ATE264682T1 - Cyclophasiges hormonverfahren das antiprogestin und progestin enthält - Google Patents

Cyclophasiges hormonverfahren das antiprogestin und progestin enthält

Info

Publication number: ATE264682T1
Authority: AT; Austria
Prior art keywords: antiprogestin; estrogen; progestin; cyclophasic; effective
Prior art date: 1994-12-19

Application number

AT95943476T

Other languages

English (en)

Inventor

Gary Ph M P H Grubb

Original Assignee

Ortho Mcneil Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-19

Filing date

1995-12-15

Publication date

2004-05-15

1995-12-15 Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc

2004-05-15 Application granted granted Critical

2004-05-15 Publication of ATE264682T1 publication Critical patent/ATE264682T1/de

Links

230000000708 anti-progestin effect Effects 0.000 title abstract 5
239000003418 antiprogestin Substances 0.000 title abstract 5
RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 title abstract 3
239000000583 progesterone congener Substances 0.000 title abstract 3
239000005556 hormone Substances 0.000 title abstract 2
229940088597 hormone Drugs 0.000 title abstract 2
229940011871 estrogen Drugs 0.000 abstract 4
239000000262 estrogen Substances 0.000 abstract 4
108010085012 Steroid Receptors Proteins 0.000 abstract 2
230000003054 hormonal effect Effects 0.000 abstract 2
102000005969 steroid hormone receptors Human genes 0.000 abstract 2
230000002357 endometrial effect Effects 0.000 abstract 1
238000002657 hormone replacement therapy Methods 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Reproductive Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)

AT95943476T 1994-12-19 1995-12-15 Cyclophasiges hormonverfahren das antiprogestin und progestin enthält ATE264682T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/359,159 US5521166A (en)	1994-12-19	1994-12-19	Antiprogestin cyclophasic hormonal regimen
PCT/US1995/016561 WO1996019227A1 (en)	1994-12-19	1995-12-15	Cyclophasic hormonal regimen containing antiprogestin and progestin

Publications (1)

Publication Number	Publication Date
ATE264682T1 true ATE264682T1 (de)	2004-05-15

Family

ID=23412581

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95943476T ATE264682T1 (de)	1994-12-19	1995-12-15	Cyclophasiges hormonverfahren das antiprogestin und progestin enthält

Country Status (11)

Country	Link
US (1)	US5521166A (de)
EP (1)	EP0799043B1 (de)
JP (1)	JPH10513152A (de)
AT (1)	ATE264682T1 (de)
AU (1)	AU711179B2 (de)
CA (1)	CA2208007A1 (de)
DE (1)	DE69532927T2 (de)
DK (1)	DK0799043T3 (de)
ES (1)	ES2219673T3 (de)
PT (1)	PT799043E (de)
WO (1)	WO1996019227A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6506390B2 (en)	1996-06-25	2003-01-14	Akzo Nobel	Progestogen-anti-progestogen regimens
US20020012694A1 (en) *	1997-09-17	2002-01-31	Alfred J. Moo-Young	Transdermal administration of ment
TR200001334T2 (tr)	1997-11-14	2000-09-21	Akzo Nobel N.V.	Progestojen-anti-progestojen rejimleri.
US6369056B1 (en)	1999-05-04	2002-04-09	American Home Products Corporation	Cyclic urea and cyclic amide derivatives
DK1173210T3 (da) *	1999-05-04	2005-01-24	Wyeth Corp	Kontraceptive forbindelser, der indeholder et antiprogestin og et progestin
US6391907B1 (en) *	1999-05-04	2002-05-21	American Home Products Corporation	Indoline derivatives
WO2000066168A1 (en) *	1999-05-04	2000-11-09	American Home Products Corporation	Compositions containing benzimidazolones and progestogens
US6306851B1 (en)	1999-05-04	2001-10-23	American Home Products Corporation	Cyclocarbamate and cyclic amide derivatives
US6498154B1 (en)	1999-05-04	2002-12-24	Wyeth	Cyclic regimens using quinazolinone and benzoxazine derivatives
US6462032B1 (en) *	1999-05-04	2002-10-08	Wyeth	Cyclic regimens utilizing indoline derivatives
US6444668B1 (en)	1999-05-04	2002-09-03	Wyeth	Combination regimens using progesterone receptor modulators
US6417214B1 (en) *	1999-05-04	2002-07-09	Wyeth	3,3-substituted indoline derivatives
US6423699B1 (en)	1999-05-04	2002-07-23	American Home Products Corporation	Combination therapies using benzimidazolones
US6380235B1 (en)	1999-05-04	2002-04-30	American Home Products Corporation	Benzimidazolones and analogues
US6380178B1 (en)	1999-05-04	2002-04-30	American Home Products Corporation	Cyclic regimens using cyclocarbamate and cyclic amide derivatives
US6319912B1 (en) *	1999-05-04	2001-11-20	American Home Products Corporation	Cyclic regimens using 2,1-benzisothiazoline 2,2-dioxides
US6509334B1 (en)	1999-05-04	2003-01-21	American Home Products Corporation	Cyclocarbamate derivatives as progesterone receptor modulators
US6355648B1 (en)	1999-05-04	2002-03-12	American Home Products Corporation	Thio-oxindole derivatives
US6407101B1 (en)	1999-05-04	2002-06-18	American Home Products Corporation	Cyanopyrroles
US6339098B1 (en)	1999-05-04	2002-01-15	American Home Products Corporation	2,1-benzisothiazoline 2,2-dioxides
US6358948B1 (en)	1999-05-04	2002-03-19	American Home Products Corporation	Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
US6399593B1 (en) *	1999-05-04	2002-06-04	Wyeth	Cyclic regimens using cyclic urea and cyclic amide derivatives
US6329416B1 (en)	1999-05-04	2001-12-11	American Home Products Corporation	Combination regimens using 3,3-substituted indoline derivatives
US6358947B1 (en)	1999-05-04	2002-03-19	American Home Products Corporation	Tetracyclic progesterone receptor modulator compounds and methods
US6476079B1 (en) *	1999-12-23	2002-11-05	Leiras Oy	Devices for the delivery of drugs having antiprogestinic properties
UA73119C2 (en)	2000-04-19	2005-06-15	American Home Products Corpoir	Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
WO2004010928A2 (en) *	2002-07-25	2004-02-05	Massachusetts Institute Of Technology	Steroid modulators in the treatment of peripheral nerve sheath tumors
ATE345804T1 (de) *	2002-08-28	2006-12-15	Robert Casper	Estrogenersatztherapie
CA2504697C (en) *	2002-11-05	2012-03-13	Corcept Therapeutics, Inc.	Methods for treating migraine
US20060052354A1 (en) *	2002-11-05	2006-03-09	Corcept Therapeutics, Inc.	Methods for treating migraine
US20060111318A1 (en) *	2003-04-18	2006-05-25	Advanced Medicine Research Institute	Agent for treating eye diseases
US20070077269A1 (en) *	2005-10-04	2007-04-05	Woodward John R	Method of birth control and hormone regulation
ES2814343T3 (es) *	2006-10-24	2021-03-26	Allergan Pharmaceuticals Int Ltd	Composiciones y métodos para suprimir las proliferaciones endometriales

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA8231B (en) *	1981-01-09	1982-11-24	Roussel Uclaf	New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
US4780461A (en) *	1983-06-15	1988-10-25	Schering Aktiengesellschaft	13α-alkyl-gonanes, their production, and pharmaceutical preparations containing same
DE3347126A1 (de) *	1983-12-22	1985-07-11	Schering AG, 1000 Berlin und 4709 Bergkamen	11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
NZ214998A (en) *	1985-02-07	1989-06-28	Schering Ag	13-(methyl or ethyl)-11-beta-phenyl-gonane derivatives; preparatory processes and pharmaceutical compositions
DE3708942A1 (de) *	1987-03-18	1988-09-29	Schering Ag	19,11ss-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate
DE19975054I2 (de) *	1987-08-08	2000-04-13	Akzo Nobel Nv	Kontrazeptives Implantat
US5256421A (en) *	1987-09-24	1993-10-26	Jencap Research Ltd.	Hormone preparation and method
US5276022A (en) *	1987-09-24	1994-01-04	Jencap Research Ltd.	Hormone preparation and method
US5108995A (en) *	1987-09-24	1992-04-28	Jencap Research Ltd.	Hormone preparation and method
DE3744054A1 (de) *	1987-12-21	1989-06-29	Schering Ag	Verwendung von antigestagenen zur herstellung von arzneimitteln
MX9301121A (es) *	1992-03-02	1993-09-01	Schering Ag	Metodo y equipo para la contracepcion oral y regulacion de la menstruacion con estrogeno/progestina/aniprogestina.
AU1918092A (en) *	1992-05-06	1993-11-29	Medical College Of Hampton Roads, The	Minimizing progestin associated breakthrough bleeding
ZA935617B (en) *	1992-08-14	1994-03-07	Akzo Nv	Antiprogestogen containing contraceptives.

