ATE261454T1 - Verfahren zur herstellung von vernetzter hyaluronsäure - Google Patents
Verfahren zur herstellung von vernetzter hyaluronsäureInfo
- Publication number
- ATE261454T1 ATE261454T1 AT98200620T AT98200620T ATE261454T1 AT E261454 T1 ATE261454 T1 AT E261454T1 AT 98200620 T AT98200620 T AT 98200620T AT 98200620 T AT98200620 T AT 98200620T AT E261454 T1 ATE261454 T1 AT E261454T1
- Authority
- AT
- Austria
- Prior art keywords
- hyaluronic acid
- linked hyaluronic
- producing cross
- dvs
- salt
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 6
- 229920002674 hyaluronan Polymers 0.000 title abstract 6
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title 1
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Surgery (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98200620A EP0939086B1 (de) | 1998-02-27 | 1998-02-27 | Verfahren zur Herstellung von vernetzter Hyaluronsäure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE261454T1 true ATE261454T1 (de) | 2004-03-15 |
Family
ID=8233426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98200620T ATE261454T1 (de) | 1998-02-27 | 1998-02-27 | Verfahren zur herstellung von vernetzter hyaluronsäure |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0939086B1 (de) |
| AT (1) | ATE261454T1 (de) |
| DE (1) | DE69822285T2 (de) |
| DK (1) | DK0939086T3 (de) |
| ES (1) | ES2217496T3 (de) |
| PT (1) | PT939086E (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6521223B1 (en) * | 2000-02-14 | 2003-02-18 | Genzyme Corporation | Single phase gels for the prevention of adhesions |
| AU2000268609A1 (en) * | 2000-09-14 | 2002-03-26 | Robert Theiler | Intraarticular agent for the treatment of osteoarthritis |
| WO2005012364A2 (fr) * | 2003-07-30 | 2005-02-10 | Anteis S.A. | Matrice complexe a usage biomedical |
| ES2706848T3 (es) | 2004-07-06 | 2019-04-01 | Zymogenetics Inc | Composición farmacéutica que comprende FGF18 y antagonista de IL-1 y método de uso |
| EP2664334B1 (de) * | 2004-12-30 | 2015-03-04 | Genzyme Corporation | Therapien zur intraartikulären Viskosupplementation |
| EP3028677A1 (de) | 2005-12-14 | 2016-06-08 | Anika Therapeutics Inc. | Behandlung von arthritis und anderen muskoloskeletalen erkrankungen mit vernetzter hyaluronsäure |
| JP5291621B2 (ja) | 2006-12-06 | 2013-09-18 | 生化学工業株式会社 | 関節疾患に対する持続的治療効果を有する薬剤 |
| NO2236523T3 (de) * | 2009-03-30 | 2018-07-21 | ||
| US9371402B2 (en) | 2009-04-09 | 2016-06-21 | Scivision Biotech Inc. | Method for producing cross-linked hyaluronic acid |
| AU2010276574B2 (en) | 2009-07-30 | 2015-08-20 | Carbylan Therapeutics, Inc. | Modified hyaluronic acid polymer compositions and related methods |
| JO3008B1 (ar) | 2009-08-13 | 2016-09-05 | Seikagaku Kogyo Co Ltd | تركيب صيدلي لتخفيف الألم |
| CN101829365B (zh) * | 2010-04-13 | 2013-04-17 | 杭州市第一人民医院 | 一种巩膜外加压生物复合材料及制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1238043A (en) * | 1983-12-15 | 1988-06-14 | Endre A. Balazs | Water insoluble preparations of hyaluronic acid and processes therefor |
| US4582865A (en) * | 1984-12-06 | 1986-04-15 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
-
1998
- 1998-02-27 DE DE69822285T patent/DE69822285T2/de not_active Expired - Lifetime
- 1998-02-27 EP EP98200620A patent/EP0939086B1/de not_active Expired - Lifetime
- 1998-02-27 ES ES98200620T patent/ES2217496T3/es not_active Expired - Lifetime
- 1998-02-27 DK DK98200620T patent/DK0939086T3/da active
- 1998-02-27 PT PT98200620T patent/PT939086E/pt unknown
- 1998-02-27 AT AT98200620T patent/ATE261454T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| DE69822285T2 (de) | 2005-01-27 |
| EP0939086B1 (de) | 2004-03-10 |
| DK0939086T3 (da) | 2004-04-13 |
| EP0939086A1 (de) | 1999-09-01 |
| DE69822285D1 (de) | 2004-04-15 |
| PT939086E (pt) | 2004-07-30 |
| ES2217496T3 (es) | 2004-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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