ATE486068T1 - Verfahren zur herstellung optisch aktiver 2-ä6- (hydroxymethyl)-1,3-dioxan-4-ylü-essigsäure- derivate - Google Patents

Verfahren zur herstellung optisch aktiver 2-ä6- (hydroxymethyl)-1,3-dioxan-4-ylü-essigsäure- derivate

Info

Publication number: ATE486068T1
Authority: AT; Austria
Prior art keywords: hydroxymethyl; optically active; acetic acid; acid derivatives; producing optically
Prior art date: 1998-08-05

Application number

AT05017110T

Other languages

English (en)

Inventor

Noriyuki Kizaki

Yukio Yamada

Yoshihiko Yasohara

Akira Nishiyama

Makoto Miyazaki

Masaru Mitsuda

Takeshi Kondo

Noboru Ueyama

Kenji Inoue

Original Assignee

Kaneka Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-05

Filing date

1999-08-05

Publication date

2010-11-15

1999-08-05 Application filed by Kaneka Corp filed Critical Kaneka Corp

2010-11-15 Application granted granted Critical

2010-11-15 Publication of ATE486068T1 publication Critical patent/ATE486068T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Wood Science & Technology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Zoology (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

AT05017110T 1998-08-05 1999-08-05 Verfahren zur herstellung optisch aktiver 2-ä6- (hydroxymethyl)-1,3-dioxan-4-ylü-essigsäure- derivate ATE486068T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP22149598		1998-08-05
JP15803399		1999-06-04

Publications (1)

Publication Number	Publication Date
ATE486068T1 true ATE486068T1 (de)	2010-11-15

Family

ID=26485288

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
AT03025159T ATE375989T1 (de)	1998-08-05	1999-08-05	Verfahren zur herstellung von 3,5-dihydroxy substituierten estern als zwischenprodukte zur herstellung optisch aktiver 2-(6-(hydroxymethyl)- 1,3-dioxan-4-yl)-essigsäure-derivate
AT99935066T ATE266656T1 (de)	1998-08-05	1999-08-05	Verfahren zur herstellung optisch aktiver 2-(6- (hydroxymethyl)-1,3-dioxan-4-yl) -essigsäure- derivate
AT05017110T ATE486068T1 (de)	1998-08-05	1999-08-05	Verfahren zur herstellung optisch aktiver 2-ä6- (hydroxymethyl)-1,3-dioxan-4-ylü-essigsäure- derivate

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
AT03025159T ATE375989T1 (de)	1998-08-05	1999-08-05	Verfahren zur herstellung von 3,5-dihydroxy substituierten estern als zwischenprodukte zur herstellung optisch aktiver 2-(6-(hydroxymethyl)- 1,3-dioxan-4-yl)-essigsäure-derivate
AT99935066T ATE266656T1 (de)	1998-08-05	1999-08-05	Verfahren zur herstellung optisch aktiver 2-(6- (hydroxymethyl)-1,3-dioxan-4-yl) -essigsäure- derivate

Country Status (14)

Country	Link
US (2)	US6472544B1 (de)
EP (3)	EP1024139B1 (de)
JP (1)	JP3803551B2 (de)
KR (1)	KR100654115B1 (de)
CN (2)	CN100376682C (de)
AT (3)	ATE375989T1 (de)
CA (1)	CA2305564C (de)
DE (3)	DE69917204T2 (de)
DK (1)	DK1619191T3 (de)
ES (2)	ES2221406T3 (de)
HU (1)	HUP0101122A3 (de)
NO (1)	NO325591B1 (de)
PT (1)	PT1619191E (de)
WO (1)	WO2000008011A1 (de)

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EP1104750B1 (de) *	1999-06-04	2004-04-14	Kaneka Corporation	Verfahren zur herstellung von 5-hydroxy-3-oxo-pentansäure-derivaten
AU1551701A (en)	1999-12-03	2001-06-12	Kaneka Corporation	Novel carbonyl reductase, gene thereof and method of using the same
GB0011120D0 (en)	2000-05-09	2000-06-28	Avecia Ltd	Process
EP1288213B1 (de) *	2000-06-05	2006-11-29	Kaneka Corporation	Verfahren für die herstellung von optisch aktiven 2-¬6-(hydroxymethyl)-1,3-dioxan-4-yl\|essigsäure-derivaten (19.12.01)
AU2006203127B2 (en) *	2000-07-19	2008-06-19	Astrazeneca Uk Limited	Process for the preparation of 2-(6-substituted-1,3-dioxane-4-yl) acetic acid derivatives
NL1015744C2 (nl)	2000-07-19	2002-01-22	Dsm Nv	Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
HRP20040116A2 (en) *	2001-07-06	2004-10-31	Teva Pharma	Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives
US6964863B2 (en)	2001-07-12	2005-11-15	Dsm Ip Assets B.V.	Process for the preparation of 2,4-dideoxyhexoses and 2,4,6-trideoxyhexoses
EP1323717A1 (de) *	2001-12-27	2003-07-02	Dsm N.V.	Prozess für die Herstellung von 2-(6-Substituierten-1,3-Dioxan-4-yl) Essigsäure Derivaten
EP1375493A1 (de)	2002-06-17	2004-01-02	Dsm N.V.	Verfahren zur Herstellung von Dioxanessigsäureester
CA2493941A1 (en) *	2002-08-09	2004-02-19	Codexis, Inc.	Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
KR100529703B1 (ko) *	2002-09-23	2005-11-17	임광민	키랄 중간체의 제조방법 및 그를 이용한 아토바스타틴의제조방법
US7081546B2 (en)	2003-01-16	2006-07-25	Lg Life Sciences Ltd.	Process for preparing a 5-hydroxy-3-oxo-hexanoic acid derivative
EP1660669A4 (de)	2003-08-11	2008-10-01	Codexis Inc	Enzymatische verfahren zur herstellung 4-substituierter 3-hydroxybuttersäure-derivate und von mit vicinalem cyano, hydroxy substituierten carbonsäureestern
EP1654356A1 (de) *	2003-08-11	2006-05-10	Codexis, Inc.	Verbesserte halohydrin dehalogenases und verwandte polynukleotide
EP1654354A1 (de) *	2003-08-11	2006-05-10	Codexis, Inc.	Verbesserte ketoreduktase polypeptide und entsprechende polynukleotide
JP2007502114A (ja) *	2003-08-11	2007-02-08	コデクシス，インコーポレイテッド	改良されたグルコースデヒドロゲナーゼポリペプチドおよび関連ポリヌクレオチド
US7541171B2 (en) *	2003-08-11	2009-06-02	Codexis, Inc.	Halohydrin dehalogenases and related polynucleotides
US7588928B2 (en) *	2003-08-11	2009-09-15	Codexis, Inc.	Halohydrin dehalogenases and related polynucleotides
US7879585B2 (en)	2006-10-02	2011-02-01	Codexis, Inc.	Ketoreductase enzymes and uses thereof
KR101130717B1 (ko) *	2008-05-14	2012-03-28	웰이앤씨 주식회사	ＨＭＧ-ＣｏＡ 환원 저해제의 제조를 위한 키랄 중간체의제조방법
WO2010080635A2 (en) *	2008-12-18	2010-07-15	Codexis, Inc.	Recombinant halohydrin dehalogenase polypeptides
CN101624390B (zh) *	2009-03-09	2014-06-11	鲁南制药集团股份有限公司	一种瑞舒伐他汀钙侧链关键中间体的制备方法
KR101157314B1 (ko) *	2009-06-05	2012-06-15	주식회사종근당	로수바스타틴의 신규한 제조방법, 이 제조에 유용한 중간체 화합물 및 그의 제조방법
GB2474687A (en) *	2009-10-23	2011-04-27	Phoenix Chemicals Ltd	A continuous process for the production of (R)-6-cyano-5-hydroxy-3-oxo-hexanoic acid tert-butyl ester (and derivatives)
GB2482525A (en) *	2010-08-05	2012-02-08	Phoenix Chemicals Ltd	A process for the production of acyloxymethyldioxanylacetic derivatives
WO2012098050A1 (en)	2011-01-18	2012-07-26	Dsm Sinochem Pharmaceuticals Netherlands B.V.	Methyltetrazole sulfides and sulfones
ES2601479T3 (es)	2011-01-18	2017-02-15	Dsm Sinochem Pharmaceuticals Netherlands B.V.	Proceso para la preparación de diolsulfonas
CN103313983B (zh)	2011-01-18	2016-06-29	中化帝斯曼制药有限公司荷兰公司	在碱存在下制备他汀类化合物的方法
CN102180862B (zh) *	2011-03-24	2013-08-28	烟台万润精细化工股份有限公司	一种(4R-cis)-6-取代-2,2-二甲基-1,3-二氧六环-4-乙酸叔丁酯的制备方法
WO2012130920A1 (en)	2011-04-01	2012-10-04	Lonza Ltd	Preparation of 3,5-dioxo hexanoate ester
JP2014529336A (ja)	2011-07-19	2014-11-06	スンシネルアケプハルマカンパニーリミテッド	スタチン薬中間体及びその製造
EP2788341B1 (de)	2011-12-09	2017-04-05	DSM Sinochem Pharmaceuticals Netherlands B.V.	Verfahren zur herstellung eines thiovorläufers für statine
CN102643757B (zh) *	2011-12-29	2013-09-11	浙江工业大学	生物催化制备6-氰基-(3r,5r)-二羟基己酸叔丁酯及菌株
GB201212777D0 (en) *	2012-07-18	2012-08-29	Bakhu Pharma Ltd	Process for crossed claisen condensation reactions promoted by lithium amide in liquid ammonia
CN103435592B (zh) *	2013-08-12	2015-02-04	南京欧信医药技术有限公司	2-((4r,6s)-6-甲醛基-2,2-二甲基-1,3二氧六环-4-基)-乙酸甲酯的制备方法
CN105622566B (zh) *	2014-11-19	2018-07-27	上海弈柯莱生物医药科技有限公司	一种3,5-二取代羟基-6-取代己酸酯衍生物的制备方法
CN105669637A (zh) *	2014-11-21	2016-06-15	南京博优康远生物医药科技有限公司	一种3,5,6-取代己酸酯衍生物的制备方法
CN104789505B (zh) *	2015-04-23	2018-03-06	苏州东和盛昌生物科技有限公司	还原制备顺式3,5‑二羟基己酸酯化合物的方法及菌种
CN106011094B (zh) *	2016-07-27	2020-11-03	苏州汉酶生物技术有限公司	工程化酮还原酶多肽及其用于制备(3r,5s)-6-氯-3,5-二羟基己酸叔丁酯的方法