1994
- 1994-12-19 US US08/359,159 patent/US5521166A/en not_active Expired - Lifetime
1995
- 1995-12-15 AU AU44730/96A patent/AU711179B2/en not_active Expired
- 1995-12-15 DK DK95943476T patent/DK0799043T3/da active
- 1995-12-15 WO PCT/US1995/016561 patent/WO1996019227A1/en not_active Ceased
- 1995-12-15 EP EP95943476A patent/EP0799043B1/de not_active Expired - Lifetime
- 1995-12-15 JP JP8519952A patent/JPH10513152A/ja active Pending
- 1995-12-15 CA CA002208007A patent/CA2208007A1/en not_active Abandoned
- 1995-12-15 ES ES95943476T patent/ES2219673T3/es not_active Expired - Lifetime
- 1995-12-15 AT AT95943476T patent/ATE264682T1/de active
- 1995-12-15 DE DE69532927T patent/DE69532927T2/de not_active Expired - Lifetime
- 1995-12-15 PT PT95943476T patent/PT799043E/pt unknown

Also Published As

Publication number	Publication date
DE69532927D1 (de)	2004-05-27
DE69532927T2 (de)	2005-04-14
AU4473096A (en)	1996-07-10
EP0799043A1 (de)	1997-10-08
ES2219673T3 (es)	2004-12-01
CA2208007A1 (en)	1996-06-27
DK0799043T3 (da)	2004-08-09
EP0799043B1 (de)	2004-04-21
WO1996019227A1 (en)	1996-06-27
AU711179B2 (en)	1999-10-07
PT799043E (pt)	2004-08-31
US5521166A (en)	1996-05-28
JPH10513152A (ja)	1998-12-15

Legal Events

Date

Code

Title

Description

2005-01-15

UEP

Publication of translation of european patent specification

Ref document number: 0799043

Country of ref document: EP

Publication	Publication Date	Title
ATE264682T1 (de)	2004-05-15	Cyclophasiges hormonverfahren das antiprogestin und progestin enthält
KR960001371B1 (ko)	1996-01-26	폐경기 전의 여성용 혼합 제형 및 이를 포함하는 팩
KR960700727A (ko)	1996-02-24	호르몬 대체 치료(hormone replacement therapy)
BR0011740A (pt)	2002-05-14	Administração de esteróides androgênicos não-orais a mulheres
ATE114116T1 (de)	1994-12-15	Kontinuierliche verabreichung des luteinisierendes hormon abgebenden hormons in kombination mit sexsteroidverabreichung als empfängnisverhütungsmittel.
NZ226316A (en)	1991-10-25	Pharmaceutical contraceptive preparations and packages containing from 20-35 unit dosages comprising an estrogen and a progestin; the unit dosages having alternating estrogen and progestin dominance
AR035564A1 (es)	2004-06-16	Moduladores selectivos de receptores de estrogenos en combinacion con estrogenos
NO986104D0 (no)	1998-12-23	Progesteron-anti-progesteron regimer
DK0836506T4 (da)	2012-01-30	Transdermalt plaster til indgivelse af 17-deacetyl norgestimat alene eller i kombination med et østrogen
YU54602A (sh)	2006-01-16	Drospirenon za terapiju zamene hormona
NO970309L (no)	1997-01-24	Anvendelse av en progesteronantagonist og av et gestagen for behandling av endometriose eller Leiomyomata uteri
AR016502A1 (es)	2001-07-04	Uso de sulfamatos estrogenos biogenicos en una terapia de reemplazo de hormonas.
Kushwaha	1992	Female sex steroid hormones and lipoprotein metabolism
Holland et al.	1994	The effect of 25-mg percutaneous estradiol implants on the bone mass of postmenopausal women
CA2248841C (en)	2008-07-22	Sequential oestrogen/progesterone antagonist combination for hormone replacement therapy
MY121568A (en)	2006-02-28	Use of a gnrh antagonist for the preparation of a medicament for the treatment of gonadal-steroid conditions
EP1605924B1 (de)	2008-11-05	Mesoprogestinen (progesteron-rezeptor-modulatoren) als bestandteil von zusammensetzungen für die hormonersatztherapie
Miller et al.	1991	Sex steroids and lipoproteins
Rudy	1990	Hormone replacement therapy: How to select the best preparation and regimen
Hart	1997	Current attitudes to hormone replacement therapy
Sojo-Aranda et al.	1995	Ethinylestradiol from contraceptive formulations and the ovarian response: an estrogen dose-dependency on natural estradiol concentrations
US7629334B1 (en)	2009-12-08	Mesoprogrestins (progesterone receptor modulations) as a component of compositions for hormone replacement therapy (HRT)
Notelovitz	1999	Management of the Late Menopause: Ultra Low-Dose Adjustive Estrogen Therapy
Li	0	Management of Steroid-Induced Osteoporosis
MXPA98007513A (en)	1999-02-24	Sequencial combination of estrogen / antagonist of progesterone for therapy of replacement of hormo