ATE263185T1 - Verfahren zur herstellung von acylierten proteinpuder - Google Patents
Verfahren zur herstellung von acylierten proteinpuderInfo
- Publication number
- ATE263185T1 ATE263185T1 AT96303974T AT96303974T ATE263185T1 AT E263185 T1 ATE263185 T1 AT E263185T1 AT 96303974 T AT96303974 T AT 96303974T AT 96303974 T AT96303974 T AT 96303974T AT E263185 T1 ATE263185 T1 AT E263185T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- protein powder
- acylated protein
- producing acylated
- isoelectric
- Prior art date
Links
- 108091005647 acylated proteins Proteins 0.000 title abstract 3
- 239000000843 powder Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000001556 precipitation Methods 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/484,220 US5700904A (en) | 1995-06-07 | 1995-06-07 | Preparation of an acylated protein powder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE263185T1 true ATE263185T1 (de) | 2004-04-15 |
Family
ID=23923252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96303974T ATE263185T1 (de) | 1995-06-07 | 1996-05-31 | Verfahren zur herstellung von acylierten proteinpuder |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5700904A (de) |
| EP (1) | EP0747391B1 (de) |
| JP (1) | JP3844504B2 (de) |
| KR (1) | KR19990022590A (de) |
| CN (1) | CN1192218A (de) |
| AT (1) | ATE263185T1 (de) |
| AU (1) | AU703032B2 (de) |
| BR (1) | BR9608729A (de) |
| CA (1) | CA2223389A1 (de) |
| CZ (1) | CZ388197A3 (de) |
| DE (1) | DE69631996T2 (de) |
| DK (1) | DK0747391T3 (de) |
| EA (1) | EA199800042A1 (de) |
| ES (1) | ES2216039T3 (de) |
| HU (1) | HUP9900877A3 (de) |
| IL (1) | IL122460A0 (de) |
| NO (1) | NO975583L (de) |
| NZ (1) | NZ309371A (de) |
| PL (1) | PL323994A1 (de) |
| TR (1) | TR199701528T1 (de) |
| WO (1) | WO1996040730A1 (de) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9316895D0 (en) | 1993-08-13 | 1993-09-29 | Guy S And St Thomas Hospitals | Hepatoselective insulin analogues |
| US5986050A (en) * | 1996-12-26 | 1999-11-16 | Poly-Med, Inc. | Peracylated proteins and synthetic polypeptides and process for making the same |
| EP0966482B1 (de) * | 1997-02-07 | 2005-04-27 | Novo Nordisk A/S | Kristallisation von proteinen |
| US5898067A (en) * | 1997-02-07 | 1999-04-27 | Novo Nordisk A/S | Crystallization of proteins |
| US6310038B1 (en) * | 1997-03-20 | 2001-10-30 | Novo Nordisk A/S | Pulmonary insulin crystals |
| US5898028A (en) * | 1997-03-20 | 1999-04-27 | Novo Nordisk A/S | Method for producing powder formulation comprising an insulin |
| IL131796A0 (en) * | 1997-03-20 | 2001-03-19 | Novo Nordisk As | Zinc free insulin crystals for use in pulmonary compositions |
| ZA989644B (en) * | 1997-10-24 | 2000-04-25 | Lilly Co Eli | Insoluble insulen compositions. |
| SV1998000125A (es) * | 1997-10-24 | 1999-05-24 | Lilly Co Eli | Composiciones de insulina insoluble ref. x-11232 |
| ZA989744B (en) * | 1997-10-31 | 2000-04-26 | Lilly Co Eli | Method for administering acylated insulin. |
| US6531448B1 (en) * | 1997-12-23 | 2003-03-11 | Eli Lilly And Company | Insoluble compositions for controlling blood glucose |
