ATE262920T1 - Kontinuierliche, niedrigdosierte zytokine- infusionstherapie - Google Patents
Kontinuierliche, niedrigdosierte zytokine- infusionstherapieInfo
- Publication number
- ATE262920T1 ATE262920T1 AT96936938T AT96936938T ATE262920T1 AT E262920 T1 ATE262920 T1 AT E262920T1 AT 96936938 T AT96936938 T AT 96936938T AT 96936938 T AT96936938 T AT 96936938T AT E262920 T1 ATE262920 T1 AT E262920T1
- Authority
- AT
- Austria
- Prior art keywords
- low dose
- cytokine
- continuous
- infusion therapy
- dose cytokine
- Prior art date
Links
- 102000004127 Cytokines Human genes 0.000 title abstract 5
- 108090000695 Cytokines Proteins 0.000 title abstract 5
- 238000001802 infusion Methods 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 208000006154 Chronic hepatitis C Diseases 0.000 abstract 1
- 208000005176 Hepatitis C Diseases 0.000 abstract 1
- 102000014150 Interferons Human genes 0.000 abstract 1
- 108010050904 Interferons Proteins 0.000 abstract 1
- 230000003292 diminished effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000010710 hepatitis C virus infection Diseases 0.000 abstract 1
- 229940079322 interferon Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/811—Interferon
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US613095P | 1995-11-02 | 1995-11-02 | |
| PCT/US1996/017085 WO1997016204A1 (en) | 1995-11-02 | 1996-10-31 | Continuous low-dose cytokine infusion therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE262920T1 true ATE262920T1 (de) | 2004-04-15 |
Family
ID=21719457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96936938T ATE262920T1 (de) | 1995-11-02 | 1996-10-31 | Kontinuierliche, niedrigdosierte zytokine- infusionstherapie |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6461605B1 (de) |
| EP (1) | EP0858343B1 (de) |
| JP (2) | JP2000507917A (de) |
| AT (1) | ATE262920T1 (de) |
| AU (1) | AU7473096A (de) |
| CA (2) | CA2236591C (de) |
| DE (1) | DE69632062T2 (de) |
| DK (1) | DK0858343T3 (de) |
| ES (1) | ES2214551T3 (de) |
| MX (1) | MX9803448A (de) |
| PT (1) | PT858343E (de) |
| WO (1) | WO1997016204A1 (de) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| US5908621A (en) | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
| CA2236591C (en) | 1995-11-02 | 2012-01-03 | Schering Corporation | Continuous low-dose cytokine infusion therapy |
| US7270809B2 (en) * | 1997-07-14 | 2007-09-18 | Bolder Biotechnology, Inc. | Cysteine variants of alpha interferon-2 |
| US20080076706A1 (en) | 1997-07-14 | 2008-03-27 | Bolder Biotechnology, Inc. | Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof |
| IL133974A0 (en) * | 1997-07-14 | 2001-04-30 | Bolder Biotechnology Inc | Derivatives of growth hormone and related proteins |
| US6753165B1 (en) * | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| SK285284B6 (sk) * | 1998-03-26 | 2006-10-05 | Schering Corporation | Vodný prostriedok umožňujúci stabilizáciu PEG-interferón alfa konjugátov, spôsob výroby lyofilizovaného prášku a výrobok s jeho obsahom |
| KR100694345B1 (ko) * | 1998-05-15 | 2007-03-12 | 쉐링 코포레이션 | 리바비린 및 인터페론 알파를 포함하는, 만성 c형 간염에 걸린 항-바이러스 치료에 대한 나이브 환자의 치료용 약제학적 조성물 |
| TR200003635T2 (tr) * | 1998-06-08 | 2001-04-20 | F.Hoffmann-La Roche Ag | Peg-IFN-ALFA ve ribavirinin kronik hepatit C tedavisinde kullanılması. |
| EP1113794A2 (de) * | 1998-09-14 | 2001-07-11 | Vertex Pharmaceuticals Incorporated | Verwendung von mycophenolsäure und mycophenolsäurederivate zur behandlung von viruserkrankungen |
| AU2158000A (en) | 1998-12-22 | 2000-07-12 | Schering Corporation | Treatment of hepatitis c virus infections with interleukin-10 |
