ATE265847T1 - Selbstemulgierbare formulierung enthaltend lipophile verbindungen - Google Patents

Selbstemulgierbare formulierung enthaltend lipophile verbindungen

Info

Publication number
ATE265847T1
ATE265847T1 AT98936889T AT98936889T ATE265847T1 AT E265847 T1 ATE265847 T1 AT E265847T1 AT 98936889 T AT98936889 T AT 98936889T AT 98936889 T AT98936889 T AT 98936889T AT E265847 T1 ATE265847 T1 AT E265847T1
Authority
AT
Austria
Prior art keywords
diglyceride
monoglyceride
self
emulsifable
formulation containing
Prior art date
Application number
AT98936889T
Other languages
English (en)
Inventor
Walter Morozowich
Ping Gao
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of ATE265847T1 publication Critical patent/ATE265847T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • AIDS & HIV (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Silicon Polymers (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT98936889T 1997-07-29 1998-07-27 Selbstemulgierbare formulierung enthaltend lipophile verbindungen ATE265847T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5401297P 1997-07-29 1997-07-29
US5407897P 1997-07-29 1997-07-29
PCT/US1998/014818 WO1999006024A1 (en) 1997-07-29 1998-07-27 Self-emulsifying formulation for lipophilic compounds

Publications (1)

Publication Number Publication Date
ATE265847T1 true ATE265847T1 (de) 2004-05-15

Family

ID=26732506

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98936889T ATE265847T1 (de) 1997-07-29 1998-07-27 Selbstemulgierbare formulierung enthaltend lipophile verbindungen

Country Status (22)