| EP1396272A1 (de) * | 1997-12-23 | 2004-03-10 | Eli Lilly & Company | Unlöslische Insulin Zusammensetzungen zur Regelung der Blutglukose |
| US6526675B1 (en) * | 1999-06-07 | 2003-03-04 | Roe-Hoan Yoon | Methods of using natural products as dewatering aids for fine particles |
| US6855260B1 (en) | 1999-06-07 | 2005-02-15 | Roe-Hoan Yoon | Methods of enhancing fine particle dewatering |
| US7169889B1 (en) | 1999-06-19 | 2007-01-30 | Biocon Limited | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin |
| US6799682B1 (en) | 2000-05-16 | 2004-10-05 | Roe-Hoan Yoon | Method of increasing flotation rate |
| US6663602B2 (en) | 2000-06-16 | 2003-12-16 | Novo Nordisk A/S | Injection device |
| US6867183B2 (en) | 2001-02-15 | 2005-03-15 | Nobex Corporation | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
| US7060675B2 (en) | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
| US6828297B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US6835802B2 (en) * | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
| US7713932B2 (en) | 2001-06-04 | 2010-05-11 | Biocon Limited | Calcitonin drug-oligomer conjugates, and uses thereof |
| US6828305B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US6713452B2 (en) * | 2001-06-04 | 2004-03-30 | Nobex Corporation | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US6858580B2 (en) * | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US7312192B2 (en) | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
| US7196059B2 (en) | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
| US7166571B2 (en) | 2001-09-07 | 2007-01-23 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
| US6770625B2 (en) | 2001-09-07 | 2004-08-03 | Nobex Corporation | Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith |
| US7030082B2 (en) * | 2001-09-07 | 2006-04-18 | Nobex Corporation | Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith |
| US6913903B2 (en) | 2001-09-07 | 2005-07-05 | Nobex Corporation | Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| EP1503754B1 (de) * | 2002-04-19 | 2005-11-23 | Yissum Research Development Company, of The Hebrew University of Jerusalem | Beta-agonisten-verbindungen mit stickoxid-donatoren-gruppen und reaktionsfähige sauerstoffspezies-fängergruppen und ihre verwendung bei der behandlung von atemwegsstörungen |
| US7601688B2 (en) | 2002-06-13 | 2009-10-13 | Biocon Limited | Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus |
| US20060247216A1 (en) * | 2002-10-25 | 2006-11-02 | Haj-Yehia Abdullah I | Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments |
| JP4565193B2 (ja) | 2003-04-23 | 2010-10-20 | バレリタス, インコーポレイテッド | 長い持続時間の医薬投与のための液圧作動式ポンプ |
| JP4886511B2 (ja) | 2003-07-30 | 2012-02-29 | ライジェル ファーマシューティカルズ, インコーポレイテッド | 2,4−ピリミジンジアミン化合物による自己免疫疾患の治療または予防方法 |
| WO2006014425A1 (en) | 2004-07-02 | 2006-02-09 | Biovalve Technologies, Inc. | Methods and devices for delivering glp-1 and uses thereof |
| MX2007000883A (es) | 2004-07-19 | 2007-04-02 | Biocon Ltd | Conjugados de insulina-oligomero, formulaciones y usos de los mismos. |
| DK1804865T3 (da) | 2004-10-21 | 2010-02-01 | Novo Nordisk As | Neddrejeindstillingsmekanisme til en pen med fjederoptræk |
