ATE263759T1 - N-substituierte dioxothiazolidyl-benzamid- derivate und verfahren zu ihrer herstellung - Google Patents

N-substituierte dioxothiazolidyl-benzamid- derivate und verfahren zu ihrer herstellung

Info

Publication number
ATE263759T1
ATE263759T1 AT96942555T AT96942555T ATE263759T1 AT E263759 T1 ATE263759 T1 AT E263759T1 AT 96942555 T AT96942555 T AT 96942555T AT 96942555 T AT96942555 T AT 96942555T AT E263759 T1 ATE263759 T1 AT E263759T1
Authority
AT
Austria
Prior art keywords
carbon atoms
denotes
groups
group
substituted
Prior art date
Application number
AT96942555T
Other languages
English (en)
Inventor
Toshio Maeda
Masahiro Nomura
Katsuya Awano
Hiroya Satoh
Koji Murakami
Masaki Tsunoda
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Application granted granted Critical
Publication of ATE263759T1 publication Critical patent/ATE263759T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT96942555T 1995-12-18 1996-12-16 N-substituierte dioxothiazolidyl-benzamid- derivate und verfahren zu ihrer herstellung ATE263759T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP34834195A JP3906935B2 (ja) 1995-12-18 1995-12-18 Ｎ−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法
PCT/JP1996/003664 WO1997022600A1 (en) 1995-12-18 1996-12-16 N-substituted dioxothiazolidylbenzamide derivatives and process for producing the same

Publications (1)

Publication Number Publication Date
ATE263759T1 true ATE263759T1 (de) 2004-04-15

Family

ID=18396383

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96942555T ATE263759T1 (de) 1995-12-18 1996-12-16 N-substituierte dioxothiazolidyl-benzamid- derivate und verfahren zu ihrer herstellung

Country Status (12)