| US8288126B2 (en) | 1999-01-14 | 2012-10-16 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| EP1175224B1 (de) * | 1999-05-04 | 2005-02-23 | Schering Corporation | Pegyliertes interferon alpha in kombination mit einem ccr5 antagonisten für eine hiv therapie |
| JP2003530838A (ja) | 2000-04-12 | 2003-10-21 | ヒューマン ゲノム サイエンシズ インコーポレイテッド | アルブミン融合タンパク質 |
| CZ2003311A3 (cs) * | 2000-08-02 | 2004-04-14 | Ortho-Mcneil Pharmaceutical, Inc. | Protivirová a protinádorová terapie za použití erythropoetinu |
| AU2002213343A1 (en) * | 2000-10-18 | 2002-04-29 | Schering Corporation | Ribavirin-pegylated interferon alfa HCV combination therapy |
| US6720000B2 (en) * | 2001-03-19 | 2004-04-13 | Three Rivers Pharmaceutical, Llc | Process for producing wet ribavirin pellets |
| BR0213861A (pt) * | 2001-11-02 | 2004-12-21 | Sandoz Ag | Processo para a preparação de composições de ribavirina de carga elevada, de dissolução rápida |
| JP2005517648A (ja) * | 2001-12-07 | 2005-06-16 | インターミューン インコーポレイテッド | 肝炎ウイルス感染症を治療するための組成物および方法 |
| KR101271635B1 (ko) * | 2001-12-21 | 2013-06-12 | 휴먼 게놈 사이언시즈, 인코포레이티드 | 알부민 융합 단백질 |
| ES2425738T3 (es) | 2001-12-21 | 2013-10-17 | Human Genome Sciences, Inc. | Proteínas de fusión de la albúmina |
| ATE444310T1 (de) * | 2002-01-17 | 2009-10-15 | Polymun Scient Immunbio Forsch | Antiidiotypische antikörper die hiv-1 neutralisierende antikörper induzieren |
| DE60332358D1 (de) | 2002-09-09 | 2010-06-10 | Hanall Pharmaceutical Co Ltd | Protease-resistente modifizierte interferon alpha polypeptide |
| US7538094B2 (en) * | 2002-09-19 | 2009-05-26 | Three Rivers Pharmacueticals, Llc | Composition containing ribavirin and use thereof |
| US7731947B2 (en) * | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| EP1594530A4 (de) | 2003-01-22 | 2006-10-11 | Human Genome Sciences Inc | Albuminfusionsproteine |
| US20070077225A1 (en) * | 2003-02-28 | 2007-04-05 | Blatt Lawrence M | Continuous delivery methods for treating hepatitis virus infection |
| JP4629964B2 (ja) * | 2003-09-12 | 2011-02-09 | 株式会社林原生物化学研究所 | ウシの消化器疾患治療剤 |
| WO2005039622A2 (en) * | 2003-10-21 | 2005-05-06 | Medtronic Minimed, Inc. | Modulation of socs expression in the therapeutic regimens |
| ATE374838T1 (de) | 2004-04-29 | 2007-10-15 | Hoffmann La Roche | Nukleotidsequenzvariation im gen ns5a als marker |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| WO2006089228A2 (en) | 2005-02-16 | 2006-08-24 | Nektar Therapeutics Al, Corporation | Conjugates of an epo moiety and a polymer |
| ES2302402B1 (es) * | 2005-06-16 | 2009-05-08 | Proyecto De Biomedicina Cima, S.L. | Uso de una citoquina de la familia de interleuquina-6 en la preparacion de una composicion para administracion combinada con interferon-alfa. |
| US20070231301A1 (en) * | 2006-03-31 | 2007-10-04 | Warren Stephen L | Parenteral low dose type 1 interferons for bladder cancer |
| PT2359808E (pt) | 2006-08-09 | 2013-08-28 | Intarcia Therapeutics Inc | Sistemas de entrega osmótica e montagens de pistão |
| ES2402172T3 (es) | 2007-04-23 | 2013-04-29 | Intarcia Therapeutics, Inc | Formulación en suspensión de péptidos insulinotrópicos y usos de los mismos |
| BRPI0814363A2 (pt) | 2007-07-25 | 2015-01-27 | Biolex Therapeutics Inc | Produtos fármacos de interferon de liberação controlada e tratamento de infecção por hcv usando os mesmos |
| WO2009046369A2 (en) * | 2007-10-05 | 2009-04-09 | Medtronic, Inc. | Use of a specific dosage regimen of ifn-alpha and ribavirin for treating hepatitis c |
