ATE260107T1 - Debromhymenialdisin und verwandte verbindungen zur behandlung von osteoarthritis - Google Patents

Debromhymenialdisin und verwandte verbindungen zur behandlung von osteoarthritis

Info

Publication number: ATE260107T1
Authority: AT; Austria
Prior art keywords: osteoarthritis; debromhymenialdisin; treatment; related compounds; debromohymenialdisine
Prior art date: 1995-06-07

Application number

AT96919079T

Other languages

English (en)

Inventor

Stewart Chipman

David John Faulkner

Original Assignee

Osteoarthritis Sciences Inc Li

Univ California

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-07

Filing date

1996-06-05

Publication date

2004-03-15

1996-06-05 Application filed by Osteoarthritis Sciences Inc Li, Univ California filed Critical Osteoarthritis Sciences Inc Li

2004-03-15 Application granted granted Critical

2004-03-15 Publication of ATE260107T1 publication Critical patent/ATE260107T1/de

Links

201000008482 osteoarthritis Diseases 0.000 title abstract 3
150000001875 compounds Chemical class 0.000 title 1
JYRJOQGKGMHTOO-VURMDHGXSA-N (4z)-4-(2-amino-4-oxo-1h-imidazol-5-ylidene)-1,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one Chemical compound N1C(N)=NC(=O)\C1=C/1C(C=CN2)=C2C(=O)NCC\1 JYRJOQGKGMHTOO-VURMDHGXSA-N 0.000 abstract 2
JYRJOQGKGMHTOO-UHFFFAOYSA-N Debromohymenialdisine hydrochloride Natural products N1C(N)=NC(=O)C1=C1C(C=CN2)=C2C(=O)NCC1 JYRJOQGKGMHTOO-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
230000008355 cartilage degradation Effects 0.000 abstract 1
230000006866 deterioration Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT96919079T 1995-06-07 1996-06-05 Debromhymenialdisin und verwandte verbindungen zur behandlung von osteoarthritis ATE260107T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/472,902 US5591740A (en)	1995-06-07	1995-06-07	Use of debromohymenialdisine for treating osteoarthritis
PCT/US1996/008822 WO1996040147A1 (en)	1995-06-07	1996-06-05	Use of debromohymenialdisine and related compounds for treating osteoarthritis

Publications (1)

Publication Number	Publication Date
ATE260107T1 true ATE260107T1 (de)	2004-03-15

Family

ID=23877364

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96919079T ATE260107T1 (de)	1995-06-07	1996-06-05	Debromhymenialdisin und verwandte verbindungen zur behandlung von osteoarthritis

Country Status (8)