Country Link
EP (1) EP0999826B1 (de)
JP (2) JP2002511099A (de)
KR (1) KR100509776B1 (de)
CN (1) CN1208047C (de)
AT (1) ATE265847T1 (de)
AU (1) AU728698B2 (de)
BR (1) BR9811058A (de)
CA (1) CA2294031E (de)
CZ (1) CZ297206B6 (de)
DE (1) DE69823663T2 (de)
DK (1) DK0999826T3 (de)
ES (1) ES2219895T3 (de)
FI (1) FI20000170A7 (de)
HU (1) HU226114B1 (de)
NO (1) NO328591B1 (de)
NZ (1) NZ502569A (de)
PL (1) PL191780B1 (de)
PT (1) PT999826E (de)
RU (1) RU2211021C2 (de)
SI (1) SI0999826T1 (de)
SK (1) SK284511B6 (de)
WO (1) WO1999006024A1 (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6964946B1 (en) * 1995-10-26 2005-11-15 Baker Norton Pharmaceuticals, Inc. Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same
CA2294032A1 (en) * 1997-07-29 1999-02-11 Pharmacia & Upjohn Company Self-emulsifying formulation for lipophilic compounds
US5922754A (en) * 1998-10-02 1999-07-13 Abbott Laboratories Pharmaceutical compositions containing paclitaxel
US6040330A (en) * 1999-01-08 2000-03-21 Bionumerik Pharmaceuticals, Inc. Pharmaceutical formulations of taxanes
GB9903547D0 (en) 1999-02-16 1999-04-07 Novartis Ag Organic compounds
US6294192B1 (en) * 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
DE19912436A1 (de) * 1999-03-19 2000-09-21 Merckle Gmbh Ibuprofen-Lösung
US6652880B1 (en) 1999-04-01 2003-11-25 R.P. Scherer Technologies, Inc. Oral pharmaceutical compositions containing long-chain triglycerides and liphophilic surfactants
EP1479382A1 (de) * 1999-06-18 2004-11-24 IVAX Research, Inc. Taxane enthaltende orale Pharmazeutische Zusammensetzungen sowie Behandlungsverfahren unter deren Verwendung
GB2355656B (en) * 1999-08-17 2004-04-07 Galena As Pharmaceutical compositions for oral and topical administration
GB0001928D0 (en) * 2000-01-27 2000-03-22 Novartis Ag Organic compounds
KR20010100194A (ko) * 2000-03-13 2001-11-14 박호군 여러 가지 물질의 가용화용 조성물과 제형 및 그들의제조방법
US6610272B1 (en) * 2000-05-01 2003-08-26 Aeropharm Technology Incorporated Medicinal aerosol formulation
US7115565B2 (en) 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
KR100425755B1 (ko) * 2001-08-27 2004-04-03 주식회사 원진신약 이트라코나졸을 함유하는 조성물 및 그 제조방법
CA2478424A1 (en) * 2002-03-01 2003-09-12 Novagali Pharma Sa Self emulsifying drug delivery systems for poorly soluble drugs
EP1340497A1 (de) * 2002-03-01 2003-09-03 Novagali Sas Selbstemulgierende Systeme zur Abgabe von schwerlöslichen Arzneimitteln
US7182950B2 (en) * 2002-06-12 2007-02-27 Nutralease Ltd. Nano-sized self-assembled liquid dilutable vehicles
KR100573289B1 (ko) * 2002-07-20 2006-04-24 대화제약 주식회사 방광내 투여를 통한 방광암치료용 파클리탁셀 조성물 및그의 제조 방법
KR100533458B1 (ko) * 2002-07-20 2005-12-07 대화제약 주식회사 파클리탁셀의 가용화용 조성물 및 그의 제조 방법
US20040185068A1 (en) * 2003-03-18 2004-09-23 Zhi-Jian Yu Self-emulsifying compositions, methods of use and preparation
JP2006521366A (ja) * 2003-03-28 2006-09-21 シグモイド・バイオテクノロジーズ・リミテッド シームレスマイクロカプセルを含む固形経口剤形
GT200500310A (es) 2004-11-19 2006-06-19 Compuestos organicos
ITRM20050418A1 (it) * 2005-08-04 2007-02-05 Sigma Tau Ind Farmaceuti Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina.
EP2061440A2 (de) 2007-04-04 2009-05-27 Sigmoid Pharma Limited Pharmazeutische tacrolimus-zusammensetzung
ES2963291T3 (es) 2007-04-26 2024-03-26 Sublimity Therapeutics Ltd Fabricación de múltiples minicápsulas
JP5812318B2 (ja) 2007-12-04 2015-11-11 レメディー ファーマシューティカルズ， インコーポレイテッド 凍結乾燥のための改良された処方物および方法ならびにそれによって提供される凍結乾燥物
WO2009097443A2 (en) * 2008-01-29 2009-08-06 Remedy Pharmaceuticals, Inc. Liquid formulations of compounds active at sulfonylurea receptors
KR20110025178A (ko) * 2008-05-16 2011-03-09 파르마 마르 에스.에이. Ｐｍ00104 및 다른 항종양제를 이용한 복합 치료법
EP2204167A1 (de) * 2009-01-05 2010-07-07 Azad Pharma AG Pharmazeutische Mikroemulsion zur Prävention von supramolekularer Aggregation von ampiphilen Molekülen
ES2530049T3 (es) 2009-05-18 2015-02-26 Sigmoid Pharma Limited Composición que comprende gotas de aceite
WO2011005646A2 (en) * 2009-07-07 2011-01-13 Boehringer Ingelheim International Gmbh Pharmaceutical composition for a hepatitis c viral protease inhibitor
BR112012002963A2 (pt) 2009-08-12 2017-10-24 Sigmoid Pharma Ltd composições imunomoduladoras compreendendo uma matriz de polímero e uma fase oleosa
US11730709B2 (en) 2010-10-29 2023-08-22 Infirst Healthcare Limited Compositions and methods for treating severe pain
US11224659B2 (en) 2010-10-29 2022-01-18 Infirst Healthcare Limited Solid solution compositions and use in severe pain
US10695432B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in severe pain