| WO2009102467A2 (en) | 2008-02-13 | 2009-08-20 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
| WO2010009762A1 (en) * | 2008-07-23 | 2010-01-28 | United Technologies Ut Ag | Interferon and an agent inducing inhibition of protein phosphatase 2a such as interleukin- 1 and optionally ribavirin for the treatment of hbv or hcv infection |
| BRPI0918653A2 (pt) * | 2008-09-17 | 2015-12-01 | Boehringer Ingelheim Int | combinação de inibidor de ns3 protese de hcv com interferon e ribavirina. |
| US20110027229A1 (en) | 2009-07-31 | 2011-02-03 | Medtronic, Inc. | Continuous subcutaneous administration of interferon-alpha to hepatitis c infected patients |
| EP3735944A1 (de) | 2009-09-28 | 2020-11-11 | Intarcia Therapeutics, Inc. | Schnelle initiierung und/oder beendigung der verabreichung substantiell stabiler arzneimittel |
| PH12012500827A1 (en) | 2009-10-30 | 2013-01-07 | Boehringer Ingelheim Int | Dosage regimens for hcv combination therapy comprising bi201335, interferon alpha and ribavirin |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| KR102650751B1 (ko) | 2015-06-03 | 2024-03-22 | 인타르시아 세라퓨틱스 인코포레이티드 | 임플란트 배치 및 제거 시스템들 |
| CN109310743A (zh) | 2016-05-16 | 2019-02-05 | 因塔西亚制药公司 | 胰高血糖素受体选择性多肽及其使用方法 |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| AU2018206539A1 (en) | 2017-01-03 | 2019-07-18 | Intarcia Therapeutics, Inc. | Methods comprising continuous administration of a GLP-1 receptor agonist and co-administration of a drug |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4211771A (en) | 1971-06-01 | 1980-07-08 | Robins Ronald K | Treatment of human viral diseases with 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide |
| USRE29835E (en) | 1971-06-01 | 1978-11-14 | Icn Pharmaceuticals | 1,2,4-Triazole nucleosides |
| US4140761A (en) | 1977-04-11 | 1979-02-20 | The United States Of America As Represented By The Department Of Health, Education & Welfare | Modification of hepatitis B virus infection in chronic carriers of hepatitis B surface antigen |
| US4530901A (en) | 1980-01-08 | 1985-07-23 | Biogen N.V. | Recombinant DNA molecules and their use in producing human interferon-like polypeptides |
| US4774091A (en) | 1983-10-14 | 1988-09-27 | Sumitomo Pharmaceuticals Company, Ltd. | Long-term sustained-release preparation |
| IL76591A0 (en) | 1984-10-05 | 1986-02-28 | Bioferon Biochem Substanz | Pharmaceutical compositions containing ifn-ypsilon and processes for the preparation thereof |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US4917888A (en) | 1985-06-26 | 1990-04-17 | Cetus Corporation | Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation |
| NZ217844A (en) | 1985-10-11 | 1989-10-27 | Sumitomo Pharma | A sustained release pharmaceutical composition containing silicone elastomer and an albumin |
| NZ219027A (en) * | 1986-01-24 | 1989-09-27 | Genentech Inc | Antiviral composition containing interferon tumour necrosis factor and/or lymphotoxin |
| JP2514950B2 (ja) | 1986-03-10 | 1996-07-10 | エフ・ホフマン―ラ ロシユ アーゲー | 化学修飾蛋白質,その製造法および中間体 |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| ZA878295B (en) | 1986-11-06 | 1988-05-03 | Amarillo Cell Culture Co. Inc. | Treatment of immuno-resistant disease |
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| US5026687A (en) | 1990-01-03 | 1991-06-25 | The United States Of America As Represented By The Department Of Health And Human Services | Treatment of human retroviral infections with 2',3'-dideoxyinosine alone and in combination with other antiviral compounds |
| US5279833A (en) | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