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US5155251A (en) *	1991-10-11	1992-10-13	Warner-Lambert Company	Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
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1999
- 1999-08-05 CA CA002305564A patent/CA2305564C/en not_active Expired - Fee Related
- 1999-08-05 AT AT03025159T patent/ATE375989T1/de not_active IP Right Cessation
- 1999-08-05 DE DE69917204T patent/DE69917204T2/de not_active Expired - Lifetime
- 1999-08-05 PT PT05017110T patent/PT1619191E/pt unknown
- 1999-08-05 AT AT99935066T patent/ATE266656T1/de not_active IP Right Cessation
- 1999-08-05 DE DE69937374T patent/DE69937374T2/de not_active Expired - Lifetime
- 1999-08-05 HU HU0101122A patent/HUP0101122A3/hu unknown
- 1999-08-05 DK DK05017110.7T patent/DK1619191T3/da active
- 1999-08-05 CN CNB2004100489936A patent/CN100376682C/zh not_active Expired - Fee Related
- 1999-08-05 ES ES99935066T patent/ES2221406T3/es not_active Expired - Lifetime
- 1999-08-05 US US09/509,998 patent/US6472544B1/en not_active Expired - Lifetime
- 1999-08-05 AT AT05017110T patent/ATE486068T1/de active
- 1999-08-05 CN CNB998012815A patent/CN1162422C/zh not_active Expired - Fee Related
- 1999-08-05 EP EP99935066A patent/EP1024139B1/de not_active Expired - Lifetime
- 1999-08-05 EP EP03025159A patent/EP1394157B1/de not_active Expired - Lifetime
- 1999-08-05 DE DE69942897T patent/DE69942897D1/de not_active Expired - Lifetime
- 1999-08-05 KR KR1020007003438A patent/KR100654115B1/ko not_active Expired - Fee Related
- 1999-08-05 EP EP05017110A patent/EP1619191B1/de not_active Expired - Lifetime
- 1999-08-05 JP JP2000563644A patent/JP3803551B2/ja not_active Expired - Fee Related
- 1999-08-05 WO PCT/JP1999/004229 patent/WO2000008011A1/ja not_active Ceased
- 1999-08-05 ES ES03025159T patent/ES2294236T3/es not_active Expired - Lifetime
2000
- 2000-04-03 NO NO20001703A patent/NO325591B1/no not_active IP Right Cessation
2002
- 2002-09-13 US US10/242,453 patent/US6903225B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US6903225B2 (en)	2005-06-07
CN1566351A (zh)	2005-01-19
CA2305564C (en)	2008-06-17
CN1162422C (zh)	2004-08-18
EP1394157B1 (de)	2007-10-17
KR100654115B1 (ko)	2006-12-05
US20030040634A1 (en)	2003-02-27
EP1619191A2 (de)	2006-01-25
EP1619191B1 (de)	2010-10-27
CN1274356A (zh)	2000-11-22
EP1394157A3 (de)	2004-03-17
EP1394157A2 (de)	2004-03-03
DE69937374T2 (de)	2008-07-24
PT1619191E (pt)	2010-12-21
DE69942897D1 (de)	2010-12-09
EP1024139A4 (de)	2002-04-17
EP1619191A3 (de)	2006-08-23
DE69917204D1 (de)	2004-06-17
ES2221406T3 (es)	2004-12-16
EP1024139A1 (de)	2000-08-02
CN100376682C (zh)	2008-03-26
ATE375989T1 (de)	2007-11-15
EP1024139B1 (de)	2004-05-12
US6472544B1 (en)	2002-10-29
ES2294236T3 (es)	2008-04-01
NO20001703D0 (no)	2000-04-03
ATE266656T1 (de)	2004-05-15
WO2000008011A1 (fr)	2000-02-17
NO325591B1 (no)	2008-06-23
NO20001703L (no)	2000-04-03
HUP0101122A2 (hu)	2001-08-28
DE69937374D1 (de)	2007-11-29
DK1619191T3 (da)	2011-01-31
HUP0101122A3 (en)	2006-02-28
JP3803551B2 (ja)	2006-08-02
KR20010030819A (ko)	2001-04-16
CA2305564A1 (en)	2000-02-17
DE69917204T2 (de)	2005-06-23

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2011-03-15

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