ATE264682T1 - Cyclophasiges hormonverfahren das antiprogestin und progestin enthält - Google Patents

Cyclophasiges hormonverfahren das antiprogestin und progestin enthält

Info

Publication number: ATE264682T1
Authority: AT; Austria
Prior art keywords: antiprogestin; estrogen; progestin; cyclophasic; effective
Prior art date: 1994-12-19

Application number

AT95943476T

Other languages

English (en)

Inventor

Gary Ph M P H Grubb

Original Assignee

Ortho Mcneil Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-19

Filing date

1995-12-15

Publication date

2004-05-15

1995-12-15 Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc

2004-05-15 Application granted granted Critical

2004-05-15 Publication of ATE264682T1 publication Critical patent/ATE264682T1/de

Links

230000000708 anti-progestin effect Effects 0.000 title abstract 5
239000003418 antiprogestin Substances 0.000 title abstract 5
RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 title abstract 3
239000000583 progesterone congener Substances 0.000 title abstract 3
239000005556 hormone Substances 0.000 title abstract 2
229940088597 hormone Drugs 0.000 title abstract 2
229940011871 estrogen Drugs 0.000 abstract 4
239000000262 estrogen Substances 0.000 abstract 4
108010085012 Steroid Receptors Proteins 0.000 abstract 2
230000003054 hormonal effect Effects 0.000 abstract 2
102000005969 steroid hormone receptors Human genes 0.000 abstract 2
230000002357 endometrial effect Effects 0.000 abstract 1
238000002657 hormone replacement therapy Methods 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)

AT95943476T 1994-12-19 1995-12-15 Cyclophasiges hormonverfahren das antiprogestin und progestin enthält ATE264682T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/359,159 US5521166A (en)	1994-12-19	1994-12-19	Antiprogestin cyclophasic hormonal regimen
PCT/US1995/016561 WO1996019227A1 (en)	1994-12-19	1995-12-15	Cyclophasic hormonal regimen containing antiprogestin and progestin

Publications (1)

Publication Number	Publication Date
ATE264682T1 true ATE264682T1 (de)	2004-05-15

Family

ID=23412581

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95943476T ATE264682T1 (de)	1994-12-19	1995-12-15	Cyclophasiges hormonverfahren das antiprogestin und progestin enthält

Country Status (11)

Country	Link
US (1)	US5521166A (de)
EP (1)	EP0799043B1 (de)
JP (1)	JPH10513152A (de)
AT (1)	ATE264682T1 (de)
AU (1)	AU711179B2 (de)
CA (1)	CA2208007A1 (de)
DE (1)	DE69532927T2 (de)
DK (1)	DK0799043T3 (de)
ES (1)	ES2219673T3 (de)
PT (1)	PT799043E (de)
WO (1)	WO1996019227A1 (de)