| JP4022595B2 (ja) * | 2004-10-26 | 2007-12-19 | コニカミノルタオプト株式会社 | 撮影装置 |
| AP2447A (en) | 2005-02-04 | 2012-08-31 | Mineral And Coal Technologies Inc | Improving the seperation of diamond from gangue minerals |
| EP1877121B1 (de) | 2005-04-24 | 2015-09-23 | Novo Nordisk A/S | Injektionsvorrichtung |
| US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| AU2006254840B2 (en) | 2005-06-08 | 2012-08-02 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the JAK pathway |
| US7741281B2 (en) * | 2005-11-03 | 2010-06-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| ES2622493T3 (es) * | 2006-02-24 | 2017-07-06 | Rigel Pharmaceuticals, Inc. | Composiciones y métodos para la inhibición de la ruta de JAK |
| JP5183499B2 (ja) | 2006-03-10 | 2013-04-17 | ノボ・ノルデイスク・エー/エス | 注射装置 |
| US8298194B2 (en) | 2006-03-10 | 2012-10-30 | Novo Nordisk A/S | Injection device and a method of changing a cartridge in the device |
| EP2004671B1 (de) * | 2006-03-30 | 2015-12-09 | Novo Nordisk A/S | Zwei-phasen fällung von proteinen |
| ES2656675T3 (es) | 2006-03-30 | 2018-02-28 | Valeritas, Inc. | Dispositivo de suministro de fluidos de múltiples cartuchos |
| US7714025B2 (en) * | 2006-05-10 | 2010-05-11 | Arizona Biomedical Research Commission | Modified chalcone compounds as antimitotic agents |
| DE602007004972D1 (de) | 2006-05-16 | 2010-04-08 | Novo Nordisk As | Getriebemechanismus für ein injektionsgerät |
| EP2023982B1 (de) | 2006-05-18 | 2012-07-11 | Novo Nordisk A/S | Injektionsgerät mit modus-arretiermittel |
| RU2468829C2 (ru) | 2007-03-23 | 2012-12-10 | Ново Нордиск А/С | Инъекционное устройство, содержащее стопорную гайку |
| BRPI0818004B8 (pt) | 2007-10-16 | 2021-05-25 | Biocon Ltd | composição farmacêutica sólida administrável por via oral e o processo da mesma. |
| EP2565193B1 (de) | 2009-01-23 | 2014-03-19 | Rigel Pharmaceuticals, Inc. | Zusammensetzungen und Verfahren zur Hemmung des JAK-Signalwegs |
| JP5892940B2 (ja) | 2009-11-25 | 2016-03-23 | アリスジェン ソシエテ アノニム | クラウン化合物及び/又は対イオンと複合体化されたペプチドを含む粘膜送達組成物 |
| CA2804199C (en) | 2010-07-28 | 2020-05-12 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| RU2014128518A (ru) | 2011-12-29 | 2016-02-20 | Ново Нордиск А/С | Механизм увеличения/уменьшения дозы для взводимого шприца-ручки |
| JP6231548B2 (ja) | 2012-03-23 | 2017-11-15 | マテオン セラピューティクス, インコーポレイテッド | カテプシンの阻害のための組成物および方法 |
| US11206846B2 (en) * | 2017-05-02 | 2021-12-28 | Leprino Foods Company | High purity alpha lactalbumin and methods of making |
| SG11202002761TA (en) | 2017-09-26 | 2020-04-29 | Biocon Biologics India Ltd | Integrated automated filtration for separation, washing and drying of peptide crystals |
| WO2020092845A1 (en) | 2018-11-01 | 2020-05-07 | Rigel Pharmaceuticals, Inc. | Method and composition embodiments for treating acute myeloid leukemia |
| WO2020243612A1 (en) | 2019-05-29 | 2020-12-03 | Rigel Pharmaceuticals, Inc. | Method of preventing and treating thrombosis |
| BR112022001418A2 (pt) | 2019-08-08 | 2022-06-07 | Rigel Pharmaceuticals Inc | Compostos e método para tratar a síndrome de liberação de citocinas |
| WO2021030526A1 (en) | 2019-08-14 | 2021-02-18 | Rigel Pharmaceuticals, Inc. | Method of blocking or ameliorating cytokine release syndrome |
| TW202346291A (zh) | 2022-03-23 | 2023-12-01 | 美商雷傑製藥公司 | 作為irak抑制劑的嘧啶—2—基—吡唑化合物 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1468831A (fr) * | 1965-10-05 | 1967-02-10 | Roussel Uclaf | Procédé de préparation de nouveaux composés polypeptidiques et produits en résultant |
| DE1902865A1 (de) * | 1968-02-01 | 1969-09-11 | American Home Prod | Substituierte Insulin-Derivate,Verfahren zu ihrer Herstellung und ihre Verwendung in pharmazeutischen Zubereitungen |
| US3591574A (en) * | 1968-05-29 | 1971-07-06 | American Home Prod | Tri-n-phenylglycyl derivatives of insulin |
| US3528960A (en) * | 1968-10-07 | 1970-09-15 | Lilly Co Eli | N-carboxyaroyl insulins |
| US3823125A (en) * | 1969-10-14 | 1974-07-09 | American Home Prod | N-aminoacyl-substituted insulins |
| US3752798A (en) * | 1969-12-02 | 1973-08-14 | G Amird | Tris-na1,nb1,nepsilonb29 - (3-x-3-oxo - 1-y-prop-1-en-1-yl)(ndelta-(4-z-6-r-pyrimidin - 2 - yl) ornithine b22)-insulins and their preparation |
| US3950517A (en) * | 1970-05-08 | 1976-04-13 | National Research Development Corporation | Insulin derivatives |
| US3869437A (en) * | 1970-05-08 | 1975-03-04 | Nat Res Dev | Mono-, di, and N{HD A1{B , N{HU B1{B , N{HU B29{B -tri-acylated insulin |
| GB1381274A (en) * | 1971-01-28 | 1975-01-22 | Nat Res Dev | Insulin derivatives |
| GB1381273A (en) * | 1971-01-28 | 1975-01-22 | Nat Res Dev | Insulin derivatives |
| US3864325A (en) * | 1971-11-18 | 1975-02-04 | Nat Res Dev | (N{HU Al{b , N{HU Bl{b , N{HU B29{B , carbamoyl)-(O{HU A14{B , O{HU B16{B , O{HU B26{B aryl) insulin derivatives |
| BE791949A (fr) * | 1971-11-27 | 1973-05-28 | Schering Ag | Derives d'insuline, leur preparation et leur utilisation |
| US3843815A (en) * | 1972-02-10 | 1974-10-22 | Gen Foods Corp | Inhibiting gel formation in meat-in-gravy products |
| US3755569A (en) * | 1972-07-25 | 1973-08-28 | American Home Prod | Acyl substituted insulins |
| DE2252157C3 (de) * | 1972-10-25 | 1976-03-18 | Hoechst Ag | Zwischenprodukte zur herstellung von insulin, insulin-analogen und -derivaten und verfahren zur herstellung von insulin, insulin analogen und derivaten |
| DE2253327A1 (de) * | 1972-10-31 | 1974-05-09 | Hoechst Ag | Verfahren zur herstellung von insulin, insulin-analogen und -derivaten |
| NL7314766A (de) * | 1972-10-31 | 1974-05-02 | ||
| DE2428412A1 (de) * | 1974-06-12 | 1976-01-15 | Hoechst Ag | Verfahren zur herstellung von insulin, insulin-analogen und -derivaten |
| DE2439296A1 (de) * | 1974-08-16 | 1976-02-26 | Hoechst Ag | Verfahren zur herstellung von insulin, insulin-analogen und -derivaten |
| GB1492997A (en) * | 1976-07-21 | 1977-11-23 | Nat Res Dev | Insulin derivatives |
| EP0014815A3 (de) * | 1978-12-20 | 1980-10-29 | Ciba-Geigy Ag | Peptidderivate, Verfahren zu deren Herstellung und Zwischenprodukte sowie pharmazeutische Präparate mit einer dieser Verbindungen |
| US4486458A (en) * | 1982-09-07 | 1984-12-04 | A. E. Staley Manufacturing Company | Non-gelling corn steep liquor |
| PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| JPS6255096A (ja) * | 1986-06-12 | 1987-03-10 | Nippon Shinyaku Co Ltd | 新規な脂肪酸アシル化合物 |
