ATE556722T1 - Herstellung von vierzähnigen peptidchelatkonjugaten zur diagnose von kolorektalem krebs - Google Patents

Herstellung von vierzähnigen peptidchelatkonjugaten zur diagnose von kolorektalem krebs

Info

Publication number
ATE556722T1
ATE556722T1 AT02701431T AT02701431T ATE556722T1 AT E556722 T1 ATE556722 T1 AT E556722T1 AT 02701431 T AT02701431 T AT 02701431T AT 02701431 T AT02701431 T AT 02701431T AT E556722 T1 ATE556722 T1 AT E556722T1
Authority
AT
Austria
Prior art keywords
preparation
colorectal cancer
conjugates
dental
diagnosing colorectal
Prior art date
Application number
AT02701431T
Other languages
English (en)
Inventor
Alan Cuthbertson
Marivi Mendizabal
Mark Dixon
Anthony Storey
Edward Bacon
Vinay Desai
Sudakar Kasina
Henry Wolfe
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Application granted granted Critical
Publication of ATE556722T1 publication Critical patent/ATE556722T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57535—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the large intestine, e.g. colon, rectum or anus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
AT02701431T 2001-03-02 2002-03-01 Herstellung von vierzähnigen peptidchelatkonjugaten zur diagnose von kolorektalem krebs ATE556722T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0105224.0A GB0105224D0 (en) 2001-03-02 2001-03-02 Improved peptide-chelate conjugates
PCT/GB2002/000857 WO2002070018A2 (en) 2001-03-02 2002-03-01 Tetradentate peptide-chelate conjugates for colorectal cancer diagnosis

Publications (1)

Publication Number Publication Date
ATE556722T1 true ATE556722T1 (de) 2012-05-15

Family

ID=9909880

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02701431T ATE556722T1 (de) 2001-03-02 2002-03-01 Herstellung von vierzähnigen peptidchelatkonjugaten zur diagnose von kolorektalem krebs

Country Status (8)

Country Link
US (1) US7608242B2 (de)
EP (1) EP1368064B1 (de)
JP (1) JP2004524323A (de)
AT (1) ATE556722T1 (de)
CA (1) CA2439579A1 (de)
ES (1) ES2385028T3 (de)
GB (1) GB0105224D0 (de)
WO (1) WO2002070018A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0224799D0 (en) * 2002-10-25 2002-12-04 Amersham Plc Improved complex compositions
NO20030115D0 (no) 2003-01-09 2003-01-09 Amersham Health As Kontrastmiddel
WO2004071436A2 (en) * 2003-02-10 2004-08-26 Thomas Jefferson University The use of gcc ligands
US7842280B2 (en) * 2006-09-06 2010-11-30 Case Western Reserve University Flexibly labeling peptides
WO2009108868A2 (en) * 2008-02-27 2009-09-03 Radiomedix Inc. Radiolabeled hedgehog derivatives for imaging and therapy
EP2355846A4 (de) * 2008-09-03 2013-06-19 Univ Michigan State Immunogenes wärmestabiles escherichia coli-enterotoxin
RU2012128509A (ru) 2009-12-07 2014-01-20 Айронвуд Фармасьютикалз, Инк. Способы лечения заболеваний желудочно-кишечного тракта
GB201016206D0 (en) * 2010-09-27 2010-11-10 Ge Healthcare Ltd Apoptosis imaging agents
GB201103696D0 (en) 2011-03-04 2011-04-20 Ge Healthcare Ltd Technetium labelled peptides
US9527887B2 (en) 2011-06-08 2016-12-27 Ironwood Pharmaceutical, Inc. Treatments for gastrointestinal disorders
US9617305B2 (en) 2011-06-08 2017-04-11 Ironwood Pharmaceuticals, Inc. Treatments for gastrointestinal disorders
GB201314936D0 (en) 2013-08-21 2013-10-02 Ge Healthcare Ltd Radiolabelling method
US20160303258A1 (en) * 2013-12-03 2016-10-20 Millennium Pharmaceuticals, Inc. Compounds and compositions for imaging gcc-expressing cells
GB201322456D0 (en) 2013-12-18 2014-02-05 Ge Healthcare Ltd Radiotracer compositions and methods

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4545931A (en) 1983-01-03 1985-10-08 Scripps Clinic And Research Foundation Synthetic heat-stable enterotoxin polypeptide of Escherichia coli
US4886663A (en) 1983-01-03 1989-12-12 Scripps Clinic And Research Foundation Synthetic heat-stable enterotoxin polypeptide of Escherichia coli and multimers thereof
US5242679A (en) * 1985-01-14 1993-09-07 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
DE69326557T2 (de) * 1992-10-08 2000-01-05 Nycomed Amersham Plc, Little Chalfont Metall-oxim chelate zur verwendung als röntgenpharmazeutische wirkstoffe
EP0720621B1 (de) 1993-06-23 2001-02-07 Diatide, Inc. Radiomarkierte somatostatin derivate zur abbildung und zur therapeutischen verwendung
EP0710228B1 (de) * 1993-07-19 1998-01-21 Resolution Pharmaceuticals Inc. Hydrazine mit einer n3s konfiguration als radionukleide chelatoren
ATE259648T1 (de) 1993-10-26 2004-03-15 Univ Jefferson Verbindungen die kolorektale krebszellen spezifisch binden und verfahren für ihre herstellung
US5518888A (en) 1993-10-26 1996-05-21 Thomas Jefferson University ST receptor binding compounds and methods of using the same
DE19536781A1 (de) * 1995-09-21 1997-03-27 Diagnostikforschung Inst Bifunktionelle sulfidhaltige Sulfonamid-Chelatbildner vom Typ XSNS für radioaktive Isotope
AU9452198A (en) 1997-10-15 1999-05-17 Nycomed Imaging As Complexing agents and targeting immunoreagents
WO1999039748A1 (en) 1998-02-06 1999-08-12 Nycomed Imaging As Targeting immunoreagents useful in therapeutic and diagnostic compositions and methods

Also Published As

Publication number Publication date
CA2439579A1 (en) 2002-09-12
ES2385028T3 (es) 2012-07-17
US20060222593A1 (en) 2006-10-05
WO2002070018A3 (en) 2002-12-05
EP1368064B1 (de) 2012-05-09
EP1368064A2 (de) 2003-12-10
WO2002070018A2 (en) 2002-09-12
JP2004524323A (ja) 2004-08-12
US7608242B2 (en) 2009-10-27
GB0105224D0 (en) 2001-04-18

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