| US5372808A (en) | 1990-10-17 | 1994-12-13 | Amgen Inc. | Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect |
| US5595732A (en) | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
| US5676942A (en) | 1992-02-10 | 1997-10-14 | Interferon Sciences, Inc. | Composition containing human alpha interferon species proteins and method for use thereof |
| WO1993020835A1 (en) * | 1992-04-14 | 1993-10-28 | Schering Corporation | Treatment of hepatitis with gm-csf |
| ATE163860T1 (de) * | 1992-08-19 | 1998-03-15 | Schering Corp | Methode zur inhibition von hiv-replikation mittels il-4 |
| US5382657A (en) | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
| MX9307733A (es) * | 1992-12-23 | 1994-06-30 | Schering Corp | Restauracion de la funcion inmunologica en pacientes asintomaticos de vih-positivo. |
| CN1072961C (zh) | 1993-03-05 | 2001-10-17 | 施塞克龙药品公司 | 治疗对干扰素治疗无反应者的丙型肝炎的方法 |
| HUT75533A (en) | 1993-11-10 | 1997-05-28 | Schering Corp | Improved interferon polymer conjugates |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| US5738846A (en) | 1994-11-10 | 1998-04-14 | Enzon, Inc. | Interferon polymer conjugates and process for preparing the same |
| US6387365B1 (en) | 1995-05-19 | 2002-05-14 | Schering Corporation | Combination therapy for chronic hepatitis C infection |
| CA2236591C (en) | 1995-11-02 | 2012-01-03 | Schering Corporation | Continuous low-dose cytokine infusion therapy |
| US5908621A (en) | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
| US5767097A (en) | 1996-01-23 | 1998-06-16 | Icn Pharmaceuticals, Inc. | Specific modulation of Th1/Th2 cytokine expression by ribavirin in activated T-lymphocytes |
| TW517067B (en) | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
| US5849800A (en) | 1997-03-28 | 1998-12-15 | The Penn State Research Foundation | Use of amantadine for treatment of Hepatitis C |
-
1996
- 1996-10-31 CA CA2236591A patent/CA2236591C/en not_active Expired - Lifetime
- 1996-10-31 WO PCT/US1996/017085 patent/WO1997016204A1/en not_active Ceased
- 1996-10-31 AT AT96936938T patent/ATE262920T1/de active
- 1996-10-31 AU AU74730/96A patent/AU7473096A/en not_active Abandoned
- 1996-10-31 PT PT96936938T patent/PT858343E/pt unknown
- 1996-10-31 ES ES96936938T patent/ES2214551T3/es not_active Expired - Lifetime
- 1996-10-31 EP EP96936938A patent/EP0858343B1/de not_active Revoked
- 1996-10-31 DE DE1996632062 patent/DE69632062T2/de not_active Expired - Lifetime
- 1996-10-31 CA CA002329474A patent/CA2329474C/en not_active Expired - Lifetime
- 1996-10-31 JP JP9517418A patent/JP2000507917A/ja not_active Withdrawn
- 1996-10-31 DK DK96936938T patent/DK0858343T3/da active
-
1998
- 1998-04-30 MX MX9803448A patent/MX9803448A/es unknown
-
2002
- 2002-03-22 US US10/104,287 patent/US6461605B1/en not_active Expired - Lifetime
-
2003
- 2003-01-27 JP JP2003017565A patent/JP2003246750A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003246750A (ja) | 2003-09-02 |
| AU7473096A (en) | 1997-05-22 |
| DE69632062T2 (de) | 2004-11-18 |
| DK0858343T3 (da) | 2004-05-10 |
| WO1997016204A1 (en) | 1997-05-09 |
| PT858343E (pt) | 2004-07-30 |
| ES2214551T3 (es) | 2004-09-16 |
| MX9803448A (es) | 1998-09-30 |
| CA2236591C (en) | 2012-01-03 |
| CA2236591A1 (en) | 1997-05-09 |
| CA2329474C (en) | 2002-02-26 |
| US6461605B1 (en) | 2002-10-08 |
| EP0858343A1 (de) | 1998-08-19 |
| EP0858343B1 (de) | 2004-03-31 |
| DE69632062D1 (de) | 2004-05-06 |
| CA2329474A1 (en) | 1997-05-09 |
| JP2000507917A (ja) | 2000-06-27 |
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