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US6506390B2 (en)	1996-06-25	2003-01-14	Akzo Nobel	Progestogen-anti-progestogen regimens
US20020012694A1 (en) *	1997-09-17	2002-01-31	Alfred J. Moo-Young	Transdermal administration of ment
AU747710B2 (en) *	1997-11-14	2002-05-23	Akzo Nobel N.V.	Progestogen-antiprogestogen regimens
ES2226833T3 (es) *	1999-05-04	2005-04-01	Wyeth	Composiciones anticonceptivas que contienen agentes antiprogestinicos y progestinicos.
US6358947B1 (en)	1999-05-04	2002-03-19	American Home Products Corporation	Tetracyclic progesterone receptor modulator compounds and methods
US6358948B1 (en)	1999-05-04	2002-03-19	American Home Products Corporation	Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
US6369056B1 (en)	1999-05-04	2002-04-09	American Home Products Corporation	Cyclic urea and cyclic amide derivatives
US6444668B1 (en)	1999-05-04	2002-09-03	Wyeth	Combination regimens using progesterone receptor modulators
US6380178B1 (en)	1999-05-04	2002-04-30	American Home Products Corporation	Cyclic regimens using cyclocarbamate and cyclic amide derivatives
US6355648B1 (en) *	1999-05-04	2002-03-12	American Home Products Corporation	Thio-oxindole derivatives
US6462032B1 (en)	1999-05-04	2002-10-08	Wyeth	Cyclic regimens utilizing indoline derivatives
US6498154B1 (en)	1999-05-04	2002-12-24	Wyeth	Cyclic regimens using quinazolinone and benzoxazine derivatives
US6423699B1 (en)	1999-05-04	2002-07-23	American Home Products Corporation	Combination therapies using benzimidazolones
US6509334B1 (en)	1999-05-04	2003-01-21	American Home Products Corporation	Cyclocarbamate derivatives as progesterone receptor modulators
US6407101B1 (en)	1999-05-04	2002-06-18	American Home Products Corporation	Cyanopyrroles
US6417214B1 (en)	1999-05-04	2002-07-09	Wyeth	3,3-substituted indoline derivatives
US6306851B1 (en)	1999-05-04	2001-10-23	American Home Products Corporation	Cyclocarbamate and cyclic amide derivatives
US6329416B1 (en) *	1999-05-04	2001-12-11	American Home Products Corporation	Combination regimens using 3,3-substituted indoline derivatives
US6391907B1 (en) *	1999-05-04	2002-05-21	American Home Products Corporation	Indoline derivatives
US6380235B1 (en)	1999-05-04	2002-04-30	American Home Products Corporation	Benzimidazolones and analogues
US6319912B1 (en)	1999-05-04	2001-11-20	American Home Products Corporation	Cyclic regimens using 2,1-benzisothiazoline 2,2-dioxides
EP1173213A1 (de) *	1999-05-04	2002-01-23	American Home Products Corporation	Zusammensetzungen die benzimidazolonen und progestagene enthalten
US6339098B1 (en)	1999-05-04	2002-01-15	American Home Products Corporation	2,1-benzisothiazoline 2,2-dioxides
US6399593B1 (en)	1999-05-04	2002-06-04	Wyeth	Cyclic regimens using cyclic urea and cyclic amide derivatives
US6476079B1 (en) *	1999-12-23	2002-11-05	Leiras Oy	Devices for the delivery of drugs having antiprogestinic properties
UA73119C2 (en) *	2000-04-19	2005-06-15	American Home Products Corpoir	Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
AU2003261233A1 (en) *	2002-07-25	2004-02-16	Massachusetts Institute Of Technology	Steroid modulators in the treatment of peripheral nerve sheath tumors
KR20050059092A (ko) *	2002-08-28	2005-06-17	로버트 캐스퍼	에스트로겐 보충 요법
US20060052354A1 (en) *	2002-11-05	2006-03-09	Corcept Therapeutics, Inc.	Methods for treating migraine
CA2504751C (en) *	2002-11-05	2013-02-05	Corcept Therapeutics, Inc.	Methods for treating gastroesophageal reflux disease
US20060111318A1 (en) *	2003-04-18	2006-05-25	Advanced Medicine Research Institute	Agent for treating eye diseases
US20070077269A1 (en) *	2005-10-04	2007-04-05	Woodward John R	Method of birth control and hormone regulation
MY150763A (en) *	2006-10-24	2014-02-28	Repros Therapeutics Inc	Compositions and methods for suppressing endometrial proliferation

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Publication number	Priority date	Publication date	Assignee	Title
ZA8231B (en) *	1981-01-09	1982-11-24	Roussel Uclaf	New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
US4780461A (en) *	1983-06-15	1988-10-25	Schering Aktiengesellschaft	13α-alkyl-gonanes, their production, and pharmaceutical preparations containing same
DE3347126A1 (de) *	1983-12-22	1985-07-11	Schering AG, 1000 Berlin und 4709 Bergkamen	11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
AU580843B2 (en) *	1985-02-07	1989-02-02	Schering Aktiengesellschaft	11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them
DE3708942A1 (de) *	1987-03-18	1988-09-29	Schering Ag	19,11ss-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate
DE19975054I2 (de) *	1987-08-08	2000-04-13	Akzo Nobel Nv	Kontrazeptives Implantat
US5256421A (en) *	1987-09-24	1993-10-26	Jencap Research Ltd.	Hormone preparation and method
US5276022A (en) *	1987-09-24	1994-01-04	Jencap Research Ltd.	Hormone preparation and method
US5108995A (en) *	1987-09-24	1992-04-28	Jencap Research Ltd.	Hormone preparation and method
DE3744054A1 (de) *	1987-12-21	1989-06-29	Schering Ag	Verwendung von antigestagenen zur herstellung von arzneimitteln
MX9301121A (es) *	1992-03-02	1993-09-01	Schering Ag	Metodo y equipo para la contracepcion oral y regulacion de la menstruacion con estrogeno/progestina/aniprogestina.
WO1993021926A1 (en) *	1992-05-06	1993-11-11	Medical College Of Hampton Roads	Minimizing progestin associated breakthrough bleeding
ZA935617B (en) *	1992-08-14	1994-03-07	Akzo Nv	Antiprogestogen containing contraceptives.