Country Link
US (1) US5948803A (de)
EP (1) EP0881219B1 (de)
JP (1) JP3906935B2 (de)
KR (1) KR100492655B1 (de)
CN (1) CN1065863C (de)
AT (1) ATE263759T1 (de)
AU (1) AU705538B2 (de)
CA (1) CA2239245C (de)
DE (1) DE69632152T2 (de)
HU (1) HUP0000449A3 (de)
TW (1) TW339333B (de)
WO (1) WO1997022600A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6147101A (en) * 1995-06-02 2000-11-14 Kyorin Pharmaceutical Co., Ltd. N-benzyldioxothiazolidylbenzamide derivatives and process for producing the same
DE69738809D1 (de) * 1996-11-08 2008-08-14 Nippon Chemiphar Co Mittel zur verringerung der eigeweidefette
US6008237A (en) 1997-12-19 1999-12-28 Merck & Co., Inc. Arylthiazolidinedione derivatives
ID24878A (id) * 1997-12-19 2000-08-31 Merck & Co Inc Turunan ariltiazolidinedion
AU770870B2 (en) 1999-06-18 2004-03-04 Merck & Co., Inc. Arylthiazolidinedione and aryloxazolidinedione derivatives
US6399640B1 (en) 1999-06-18 2002-06-04 Merck & Co., Inc. Arylthiazolidinedione and aryloxazolidinedione derivatives
CN1155586C (zh) * 1999-08-23 2004-06-30 杏林制药株式会社 取代的苄基噻唑烷-2,4-二酮衍生物
DE60020375T2 (de) 1999-08-23 2006-11-23 Kyorin Pharmaceutical Co., Ltd. Substituierte benzylthiazolidin-2,4-dion derivate
CA2382581C (en) * 1999-08-23 2007-06-12 Kyorin Pharmaceutical Co., Ltd. Substituted benzylthiazolidine-2,4-dione derivatives
US6706763B1 (en) * 1999-09-17 2004-03-16 Kyorin Pharmaceutical Co., Ltd. O-anisamide derivatives
AU2002222574A1 (en) 2000-12-05 2002-06-18 Kyorin Pharmaceutical Co. Ltd. Substituted carboxylic acid derivatives
CN101444496B (zh) * 2001-06-12 2011-04-13 维尔斯达医疗公司 用于治疗代谢失调的化合物
WO2003042190A1 (en) 2001-11-12 2003-05-22 Pfizer Products Inc. N-alkyl-adamantyl derivatives as p2x7-receptor antagonists
PA8557501A1 (es) 2001-11-12 2003-06-30 Pfizer Prod Inc Benzamida, heteroarilamida y amidas inversas
ITRM20020016A1 (it) * 2002-01-15 2003-07-15 Sigma Tau Ind Farmaceuti Derivati di acidi fenil(alchil)carbossilici e derivati fenilalchileterociclici dionici, loro uso come medicamenti ad attivita' ipoglicemizza
US20050119314A1 (en) * 2002-04-05 2005-06-02 Sankyo Company, Limited Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent
PA8591801A1 (es) 2002-12-31 2004-07-26 Pfizer Prod Inc Inhibidores benzamidicos del receptor p2x7.
US7071223B1 (en) 2002-12-31 2006-07-04 Pfizer, Inc. Benzamide inhibitors of the P2X7 receptor
EP1837330B1 (de) * 2003-05-12 2012-10-24 Pfizer Products Inc. Benzamidinhibitoren des P2X7-Rezeptors
ATE355273T1 (de) 2003-05-12 2006-03-15 Pfizer Prod Inc Benzamidinhibitoren des p2x7-rezeptors
EP1763353A1 (de) * 2004-06-29 2007-03-21 Warner-Lambert Company LLC KOMBINATIONSTHERAPIEN MIT BENZAMID-HEMMERN DES P2X<SB>7</SB> REZEPTORS
WO2006003500A1 (en) * 2004-06-29 2006-01-12 Pfizer Products Inc. Method for preparing 5-`4-(2-hydroxy-propyl)-3,5-dioxo-4,5-dihydro-3h`1,2,4!triazin-2-yl!-benzamide derivatives by deprotecting the hydroxyl-protected precursers
MXPA06015273A (es) * 2004-06-29 2007-03-15 Pfizer Prod Inc Procedimiento para preparar derivados de 5-[4-(2-hidroxi -etil)-3, 5-dioxo-4, 5-dihidro-3h-[1, 2, 4]-triazin -2-il]-benzamida con actividad inhibidora de p2x7 mediante reaccion del derivado no sustituido en posicion 4 de la triazina con un oxirano en
KR20080098615A (ko) * 2006-02-28 2008-11-11 웰스태트 테러퓨틱스 코포레이션 물질대사 장애의 치료용 화합물
JP2011057661A (ja) * 2009-08-14 2011-03-24 Bayer Cropscience Ag 殺虫性カルボキサミド類
WO2011160206A1 (en) 2010-06-23 2011-12-29 Morin Ryan D Biomarkers for non-hodgkin lymphomas and uses thereof
BR112013005806B1 (pt) 2010-09-10 2022-05-10 Epizyme, Inc Métodos para detectar se um indivíduo é um candidato para o tratamento com ou responsivo a um inibidor de ezh2 e usos terapêuticos do dito inibidor de ezh2
US9175331B2 (en) 2010-09-10 2015-11-03 Epizyme, Inc. Inhibitors of human EZH2, and methods of use thereof
WO2012118812A2 (en) 2011-02-28 2012-09-07 Epizyme, Inc. Substituted 6,5-fused bicyclic heteroaryl compounds
TW201733984A (zh) 2011-04-13 2017-10-01 雅酶股份有限公司 經取代之苯化合物
JO3363B1 (ar) 2011-04-13 2019-03-13 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
US9394283B2 (en) 2012-04-13 2016-07-19 Epizyme, Inc. Salt form of a human histone methyltransferase EZH2 inhibitor
PE20150887A1 (es) 2012-10-15 2015-06-04 Epizyme Inc Compuestos de benceno sustituidos
KR102142177B1 (ko) 2013-10-16 2020-08-07 에피자임, 인코포레이티드 Ezh2 억제용 하이드로클로라이드 염 형태
CN108929263B (zh) * 2017-05-26 2022-07-22 中国医学科学院药物研究所 芳酰胺类Kv2.1抑制剂及其制备方法、药物组合物和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6610081A (en) * 1980-01-24 1981-07-30 Senju Pharmaceutical Co., Ltd. Thiazolidine derivatives
JPS5728073A (en) * 1980-07-29 1982-02-15 Takeda Chem Ind Ltd Inhibitor for aldose reducing enzyme
WO1989008652A1 (en) * 1988-03-08 1989-09-21 Pfizer Inc. Thiazolidinedione derivatives as hypoglycemic agents
WO1989008650A1 (en) * 1988-03-08 1989-09-21 Pfizer Inc. Thiazolidinedione hypoglycemic agents
GB9023584D0 (en) * 1990-10-30 1990-12-12 Beecham Group Plc Novel compounds
JP3053490B2 (ja) * 1991-02-25 2000-06-19 杏林製薬株式会社 チアゾリジン−２，４−ジオン誘導体とその塩及び製造法
JPH04270273A (ja) * 1991-02-25 1992-09-25 Kyorin Pharmaceut Co Ltd チアゾリジン−２，４−ジオン誘導体とその塩及びその製造法
FR2696743B1 (fr) * 1992-10-12 1994-12-23 Adir Nouveaux composés de thiazolidine dione, leur procédé de préparation et les compositions pharmaceutiques les contenant.

Also Published As

Publication number Publication date
TW339333B (en) 1998-09-01
EP0881219A1 (de) 1998-12-02
AU705538B2 (en) 1999-05-27
JP3906935B2 (ja) 2007-04-18
CN1065863C (zh) 2001-05-16
KR20000064428A (ko) 2000-11-06
HUP0000449A2 (hu) 2001-02-28
US5948803A (en) 1999-09-07
CA2239245A1 (en) 1997-06-26
DE69632152T2 (de) 2005-02-24
DE69632152D1 (de) 2004-05-13
EP0881219B1 (de) 2004-04-07
WO1997022600A1 (en) 1997-06-26
HUP0000449A3 (en) 2001-04-28
KR100492655B1 (ko) 2005-09-07
EP0881219A4 (de) 2000-01-26
AU2011697A (en) 1997-07-14
CN1205695A (zh) 1999-01-20
CA2239245C (en) 2004-03-30
JPH09169746A (ja) 1997-06-30

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