New process
US5931809A (en)	1995-07-14	1999-08-03	Depotech Corporation	Epidural administration of therapeutic compounds with sustained rate of release
GB9600235D0 (en) *	1996-01-05	1996-03-06	Pfizer Ltd	Therapeutic agents
DE19642591A1 (de) *	1996-10-15	1998-04-16	Basf Ag	Neue Piperidin-Ketocarbonsäure-Derivate, deren Herstellung und Anwendung
TW548271B (en) *	1996-12-20	2003-08-21	Astra Pharma Inc	Novel piperidine derivatives having an exocyclic double bond with analgesic effects
SE9604786D0 (sv) *	1996-12-20	1996-12-20	Astra Pharma Inc	New compounds
RU2125878C1 (ru) *	1996-12-26	1999-02-10	Новокузнецкий научно-исследовательский химико-фармацевтический институт	Анальгетическое средство
RU2117481C1 (ru) *	1997-07-15	1998-08-20	Государственный научно-исследовательский институт органической химии и технологии	Анальгетическое средство и способ его приготовления
US7799337B2 (en)	1997-07-21	2010-09-21	Levin Bruce H	Method for directed intranasal administration of a composition
US20020102291A1 (en) *	1997-12-15	2002-08-01	Noven Pharmaceuticals, Inc.	Compositions and method for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate
SE9803239D0 (sv) *	1998-09-24	1998-09-24	Diabact Ab	Composition for the treatment of acute pain
SE9803240D0 (sv) *	1998-09-24	1998-09-24	Diabact Ab	A pharmaceutical composition having a rapid action
JP4280073B2 (ja) *	2001-04-12	2009-06-17	ファーマコペイアドラッグディスカバリー，インコーポレイテッド	Ｍｃｈアンタゴニストとして使用されるアリールピペリジンおよびビアリールピペリジン
RU2203041C1 (ru) *	2001-12-27	2003-04-27	Закрытое акционерное общество "Брынцалов-А"	Спазмолитические таблетки бралангин
ES2356306T3 (es) *	2002-02-08	2011-04-06	Ono Pharmaceutical Co., Ltd.	Compuestos y fármacos derivados de piperidina que contienen los compuestos como principio activo.
AU2003300902A1 (en) *	2002-12-13	2004-07-09	Smithkline Beecham Corporation	Piperidine derivatives as CCR5 antagonists
WO2008045564A2 (en) *	2006-10-12	2008-04-17	Epix Delaware, Inc.	Carboxamide compounds and their use as antagonists of the chemokine ccr2 receptor
BRPI0820701A2 (pt)	2007-12-11	2015-06-16	Cytopathfinder Inc	Composto de carboxamida e seu uso como agonistas do receptor de quimiocina
US8473062B2 (en)	2008-05-01	2013-06-25	Autonomic Technologies, Inc.	Method and device for the treatment of headache
US8412336B2 (en)	2008-12-29	2013-04-02	Autonomic Technologies, Inc.	Integrated delivery and visualization tool for a neuromodulation system
US9320908B2 (en)	2009-01-15	2016-04-26	Autonomic Technologies, Inc.	Approval per use implanted neurostimulator
US8494641B2 (en)	2009-04-22	2013-07-23	Autonomic Technologies, Inc.	Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
US20220096452A1 (en)	2019-01-22	2022-03-31	Icm (Institut Du Cerveau Et De La Moelle Épinière)	Local anesthetic for the treatment of neurological symptoms resulting from brain dysfunctions

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE96980C1 (is)
US2486796A (en) *	1943-06-25	1949-11-01	Ciba Pharm Prod Inc	Esters of 1-alkyl-4-hydroxyphenylpiperidyl-4-ketones
US3334106A (en) *	1964-10-20	1967-08-01	Aldrich Chem Co Inc	N(aryl)n(hydrocarbyl)-omega-(4-phenyl-4-piperidinocarbonylheteroamine) alkanoamide
US3539580A (en) *	1967-06-26	1970-11-10	Janssen Pharm	4-aryl-4-aminoalkoxy-piperidines
CH498836A (de) *	1968-12-20	1970-11-15	Geigy Ag J R	Verfahren zur Herstellung von neuen Piperidinderivaten
US3737538A (en) *	1968-12-30	1973-06-05	Ciba Geigy Corp	Antitussive compositions and method with isonipecotic acid derivatives
FR2156470A2 (en) *	1971-10-21	1973-06-01	Synthelabo	1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents
ZA899436B (en) *	1988-12-12	1990-08-29	Ciba Geigy	Piperidine derivatives
US5100903A (en) *	1989-05-12	1992-03-31	Anaquest, Inc.	N-aryl-n-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds

1989
- 1989-12-21 SE SE8904298A patent/SE8904298D0/xx unknown
1990
- 1990-11-30 NZ NZ236293A patent/NZ236293A/xx unknown
- 1990-12-10 ZA ZA909903A patent/ZA909903B/xx unknown
- 1990-12-11 IL IL9663690A patent/IL96636A/en not_active IP Right Cessation
- 1990-12-12 DZ DZ900223A patent/DZ1468A1/xx active
- 1990-12-12 YU YU234690A patent/YU48086B/sh unknown
- 1990-12-12 SI SI9012346A patent/SI9012346B/sl not_active IP Right Cessation
- 1990-12-17 SG SG1996004491A patent/SG46413A1/en unknown
- 1990-12-17 JP JP3501896A patent/JP2656152B2/ja not_active Expired - Fee Related
- 1990-12-17 UA UA5052485A patent/UA26403A/uk unknown
- 1990-12-17 CA CA002069608A patent/CA2069608C/en not_active Expired - Fee Related
- 1990-12-17 EP EP91901571A patent/EP0506778B1/en not_active Expired - Lifetime
- 1990-12-17 ES ES91901571T patent/ES2087280T3/es not_active Expired - Lifetime
- 1990-12-17 DK DK91901571.9T patent/DK0506778T3/da active
- 1990-12-17 HU HU9202044A patent/HU213110B/hu unknown
- 1990-12-17 AU AU69783/91A patent/AU647068B2/en not_active Ceased
- 1990-12-17 IS IS3659A patent/IS1664B/is unknown
- 1990-12-17 RO RO92-0832A patent/RO112864B1/ro unknown
- 1990-12-17 DE DE69027221T patent/DE69027221T2/de not_active Expired - Fee Related
- 1990-12-17 WO PCT/SE1990/000818 patent/WO1991009845A1/en not_active Ceased
- 1990-12-17 AT AT91901571T patent/ATE138650T1/de not_active IP Right Cessation
- 1990-12-17 IE IE453490A patent/IE74855B1/en not_active IP Right Cessation
- 1990-12-17 KR KR1019920701484A patent/KR0179382B1/ko not_active Expired - Fee Related
- 1990-12-20 EG EG74690A patent/EG19361A/xx active
- 1990-12-20 PT PT96303A patent/PT96303B/pt active IP Right Grant
- 1990-12-21 CZ CS906581A patent/CZ278035B6/cs not_active IP Right Cessation
- 1990-12-21 CN CN90106009A patent/CN1037841C/zh not_active Expired - Fee Related
- 1990-12-21 US US07/633,246 patent/US5227389A/en not_active Expired - Lifetime
- 1990-12-21 SK SK6581-90A patent/SK658190A3/sk unknown
- 1990-12-21 PL PL90288409A patent/PL163591B1/pl not_active IP Right Cessation
1991
- 1991-01-09 SA SA91110209A patent/SA91110209B1/ar unknown
1992
- 1992-06-17 FI FI922806A patent/FI100881B/fi not_active IP Right Cessation
- 1992-06-17 NO NO922380A patent/NO178858C/no unknown
- 1992-06-19 RU SU925052485A patent/RU2039043C1/ru not_active IP Right Cessation
- 1992-06-19 BG BG96513A patent/BG60912B1/bg unknown
- 1992-09-29 HR HRP-2346/90A patent/HRP920591B1/xx not_active IP Right Cessation
1993
- 1993-07-12 US US08/090,416 patent/US5360805A/en not_active Expired - Lifetime
- 1993-08-27 LV LVP-93-1042A patent/LV10949B/lv unknown
- 1993-12-30 LT LTIP1731A patent/LT4005B/lt not_active IP Right Cessation
1996
- 1996-07-17 LV LV960262A patent/LV5766B4/xx unknown
1997
- 1997-02-27 HK HK22997A patent/HK22997A/en not_active IP Right Cessation
- 1997-04-30 BR BR1100379-0A patent/BR1100379A/pt active IP Right Grant