1994
- 1994-12-19 US US08/359,159 patent/US5521166A/en not_active Expired - Lifetime
1995
- 1995-12-15 ES ES95943476T patent/ES2219673T3/es not_active Expired - Lifetime
- 1995-12-15 AT AT95943476T patent/ATE264682T1/de active
- 1995-12-15 CA CA002208007A patent/CA2208007A1/en not_active Abandoned
- 1995-12-15 DK DK95943476T patent/DK0799043T3/da active
- 1995-12-15 WO PCT/US1995/016561 patent/WO1996019227A1/en not_active Ceased
- 1995-12-15 DE DE69532927T patent/DE69532927T2/de not_active Expired - Lifetime
- 1995-12-15 JP JP8519952A patent/JPH10513152A/ja active Pending
- 1995-12-15 PT PT95943476T patent/PT799043E/pt unknown
- 1995-12-15 AU AU44730/96A patent/AU711179B2/en not_active Expired
- 1995-12-15 EP EP95943476A patent/EP0799043B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0799043A1 (de)	1997-10-08
ES2219673T3 (es)	2004-12-01
DK0799043T3 (da)	2004-08-09
PT799043E (pt)	2004-08-31
WO1996019227A1 (en)	1996-06-27
AU711179B2 (en)	1999-10-07
DE69532927D1 (de)	2004-05-27
JPH10513152A (ja)	1998-12-15
AU4473096A (en)	1996-07-10
DE69532927T2 (de)	2005-04-14
EP0799043B1 (de)	2004-04-21
CA2208007A1 (en)	1996-06-27
US5521166A (en)	1996-05-28

Legal Events

Date

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Title

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2005-01-15

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Publication	Publication Date	Title
DE69532927D1 (de)	2004-05-27	Cyclophasiges hormonverfahren das antiprogestin und progestin enthält
KR960001371B1 (ko)	1996-01-26	폐경기 전의 여성용 혼합 제형 및 이를 포함하는 팩
ES2200384T3 (es)	2004-03-01	Medio anticonceptivo hormonal.
ATE114116T1 (de)	1994-12-15	Kontinuierliche verabreichung des luteinisierendes hormon abgebenden hormons in kombination mit sexsteroidverabreichung als empfängnisverhütungsmittel.
UA48973C2 (uk)	2002-09-16	Трансдермальний пластир на основі 17-деацетилноргестимату для попередження овуляції
AR035564A1 (es)	2004-06-16	Moduladores selectivos de receptores de estrogenos en combinacion con estrogenos
NO986104L (no)	1998-12-23	Progesteron-anti-progesteron regimer
BG99880A (bg)	1996-02-28	Метод за хормонзаместващо лечение
NO970309L (no)	1997-01-24	Anvendelse av en progesteronantagonist og av et gestagen for behandling av endometriose eller Leiomyomata uteri
AR016502A1 (es)	2001-07-04	Uso de sulfamatos estrogenos biogenicos en una terapia de reemplazo de hormonas.
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Meyer III et al.	1981	Physical and hormonal evaluation of transsexual patients during hormonal therapy
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Holland et al.	1994	The effect of 25-mg percutaneous estradiol implants on the bone mass of postmenopausal women
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Miller et al.	1991	Sex steroids and lipoproteins
Huovinen et al.	1991	Serum lipids and lipoproteins during therapeutic amenorrhea induced by lynestrenol and depot-medroxyprogesterone acetate
Hart	1997	Current attitudes to hormone replacement therapy
Sojo-Aranda et al.	1995	Ethinylestradiol from contraceptive formulations and the ovarian response: an estrogen dose-dependency on natural estradiol concentrations
US7629334B1 (en)	2009-12-08	Mesoprogrestins (progesterone receptor modulations) as a component of compositions for hormone replacement therapy (HRT)
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Naessen et al.	1996	F088 Bone loss in women over 60 years prevented by ultra-low doses of 17-β estradiol
MXPA98007513A (en)	1999-02-24	Sequencial combination of estrogen / antagonist of progesterone for therapy of replacement of hormo