ATE262328T1 - Sulfonamidverbindungen des hydroxydiphenylharnstoffs als il-8 rezeptorantagonisten - Google Patents

Sulfonamidverbindungen des hydroxydiphenylharnstoffs als il-8 rezeptorantagonisten

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Publication number
ATE262328T1
ATE262328T1 AT99965288T AT99965288T ATE262328T1 AT E262328 T1 ATE262328 T1 AT E262328T1 AT 99965288 T AT99965288 T AT 99965288T AT 99965288 T AT99965288 T AT 99965288T AT E262328 T1 ATE262328 T1 AT E262328T1
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Austria
Prior art keywords
hydroxydiphenyl
urea
receptor antagonists
sulfonamide compounds
sulfonamide
Prior art date
Application number
AT99965288T
Other languages
English (en)
Inventor
Qi Jin
Brent W Mccleland
Michael R Palovich
Katherine L Widdowson
Original Assignee
Smithkline Beecham Corp
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Publication date
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Publication of ATE262328T1 publication Critical patent/ATE262328T1/de

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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AT99965288T 1998-12-16 1999-12-15 Sulfonamidverbindungen des hydroxydiphenylharnstoffs als il-8 rezeptorantagonisten ATE262328T1 (de)

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US11248198P 1998-12-16 1998-12-16
US13700399P 1999-06-01 1999-06-01
PCT/US1999/029940 WO2000035442A1 (en) 1998-12-16 1999-12-15 Hydroxy diphenyl urea sulfonamides as il-8 receptor antagonists

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Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7517880B2 (en) * 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
EP1158985B1 (de) 1999-01-13 2011-12-28 Bayer HealthCare LLC GAMMA CARBOXYARYLSUBSTITUIERTE DIPHENYLHARNSTOFFVERBINDUNGEN ALS p38 KINASEHEMMER
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
ME00275B (me) 1999-01-13 2011-02-10 Bayer Corp ω-KARBOKSIARIL SUPSTITUISANI DIFENIL KARBAMIDI KAO INHIBITORI RAF KINAZE
EP1140840B1 (de) * 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituierte diphenyl harnstoffe als raf kinase inhibitoren
AR029637A1 (es) 1999-05-28 2003-07-10 Smithkline Beecham Corp Compuestos de guanidina, antagonistas de los receptores de la il-8, una composicion farmaceutica que los contiene y el uso de los mismos para la manufactura de un medicamento
WO2001064691A1 (en) * 2000-03-01 2001-09-07 Smithkline Beecham Corporation Il-8 receptor antagonists
JP2004504270A (ja) * 2000-03-10 2004-02-12 スミスクライン・ビーチャム・コーポレイション Ｉｌ−８受容体アンタゴニスト
MY133845A (en) * 2000-03-10 2007-11-30 Smithkline Beecham Corp Il-8 receptor antagonists
AR030689A1 (es) * 2000-03-14 2003-09-03 Smithkline Beecham Corp Compuestos de 3-aminosulfonil-2-hidroxifenil urea, composiciones farmaceuticas que los comprenden, y uso de dichos compuestos en la manufactura de medicamentos para tratar enfermedades mediadas por quimioquinas
JP2003527360A (ja) * 2000-03-14 2003-09-16 スミスクライン・ビーチャム・コーポレイション Ｉｌ−８受容体アンタゴニスト
CO5280089A1 (es) * 2000-03-16 2003-05-30 Smithkline Beecham Corp Antagonistas del receptor il-8
US6664259B2 (en) * 2000-03-16 2003-12-16 Smithkline Beecham Corporation Il-8 receptor antagonists
UY26627A1 (es) * 2000-03-24 2001-09-28 Smithkline Beecham Corp Antagonistas de receptores de il-8
US6653310B2 (en) 2000-04-07 2003-11-25 Smithkline Beecham Corporation IL-8 receptor antagonists
WO2002012243A2 (en) * 2000-08-09 2002-02-14 Boehringer Ingelheim Pharmaceuticals, Inc. SYNTHESIS OF (R)-3-(4-BROMOBENZYL)-1-(3,5-DICHLOROPHENYL)-5-IODO-3-METHYL-1-H-IMIDAZO[1,2-a]IMIDAZOL-2-ONE
JP4224566B2 (ja) * 2000-12-18 2009-02-18 株式会社医薬分子設計研究所 炎症性サイトカイン産生遊離抑制剤
DE60216229T2 (de) * 2001-01-16 2007-10-04 Smithkline Beecham Corp. Il-8-rezeptorantagonisten
EP1383488A2 (de) * 2001-03-30 2004-01-28 SmithKline Beecham Corporation Verfahren zur synthese phenolhaltiger verbindungen
TW200303742A (en) * 2001-11-21 2003-09-16 Novartis Ag Organic compounds
US20030207872A1 (en) * 2002-01-11 2003-11-06 Bayer Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
SI1478358T1 (sl) 2002-02-11 2013-09-30 Bayer Healthcare Llc Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi
EP1512396A4 (de) * 2002-06-05 2008-12-31 Inst Med Molecular Design Inc Hemmer gegen aktivierung von ap-1 und nfat
CA2488363C (en) 2002-06-06 2011-01-04 Institute Of Medicinal Molecular Design, Inc. O-substituted hydroxyaryl derivatives
TW200418812A (en) * 2002-10-29 2004-10-01 Smithkline Beecham Corp IL-8 receptor antagonists
US7557129B2 (en) 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
EP1636585B2 (de) 2003-05-20 2012-06-13 Bayer HealthCare LLC Diaryl-harnstoffe mit kinasehemmender wirkung
EP1663978B1 (de) 2003-07-23 2007-11-28 Bayer Pharmaceuticals Corporation Fluorsubstituierter omega-carboxyaryldiphenylharnstoff zur behandlung und prävention von krankheiten und leiden
EP1812008A4 (de) * 2004-10-20 2008-10-29 Smithkline Beecham Corp Il-8-rezeptorantagonisten
PL2009992T3 (pl) 2006-04-21 2012-11-30 Glaxosmithkline Llc Antagoniści receptora IL-8
US8097626B2 (en) * 2006-04-21 2012-01-17 Glaxosmithkline Llc IL-8 receptor antagonists
US7671058B2 (en) 2006-06-21 2010-03-02 Institute Of Medicinal Molecular Design, Inc. N-(3,4-disubstituted phenyl) salicylamide derivatives
CL2007001829A1 (es) * 2006-06-23 2008-01-25 Smithkline Beecham Corp P-toluensulfonato de n-[4-cloro-2-hidroxi-3-(piperazina-1-sulfonil)fenil]-n-(2-cloro-3-fluorofenil)urea;procedimiento de preparacion;composicion farmaceutica;combinacion farmaceutica;y uso en el tratamiento de una enfermedad mediada por la quiimioquina il-8, tales como asma y epoc.
EP2203432A4 (de) * 2007-09-21 2011-04-27 Glaxosmithkline Llc Behandlungsverfahren
EP2110019A1 (de) 2008-04-19 2009-10-21 Bayer CropScience AG Herbizide Verbindungen auf Basis von N-Azinyl-N'-phenylsulfonylharnstoffen
US20120121515A1 (en) 2009-03-13 2012-05-17 Lenny Dang Methods and compositions for cell-proliferation-related disorders
TWI598337B (zh) 2009-06-29 2017-09-11 阿吉歐斯製藥公司 治療化合物及組成物
EP2491015A1 (de) * 2009-10-21 2012-08-29 Bayer Pharma Aktiengesellschaft Substituierte benzosulfonamide
WO2011050210A1 (en) 2009-10-21 2011-04-28 Agios Pharmaceuticals, Inc. Methods and compositions for cell-proliferation-related disorders
EP2525790B1 (de) 2009-10-21 2020-05-27 Agios Pharmaceuticals, Inc. Verfahren und zusammensetzungen für zellproliferationsbedingte erkrankungen
EP2512465A1 (de) 2009-12-17 2012-10-24 Galderma Research & Development Verwendung von verbindungen bei der behandlung oder prävention von hauterkrankungen
SMT202400081T1 (it) 2011-05-03 2024-03-13 Agios Pharmaceuticals Inc Attivatori della piruvato chinasi per uso in terapia
CN102827073A (zh) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
CN102827170A (zh) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
PE20142098A1 (es) 2012-01-06 2015-01-08 Agios Pharmaceuticals Inc Compuestos terapeuticamente activos y sus metodos de uso
US9474779B2 (en) 2012-01-19 2016-10-25 Agios Pharmaceuticals, Inc. Therapeutically active compositions and their methods of use
EP2906212A4 (de) 2012-10-15 2016-06-08 Agios Pharmaceuticals Inc Therapeutische verbindungen und zusammensetzungen
WO2015003360A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
CN105593215B (zh) 2013-07-11 2019-01-15 安吉奥斯医药品有限公司 用于治疗癌症的作为idh2突变体抑制剂的2,4-或4,6-二氨基嘧啶化合物
AU2014287122B9 (en) 2013-07-11 2018-11-01 Les Laboratoires Servier N,6-bis(aryl or heteroaryl)-1,3,5-triazine-2,4-diamine compounds as IDH2 mutants inhibitors for the treatment of cancer
WO2015003355A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
WO2015010297A1 (en) 2013-07-25 2015-01-29 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
NZ723859A (en) 2014-03-14 2023-01-27 Servier Lab Pharmaceutical compositions of therapeutically active compounds and their uses
FR3030515B1 (fr) * 2014-12-23 2017-01-20 Galderma Res & Dev Nouveaux composes antagonistes des recepteurs cxcr1 et cxcr2 aux chimiokines, et leur utilisation dans le traitement de pathologies mediees par des chimiokines
CA2989111C (en) 2015-06-11 2023-10-03 Agios Pharmaceuticals, Inc. Methods of using pyruvate kinase activators
FI3362065T3 (fi) 2015-10-15 2024-06-19 Servier Lab Ivosidenibiä, sytarabiinia ja daunorubisiinia tai idarubisiinia käsittävä yhdistelmähoito akuutin myelooisen leukemian hoitamiseksi
KR102699521B1 (ko) 2015-10-15 2024-08-26 르 라보레또레 쎄르비에르 악성 종양의 치료를 위한 조합물 요법
US10980788B2 (en) 2018-06-08 2021-04-20 Agios Pharmaceuticals, Inc. Therapy for treating malignancies
CN112778167A (zh) * 2019-11-01 2021-05-11 邵阳学院 一种快速制备n-苯磺酰基氨基酸酯类化合物的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3972886A (en) * 1972-07-13 1976-08-03 Leo Pharmaceutical Products Ltd. Certain 4-phenoxy-3-heteroarylmethyl or ethyl sulfamyl benzoic acid derivatives
US4155930A (en) 1978-07-11 1979-05-22 American Cyanamid Company Ureylene phenylene anionic naphthalenesulfonic acids
US4786316A (en) 1984-07-13 1988-11-22 E. I. Du Pont De Nemours And Company Herbicidal ortho-sulfamoyl sulfonamides
US6271261B1 (en) * 1996-06-27 2001-08-07 Smithkline Beecham Corporation IL-8 receptor antagonists
EP0932405A4 (de) * 1996-06-27 2001-10-17 Smithkline Beckman Corp Il-8 rezeptor-antagonisten
DE69826695T2 (de) * 1997-05-23 2006-02-02 Bayer Pharmaceuticals Corp., West Haven Arylharnstoffderivate zur behandlung von inflammatorischen oder immunomodulatorischen erkrankungen

