ATE264842T1 - Verfahren zur herstellung von n-(1,1- dimethylethyl)-4-((5'-ethoxy-4-cis-(2-(4- morpholino)ethoxy)-2'-oxospiro(cyclohexan-1,3'- (3h)indol-1'(2h)-yl-sulfonyl)-3-methoxybenzamid und deren salzen - Google Patents

Verfahren zur herstellung von n-(1,1- dimethylethyl)-4-((5'-ethoxy-4-cis-(2-(4- morpholino)ethoxy)-2'-oxospiro(cyclohexan-1,3'- (3h)indol-1'(2h)-yl-sulfonyl)-3-methoxybenzamid und deren salzen

Info

Publication number: ATE264842T1
Authority: AT; Austria
Prior art keywords: ethoxy; salts; oxospiro; methoxybenzamide; cyclohexan
Prior art date: 1999-07-15

Application number

AT00949822T

Other languages

English (en)

Inventor

Gergely Heja

Eva Csikos

Takacsy Tuende Erosne

Csaba Goenczi

Judit Halasz

Istvan Hermecz

Csilla Majlath

Lajos Nagy

Csutor Andrea Santane

Peter Sarosi

Kalman Simon

Tiborne Szomor

Gyoergyne Szvoboda

Original Assignee

Sanofi Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-15

Filing date

2000-07-13

Publication date

2004-05-15

2000-07-13 Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo

2004-05-15 Application granted granted Critical

2004-05-15 Publication of ATE264842T1 publication Critical patent/ATE264842T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
230000001131 transforming effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT00949822T 1999-07-15 2000-07-13 Verfahren zur herstellung von n-(1,1- dimethylethyl)-4-((5'-ethoxy-4-cis-(2-(4- morpholino)ethoxy)-2'-oxospiro(cyclohexan-1,3'- (3h)indol-1'(2h)-yl-sulfonyl)-3-methoxybenzamid und deren salzen ATE264842T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU9902376A HUP9902376A3 (en)	1999-07-15	1999-07-15	Process for producing n-(1,1-dimethyl)-4-[[s'-ethoxi-4-cis-[2-(4-morpholino)-ethoxi]-2'-oxospiro[cyclohexane-1,3'-[3h]indole]-1'(2'h)yl]-sulfonyl]-3-methoxybenzamide and its salts
PCT/HU2000/000078 WO2001005791A2 (en)	1999-07-15	2000-07-13	NEW PROCESS FOR THE PREPARATION OF N-(1,1-DIMETHYLETHYL)-4-[[5'-ETHOXY-4-cis-[2-(4-MORFOLINO)ETHOXY]-2'-OXOSPIRO[CYCLOHEXAN-1,3'-[H]INDOL]-1'(2'H)-yl]-SULFONYL]-3-METHOXYBENZAMIDE AND ITS SALTS

Publications (1)

Publication Number	Publication Date
ATE264842T1 true ATE264842T1 (de)	2004-05-15

Family

ID=89998742

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00949822T ATE264842T1 (de)	1999-07-15	2000-07-13	Verfahren zur herstellung von n-(1,1- dimethylethyl)-4-((5'-ethoxy-4-cis-(2-(4- morpholino)ethoxy)-2'-oxospiro(cyclohexan-1,3'- (3h)indol-1'(2h)-yl-sulfonyl)-3-methoxybenzamid und deren salzen

Country Status (17)

Country	Link
US (1)	US6600039B1 (de)
EP (1)	EP1196381B1 (de)
JP (1)	JP2003505389A (de)
CN (1)	CN1174969C (de)
AT (1)	ATE264842T1 (de)
AU (1)	AU6308100A (de)
BR (1)	BR0012425A (de)
CA (1)	CA2378087C (de)
CZ (1)	CZ2002145A3 (de)
DE (1)	DE60010083T2 (de)
ES (1)	ES2216927T3 (de)
HR (1)	HRP20020142B1 (de)
HU (1)	HUP9902376A3 (de)
MX (1)	MXPA01013344A (de)
PL (1)	PL195787B1 (de)
SK (1)	SK285818B6 (de)
WO (1)	WO2001005791A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4823614A (en) *	1986-04-28	1989-04-25	Dahlin Erik B	Coriolis-type mass flowmeter
DK1421064T3 (da) *	2001-07-31	2005-08-29	Sanofi Aventis	Fremgangsmåde til fremstilling af 3-spiro[cyclohexan-1,3'-[3H]indolin-2'-on] derivater

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2740136B1 (fr)	1995-10-24	1998-01-09	Sanofi Sa	Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant
FR2757157B1 (fr) *	1996-12-13	1999-12-31	Sanofi Sa	Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant

1999
- 1999-07-15 HU HU9902376A patent/HUP9902376A3/hu unknown
2000
- 2000-07-13 BR BR0012425-7A patent/BR0012425A/pt not_active IP Right Cessation
- 2000-07-13 DE DE60010083T patent/DE60010083T2/de not_active Expired - Lifetime
- 2000-07-13 CZ CZ2002145A patent/CZ2002145A3/cs unknown
- 2000-07-13 AU AU63081/00A patent/AU6308100A/en not_active Abandoned
- 2000-07-13 HR HR20020142A patent/HRP20020142B1/xx not_active IP Right Cessation
- 2000-07-13 CA CA002378087A patent/CA2378087C/en not_active Expired - Fee Related
- 2000-07-13 MX MXPA01013344A patent/MXPA01013344A/es active IP Right Grant
- 2000-07-13 US US10/030,647 patent/US6600039B1/en not_active Expired - Fee Related
- 2000-07-13 EP EP00949822A patent/EP1196381B1/de not_active Expired - Lifetime
- 2000-07-13 ES ES00949822T patent/ES2216927T3/es not_active Expired - Lifetime
- 2000-07-13 JP JP2001511450A patent/JP2003505389A/ja not_active Ceased
- 2000-07-13 PL PL00352465A patent/PL195787B1/pl not_active IP Right Cessation
- 2000-07-13 WO PCT/HU2000/000078 patent/WO2001005791A2/en not_active Ceased
- 2000-07-13 AT AT00949822T patent/ATE264842T1/de not_active IP Right Cessation
- 2000-07-13 SK SK46-2002A patent/SK285818B6/sk not_active IP Right Cessation
- 2000-07-13 CN CNB008103143A patent/CN1174969C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE60010083T2 (de)	2005-03-31
HUP9902376A3 (en)	2002-11-28
PL195787B1 (pl)	2007-10-31
CA2378087A1 (en)	2001-01-25
DE60010083D1 (de)	2004-05-27
WO2001005791A3 (en)	2001-07-19
CA2378087C (en)	2007-12-18
CN1174969C (zh)	2004-11-10
ES2216927T3 (es)	2004-11-01
EP1196381A2 (de)	2002-04-17
AU6308100A (en)	2001-02-05
CZ2002145A3 (cs)	2002-11-13
HU9902376D0 (en)	1999-10-28
PL352465A1 (en)	2003-08-25
SK462002A3 (en)	2003-03-04
BR0012425A (pt)	2002-06-11
US6600039B1 (en)	2003-07-29
CN1420868A (zh)	2003-05-28
MXPA01013344A (es)	2002-08-20
HRP20020142B1 (en)	2010-09-30
HRP20020142A2 (en)	2003-12-31
JP2003505389A (ja)	2003-02-12
WO2001005791A2 (en)	2001-01-25
EP1196381B1 (de)	2004-04-21
SK285818B6 (sk)	2007-09-06
HUP9902376A2 (hu)	2001-05-28

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Legal Events

Date	Code	Title	Description
2004-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties