ATE262521T1 - Pyrimidinyl methyl indolderivate mit antibakterieller wirkung - Google Patents
Pyrimidinyl methyl indolderivate mit antibakterieller wirkungInfo
- Publication number
- ATE262521T1 ATE262521T1 AT01936261T AT01936261T ATE262521T1 AT E262521 T1 ATE262521 T1 AT E262521T1 AT 01936261 T AT01936261 T AT 01936261T AT 01936261 T AT01936261 T AT 01936261T AT E262521 T1 ATE262521 T1 AT E262521T1
- Authority
- AT
- Austria
- Prior art keywords
- cycloalkyl
- alkyl
- indole derivatives
- heterocyclylalkyl
- phenylalkyl
- Prior art date
Links
- HNCSYDVMBFLNSQ-UHFFFAOYSA-N 2-methyl-3-pyrimidin-2-yl-1h-indole Chemical class CC=1NC2=CC=CC=C2C=1C1=NC=CC=N1 HNCSYDVMBFLNSQ-UHFFFAOYSA-N 0.000 title 1
- 230000000844 anti-bacterial effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 238000004519 manufacturing process Methods 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 3
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 3
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000005144 cycloalkylsulfonyl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00108944 | 2000-04-27 | ||
| PCT/EP2001/004542 WO2001083474A1 (en) | 2000-04-27 | 2001-04-20 | Pyrimidinyl methyl indole derivatives with antibacterial activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE262521T1 true ATE262521T1 (de) | 2004-04-15 |
Family
ID=8168564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01936261T ATE262521T1 (de) | 2000-04-27 | 2001-04-20 | Pyrimidinyl methyl indolderivate mit antibakterieller wirkung |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6703397B2 (de) |
| EP (1) | EP1280796B1 (de) |
| JP (1) | JP4048054B2 (de) |
| KR (1) | KR20020093965A (de) |
| CN (1) | CN1186339C (de) |
| AT (1) | ATE262521T1 (de) |
| AU (1) | AU2001262220A1 (de) |
| BR (1) | BR0110363A (de) |
| CA (1) | CA2405607A1 (de) |
| DE (1) | DE60102461T2 (de) |
| DK (1) | DK1280796T3 (de) |
| ES (1) | ES2215901T3 (de) |
| MX (1) | MXPA02010517A (de) |
| WO (1) | WO2001083474A1 (de) |
| ZA (1) | ZA200208132B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8716280B2 (en) * | 2009-01-21 | 2014-05-06 | Basilea Pharmaceutica Ag | Bicyclic antibiotics |
| PL3153505T3 (pl) * | 2015-10-05 | 2018-10-31 | Sanko Tekstil Isletmeleri San. Ve Tic. A.S. | Nowe bis-indolilometany, sposób ich wytwarzania oraz ich zastosowania |
| WO2022150468A1 (en) * | 2021-01-06 | 2022-07-14 | New Mexico Tech University Research Park Corporation | Small molecules with antibacterial activity |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT290523B (de) | 1962-01-05 | 1971-06-11 | Merck & Co Inc | Verfahren zur Herstellung neuer α-(3-Indolyl)-carbonsäuren |
| US4590271A (en) | 1982-05-01 | 1986-05-20 | Burroughs Wellcome Co. | 2,4-diamino-5-(substituted)pyrimidines, useful as antimicrobials |
| US5721242A (en) | 1993-06-17 | 1998-02-24 | Hoffmann-La Roche Inc. | Antibiotic combination |
-
2001
- 2001-04-20 CA CA002405607A patent/CA2405607A1/en not_active Abandoned
- 2001-04-20 JP JP2001580902A patent/JP4048054B2/ja not_active Expired - Fee Related
- 2001-04-20 US US10/258,687 patent/US6703397B2/en not_active Expired - Fee Related
- 2001-04-20 WO PCT/EP2001/004542 patent/WO2001083474A1/en not_active Ceased
- 2001-04-20 EP EP01936261A patent/EP1280796B1/de not_active Expired - Lifetime
- 2001-04-20 BR BR0110363-6A patent/BR0110363A/pt not_active IP Right Cessation
- 2001-04-20 DE DE60102461T patent/DE60102461T2/de not_active Expired - Lifetime
- 2001-04-20 DK DK01936261T patent/DK1280796T3/da active
- 2001-04-20 AU AU2001262220A patent/AU2001262220A1/en not_active Abandoned
- 2001-04-20 AT AT01936261T patent/ATE262521T1/de not_active IP Right Cessation
- 2001-04-20 KR KR1020027014435A patent/KR20020093965A/ko not_active Ceased
- 2001-04-20 ES ES01936261T patent/ES2215901T3/es not_active Expired - Lifetime
- 2001-04-20 CN CNB018085970A patent/CN1186339C/zh not_active Expired - Fee Related
- 2001-04-20 MX MXPA02010517A patent/MXPA02010517A/es unknown
-
2002
- 2002-10-09 ZA ZA200208132A patent/ZA200208132B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60102461D1 (de) | 2004-04-29 |
| KR20020093965A (ko) | 2002-12-16 |
| EP1280796A1 (de) | 2003-02-05 |
| AU2001262220A1 (en) | 2001-11-12 |
| CA2405607A1 (en) | 2001-11-08 |
| CN1186339C (zh) | 2005-01-26 |
| WO2001083474A1 (en) | 2001-11-08 |
| MXPA02010517A (es) | 2003-03-10 |
| ZA200208132B (en) | 2004-01-22 |
| CN1426408A (zh) | 2003-06-25 |
| DK1280796T3 (da) | 2004-08-02 |
| DE60102461T2 (de) | 2005-02-24 |
| US6703397B2 (en) | 2004-03-09 |
| JP4048054B2 (ja) | 2008-02-13 |
| JP2003531902A (ja) | 2003-10-28 |
| BR0110363A (pt) | 2003-03-05 |
| US20030119857A1 (en) | 2003-06-26 |
| EP1280796B1 (de) | 2004-03-24 |
| ES2215901T3 (es) | 2004-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1280796 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |