ATE265213T1 - Noribogain zur behandlung von schmerzen und drogenabhängigkeit - Google Patents
Noribogain zur behandlung von schmerzen und drogenabhängigkeitInfo
- Publication number
- ATE265213T1 ATE265213T1 AT98944698T AT98944698T ATE265213T1 AT E265213 T1 ATE265213 T1 AT E265213T1 AT 98944698 T AT98944698 T AT 98944698T AT 98944698 T AT98944698 T AT 98944698T AT E265213 T1 ATE265213 T1 AT E265213T1
- Authority
- AT
- Austria
- Prior art keywords
- noribogain
- drug dependence
- treat pain
- noribogaine
- pain
- Prior art date
Links
- 206010013663 drug dependence Diseases 0.000 title 1
- 208000011117 substance-related disease Diseases 0.000 title 1
- RAUCDOKTMDOIPF-UHFFFAOYSA-N hydroxyibogamine Natural products CCC1CC(C2)CC3C1N2CCC1=C3NC2=CC=C(O)C=C12 RAUCDOKTMDOIPF-UHFFFAOYSA-N 0.000 abstract 3
- RAUCDOKTMDOIPF-RYRUWHOVSA-N noribogaine Chemical compound N1([C@@H]2[C@H]3C[C@H](C1)C[C@@H]2CC)CCC1=C3NC2=CC=C(O)C=C12 RAUCDOKTMDOIPF-RYRUWHOVSA-N 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 abstract 1
- 229960004127 naloxone Drugs 0.000 abstract 1
- 239000003401 opiate antagonist Substances 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5792197P | 1997-09-04 | 1997-09-04 | |
| PCT/US1998/018284 WO1999011250A2 (en) | 1997-09-04 | 1998-09-03 | Noribogaine in the treatment of pain and drug addiction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE265213T1 true ATE265213T1 (de) | 2004-05-15 |
Family
ID=22013572
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03075683T ATE510542T1 (de) | 1997-09-04 | 1998-09-03 | Noribogain zur behandlung von schmerzen und drogenabhängigkeit |
| AT98944698T ATE265213T1 (de) | 1997-09-04 | 1998-09-03 | Noribogain zur behandlung von schmerzen und drogenabhängigkeit |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03075683T ATE510542T1 (de) | 1997-09-04 | 1998-09-03 | Noribogain zur behandlung von schmerzen und drogenabhängigkeit |
Country Status (9)
| Country | Link |
|---|---|
| US (6) | US7754710B2 (de) |
| EP (4) | EP1327447B1 (de) |
| AT (2) | ATE510542T1 (de) |
| AU (1) | AU754088B2 (de) |
| CA (1) | CA2302754C (de) |
| DE (1) | DE69823520T2 (de) |
| ES (3) | ES2435722T3 (de) |
| IL (2) | IL134796A0 (de) |
| WO (1) | WO1999011250A2 (de) |
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|---|---|---|---|---|
| WO2001052851A1 (en) * | 2000-01-22 | 2001-07-26 | Albert Shulman | Methods for the treatment of substance abuse |
| CN1592609A (zh) * | 2001-05-11 | 2005-03-09 | 恩德制药公司 | 抗滥用阿片样物质剂型 |
| CN1525851A (zh) | 2001-05-11 | 2004-09-01 | ������ҩ������˾ | 抗滥用阿片样物质控释剂型 |
| CA2478515C (en) | 2002-04-05 | 2010-09-28 | Purdue Pharma | Pharmaceutical preparation containing oxycodone and naloxone |
| EP1702558A1 (de) | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Verfahren und Vorrichtung zur Darmtätigkeitserfassung |
| WO2010103039A1 (en) | 2009-03-10 | 2010-09-16 | Euro-Celtique S.A. | Immediate release pharmaceutical compositions comprising oxycodone and naloxone |
| US8765737B1 (en) | 2010-05-11 | 2014-07-01 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US8362007B1 (en) * | 2010-05-11 | 2013-01-29 | Demerx, Inc. | Substituted noribogaine |
| US9394294B2 (en) | 2010-05-11 | 2016-07-19 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US9586954B2 (en) | 2010-06-22 | 2017-03-07 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| US8741891B1 (en) | 2010-06-22 | 2014-06-03 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| US8802832B2 (en) | 2010-06-22 | 2014-08-12 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| US8637648B1 (en) | 2010-06-22 | 2014-01-28 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| JP6049615B2 (ja) * | 2010-07-23 | 2016-12-21 | デマークス・インコーポレイテッドＤｅｍｅｒｘ，Ｉｎｃ． | ノリボガイン組成物 |
