ATE486068T1 - Verfahren zur herstellung optisch aktiver 2-ä6- (hydroxymethyl)-1,3-dioxan-4-ylü-essigsäure- derivate - Google Patents

Verfahren zur herstellung optisch aktiver 2-ä6- (hydroxymethyl)-1,3-dioxan-4-ylü-essigsäure- derivate

Info

Publication number
ATE486068T1
ATE486068T1 AT05017110T AT05017110T ATE486068T1 AT E486068 T1 ATE486068 T1 AT E486068T1 AT 05017110 T AT05017110 T AT 05017110T AT 05017110 T AT05017110 T AT 05017110T AT E486068 T1 ATE486068 T1 AT E486068T1
Authority
AT
Austria
Prior art keywords
hydroxymethyl
optically active
acetic acid
acid derivatives
producing optically
Prior art date
Application number
AT05017110T
Other languages
English (en)
Inventor
Noriyuki Kizaki
Yukio Yamada
Yoshihiko Yasohara
Akira Nishiyama
Makoto Miyazaki
Masaru Mitsuda
Takeshi Kondo
Noboru Ueyama
Kenji Inoue
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Application granted granted Critical
Publication of ATE486068T1 publication Critical patent/ATE486068T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
AT05017110T 1998-08-05 1999-08-05 Verfahren zur herstellung optisch aktiver 2-ä6- (hydroxymethyl)-1,3-dioxan-4-ylü-essigsäure- derivate ATE486068T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22149598 1998-08-05
JP15803399 1999-06-04

Publications (1)

Publication Number Publication Date
ATE486068T1 true ATE486068T1 (de) 2010-11-15

Family

ID=26485288

Family Applications (3)

Application Number Title Priority Date Filing Date
AT05017110T ATE486068T1 (de) 1998-08-05 1999-08-05 Verfahren zur herstellung optisch aktiver 2-ä6- (hydroxymethyl)-1,3-dioxan-4-ylü-essigsäure- derivate
AT03025159T ATE375989T1 (de) 1998-08-05 1999-08-05 Verfahren zur herstellung von 3,5-dihydroxy substituierten estern als zwischenprodukte zur herstellung optisch aktiver 2-(6-(hydroxymethyl)- 1,3-dioxan-4-yl)-essigsäure-derivate
AT99935066T ATE266656T1 (de) 1998-08-05 1999-08-05 Verfahren zur herstellung optisch aktiver 2-(6- (hydroxymethyl)-1,3-dioxan-4-yl) -essigsäure- derivate

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT03025159T ATE375989T1 (de) 1998-08-05 1999-08-05 Verfahren zur herstellung von 3,5-dihydroxy substituierten estern als zwischenprodukte zur herstellung optisch aktiver 2-(6-(hydroxymethyl)- 1,3-dioxan-4-yl)-essigsäure-derivate
AT99935066T ATE266656T1 (de) 1998-08-05 1999-08-05 Verfahren zur herstellung optisch aktiver 2-(6- (hydroxymethyl)-1,3-dioxan-4-yl) -essigsäure- derivate

Country Status (14)

