ATE262350T1 - Flüssige pharmazeutische zusammensetzung zur oralen verabreichung bitterschmeckender hydrolyseempfindlicher aktivstoffe - Google Patents

Flüssige pharmazeutische zusammensetzung zur oralen verabreichung bitterschmeckender hydrolyseempfindlicher aktivstoffe

Info

Publication number: ATE262350T1
Authority: AT; Austria
Prior art keywords: bitter; hydrolysis; pharmaceutical composition; oral administration; liquid pharmaceutical
Prior art date: 1999-06-10

Application number

AT00935230T

Other languages

English (en)

Inventor

Carreras Manel Roig

Arino Pere Tubau

Rubio Jordi Julve

Original Assignee

S A L V A T Lab Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-06-10

Filing date

2000-06-08

Publication date

2004-04-15

2000-06-08 Application filed by S A L V A T Lab Sa filed Critical S A L V A T Lab Sa

2004-04-15 Application granted granted Critical

2004-04-15 Publication of ATE262350T1 publication Critical patent/ATE262350T1/de

Links

239000007788 liquid Substances 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
239000013543 active substance Substances 0.000 abstract 3
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 2
MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 abstract 2
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 abstract 1
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
235000013162 Cocos nucifera Nutrition 0.000 abstract 1
244000060011 Cocos nucifera Species 0.000 abstract 1
UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 abstract 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
239000001856 Ethyl cellulose Substances 0.000 abstract 1
240000007049 Juglans regia Species 0.000 abstract 1
235000009496 Juglans regia Nutrition 0.000 abstract 1
229930195725 Mannitol Natural products 0.000 abstract 1
240000008790 Musa x paradisiaca Species 0.000 abstract 1
235000018290 Musa x paradisiaca Nutrition 0.000 abstract 1
WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
239000001913 cellulose Substances 0.000 abstract 1
229920002678 cellulose Polymers 0.000 abstract 1
229960003405 ciprofloxacin Drugs 0.000 abstract 1
235000020186 condensed milk Nutrition 0.000 abstract 1
239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 abstract 1
229960003276 erythromycin Drugs 0.000 abstract 1
BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 abstract 1
229920001249 ethyl cellulose Polymers 0.000 abstract 1
239000000796 flavoring agent Substances 0.000 abstract 1
235000013355 food flavoring agent Nutrition 0.000 abstract 1
235000003599 food sweetener Nutrition 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
239000000594 mannitol Substances 0.000 abstract 1
235000010355 mannitol Nutrition 0.000 abstract 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 abstract 1
239000004292 methyl p-hydroxybenzoate Substances 0.000 abstract 1
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 abstract 1
229960005489 paracetamol Drugs 0.000 abstract 1
229950008882 polysorbate Drugs 0.000 abstract 1
229920000136 polysorbate Polymers 0.000 abstract 1
239000003755 preservative agent Substances 0.000 abstract 1
230000002335 preservative effect Effects 0.000 abstract 1
229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
229960001462 sodium cyclamate Drugs 0.000 abstract 1
235000010199 sorbic acid Nutrition 0.000 abstract 1
239000004334 sorbic acid Substances 0.000 abstract 1
229940075582 sorbic acid Drugs 0.000 abstract 1
239000008347 soybean phospholipid Substances 0.000 abstract 1
239000004094 surface-active agent Substances 0.000 abstract 1
239000003765 sweetening agent Substances 0.000 abstract 1
239000002562 thickening agent Substances 0.000 abstract 1
150000003626 triacylglycerols Chemical class 0.000 abstract 1
235000020234 walnut Nutrition 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pain & Pain Management (AREA)
Molecular Biology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT00935230T 1999-06-10 2000-06-08 Flüssige pharmazeutische zusammensetzung zur oralen verabreichung bitterschmeckender hydrolyseempfindlicher aktivstoffe ATE262350T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES009901281A ES2153786B1 (es)	1999-06-10	1999-06-10	Composicion farmaceutica liquida para la administracion oral de principios activos amargos y susceptibles de hidrolisis.
PCT/ES2000/000206 WO2000076549A1 (es)	1999-06-10	2000-06-08	Composicion farmaceutica liquida para la administracion oral de principios activos amargos y susceptibles de hidrolisis

Publications (1)

Publication Number	Publication Date
ATE262350T1 true ATE262350T1 (de)	2004-04-15

Family

ID=8308775

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00935230T ATE262350T1 (de)	1999-06-10	2000-06-08	Flüssige pharmazeutische zusammensetzung zur oralen verabreichung bitterschmeckender hydrolyseempfindlicher aktivstoffe

Country Status (5)