Also Published As

Publication number	Publication date
DZ1468A1 (fr)	2004-09-13
SK278283B6 (en)	1996-08-07
WO1991009845A1 (en)	1991-07-11
CA2069608A1 (en)	1991-06-22
HRP920591B1 (en)	1998-12-31
KR0179382B1 (ko)	1999-03-20
PT96303B (pt)	1998-07-31
YU234690A (sh)	1993-10-20
ZA909903B (en)	1991-08-28
LT4005B (en)	1996-07-25
NZ236293A (en)	1992-10-28
SE8904298D0 (sv)	1989-12-21
EP0506778A1 (en)	1992-10-07
US5227389A (en)	1993-07-13
CA2069608C (en)	2001-07-10
SG46413A1 (en)	1998-02-20
CN1053605A (zh)	1991-08-07
HU213110B (en)	1997-02-28
JPH05502869A (ja)	1993-05-20
FI922806A0 (fi)	1992-06-17
DK0506778T3 (da)	1996-10-07
JP2656152B2 (ja)	1997-09-24
NO178858B (no)	1996-03-11
EG19361A (en)	1994-12-30
EP0506778B1 (en)	1996-05-29
BR1100379A (pt)	1999-12-07
RU2039043C1 (ru)	1995-07-09
DE69027221T2 (de)	1996-10-10
IS3659A7 (is)	1991-06-22
SI9012346B (sl)	1999-08-31
HUT64518A (en)	1994-01-28
BG96513A (bg)	1993-12-24
ES2087280T3 (es)	1996-07-16
YU48086B (sh)	1997-01-08
SA91110209B1 (ar)	2004-05-08
PL288409A1 (en)	1991-12-02
LV10949B (en)	1996-06-20
NO922380L (no)	1992-06-17
SI9012346A (sl)	1998-08-31
PL163591B1 (pl)	1994-04-29
PT96303A (pt)	1991-09-30
CZ658190A3 (en)	1993-01-13
LV5766B4 (lv)	1997-06-20
IE904534A1 (en)	1991-07-03
NO178858C (no)	1996-06-19
CZ278035B6 (en)	1993-07-14
CN1037841C (zh)	1998-03-25
IL96636A (en)	1994-11-28
ATE138650T1 (de)	1996-06-15
AU647068B2 (en)	1994-03-17
HK22997A (en)	1997-02-27
US5360805A (en)	1994-11-01
AU6978391A (en)	1991-07-24
NO922380D0 (no)	1992-06-17
HRP920591A2 (en)	1997-08-31
HU9202044D0 (en)	1992-09-28
LTIP1731A (en)	1995-07-25
BG60912B1 (bg)	1996-06-28
LV5766A4 (lv)	1996-12-20
IE74855B1 (en)	1997-08-13
IL96636A0 (en)	1991-09-16
UA26403A (uk)	1999-08-30
DE69027221D1 (de)	1996-07-04
LV10949A (lv)	1995-12-20
SK658190A3 (en)	1996-08-07
RO112864B1 (ro)	1998-01-30
FI922806L (fi)	1992-06-17
FI100881B (fi)	1998-03-13
KR927003531A (ko)	1992-12-18

Publication	Publication Date	Title
IS1664B (is)	1997-07-04	Ný aðferð við að framleiða útskipt 4-fenýl-4-píperídínkarboxamíð sem hefur bæði staðbundin deyfandiog kvalastillandi áhrif
SE9401728D0 (sv)	1994-05-18	New compounds II
AU582235B2 (en)	1989-03-16	Quinolylglycinamide derivatives,the process for preparation thereof and their therapeutic application as psychotropic drugs
SE9400447D0 (sv)	1994-02-11	New compounds
SE9401596D0 (sv)	1994-05-06	New compounds
JO1652B1 (en)	1991-11-27	New compounds for local anesthesia and a way to prepare them
SE8900685D0 (sv)	1989-02-28	New compounds
JO1658B1 (en)	1991-11-27	New vehicles
UY26509A1 (es)	2001-01-31	Bases pirrolicas sustituidas de mannich, procedimiento para su preparación, medicamentos que contienen estos compuestos, y uso del compuesto para la preparación de medicamentos.