Country Link
US (2) US6472544B1 (de)
EP (3) EP1024139B1 (de)
JP (1) JP3803551B2 (de)
KR (1) KR100654115B1 (de)
CN (2) CN1162422C (de)
AT (3) ATE486068T1 (de)
CA (1) CA2305564C (de)
DE (3) DE69917204T2 (de)
DK (1) DK1619191T3 (de)
ES (2) ES2294236T3 (de)
HU (1) HUP0101122A3 (de)
NO (1) NO325591B1 (de)
PT (1) PT1619191E (de)
WO (1) WO2000008011A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010072175A (ko) * 1999-06-04 2001-07-31 후루타 타케시 5-히드록시-3-옥소펜탄산 유도체 제조방법
AU1551701A (en) * 1999-12-03 2001-06-12 Kaneka Corporation Novel carbonyl reductase, gene thereof and method of using the same
GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
WO2001094337A1 (en) 2000-06-05 2001-12-13 Kaneka Corporation Process for preparing optically active 2-[6-(hydroxy-methyl)-1,3-dioxan-4-yl]acetic acid derivatives
NL1015744C2 (nl) 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
AU2006203127B2 (en) * 2000-07-19 2008-06-19 Astrazeneca Uk Limited Process for the preparation of 2-(6-substituted-1,3-dioxane-4-yl) acetic acid derivatives
HUP0401014A2 (hu) * 2001-07-06 2004-08-30 Teva Pharmaceutical Industries Ltd. Eljárás 7-amino-szin-3,5-dihidroxi-heptánsavszármazékok előállítására, 6-ciano-szin-3,5-dihidroxi-hexánsav származékokon keresztül
CA2448517A1 (en) 2001-07-12 2003-01-23 Dsm Ip Assets B.V. Process for the preparation of 2,4-dideoxyhexoses and 2,4,6-trideoxyhexoses
EP1323717A1 (de) * 2001-12-27 2003-07-02 Dsm N.V. Prozess für die Herstellung von 2-(6-Substituierten-1,3-Dioxan-4-yl) Essigsäure Derivaten
EP1375493A1 (de) 2002-06-17 2004-01-02 Dsm N.V. Verfahren zur Herstellung von Dioxanessigsäureester
AU2003258187A1 (en) * 2002-08-09 2004-02-25 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
KR100529703B1 (ko) * 2002-09-23 2005-11-17 임광민 키랄 중간체의 제조방법 및 그를 이용한 아토바스타틴의제조방법
KR100979496B1 (ko) 2003-01-16 2010-09-02 주식회사 엘지생명과학 5-히드록시-3-옥소-헥사노익산 유도체의 신규한 제조방법
US7541171B2 (en) * 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
KR20060064617A (ko) * 2003-08-11 2006-06-13 코덱시스, 인코포레이티드 개량된 할로히드린 디할로게나제 및 관련 폴리뉴클레오티드
US7629157B2 (en) * 2003-08-11 2009-12-08 Codexis, Inc. Ketoreductase polypeptides and related polynucleotides
WO2005018579A2 (en) * 2003-08-11 2005-03-03 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters
US7588928B2 (en) * 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
MXPA06001719A (es) * 2003-08-11 2006-05-19 Codexis Inc Polipeptidos de glucosa deshidrogenasa mejorados, y polinucleotidos relacionados.
WO2008042876A2 (en) 2006-10-02 2008-04-10 Codexis, Inc. Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor
KR101130717B1 (ko) * 2008-05-14 2012-03-28 웰이앤씨 주식회사 ＨＭＧ-ＣｏＡ 환원 저해제의 제조를 위한 키랄 중간체의제조방법
WO2010080635A2 (en) * 2008-12-18 2010-07-15 Codexis, Inc. Recombinant halohydrin dehalogenase polypeptides
CN101624390B (zh) * 2009-03-09 2014-06-11 鲁南制药集团股份有限公司 一种瑞舒伐他汀钙侧链关键中间体的制备方法
KR101157314B1 (ko) * 2009-06-05 2012-06-15 주식회사종근당 로수바스타틴의 신규한 제조방법, 이 제조에 유용한 중간체 화합물 및 그의 제조방법
GB2474687A (en) * 2009-10-23 2011-04-27 Phoenix Chemicals Ltd A continuous process for the production of (R)-6-cyano-5-hydroxy-3-oxo-hexanoic acid tert-butyl ester (and derivatives)
GB2482525A (en) * 2010-08-05 2012-02-08 Phoenix Chemicals Ltd A process for the production of acyloxymethyldioxanylacetic derivatives
CN103313984B (zh) 2011-01-18 2016-01-13 中化帝斯曼制药有限公司荷兰公司 甲基四唑硫化物和砜
HUE025730T2 (en) 2011-01-18 2016-04-28 Dsm Sinochem Pharm Nl Bv A method for producing statins using a base
CN103328470A (zh) 2011-01-18 2013-09-25 中化帝斯曼制药有限公司荷兰公司 制备二醇砜的方法
CN102180862B (zh) * 2011-03-24 2013-08-28 烟台万润精细化工股份有限公司 一种(4R-cis)-6-取代-2,2-二甲基-1,3-二氧六环-4-乙酸叔丁酯的制备方法
CA2830134C (en) 2011-04-01 2018-03-06 Lonza Ltd Preparation of 3,5-dioxo hexanoate ester in two steps
EP2734513A4 (de) 2011-07-19 2014-11-26 Sunshine Lake Pharma Co Ltd Zwischenprodukt von statin-arzneimitteln und ihre herstellung
ES2623495T3 (es) 2011-12-09 2017-07-11 Dsm Sinochem Pharmaceuticals Netherlands B.V. Procedimiento para la preparación de un tioprecursor para estatinas
CN102643757B (zh) * 2011-12-29 2013-09-11 浙江工业大学 生物催化制备6-氰基-(3r,5r)-二羟基己酸叔丁酯及菌株
GB201212777D0 (en) * 2012-07-18 2012-08-29 Bakhu Pharma Ltd Process for crossed claisen condensation reactions promoted by lithium amide in liquid ammonia
CN103435592B (zh) * 2013-08-12 2015-02-04 南京欧信医药技术有限公司 2-((4r,6s)-6-甲醛基-2,2-二甲基-1,3二氧六环-4-基)-乙酸甲酯的制备方法
CN105622566B (zh) * 2014-11-19 2018-07-27 上海弈柯莱生物医药科技有限公司 一种3,5-二取代羟基-6-取代己酸酯衍生物的制备方法
CN105669637A (zh) * 2014-11-21 2016-06-15 南京博优康远生物医药科技有限公司 一种3,5,6-取代己酸酯衍生物的制备方法
CN104789505B (zh) * 2015-04-23 2018-03-06 苏州东和盛昌生物科技有限公司 还原制备顺式3,5‑二羟基己酸酯化合物的方法及菌种
CN106011094B (zh) * 2016-07-27 2020-11-03 苏州汉酶生物技术有限公司 工程化酮还原酶多肽及其用于制备(3r,5s)-6-氯-3,5-二羟基己酸叔丁酯的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE56322B1 (en) 1982-12-06 1991-06-19 Sigma Tau Ind Farmaceuti Process for preparing l-carnitine and chemical intermediates employed therein
JPS6322056A (ja) * 1986-04-30 1988-01-29 サンド・アクチエンゲゼルシヤフト オレフイン性化合物の製造法
DE3741509A1 (de) * 1987-12-08 1989-06-22 Hoechst Ag Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte
US5155251A (en) * 1991-10-11 1992-10-13 Warner-Lambert Company Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
US5278313A (en) 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
JP3149265B2 (ja) * 1992-05-12 2001-03-26 鐘淵化学工業株式会社 光学活性な３，５−ジヒドロキシ脂肪酸エステル誘導体の製造法
US5324662A (en) 1992-05-15 1994-06-28 E. R. Squibb & Sons, Inc. Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
GB9512837D0 (en) * 1995-06-23 1995-08-23 Zeneca Ltd reduction of ketone groups

