ATE264849T1 - Ein verbessertes verfahren zur herstellung von statinen - Google Patents

Ein verbessertes verfahren zur herstellung von statinen

Info

Publication number: ATE264849T1
Authority: AT; Austria
Prior art keywords: statins; solvent; lactonization; reaction; improved process
Prior art date: 1998-04-22

Application number

AT98123252T

Other languages

English (en)

Inventor

Yatendra Kumar

Rajest Kumar Thaper

S M Dileep Kumar

Jag Mohan Khanna

Original Assignee

Ranbaxy Lab Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-22

Filing date

1998-12-07

Publication date

2004-05-15

1998-04-22 Priority claimed from US09/064,285 external-priority patent/US5917058A/en

1998-12-07 Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd

2004-05-15 Application granted granted Critical

2004-05-15 Publication of ATE264849T1 publication Critical patent/ATE264849T1/de

Links

229940121710 HMGCoA reductase inhibitor Drugs 0.000 title abstract 5
239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title abstract 5
238000004519 manufacturing process Methods 0.000 title 1
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 6
238000007273 lactonization reaction Methods 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
239000011541 reaction mixture Substances 0.000 abstract 2
PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 abstract 1
RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 abstract 1
239000003377 acid catalyst Substances 0.000 abstract 1
239000012296 anti-solvent Substances 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
150000001261 hydroxy acids Chemical group 0.000 abstract 1
150000002596 lactones Chemical group 0.000 abstract 1
PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 abstract 1
229960004844 lovastatin Drugs 0.000 abstract 1
QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 abstract 1
229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 abstract 1
229960002855 simvastatin Drugs 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Pyrane Compounds (AREA)
Glass Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT98123252T 1998-04-22 1998-12-07 Ein verbessertes verfahren zur herstellung von statinen ATE264849T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US09/064,285 US5917058A (en)	1997-10-28	1998-04-22	Process of lactonization in the preparation of statins

Publications (1)

Publication Number	Publication Date
ATE264849T1 true ATE264849T1 (de)	2004-05-15

Family

ID=22054869

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98123252T ATE264849T1 (de)	1998-04-22	1998-12-07	Ein verbessertes verfahren zur herstellung von statinen

Country Status (9)

Country	Link
EP (1)	EP0955297B9 (de)
AT (1)	ATE264849T1 (de)
DE (1)	DE69823333T2 (de)
DK (1)	DK0955297T3 (de)
ES (1)	ES2217485T3 (de)
HU (1)	HUP9802936A3 (de)
PT (1)	PT955297E (de)
RU (1)	RU2214407C2 (de)
ZA (1)	ZA9810764B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2127500A (en)	1999-11-11	2001-06-06	Biocon India Limited	Process for manufacturing simvastatin and the novel intermediates
US6573385B1 (en)	1999-11-11	2003-06-03	Biocon India Limited	Process for manufacturing simvastatin and novel intermediates thereof
EP1294706A1 (de) *	2001-05-18	2003-03-26	Aurobindo Pharma Limited	Prozess zur herstellung von simvastatin durch lactonisierung
KR100407758B1 (ko) *	2001-08-27	2003-12-01	씨제이 주식회사	스타틴의 제조에 있어서 락톤화 방법
US6603022B1 (en)	2002-05-10	2003-08-05	Biocon India Limited	Process for manufacturing Simvastatin and novel intermediates thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4820850A (en) *	1987-07-10	1989-04-11	Merck & Co., Inc.	Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US4916239A (en) *	1988-07-19	1990-04-10	Merck & Co., Inc.	Process for the lactonization of mevinic acids and analogs thereof
US5159104A (en) *	1991-05-01	1992-10-27	Merck & Co., Inc.	Process to simvastatin ester
US5393893A (en) *	1993-11-08	1995-02-28	Apotex, Inc.	Process for producing simvastatin and analogs thereof

1998
- 1998-11-25 ZA ZA9810764A patent/ZA9810764B/xx unknown
- 1998-12-07 ES ES98123252T patent/ES2217485T3/es not_active Expired - Lifetime
- 1998-12-07 DK DK98123252T patent/DK0955297T3/da active
- 1998-12-07 AT AT98123252T patent/ATE264849T1/de not_active IP Right Cessation
- 1998-12-07 PT PT98123252T patent/PT955297E/pt unknown
- 1998-12-07 DE DE69823333T patent/DE69823333T2/de not_active Expired - Fee Related
- 1998-12-07 EP EP98123252A patent/EP0955297B9/de not_active Expired - Lifetime
- 1998-12-09 RU RU98122366/04A patent/RU2214407C2/ru not_active IP Right Cessation
- 1998-12-16 HU HU9802936A patent/HUP9802936A3/hu unknown

Also Published As

Publication number	Publication date
RU2214407C2 (ru)	2003-10-20
DE69823333T2 (de)	2005-04-07
EP0955297B1 (de)	2004-04-21
HUP9802936A3 (en)	2000-04-28
DE69823333D1 (de)	2004-05-27
ZA9810764B (en)	1999-08-13
ES2217485T3 (es)	2004-11-01
PT955297E (pt)	2004-08-31
HK1023572A1 (en)	2000-09-15
HUP9802936A2 (hu)	1999-11-29
DK0955297T3 (da)	2004-08-16
EP0955297B9 (de)	2004-12-15
HU9802936D0 (en)	1999-02-01
EP0955297A1 (de)	1999-11-10

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2005-11-15

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