ATE265443T1 - Gegebenenfalls durch tc oder re radioaktiv markierte n3s2-chelate, geeignet für diagnostische oder therapeutische anwendungen - Google Patents

Gegebenenfalls durch tc oder re radioaktiv markierte n3s2-chelate, geeignet für diagnostische oder therapeutische anwendungen

Info

Publication number
ATE265443T1
ATE265443T1 AT95933283T AT95933283T ATE265443T1 AT E265443 T1 ATE265443 T1 AT E265443T1 AT 95933283 T AT95933283 T AT 95933283T AT 95933283 T AT95933283 T AT 95933283T AT E265443 T1 ATE265443 T1 AT E265443T1
Authority
AT
Austria
Prior art keywords
chelates
diagnostic
applicable
therapeutic applications
radioactively labeled
Prior art date
Application number
AT95933283T
Other languages
English (en)
Inventor
Richard J Flanagan
Jean-Marc Dufour
Keith T Hogan
Original Assignee
Merck Frosst Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc
Application granted granted Critical
Publication of ATE265443T1 publication Critical patent/ATE265443T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
    • C07C331/16—Isothiocyanates
    • C07C331/28—Isothiocyanates having isothiocyanate groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
AT95933283T 1994-10-13 1995-10-11 Gegebenenfalls durch tc oder re radioaktiv markierte n3s2-chelate, geeignet für diagnostische oder therapeutische anwendungen ATE265443T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/322,881 US5632969A (en) 1994-10-13 1994-10-13 N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
PCT/CA1995/000572 WO1996011918A1 (en) 1994-10-13 1995-10-11 NOVEL N3S2 CHELATING LIGANDS OPTIONALLY RADIOLABELLED WITH Tc OR Re, USEFUL FOR DIAGNOSTIC OR THERAPEUTIC APPLICATIONS

Publications (1)

Publication Number Publication Date
ATE265443T1 true ATE265443T1 (de) 2004-05-15

Family

ID=23256855

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95933283T ATE265443T1 (de) 1994-10-13 1995-10-11 Gegebenenfalls durch tc oder re radioaktiv markierte n3s2-chelate, geeignet für diagnostische oder therapeutische anwendungen

Country Status (7)

Country Link
US (1) US5632969A (de)
EP (1) EP0785928B1 (de)
AT (1) ATE265443T1 (de)
AU (1) AU3602695A (de)
CA (1) CA2199145C (de)
DE (1) DE69532965T2 (de)
WO (1) WO1996011918A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985240A (en) * 1989-08-09 1999-11-16 Rhomed Incorporated Peptide radiopharmaceutical applications
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
US6004529A (en) * 1997-04-11 1999-12-21 Nycomed Imaging As Chelating agents
CN100352805C (zh) 2000-11-08 2007-12-05 鲁汶天主教大学研究开发部 用作造影剂的取代的联吲哚衍生物、包含它们的药物组合物以及制造它们的中间体
US6623721B2 (en) 2000-12-18 2003-09-23 Draximage, Inc. Bifunctional chelating compounds containing hydroxamic acid residues
KR100500475B1 (ko) * 2003-11-10 2005-07-12 삼성전자주식회사 케미컬 혼합장치

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4707352A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
DE3522638A1 (de) * 1985-06-25 1987-01-08 Diamalt Ag Neue somatostatin-derivate
AU593611B2 (en) * 1986-02-14 1990-02-15 Nihon Medi-Physics Co., Ltd. High molecular compounds having amino groups, and their utilization
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
NL194729C (nl) * 1986-10-13 2003-01-07 Novartis Ag Werkwijze voor de bereiding van peptidealcoholen via vaste fase.
CH679045A5 (de) * 1987-06-29 1991-12-13 Sandoz Ag
EP0322876A3 (de) * 1987-12-29 1990-09-05 Nihon Medi-Physics Co., Ltd. Chelierende Verbindungen und deren Verwendung
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
US4986979A (en) * 1989-03-14 1991-01-22 Neorx Corporation Imaging tissue sites of inflammation
US5101041A (en) * 1989-04-26 1992-03-31 The Curators Of The University Of Missouri Triamines and their derivatives as bifunctional chelating agents
US5395608A (en) * 1989-04-26 1995-03-07 The Curators Of The University Of Missouri Triamine chelants, their derivatives, complexes and conjugates
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5324503A (en) * 1992-02-06 1994-06-28 Mallinckrodt Medical, Inc. Iodo-phenylated chelates for x-ray contrast
DE4311021A1 (de) * 1993-03-31 1994-10-27 Diagnostikforschung Inst Bifunktionelle Chelatbildner, deren Technetium- und Rhenium-Komplexe, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Mittel
US5608110A (en) * 1993-06-15 1997-03-04 Bracco International B.V. Heteroatom-bearing ligands and metal complexes thereof
US5405601A (en) * 1993-07-02 1995-04-11 Mallinckrodt Medical Inc. Functionalized tripodal ligands for imaging applications
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications

Also Published As

Publication number Publication date
AU3602695A (en) 1996-05-06
EP0785928B1 (de) 2004-04-28
CA2199145C (en) 2007-12-04
WO1996011918A1 (en) 1996-04-25
EP0785928A1 (de) 1997-07-30
CA2199145A1 (en) 1996-04-25
DE69532965T2 (de) 2005-06-09
DE69532965D1 (de) 2004-06-03
US5632969A (en) 1997-05-27

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