Country	Link
EP (1)	EP1190720B1 (de)
AT (1)	ATE262350T1 (de)
DE (1)	DE60009290D1 (de)
ES (2)	ES2153786B1 (de)
WO (1)	WO2000076549A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MXPA03008056A (es)	2001-03-05	2004-10-15	Johnson & Johnson	Composiciones farmaceuticas liquidas con sabor oculto.
EP1401402B1 (de) *	2001-05-29	2016-09-07	Takeda Pharmaceuticals U.S.A., Inc.	Erhöhung der oralen bioverfügbarkeit einer nicht-emulgierten formulierung cefditoren pivoxil mit lecithin
GB2380936B (en) *	2001-10-18	2003-07-09	Reckitt Benckiser Healthcare	Improvements in or relating to compositions
EP2197555B1 (de)	2007-05-07	2015-12-02	Koninklijke Philips N.V.	Verfahren zur reinigung von zahnbelag von zähnen mit einem abziehbaren haftgel
GB0720967D0 (en) *	2007-10-25	2007-12-05	Protophama Ltd	Anti-material pharmaceutical composition
DE102010015143A1 (de) *	2010-04-16	2011-10-20	Cts Chemical Industries Ltd.	Stabile flüssige ölige gebrauchsfertige Formulierungen, Herstellung davon und Verwendung davon
PL3069733T3 (pl) *	2013-11-13	2023-02-13	National Defense Education And Research Foundation	Nowa kompozycja związku stanowiącego acetaminofen niepowodująca w wątrobie działań niepożądanych
JP6858729B2 (ja) *	2018-05-25	2021-04-14	▲財▼▲団▼法人国防教育研究基金会ＮａｔｉｏｎａｌＤｅｆｅｎｓｅＥｄｕｃａｔｉｏｎＡｎｄＲｅｓｅａｒｃｈＦｏｕｎｄａｔｉｏｎ	肝臓に対する副作用がない、新しいアセトアミノフェン複合組成
US12605388B2 (en)	2024-09-25	2026-04-21	Azurity Pharmaceuticals Ireland Limited	Lamotrigine salts, co-crystals, and compositions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0548238A1 (de) *	1990-09-13	1993-06-30	Smithkline Beecham Corporation	Nichtwässrige flüssige orale suspensionen
JP3419957B2 (ja) *	1995-06-06	2003-06-23	花王株式会社	味覚改質剤
ES2105970B1 (es) *	1995-08-02	1998-07-01	S A L V A T Lab Sa	Composicion farmaceutica oral de ciprofloxacino, no acuosa, estable y con caracteristicas organolepticas mejoradas.

1999
- 1999-06-10 ES ES009901281A patent/ES2153786B1/es not_active Expired - Lifetime
2000
- 2000-06-08 WO PCT/ES2000/000206 patent/WO2000076549A1/es not_active Ceased
- 2000-06-08 EP EP00935230A patent/EP1190720B1/de not_active Expired - Lifetime
- 2000-06-08 AT AT00935230T patent/ATE262350T1/de not_active IP Right Cessation
- 2000-06-08 ES ES00935230T patent/ES2215665T3/es not_active Expired - Lifetime
- 2000-06-08 DE DE60009290T patent/DE60009290D1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO2000076549A1 (es)	2000-12-21
ES2153786B1 (es)	2001-10-16
EP1190720B1 (de)	2004-03-24
ES2215665T3 (es)	2004-10-16
DE60009290D1 (de)	2004-04-29
EP1190720A1 (de)	2002-03-27
ES2153786A1 (es)	2001-03-01

Legal Events

Date	Code	Title	Description
2004-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
BR0211794A (pt)	2004-11-03	Composição farmacêutica e método para mascarar o sabor de pelo menos um composto farmaceuticamente ativo de sabor desagradável
JP2009102389A (ja)	2009-05-14	経口投与用医薬組成物
ATE262350T1 (de)	2004-04-15	Flüssige pharmazeutische zusammensetzung zur oralen verabreichung bitterschmeckender hydrolyseempfindlicher aktivstoffe
WO2002064148A3 (en)	2002-11-21	Oral formulations containing mucopolysaccharide for small intestine delivery and their use in the treatment circulatory disorders
JP4051717B2 (ja)	2008-02-27	ビオチン含有内服液剤
ES2791775B2 (es)	2023-01-20	Formulaciones de epinefrina intranasal y metodos para el tratamiento de enfermedades
EP0548238A1 (de)	1993-06-30	Nichtwässrige flüssige orale suspensionen
US20250000984A1 (en)	2025-01-02	Diphenhydramine syrup formulation or suspension
BE900749A (fr)	1985-02-01	Medicament microencapsule dans une matrice sucree.
ATE429217T1 (de)	2009-05-15	Nateglinid enthaltende hydrophile arzneimittelpräparate
EP0315332B1 (de)	1992-04-15	Phenol enthaltende, flüssige Antitussiv-Zusammensetzungen
JP4373649B2 (ja)	2009-11-25	経口用液剤
ES2318277T3 (es)	2009-05-01	Composicion farmaceutica que compresnde acido 5-metil-2-(2'-cloro-6'-fluoroanilino)fenilacetico.
JP2003231647A (ja)	2003-08-19	内服液組成物
JP2905210B2 (ja)	1999-06-14	経皮、経粘膜吸収促進剤および経皮、経粘膜製剤
Thosar	2011	Intra oral sprays-An overview.
US6194462B1 (en)	2001-02-27	Pharmaceutical preparation containing nimesulide for oral administration
ES2338972B1 (es)	2011-03-10	Composicion farmaceutica liquida de ibuprofeno y codeina para su administracion por via oral, su procedimiento de preparacion y utilizacionde la misma.
US20060198856A1 (en)	2006-09-07	Ibuprofen suspension stabilized with docusate sodium
US20060100271A1 (en)	2006-05-11	Stabilized aqueous ranitidine compositions
JPH1036252A (ja)	1998-02-10	ベラドンナ（総）アルカロイド配合内服液剤
JPH09286723A (ja)	1997-11-04	改善された経口液剤
BG61892B2 (bg)	1998-08-31	Състав на основата на ибупрофен за орална употреба
WO2011107617A1 (es)	2011-09-09	Composición farmacéutica líquida de ibuprofeno y codeína para su administración por vía oral, su procedimiento de preparación y utilización de la misma
JPH10203971A (ja)	1998-08-04	水性経口液剤