| EP2481740B1 (de) * | 2011-01-26 | 2015-11-04 | DemeRx, Inc. | Verfahren und Zusammensetzungen zur Herstellung von Noribogain aus Voacangin |
| US8742096B2 (en) * | 2011-03-28 | 2014-06-03 | Demerx, Inc. | Methods and compositions for preparing noribogaine from voacangine |
| US9617274B1 (en) | 2011-08-26 | 2017-04-11 | Demerx, Inc. | Synthetic noribogaine |
| SG2014011811A (en) * | 2011-09-15 | 2014-05-29 | Demerx Inc | Noribogaine salt ansolvates |
| CA3122767C (en) * | 2011-12-08 | 2023-03-28 | Demerx, Inc. | Stereoselective total synthesis of noribogaine |
| WO2013085849A2 (en) * | 2011-12-09 | 2013-06-13 | Demerx, Inc. | Sulfate esters of noribogaine |
| EP2788003A4 (de) * | 2011-12-09 | 2015-05-27 | Demerx Inc | Phosphatester von noribogain |
| US9150584B2 (en) | 2012-01-25 | 2015-10-06 | Demerx, Inc. | Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them |
| CA2858820C (en) | 2012-01-25 | 2021-08-17 | Demerx, Inc. | Synthetic voacangine |
| US9045481B2 (en) | 2012-12-20 | 2015-06-02 | Demerx, Inc. | Substituted noribogaine |
| US8940728B2 (en) | 2012-12-20 | 2015-01-27 | Demerx, Inc. | Substituted noribogaine |
| CA2896133A1 (en) | 2012-12-20 | 2014-06-26 | Demerx, Inc. | Substituted noribogaine |
| CA2942638C (en) | 2013-03-15 | 2026-03-10 | Demerx, Inc. | Method for noribogaine treatment of addiction in patients on methadone |
| KR20180037074A (ko) | 2013-07-23 | 2018-04-10 | 유로-셀티큐 에스.에이. | 장내 세균총이상을 초래하고/하거나 장내 박테리아 전위에 대한 위험을 증가시키는 질환과 통증으로 인해 고통받고 있는 환자에서 통증을 치료하는데 사용하기 위한 옥시코돈과 날록손의 조합물 |
| EP3082816B1 (de) | 2013-12-20 | 2019-03-20 | Indivior UK Limited | Intranasale naloxonzusammensetzungen und verfahren zur herstellung und verwendung davon |
| EA201691656A2 (ru) * | 2014-02-18 | 2017-03-31 | Демеркс, Инк. | Терапевтические способы с применением норибогаина и родственных соединений |
| US9345711B2 (en) * | 2014-02-18 | 2016-05-24 | Demerx, Inc. | Methods for acute and long-term treatment of drug addiction |
| US9561232B2 (en) | 2014-02-18 | 2017-02-07 | Demerx, Inc. | Low dose noribogaine for treating nicotine addiction and preventing relapse of nicotine use |
| AU2014383143A1 (en) | 2014-02-18 | 2016-09-29 | Demerx, Inc. | Methods for acute and long-term treatment of drug addiction |
| US20150246055A1 (en) * | 2014-03-03 | 2015-09-03 | Demerx, Inc. | Methods for acute and long-term treatment of opioid and opioid-like drug addiction |
| US20150258111A1 (en) * | 2014-03-13 | 2015-09-17 | Demerx, Inc. | Methods and compositions for reducing tolerance to opioid analgesics using ibogaine and derivatives thereof |
| US9591978B2 (en) | 2014-03-13 | 2017-03-14 | Demerx, Inc. | Methods and compositions for pre-screening patients for treatment with noribogaine |
| WO2015142346A1 (en) * | 2014-03-20 | 2015-09-24 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| WO2015195673A2 (en) | 2014-06-18 | 2015-12-23 | Demerx, Inc. | Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them |
| US9549935B2 (en) | 2014-07-14 | 2017-01-24 | Demerx, Inc. | Methods and compositions for treating migraines using noribogaine |
| US9592239B2 (en) | 2014-09-12 | 2017-03-14 | Demerx, Inc. | Methods and compositions for ibogaine treatment of impulse control disorder, anxiety-related disorders, violence and/or anger, or regulating food intake |
| ES2867174T3 (es) | 2014-11-26 | 2021-10-20 | Demerx Inc | Métodos y composiciones para potenciar la acción de analgésicos opioides mediante el uso de alcaloides de iboga |
| CA3024081A1 (en) * | 2015-05-11 | 2016-11-17 | Demerx, Inc. | Methods for treatment of opioid dependency and withdrawal using noribogaine |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| JP2022529781A (ja) | 2019-04-17 | 2022-06-24 | コンパス パスファインダー リミテッド | サイロシビンによるうつ病及び他の様々な障害の治療 |
| WO2025259800A2 (en) * | 2024-06-11 | 2025-12-18 | Demerx, Inc. | Method of treating chemical dependency |
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-
1998
- 1998-09-03 ES ES10180121T patent/ES2435722T3/es not_active Expired - Lifetime
- 1998-09-03 ES ES98944698T patent/ES2224430T3/es not_active Expired - Lifetime
- 1998-09-03 EP EP03075683A patent/EP1327447B1/de not_active Expired - Lifetime
- 1998-09-03 WO PCT/US1998/018284 patent/WO1999011250A2/en not_active Ceased
- 1998-09-03 AT AT03075683T patent/ATE510542T1/de active
- 1998-09-03 IL IL13479698A patent/IL134796A0/xx active IP Right Grant
- 1998-09-03 EP EP98944698A patent/EP1009407B1/de not_active Expired - Lifetime
- 1998-09-03 CA CA2302754A patent/CA2302754C/en not_active Expired - Fee Related
- 1998-09-03 EP EP10170898A patent/EP2246058A1/de not_active Withdrawn
- 1998-09-03 AT AT98944698T patent/ATE265213T1/de active
- 1998-09-03 AU AU92174/98A patent/AU754088B2/en not_active Ceased
- 1998-09-03 ES ES03075683T patent/ES2395268T3/es not_active Expired - Lifetime
- 1998-09-03 DE DE69823520T patent/DE69823520T2/de not_active Expired - Lifetime
- 1998-09-03 EP EP10180121.5A patent/EP2338494B1/de not_active Expired - Lifetime
-
2000
- 2000-02-29 IL IL134796A patent/IL134796A/en not_active IP Right Cessation
-
2007
- 2007-04-06 US US11/784,343 patent/US7754710B2/en not_active Expired - Fee Related
-
2010
- 2010-06-08 US US12/796,247 patent/US20100311723A1/en not_active Abandoned
- 2010-06-08 US US12/796,241 patent/US20100311722A1/en not_active Abandoned
- 2010-06-08 US US12/796,249 patent/US8178524B2/en not_active Expired - Fee Related
- 2010-06-15 US US12/815,908 patent/US20100311725A1/en not_active Abandoned
-
2011
- 2011-12-08 US US13/315,127 patent/US20120083485A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU754088B2 (en) | 2002-11-07 |
| CA2302754C (en) | 2011-11-08 |
| DE69823520T2 (de) | 2005-05-12 |
| EP1009407B1 (de) | 2004-04-28 |
| US20100311724A1 (en) | 2010-12-09 |
| EP2338494B1 (de) | 2013-07-10 |
| US7754710B2 (en) | 2010-07-13 |
| IL134796A0 (en) | 2001-04-30 |
| EP1009407A2 (de) | 2000-06-21 |
| ATE510542T1 (de) | 2011-06-15 |
| IL134796A (en) | 2008-11-26 |
| US20100311722A1 (en) | 2010-12-09 |
| EP2246058A1 (de) | 2010-11-03 |
| US20100311725A1 (en) | 2010-12-09 |
| CA2302754A1 (en) | 1999-03-11 |
| US20120083485A1 (en) | 2012-04-05 |
| EP2338494A1 (de) | 2011-06-29 |
| EP1327447B1 (de) | 2011-05-25 |
| ES2224430T3 (es) | 2005-03-01 |
| WO1999011250A2 (en) | 1999-03-11 |
| ES2395268T3 (es) | 2013-02-11 |
| AU9217498A (en) | 1999-03-22 |
| EP1327447A1 (de) | 2003-07-16 |
| WO1999011250A3 (en) | 1999-08-05 |
| US8178524B2 (en) | 2012-05-15 |
| US20070185085A1 (en) | 2007-08-09 |
| ES2435722T3 (es) | 2013-12-23 |
| US20100311723A1 (en) | 2010-12-09 |
| DE69823520D1 (de) | 2004-06-03 |
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