Country	Link
US (1)	US5591740A (de)
EP (1)	EP0831834B1 (de)
JP (1)	JPH11507048A (de)
AT (1)	ATE260107T1 (de)
AU (1)	AU699872B2 (de)
CA (1)	CA2223581A1 (de)
DE (1)	DE69631656T2 (de)
WO (1)	WO1996040147A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2231509C (en) *	1995-09-11	2008-07-08	Osteoarthritis Sciences, Inc.	Protein tyrosine kinase inhibitors for treating osteoarthritis
GB9608133D0 (en) *	1996-04-19	1996-06-26	Gemini International Holdings	Diagnostic method and apparatus
US7067144B2 (en) *	1998-10-20	2006-06-27	Omeros Corporation	Compositions and methods for systemic inhibition of cartilage degradation
US6211361B1 (en) *	1999-07-20	2001-04-03	State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon, State Univeristy	Method for making debromohymenialdisine and analogs thereof
CN1402642A (zh) *	1999-07-21	2003-03-12	奥默罗斯公司	用于抑制疼痛,炎症和软骨退化的溶液及方法
RU2197238C2 (ru) *	1999-11-22	2003-01-27	Российский научный центр "Восстановительная травматология и ортопедия" им. академика Г.А. Илизарова	Способ профилактики и лечения остеоартроза, средство для его осуществления и способ получения средства для лечения остеоартроза
DE69912808T2 (de)	1999-12-08	2004-09-30	Centre National De La Recherche Scientifique (C.N.R.S.)	Verwendung von Hymenialdisin und dessen Derivaten zur Herstellung therapeutischer Mittel
AU2968701A (en) *	2000-01-24	2001-07-31	Genzyme Corporation	Jak/stat pathway inhibitors and the uses thereof
KR100404580B1 (ko) *	2000-04-20	2003-11-05	한국해양연구원	원도닌 ａ 및 그의 제조방법
KR100944204B1 (ko) *	2001-09-15	2010-02-26	러쉬 유니버시티 메디컬 센터	중층 연골 조직 및 그것을 조작하는 방법
US20030165473A1 (en) *	2001-11-09	2003-09-04	Rush-Presbyterian-St. Luke's Medical Center	Engineered intervertebral disc tissue
RU2205609C1 (ru) *	2002-04-30	2003-06-10	Юрьев Валерий Андреевич	Способ лечения суставных осложнений ревматических заболеваний
BR0317430A (pt) *	2002-12-20	2005-10-25	Pharmacia Corp	Compostos inibidores de quinase-2 de proteìna ativada por quinase de proteìna ativada por mitógeno
US7385055B2 (en) *	2003-05-19	2008-06-10	Board Of Trustees Of Michigan State University	Preparation of hymenialdisine derivatives and use thereof
US20050074744A1 (en) *	2003-10-02	2005-04-07	Dibenedetto Peter	Assays for evaluating anti-osteoarthritic activity
US8697139B2 (en)	2004-09-21	2014-04-15	Frank M. Phillips	Method of intervertebral disc treatment using articular chondrocyte cells
US20070259030A1 (en) *	2006-05-05	2007-11-08	Drapeau Susan J	Methods, systems and reagents for tendon and ligament therapy
US8304408B2 (en) *	2007-05-24	2012-11-06	The Regents Of The University Of California	Wnt signaling inhibitors, and methods for making and using them
RU2350271C1 (ru) *	2007-08-20	2009-03-27	Федеральное государственное учреждение "Российский научный центр "Восстановительная травматология и ортопедия" имени академика Г.А. Илизарова Федерального агентства по высокотехнологичной медицинской помощи", ФГУ "РНЦ "ВТО" им. акад. Г.А. Илизарова Росмедтехнологий"	Способ лечения ранних стадий остеоартроза тазобедренного сустава
US20090281150A1 (en) *	2008-04-09	2009-11-12	Nicola Frances Bateman	Compound 249

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5565448A (en) *	1992-02-24	1996-10-15	Smithkline Beecham Corporation	Medicament

1995
- 1995-06-07 US US08/472,902 patent/US5591740A/en not_active Expired - Fee Related
1996
- 1996-06-05 EP EP96919079A patent/EP0831834B1/de not_active Expired - Lifetime
- 1996-06-05 AT AT96919079T patent/ATE260107T1/de not_active IP Right Cessation
- 1996-06-05 WO PCT/US1996/008822 patent/WO1996040147A1/en not_active Ceased
- 1996-06-05 JP JP9501307A patent/JPH11507048A/ja not_active Ceased
- 1996-06-05 AU AU61516/96A patent/AU699872B2/en not_active Ceased
- 1996-06-05 CA CA002223581A patent/CA2223581A1/en not_active Abandoned
- 1996-06-05 DE DE69631656T patent/DE69631656T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69631656T2 (de)	2004-12-16
AU699872B2 (en)	1998-12-17
JPH11507048A (ja)	1999-06-22
EP0831834B1 (de)	2004-02-25
US5591740A (en)	1997-01-07
EP0831834A1 (de)	1998-04-01
DE69631656D1 (de)	2004-04-01
CA2223581A1 (en)	1996-12-19
AU6151696A (en)	1996-12-30
WO1996040147A1 (en)	1996-12-19

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Legal Events

Date	Code	Title	Description
2004-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties