MA25366A1 - Sulfonamides d'hydroxy-diphenyl cree en tant qu'antagonistes du recepteur il-8. - Google Patents
Sulfonamides d'hydroxy-diphenyl cree en tant qu'antagonistes du recepteur il-8.Info
- Publication number
- MA25366A1 MA25366A1 MA26236A MA26236A MA25366A1 MA 25366 A1 MA25366 A1 MA 25366A1 MA 26236 A MA26236 A MA 26236A MA 26236 A MA26236 A MA 26236A MA 25366 A1 MA25366 A1 MA 25366A1
- Authority
- MA
- Morocco
- Prior art keywords
- sulfonamides
- diphenyl
- hydroxy
- created
- receptor antagonists
- Prior art date
Links
- 108090001007 Interleukin-8 Proteins 0.000 title 1
- 239000004305 biphenyl Substances 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 229940124530 sulfonamide Drugs 0.000 title 1
Classifications
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
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- Neurosurgery (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11248198P | 1998-12-16 | 1998-12-16 | |
| US13700399P | 1999-06-01 | 1999-06-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA25366A1 true MA25366A1 (fr) | 2002-04-01 |
Family
ID=26810001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA26236A MA25366A1 (fr) | 1998-12-16 | 2001-06-13 | Sulfonamides d'hydroxy-diphenyl cree en tant qu'antagonistes du recepteur il-8. |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US6500863B1 (fr) |
| EP (1) | EP1161232B1 (fr) |
| JP (1) | JP2002532419A (fr) |
| KR (1) | KR20010101243A (fr) |
| CN (1) | CN1334726A (fr) |
| AR (1) | AR029605A1 (fr) |
| AT (1) | ATE262328T1 (fr) |
| AU (1) | AU748799B2 (fr) |
| BG (1) | BG105661A (fr) |
| BR (1) | BR9916159A (fr) |
| CA (1) | CA2355890A1 (fr) |
| CO (1) | CO4990929A1 (fr) |
| CZ (1) | CZ20012150A3 (fr) |
| DE (1) | DE69915888T2 (fr) |
| DK (1) | DK1161232T3 (fr) |
| DZ (1) | DZ2964A1 (fr) |
| EA (1) | EA005210B1 (fr) |
| ES (1) | ES2217871T3 (fr) |
| HK (1) | HK1043535B (fr) |
| HU (1) | HUP0104686A3 (fr) |
| IL (1) | IL143507A0 (fr) |
| MA (1) | MA25366A1 (fr) |
| NO (1) | NO20012948L (fr) |
| NZ (1) | NZ511993A (fr) |
| OA (1) | OA11731A (fr) |
| PE (1) | PE20001323A1 (fr) |
| PL (1) | PL348179A1 (fr) |
| PT (1) | PT1161232E (fr) |
| SK (1) | SK8222001A3 (fr) |
| TR (1) | TR200101772T2 (fr) |
| UY (1) | UY25842A1 (fr) |
| WO (1) | WO2000035442A1 (fr) |
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|---|---|---|---|---|
| US7517880B2 (en) * | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| RU2319693C9 (ru) | 1999-01-13 | 2008-08-20 | Байер Копэрейшн | Производные мочевины (варианты), фармацевтическая композиция (варианты) и способ лечения заболевания, связанного с ростом раковых клеток (варианты) |
| EP1140840B1 (fr) * | 1999-01-13 | 2006-03-22 | Bayer Pharmaceuticals Corp. | Diphenylurees a substituants -g(v)-carboxyaryles, inhibitrices de kinase raf |
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| ATE538794T1 (de) | 1999-01-13 | 2012-01-15 | Bayer Healthcare Llc | Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer |
| AR029637A1 (es) | 1999-05-28 | 2003-07-10 | Smithkline Beecham Corp | Compuestos de guanidina, antagonistas de los receptores de la il-8, una composicion farmaceutica que los contiene y el uso de los mismos para la manufactura de un medicamento |
| EP1265905A4 (fr) * | 2000-03-01 | 2003-03-12 | Smithkline Beecham Corp | Antagonistes du recepteur de l'interleukine 8 (il-8) |
| JP2004504270A (ja) * | 2000-03-10 | 2004-02-12 | スミスクライン・ビーチャム・コーポレイション | Il−8受容体アンタゴニスト |
| MY133845A (en) * | 2000-03-10 | 2007-11-30 | Smithkline Beecham Corp | Il-8 receptor antagonists |
| AU2001245724A1 (en) * | 2000-03-14 | 2001-09-24 | Smith Kline Beecham Corporation | Il-8 receptor antagonists |
| AR030689A1 (es) * | 2000-03-14 | 2003-09-03 | Smithkline Beecham Corp | Compuestos de 3-aminosulfonil-2-hidroxifenil urea, composiciones farmaceuticas que los comprenden, y uso de dichos compuestos en la manufactura de medicamentos para tratar enfermedades mediadas por quimioquinas |
| CO5280089A1 (es) * | 2000-03-16 | 2003-05-30 | Smithkline Beecham Corp | Antagonistas del receptor il-8 |
| US6664259B2 (en) * | 2000-03-16 | 2003-12-16 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| UY26627A1 (es) * | 2000-03-24 | 2001-09-28 | Smithkline Beecham Corp | Antagonistas de receptores de il-8 |
| JP2003530328A (ja) | 2000-04-07 | 2003-10-14 | スミスクライン・ビーチャム・コーポレイション | Il−8受容体アンタゴニスト |
| US6414161B1 (en) * | 2000-08-09 | 2002-07-02 | Boehringer Ingelheim Pharmaceuticals, Inc. | Synthesis of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1-H-imidazo[1,2-a]imidazol-2-one |
| CN101849953B (zh) * | 2000-12-18 | 2012-04-25 | 株式会社医药分子设计研究所 | 炎症性细胞因子产生游离抑制剂 |
| EP1351933B1 (fr) * | 2001-01-16 | 2006-11-22 | SmithKline Beecham Corporation | Antagonistes des recepteurs de l'il-8 |
| CA2442480A1 (fr) * | 2001-03-30 | 2002-10-10 | Katherine L. Widdowson | Procedes de synthese de composes contenant un phenol |
| TW200303742A (en) | 2001-11-21 | 2003-09-16 | Novartis Ag | Organic compounds |
| US20030207872A1 (en) * | 2002-01-11 | 2003-11-06 | Bayer Corporation | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| US7838541B2 (en) | 2002-02-11 | 2010-11-23 | Bayer Healthcare, Llc | Aryl ureas with angiogenesis inhibiting activity |
| WO2003103647A1 (fr) * | 2002-06-05 | 2003-12-18 | 株式会社医薬分子設計研究所 | Inhibiteurs de l'activation de ap-1 et de nfat |
| AU2003242118B2 (en) | 2002-06-06 | 2008-09-11 | Institute Of Medicinal Molecular Design, Inc | O-substituted hydroxyaryl derivatives |
| WO2009039091A1 (fr) * | 2007-09-21 | 2009-03-26 | Smithkline Beecham Corporation | Procédé de traitement |
| AR041834A1 (es) * | 2002-10-29 | 2005-06-01 | Smithkline Beecham Corp | Compuesto de difenilurea sustituido con sulfonamida, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion |
| UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
| WO2004113274A2 (fr) | 2003-05-20 | 2004-12-29 | Bayer Pharmaceuticals Corporation | Diaryl-urees presentant une activite d'inhibition des kinases |
| RS52625B (sr) | 2003-07-23 | 2013-06-28 | Bayer Healthcare Llc | Fluoro supstituisana omega-karboksiaril difenil urea za lečenje i prevenciju bolesti i stanja bolesti |
| EP1812008A4 (fr) * | 2004-10-20 | 2008-10-29 | Smithkline Beecham Corp | Antagonistes du récepteur il-8 |
| CN101495113A (zh) * | 2006-04-21 | 2009-07-29 | 史密丝克莱恩比彻姆公司 | Il-8受体拮抗剂 |
| MY145810A (en) * | 2006-04-21 | 2012-04-30 | Smithkline Beecham Corp | Il-8 receptor antagonists |
| US7671058B2 (en) | 2006-06-21 | 2010-03-02 | Institute Of Medicinal Molecular Design, Inc. | N-(3,4-disubstituted phenyl) salicylamide derivatives |
| AR061571A1 (es) * | 2006-06-23 | 2008-09-03 | Smithkline Beecham Corp | Compuesto sal del acido toluenosulfonico de 4-{[6-cloro-3-({[(2- cloro-3-fluorofenil) amino]carbonil} amino)- 2- hidroxifenil]sulfonil] -1- piperazinacarbxilato de 1.1-dimetiletilo, composicion farmaceutica que lo comprende su uso para la fabricacion de un medicamento combinacion farmaceutica con un |
| EP2110019A1 (fr) | 2008-04-19 | 2009-10-21 | Bayer CropScience AG | Composés herbicides à base de N-azinyl-N'-pyridylsulfonylurées |
| JP6067226B2 (ja) | 2009-03-13 | 2017-01-25 | アジオス ファーマシューティカルズ, インコーポレイテッド | 細胞増殖関連疾患のための方法および組成物 |
| CR20170071A (es) | 2009-06-29 | 2017-03-28 | Agios Pharmaceuticals Inc | Compuestos terapeuticos y composiciones |
| JP2013508318A (ja) * | 2009-10-21 | 2013-03-07 | バイエル・ファルマ・アクチェンゲゼルシャフト | 置換されたベンゾスルホンアミド誘導体 |
| CA2793836C (fr) | 2009-10-21 | 2020-03-24 | Agios Pharmaceuticals, Inc. | Procedes et compositions pour troubles associes a la proliferation cellulaire |
| WO2011050210A1 (fr) | 2009-10-21 | 2011-04-28 | Agios Pharmaceuticals, Inc. | Procedes et compositions pour des troubles relatifs |
| JP2013514313A (ja) | 2009-12-17 | 2013-04-25 | ガルデルマ・リサーチ・アンド・デヴェロップメント | 皮膚障害の治療又は予防における化合物の使用 |
| ME03074B (fr) | 2011-05-03 | 2019-01-20 | Agios Pharmaceuticals Inc | Activateurs de la pyruvate kinase destinés à être utilisés en thérapie |
| CN102827170A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| CN102827073A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| KR101893112B1 (ko) | 2012-01-06 | 2018-08-30 | 아지오스 파마슈티컬스 아이엔씨. | 치료학적으로 활성인 화합물 및 이의 이용 방법 |
| US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
| WO2014062511A1 (fr) * | 2012-10-15 | 2014-04-24 | Agios Pharmaceuticals, Inc. | Composés et compositions thérapeutiques |
| US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| CA2917671A1 (fr) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Composes de 2,4 ou de 4,6-diaminopyrimidine en tant qu'inhibiteurs des mutants idh2 pour le traitement du cancer |
| WO2015003355A2 (fr) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Composés thérapeutiquement actifs et leurs méthodes d'utilisation |
| WO2015003360A2 (fr) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Composés thérapeutiquement actifs et leurs méthodes d'utilisation |
| PE20160744A1 (es) | 2013-07-11 | 2016-08-01 | Agios Pharmaceuticals Inc | Compuestos de n,6-bis(aril o heteroaril)-1,3,5-triazin-2,4-diamina como inhibidores de idh2 mutantes para el tratamiento de cancer |
| US20150031627A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| PH12021551647A1 (en) | 2014-03-14 | 2022-06-06 | Agios Pharmaceuticals Inc | Pharmaceutical compositions of therapeutically active compounds |
| FR3030515B1 (fr) | 2014-12-23 | 2017-01-20 | Galderma Res & Dev | Nouveaux composes antagonistes des recepteurs cxcr1 et cxcr2 aux chimiokines, et leur utilisation dans le traitement de pathologies mediees par des chimiokines |
| MA44392B1 (fr) | 2015-06-11 | 2023-10-31 | Agios Pharmaceuticals Inc | Procédés d'utilisation d'activateurs de la pyruvate kinase |
| ES2897959T3 (es) | 2015-10-15 | 2022-03-03 | Servier Lab | Terapia de combinación para tratar neoplasias malignas |
| KR20250126877A (ko) | 2015-10-15 | 2025-08-25 | 르 라보레또레 쎄르비에르 | 악성 종양의 치료를 위한 조합물 요법 |
| US10980788B2 (en) | 2018-06-08 | 2021-04-20 | Agios Pharmaceuticals, Inc. | Therapy for treating malignancies |
| CN112778167A (zh) * | 2019-11-01 | 2021-05-11 | 邵阳学院 | 一种快速制备n-苯磺酰基氨基酸酯类化合物的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3972886A (en) * | 1972-07-13 | 1976-08-03 | Leo Pharmaceutical Products Ltd. | Certain 4-phenoxy-3-heteroarylmethyl or ethyl sulfamyl benzoic acid derivatives |
| US4155930A (en) * | 1978-07-11 | 1979-05-22 | American Cyanamid Company | Ureylene phenylene anionic naphthalenesulfonic acids |
| US4786316A (en) * | 1984-07-13 | 1988-11-22 | E. I. Du Pont De Nemours And Company | Herbicidal ortho-sulfamoyl sulfonamides |
| KR20000022273A (ko) * | 1996-06-27 | 2000-04-25 | 스튜어트 알. 수터, 스티븐 베네티아너, 피터 존 기딩스 | Il-8 수용체 길항제 |
| JP2000513360A (ja) * | 1996-06-27 | 2000-10-10 | スミスクライン・ビーチャム・コーポレイション | Il―8レセプターアンタゴニスト |
| DE69826695T2 (de) * | 1997-05-23 | 2006-02-02 | Bayer Pharmaceuticals Corp., West Haven | Arylharnstoffderivate zur behandlung von inflammatorischen oder immunomodulatorischen erkrankungen |
-
1999
- 1999-12-09 UY UY25842A patent/UY25842A1/es unknown
- 1999-12-12 DZ DZ990264A patent/DZ2964A1/fr active
- 1999-12-13 CO CO99077673A patent/CO4990929A1/es unknown
- 1999-12-14 PE PE1999001243A patent/PE20001323A1/es not_active Application Discontinuation
- 1999-12-14 AR ARP990106373A patent/AR029605A1/es not_active Application Discontinuation
- 1999-12-15 DE DE1999615888 patent/DE69915888T2/de not_active Expired - Lifetime
- 1999-12-15 TR TR2001/01772T patent/TR200101772T2/xx unknown
- 1999-12-15 WO PCT/US1999/029940 patent/WO2000035442A1/fr not_active Ceased
- 1999-12-15 AT AT99965288T patent/ATE262328T1/de active
- 1999-12-15 BR BR9916159-1A patent/BR9916159A/pt not_active IP Right Cessation
- 1999-12-15 CA CA002355890A patent/CA2355890A1/fr not_active Abandoned
- 1999-12-15 IL IL14350799A patent/IL143507A0/xx unknown
- 1999-12-15 PL PL99348179A patent/PL348179A1/xx not_active Application Discontinuation
- 1999-12-15 KR KR1020017007504A patent/KR20010101243A/ko not_active Ceased
- 1999-12-15 NZ NZ511993A patent/NZ511993A/en not_active IP Right Cessation
- 1999-12-15 DK DK99965288T patent/DK1161232T3/da active
- 1999-12-15 EA EA200100659A patent/EA005210B1/ru not_active IP Right Cessation
- 1999-12-15 EP EP99965288A patent/EP1161232B1/fr not_active Expired - Lifetime
- 1999-12-15 AU AU31237/00A patent/AU748799B2/en not_active Ceased
- 1999-12-15 OA OA1200100154A patent/OA11731A/en unknown
- 1999-12-15 JP JP2000587762A patent/JP2002532419A/ja not_active Ceased
- 1999-12-15 CZ CZ20012150A patent/CZ20012150A3/cs unknown
- 1999-12-15 PT PT99965288T patent/PT1161232E/pt unknown
- 1999-12-15 US US09/868,165 patent/US6500863B1/en not_active Expired - Fee Related
- 1999-12-15 CN CN99816125A patent/CN1334726A/zh active Pending
- 1999-12-15 HK HK02103608.6A patent/HK1043535B/en not_active IP Right Cessation
- 1999-12-15 SK SK822-2001A patent/SK8222001A3/sk unknown
- 1999-12-15 ES ES99965288T patent/ES2217871T3/es not_active Expired - Lifetime
- 1999-12-15 HU HU0104686A patent/HUP0104686A3/hu unknown
-
2001
- 2001-06-13 MA MA26236A patent/MA25366A1/fr unknown
- 2001-06-14 NO NO20012948A patent/NO20012948L/no not_active Application Discontinuation
- 2001-06-29 BG BG105661A patent/BG105661A/xx unknown
-
2002
- 2002-11-18 US US10/299,503 patent/US20030109527A1/en not_active Abandoned
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