Also Published As

Publication number Publication date
CN1162422C (zh) 2004-08-18
DE69917204D1 (de) 2004-06-17
NO325591B1 (no) 2008-06-23
DE69942897D1 (de) 2010-12-09
ATE375989T1 (de) 2007-11-15
KR100654115B1 (ko) 2006-12-05
EP1024139B1 (de) 2004-05-12
CA2305564C (en) 2008-06-17
NO20001703D0 (no) 2000-04-03
EP1619191B1 (de) 2010-10-27
CN1274356A (zh) 2000-11-22
DE69917204T2 (de) 2005-06-23
EP1394157A2 (de) 2004-03-03
HUP0101122A3 (en) 2006-02-28
CN1566351A (zh) 2005-01-19
EP1024139A4 (de) 2002-04-17
EP1619191A3 (de) 2006-08-23
CN100376682C (zh) 2008-03-26
WO2000008011A1 (fr) 2000-02-17
PT1619191E (pt) 2010-12-21
ES2221406T3 (es) 2004-12-16
US20030040634A1 (en) 2003-02-27
DE69937374D1 (de) 2007-11-29
EP1394157A3 (de) 2004-03-17
EP1394157B1 (de) 2007-10-17
HUP0101122A2 (hu) 2001-08-28
EP1024139A1 (de) 2000-08-02
NO20001703L (no) 2000-04-03
ATE266656T1 (de) 2004-05-15
KR20010030819A (ko) 2001-04-16
DK1619191T3 (da) 2011-01-31
US6903225B2 (en) 2005-06-07
CA2305564A1 (en) 2000-02-17
ES2294236T3 (es) 2008-04-01
EP1619191A2 (de) 2006-01-25
JP3803551B2 (ja) 2006-08-02
DE69937374T2 (de) 2008-07-24
US6472544B1 (en) 2002-10-29

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