ATE263181T1 - Chemische synthese von 6-o-alkyl erythromycin a - Google Patents

Chemische synthese von 6-o-alkyl erythromycin a

Info

Publication number: ATE263181T1
Authority: AT; Austria
Prior art keywords: chemical synthesis; protecting; erythromycin; hydroxyl; alkyl erythromycin
Prior art date: 1997-11-17

Application number

AT98958048T

Other languages

English (en)

Inventor

Hemantkumar H Patel

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-17

Filing date

1998-11-17

Publication date

2004-04-15

1998-11-17 Application filed by Abbott Lab filed Critical Abbott Lab

2004-04-15 Application granted granted Critical

2004-04-15 Publication of ATE263181T1 publication Critical patent/ATE263181T1/de

Links

229930006677 Erythromycin A Natural products 0.000 title abstract 3
229960003276 erythromycin Drugs 0.000 title abstract 3
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title abstract 2
238000003786 synthesis reaction Methods 0.000 title 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
HOSGXJWQVBHGLT-UHFFFAOYSA-N 6-hydroxy-3,4-dihydro-1h-quinolin-2-one Chemical group N1C(=O)CCC2=CC(O)=CC=C21 HOSGXJWQVBHGLT-UHFFFAOYSA-N 0.000 abstract 1
230000002152 alkylating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT98958048T 1997-11-17 1998-11-17 Chemische synthese von 6-o-alkyl erythromycin a ATE263181T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/972,155 US5852180A (en)	1997-11-17	1997-11-17	Chemical synthesis of 6-O-alkyl erythromycin A
PCT/US1998/024539 WO1999025723A1 (en)	1997-11-17	1998-11-17	Chemical synthesis of 6-o-alkyl erythromycin a

Publications (1)

Publication Number	Publication Date
ATE263181T1 true ATE263181T1 (de)	2004-04-15

Family

ID=25519256

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98958048T ATE263181T1 (de)	1997-11-17	1998-11-17	Chemische synthese von 6-o-alkyl erythromycin a

Country Status (13)

Country	Link
US (1)	US5852180A (de)
EP (1)	EP1032581B1 (de)
JP (1)	JP2001523685A (de)
KR (1)	KR100565025B1 (de)
AT (1)	ATE263181T1 (de)
AU (1)	AU1416699A (de)
CA (2)	CA2309256C (de)
DE (1)	DE69822871T2 (de)
DK (1)	DK1032581T3 (de)
ES (1)	ES2221225T3 (de)
IL (2)	IL135517A0 (de)
PT (1)	PT1032581E (de)
WO (1)	WO1999025723A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6437106B1 (en)	1999-06-24	2002-08-20	Abbott Laboratories	Process for preparing 6-o-substituted erythromycin derivatives
GB9915745D0 (en) *	1999-07-06	1999-09-08	Biochemie Sa	Organic compounds
WO2001044262A1 (en)	1999-12-16	2001-06-21	Teva Pharmaceutical Industries Ltd.	Processes for preparing clarithromycin polymorphs and novel polymorph iv
AU2001222619C1 (en)	2000-01-11	2006-01-12	Teva Pharmaceutical Industries Ltd.	Processes for preparing clarithromycin polymorphs
US6544555B2 (en)	2000-02-24	2003-04-08	Advancis Pharmaceutical Corp.	Antibiotic product, use and formulation thereof
US6565882B2 (en)	2000-02-24	2003-05-20	Advancis Pharmaceutical Corp	Antibiotic composition with inhibitor
EP1313486A1 (de)	2000-02-29	2003-05-28	Teva Pharmaceutical Industries Ltd.	Verfahren zur herstellung des clarithromycins und eines clarithromycin-zwischenprodukt; clarithromycin wesentlich frei von oxime; und pharmazeutische zusammensetzung die sie enthalten
US6541014B2 (en)	2000-10-13	2003-04-01	Advancis Pharmaceutical Corp.	Antiviral product, use and formulation thereof
US20020068078A1 (en)	2000-10-13	2002-06-06	Rudnic Edward M.	Antifungal product, use and formulation thereof
US6455680B1 (en) *	2000-12-21	2002-09-24	Abbott Laboratories	Methods utilizing aryl thioimines in synthesis of erythromycin derivatives
AU2004258949B2 (en)	2003-07-21	2011-02-10	Shionogi, Inc.	Antibiotic product, use and formulation thereof
JP2006528185A (ja)	2003-07-21	2006-12-14	アドバンシスファーマスーティカルコーポレイション	抗生物質製剤、その使用法及び作成方法
JP2006528190A (ja)	2003-07-21	2006-12-14	アドバンシスファーマスーティカルコーポレイション	抗生物質製剤、その使用法及び作成方法
EP1653925A1 (de)	2003-08-11	2006-05-10	Advancis Pharmaceutical Corporation	Robustes pellet
WO2005016278A2 (en)	2003-08-12	2005-02-24	Advancis Pharmaceuticals Corporation	Antibiotic product, use and formulation thereof
WO2005023184A2 (en)	2003-08-29	2005-03-17	Advancis Pharmaceuticals Corporation	Antibiotic product, use and formulation thereof
US8460710B2 (en)	2003-09-15	2013-06-11	Shionogi, Inc.	Antibiotic product, use and formulation thereof
AU2005269981A1 (en)	2004-07-02	2006-02-09	Bonck, John A	Tablet for pulsed delivery
US8778924B2 (en)	2006-12-04	2014-07-15	Shionogi Inc.	Modified release amoxicillin products
US8357394B2 (en)	2005-12-08	2013-01-22	Shionogi Inc.	Compositions and methods for improved efficacy of penicillin-type antibiotics
US7595300B2 (en)	2005-12-13	2009-09-29	Kosan Biosciences Incorporated	7-quinolyl ketolide antibacterial agents
US8299052B2 (en)	2006-05-05	2012-10-30	Shionogi Inc.	Pharmaceutical compositions and methods for improved bacterial eradication
US20090054634A1 (en) *	2007-08-09	2009-02-26	Vinod Kumar Kansal	Process for the preparation of clarithromycin

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1221088A (en) *	1967-08-03	1971-02-03	Pliva Pharm & Chem Works	Improvements in or relating to erythromycin oxime acyl derivatives
US3869444A (en) *	1972-10-10	1975-03-04	Abbott Lab	Esters of erythromycin oxime
ES434842A1 (es) *	1975-02-19	1976-12-01	Andreu Sa Dr	Procedimiento para la preparacion de esteres de la oxima deeritromicina.
US4331803A (en) *	1980-06-04	1982-05-25	Taisho Pharmaceutical Co., Ltd.	Novel erythromycin compounds
JPS60214796A (ja) *	1984-04-06	1985-10-28	Taisho Pharmaceut Co Ltd	６−０−メチルエリスロマイシン類の製法
JPS61103890A (ja) *	1984-10-26	1986-05-22	Taisho Pharmaceut Co Ltd	６−０−メチルエリスロマイシンａ誘導体
US4670549A (en) *	1985-03-18	1987-06-02	Taisho Pharmaceutical Co., Ltd.	Method for selective methylation of erythromycin a derivatives
JPS61229895A (ja) *	1985-04-03	1986-10-14	Nippon Zeon Co Ltd	保護化デス−ｎ−メチルエリスロマイシン誘導体
EP0260938B1 (de) *	1986-09-18	1992-12-09	Taisho Pharmaceutical Co. Ltd	Erythromycin-A-Derivate und Verfahren zu ihrer Herstellung
KR960000434B1 (ko) *	1986-12-17	1996-01-06	다이쇼 세이야꾸 가부시끼가이샤	에리스로마이신 a유도체 및 그의 제조 방법
JP2751385B2 (ja) *	1988-05-19	1998-05-18	大正製薬株式会社	エリスロマイシンａオキシム及びその塩の製造方法

1997
- 1997-11-17 US US08/972,155 patent/US5852180A/en not_active Expired - Lifetime
1998
- 1998-11-17 PT PT98958048T patent/PT1032581E/pt unknown
- 1998-11-17 ES ES98958048T patent/ES2221225T3/es not_active Expired - Lifetime
- 1998-11-17 DE DE69822871T patent/DE69822871T2/de not_active Expired - Fee Related
- 1998-11-17 AU AU14166/99A patent/AU1416699A/en not_active Abandoned
- 1998-11-17 IL IL13551798A patent/IL135517A0/xx active IP Right Grant
- 1998-11-17 EP EP98958048A patent/EP1032581B1/de not_active Expired - Lifetime
- 1998-11-17 DK DK98958048T patent/DK1032581T3/da active
- 1998-11-17 KR KR1020007005327A patent/KR100565025B1/ko not_active Expired - Fee Related
- 1998-11-17 JP JP2000521103A patent/JP2001523685A/ja active Pending
- 1998-11-17 AT AT98958048T patent/ATE263181T1/de not_active IP Right Cessation
- 1998-11-17 CA CA002309256A patent/CA2309256C/en not_active Expired - Fee Related
- 1998-11-17 CA CA002628019A patent/CA2628019A1/en not_active Abandoned
- 1998-11-17 WO PCT/US1998/024539 patent/WO1999025723A1/en not_active Ceased
2000
- 2000-04-06 IL IL135517A patent/IL135517A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP1032581B1 (de)	2004-03-31
AU1416699A (en)	1999-06-07
US5852180A (en)	1998-12-22
DE69822871T2 (de)	2005-03-03
CA2628019A1 (en)	1999-05-27
IL135517A0 (en)	2001-05-20
CA2309256C (en)	2008-05-20
KR100565025B1 (ko)	2006-03-30
PT1032581E (pt)	2004-08-31
DK1032581T3 (da)	2004-08-02
IL135517A (en)	2008-06-05
ES2221225T3 (es)	2004-12-16
CA2309256A1 (en)	1999-05-27
EP1032581A1 (de)	2000-09-06
JP2001523685A (ja)	2001-11-27
WO1999025723A1 (en)	1999-05-27
DE69822871D1 (en)	2004-05-06
KR20010032140A (ko)	2001-04-16

Legal Events

Date

Code

Title

Description

2004-12-15

UEP

Publication of translation of european patent specification

Ref document number: 1032581

Country of ref document: EP

2010-08-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE263181T1 (de)	2004-04-15	Chemische synthese von 6-o-alkyl erythromycin a
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EP0743047A3 (de)	1997-03-26	Anatomisch geformte Vorrichtung zur Gefässokklusion sowie deren Herstellungsverfahren
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NL300077I1 (nl)	2002-03-01	Erythromycineverbindingen, werkwijze voor hun bereiding en hun toepassing als geneesmiddel.
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