US9744132B2 (en) 2010-10-29 2017-08-29 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US9271950B2 (en) 2010-10-29 2016-03-01 Infirst Healthcare Limited Compositions for treating chronic inflammation and inflammatory diseases
US11202831B2 (en) 2010-10-29 2021-12-21 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
US9504664B2 (en) 2010-10-29 2016-11-29 Infirst Healthcare Limited Compositions and methods for treating severe pain
US9308213B2 (en) 2010-10-29 2016-04-12 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US8895536B2 (en) 2010-10-29 2014-11-25 Infirst Healthcare Ltd. Compositions and methods for treating chronic inflammation and inflammatory diseases
US10695431B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
HUE037660T2 (hu) * 2011-01-26 2018-09-28 Allergan Inc Androgén készítmény szembetegség kezelésére
GB2488788B (en) * 2011-03-07 2013-07-10 Natco Pharma Ltd Oral formulation of phenylaminopyrymidine compound with enhanced bioavailability and pharmacological response
PH12013501800A1 (en) 2011-03-15 2013-10-14 L Livermore Nat Security Llc Tricyclic gyrase inhibitors
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
SG11201505076UA (en) 2012-12-31 2015-07-30 Jrx Biotechnology Inc Liquid topical pharmaceutical nano-emulsion formulations
CN105007947B (zh) * 2013-01-14 2019-02-15 因佛斯特医疗有限公司 固溶体组合物及其在心血管疾病中的用途
RU2677346C2 (ru) * 2013-01-14 2019-01-16 ИнФерст Хэлткэр Лимитед Композиции и способы для лечения сильной боли
KR20150129664A (ko) * 2013-02-04 2015-11-20 인퍼스트 헬스케어 리미티드 만성 염증 및 염증성 질병을 치료하기 위한 조성물 및 방법
CA2922351C (en) * 2013-08-29 2019-08-06 Abbott Laboratories Nutritional composition having lipophilic compounds with improved solubility and bioavailability
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
CN104706591B (zh) * 2013-12-16 2018-09-04 天津迈迪瑞康生物医药科技有限公司 一种前列地尔药物组合物、其制备方法及用途
JP6704345B2 (ja) * 2014-01-17 2020-06-03 オンコラル ファーマ エーピーエス 癌治療のためのイリノテカンの固体経口剤形
EP3157505B1 (de) 2014-06-17 2019-07-24 Merck Sharp & Dohme B.V. Stabile formulierungen von testosteron-undecanoat
CN104274532A (zh) * 2014-10-21 2015-01-14 河南牧翔动物药业有限公司 复方灰黄霉素抗菌药物
EA036036B1 (ru) 2014-11-07 2020-09-16 Сигмойд Фарма Лимитед Композиции, содержащие циклоспорин
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
KR101587385B1 (ko) * 2015-07-29 2016-01-21 국제약품공업주식회사 사이클로스포린 함유 무자극성의 안약조성물 및 편리한 제조방법
US11260018B2 (en) 2015-09-17 2022-03-01 Jrx Biotechnology, Inc. Approaches for improving skin hydration and moisturization
US9931349B2 (en) 2016-04-01 2018-04-03 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB981926A (en) * 1963-01-22 1965-01-27 Wm Stewart & Arnold Ltd Method of preparing liquid and dried egg
DE2556592C2 (de) * 1975-12-16 1986-10-09 A. Nattermann & Cie GmbH, 5000 Köln Arzneimittelzubereitungen auf Basis öliger Lösungen von Phospholipiden
JPS6030652B2 (ja) * 1979-05-07 1985-07-17 株式会社ミドリ十字 静脈注射用脂肪乳剤
US4338307A (en) * 1980-11-10 1982-07-06 Abbott Laboratories 2'-N-Des-β-lysyl antibiotic AX-127B-1 and 4-N-acyl and alkyl derivatives thereof
SU1346159A1 (ru) * 1984-12-03 1987-10-23 Куйбышевский медицинский институт им.Д.И.Ульянова Способ получени лекарственных масл ных эмульсий внутреннего применени
US5371109A (en) * 1986-07-01 1994-12-06 Drilletten Ab Controlled release composition for a biologically active material dissolved or dispersed in an L2-phase
DE3629386A1 (de) * 1986-08-29 1988-03-03 Scherer Gmbh R P Gelatinekapseln und verfahren zu ihrer herstellung
EP0267617B1 (de) * 1986-11-14 1992-06-24 Theratech, Inc. Erhöhung des Penetrationsvermögens mittels eines aus die Zellhülle verändernden Substanzen und kurzkettigen Alkoholen bestehenden binären Systems
DK0448091T3 (da) * 1990-03-23 1999-05-03 Yoshitomi Pharmaceutical Farmaceutisk præparat indeholdende et i ringe grad vandopløseligt medikament
GB9113872D0 (en) * 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
JPH0734724B2 (ja) * 1992-02-03 1995-04-19 日清製油株式会社 抱水性クリーム状組成物
GB9208712D0 (en) * 1992-04-22 1992-06-10 Sandoz Ltd Pharmaceutical compositions containing cyclosporin derivates
DK0589843T3 (da) * 1992-09-25 2002-04-02 Novartis Ag Cyclosporinholdige farmaceutiske præparater
IL129871A (en) * 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
EP0825849A1 (de) * 1995-05-19 1998-03-04 Abbott Laboratories Selbstemulgierbare arzneiformulierungen für lipophile arzneimittel
DE19537012A1 (de) * 1995-10-04 1997-04-10 Dietl Hans Cyclosporin(e) enhaltende pharmazeutische Zubereitung zur oralen Applikation und Verfahren zu ihrer Herstellung
ZA9710071B (en) * 1996-11-21 1998-05-25 Abbott Lab Pharmaceutical composition.
CA2294032A1 (en) * 1997-07-29 1999-02-11 Pharmacia & Upjohn Company Self-emulsifying formulation for lipophilic compounds

Also Published As

Publication number Publication date
BR9811058A (pt) 2000-09-05
NO328591B1 (no) 2010-03-29
FI20000170L (fi) 2000-01-28
NO20000467D0 (no) 2000-01-28
AU8573998A (en) 1999-02-22
HU226114B1 (en) 2008-04-28
CZ2000157A3 (cs) 2000-05-17
DK0999826T3 (da) 2004-07-26
NZ502569A (en) 2002-05-31
PL338509A1 (en) 2000-11-06
KR100509776B1 (ko) 2005-08-24
RU2211021C2 (ru) 2003-08-27
CN1261790A (zh) 2000-08-02
JP5227301B2 (ja) 2013-07-03
JP2002511099A (ja) 2002-04-09
HUP0002486A3 (en) 2001-03-28
PT999826E (pt) 2004-09-30
SK172000A3 (en) 2000-07-11
HK1028883A1 (zh) 2001-03-09
EP0999826A1 (de) 2000-05-17
AU728698B2 (en) 2001-01-18
CA2294031A1 (en) 1999-02-11
NO20000467L (no) 2000-03-29
EP0999826B1 (de) 2004-05-06
SI0999826T1 (en) 2004-12-31
WO1999006024A1 (en) 1999-02-11
CA2294031E (en) 2012-04-03
DE69823663T2 (de) 2005-05-19
HUP0002486A1 (hu) 2000-12-28
CA2294031C (en) 2005-01-18
SK284511B6 (sk) 2005-05-05
JP2010070562A (ja) 2010-04-02
CZ297206B6 (cs) 2006-10-11
ES2219895T3 (es) 2004-12-01
DE69823663D1 (de) 2004-06-09
CN1208047C (zh) 2005-06-29
PL191780B1 (pl) 2006-07-31
KR20010022365A (ko) 2001-03-15
FI20000170A7 (fi) 2000-01-28

Similar Documents

Publication Publication Date Title
DE69823663D1 (de) Selbstemulgierbare formulierung enthaltend lipophile verbindungen
ATE215370T1 (de) Selbstemulgierende formulierung enthaltend lipophile verbindungen
ES2529167T3 (es) Método para utilizar lípidos neutros para modificar la liberación in vivo desde liposomas multivesiculares
CL2009001870A1 (es) Composicion farmaceutica que comprende: a) un agente activo de prostaglandina que es 13,14-dihidro-15-ceto-20-etil-pgf2alfa isopropil ester, b) un primer tensoactivo no ionico, c) un segundo tensoactivo no ionico, d) un vehiculo oftalmicamente aceptable, util en el tratamiento de la hipertension ocular (divisional de la solicitud 557-98).
DK1173153T3 (da) Orale farmaceutiske præparater, som indeholder langkædede triglycerider og lipofile overfladeaktive midler
CO4930289A1 (es) Composiciones galenicas, en donde el ingrediente activo es un agente activo dificilmente soluble
DK0904064T3 (da) Orale farmaceutiske præparater indeholdende kønshormoner
UY27320A1 (es) Nuevas composiciones farmacéuticas
PT1092429E (pt) Preparados farmaceuticos para substancias activas de dificil dissolucao
NO974104L (no) Faste diacyl-organiske peroksyd-dispersjoner
NO304261B1 (no) Preparat omfattende en lipofil forbindelse
AR043106A2 (es) Formulaciones farmaceuticas para la administracion oral y topica y formas de dosis farmaceutica
CO4970826A1 (es) Preparaciones de capsula suave que contienen ciclosporina
MX9204382A (es) Composiciones
AR021921A1 (es) Formulaciones farmaceuticas en aerosol que contienen fluoroalcanos y budesonido.
CA2217767A1 (en) Low ph skin-treatment composition
BR9706804A (pt) Preparações de cápsula macia contendo ciclosporina.
BR9711501A (pt) Inibição viral por álcoois, alcanos, ácidos graxos e amidas de cadeia longa
EE200200368A (et) Tramadoolvesinikkloriidi sisaldav toimeainet reguleeritult vabastav ravimkoostis ja meetod selle valmistamiseks
KR950703333A (ko) 비이온계 계면활성제 함유 약학 조성물(Pharmaceutical Compositions Containing Nonionic Surfactants)
ECSP972157A (es) Preparaciones de capsula suave que contienen ciclosporina

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0999826

Country of ref document: EP

EEIH Change in the person of patent owner