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ES2217871T3 (es) 2004-11-01
PL348179A1 (en) 2002-05-06
CN1334726A (zh) 2002-02-06
BG105661A (en) 2002-02-28
SK8222001A3 (en) 2001-12-03
EP1161232A1 (de) 2001-12-12
NZ511993A (en) 2003-12-19
OA11731A (en) 2005-05-12
AU3123700A (en) 2000-07-03
CZ20012150A3 (cs) 2001-11-14
HK1043535A1 (en) 2002-09-20
HUP0104686A3 (en) 2005-06-28
DZ2964A1 (fr) 2004-03-15
AU748799B2 (en) 2002-06-13
TR200101772T2 (tr) 2002-04-22
MA25366A1 (fr) 2002-04-01
PE20001323A1 (es) 2001-01-07
WO2000035442A1 (en) 2000-06-22
DK1161232T3 (da) 2004-07-26
NO20012948D0 (no) 2001-06-14
DE69915888T2 (de) 2005-01-13
KR20010101243A (ko) 2001-11-14
JP2002532419A (ja) 2002-10-02
EA005210B1 (ru) 2004-12-30
HUP0104686A2 (hu) 2002-04-29
HK1043535B (en) 2005-01-07
EA200100659A1 (ru) 2001-12-24
CA2355890A1 (en) 2000-06-22
IL143507A0 (en) 2002-04-21
US6500863B1 (en) 2002-12-31
DE69915888D1 (de) 2004-04-29
UY25842A1 (es) 2001-04-30
EP1161232A4 (de) 2002-09-18
BR9916159A (pt) 2001-12-04
CO4990929A1 (es) 2000-12-26
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AR029605A1 (es) 2003-07-10
EP1161232B1 (de) 2004-03-24
US20030109527A1 (en) 2003-06-12

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