| JPH01254699A (ja) * | 1988-04-05 | 1989-10-11 | Kodama Kk | インスリン誘導体及びその用途 |
| IL93282A (en) * | 1989-02-09 | 1995-08-31 | Lilly Co Eli | Insulin analogues |
| AU8091091A (en) * | 1990-07-26 | 1992-02-18 | University Of Iowa Research Foundation, The | Novel drug delivery systems for proteins and peptides using albumin as a carrier molecule |
| US5304473A (en) * | 1991-06-11 | 1994-04-19 | Eli Lilly And Company | A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production |
| CA2150470A1 (en) * | 1992-11-30 | 1994-06-09 | S.P.I. Synthetic Peptides Incorporated | Polyunsaturated fatty acyl-peptide composition |
-
1995
- 1995-06-07 US US08/484,220 patent/US5700904A/en not_active Expired - Fee Related
-
1996
- 1996-05-31 ES ES96303974T patent/ES2216039T3/es not_active Expired - Lifetime
- 1996-05-31 DE DE69631996T patent/DE69631996T2/de not_active Expired - Fee Related
- 1996-05-31 EP EP96303974A patent/EP0747391B1/de not_active Expired - Lifetime
- 1996-05-31 AT AT96303974T patent/ATE263185T1/de not_active IP Right Cessation
- 1996-05-31 DK DK96303974T patent/DK0747391T3/da active
- 1996-06-04 WO PCT/US1996/007963 patent/WO1996040730A1/en not_active Ceased
- 1996-06-04 CN CN96195951A patent/CN1192218A/zh active Pending
- 1996-06-04 EA EA199800042A patent/EA199800042A1/ru unknown
- 1996-06-04 NZ NZ309371A patent/NZ309371A/en unknown
- 1996-06-04 KR KR1019970709071A patent/KR19990022590A/ko not_active Ceased
- 1996-06-04 TR TR97/01528T patent/TR199701528T1/xx unknown
- 1996-06-04 AU AU59513/96A patent/AU703032B2/en not_active Ceased
- 1996-06-04 BR BR9608729A patent/BR9608729A/pt not_active Application Discontinuation
- 1996-06-04 PL PL96323994A patent/PL323994A1/xx unknown
- 1996-06-04 HU HU9900877A patent/HUP9900877A3/hu unknown
- 1996-06-04 IL IL12246096A patent/IL122460A0/xx unknown
- 1996-06-04 CZ CZ973881A patent/CZ388197A3/cs unknown
- 1996-06-04 JP JP50083297A patent/JP3844504B2/ja not_active Expired - Fee Related
- 1996-06-04 CA CA002223389A patent/CA2223389A1/en not_active Abandoned
-
1997
- 1997-12-03 NO NO975583A patent/NO975583L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL323994A1 (en) | 1998-04-27 |
| JPH11506738A (ja) | 1999-06-15 |
| US5700904A (en) | 1997-12-23 |
| CZ388197A3 (cs) | 1998-05-13 |
| NZ309371A (en) | 1999-09-29 |
| AU5951396A (en) | 1996-12-30 |
| JP3844504B2 (ja) | 2006-11-15 |
| DE69631996T2 (de) | 2005-01-27 |
| ES2216039T3 (es) | 2004-10-16 |
| CA2223389A1 (en) | 1996-12-19 |
| TR199701528T1 (xx) | 1998-03-21 |
| EP0747391A2 (de) | 1996-12-11 |
| BR9608729A (pt) | 1999-06-29 |
| DE69631996D1 (de) | 2004-05-06 |
| MX9709657A (es) | 1998-07-31 |
| NO975583D0 (no) | 1997-12-03 |
| EP0747391A3 (de) | 1997-05-21 |
| NO975583L (no) | 1997-12-03 |
| AU703032B2 (en) | 1999-03-11 |
| KR19990022590A (ko) | 1999-03-25 |
| WO1996040730A1 (en) | 1996-12-19 |
| HUP9900877A3 (en) | 1999-11-29 |
| CN1192218A (zh) | 1998-09-02 |
| EA199800042A1 (ru) | 1998-08-27 |
| HUP9900877A2 (hu) | 1999-07-28 |
| IL122460A0 (en) | 1998-06-15 |
| EP0747391B1 (de) | 2004-03-31 |
| DK0747391T3 (da) | 2004-07-19 |
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