ATE26584T1 - In-vivo abbaubares polypeptid und dessen anwendung zur verzoegerten freigabe von medikamenten. - Google Patents

In-vivo abbaubares polypeptid und dessen anwendung zur verzoegerten freigabe von medikamenten.

Info

Publication number
ATE26584T1
ATE26584T1 AT84810156T AT84810156T ATE26584T1 AT E26584 T1 ATE26584 T1 AT E26584T1 AT 84810156 T AT84810156 T AT 84810156T AT 84810156 T AT84810156 T AT 84810156T AT E26584 T1 ATE26584 T1 AT E26584T1
Authority
AT
Austria
Prior art keywords
pct
medications
application
delayed release
vivo degradable
Prior art date
Application number
AT84810156T
Other languages
English (en)
Inventor
Daniel Bichon
Original Assignee
Battelle Memorial Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Battelle Memorial Institute filed Critical Battelle Memorial Institute
Application granted granted Critical
Publication of ATE26584T1 publication Critical patent/ATE26584T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/10—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
    • C08G73/1092—Polysuccinimides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/29—Polyamino acid or polypeptide with an uninterrupted series of peptide repeating units

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Polyamides (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
AT84810156T 1983-07-01 1984-04-02 In-vivo abbaubares polypeptid und dessen anwendung zur verzoegerten freigabe von medikamenten. ATE26584T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH361983 1983-07-01
EP84810156A EP0130935B1 (de) 1983-07-01 1984-04-02 In-vivo abbaubares Polypeptid und dessen Anwendung zur verzögerten Freigabe von Medikamenten

Publications (1)

Publication Number Publication Date
ATE26584T1 true ATE26584T1 (de) 1987-05-15

Family

ID=4259870

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84810156T ATE26584T1 (de) 1983-07-01 1984-04-02 In-vivo abbaubares polypeptid und dessen anwendung zur verzoegerten freigabe von medikamenten.

Country Status (11)

Country Link
US (1) US4675381A (de)
EP (2) EP0150184A1 (de)
JP (1) JPS60501759A (de)
AT (1) ATE26584T1 (de)
AU (1) AU2698684A (de)
CA (1) CA1241322A (de)
DE (1) DE3463211D1 (de)
DK (1) DK88385A (de)
FI (1) FI73448C (de)
NO (1) NO850771L (de)
WO (1) WO1985000372A1 (de)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5288498A (en) * 1985-05-01 1994-02-22 University Of Utah Research Foundation Compositions of oral nondissolvable matrixes for transmucosal administration of medicaments
JPS60237015A (ja) * 1984-05-11 1985-11-25 Koken:Kk 医薬徐放剤
US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
EP0179023B1 (de) * 1984-10-19 1991-01-23 Battelle Memorial Institute Durch Mikroorganismen abbaubares Polypeptid und seine Verwendung für die fortschreitende Abgabe von Medikamenten
US4863735A (en) * 1985-02-19 1989-09-05 Massachusetts Institute Of Technology Biodegradable polymeric drug delivery system with adjuvant activity
CS252559B1 (en) * 1985-03-22 1987-09-17 Frantisek Rypacek Polymer stabilizer of emulsion type water in oil
US4895724A (en) * 1985-06-07 1990-01-23 Pfizer Inc. Chitosan compositions for controlled and prolonged release of macromolecules
CH667874A5 (fr) * 1985-12-19 1988-11-15 Battelle Memorial Institute Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments.
IL78826A (en) * 1986-05-19 1991-05-12 Yissum Res Dev Co Precursor composition for the preparation of a biodegradable implant for the sustained release of an active material and such implants prepared therefrom
CA1257199A (en) * 1986-05-20 1989-07-11 Paul Y. Wang Preparation containing bioactive macromolecular substance for multi-months release in vivo
DE3700128A1 (de) * 1987-01-03 1988-07-14 Hoechst Ag Biologisch abbaubare poly- (hydroxyalkyl)- aminodicarbonsaeure-derivate, verfahren zu ihrer herstellung und verwendung derselben fuer depotzubereitungen mit kontrollierter wirkstoffabgabe
US4916204A (en) * 1987-07-31 1990-04-10 Massachusetts Institute Of Technology Pure polyanhydride from dicarboxylic acid and coupling agent
US5681543A (en) * 1988-02-29 1997-10-28 Shering Aktiengesellschaft Polymer-bonded complexing agents and pharmaceutical agents containing them for MRI
GB8805286D0 (en) * 1988-03-05 1988-04-07 Schering Agrochemicals Ltd Trypanocides
US5023080A (en) * 1988-06-17 1991-06-11 Basic Bio Systems, Inc. Time release protein
US5700479A (en) * 1988-12-23 1997-12-23 Guidor Ab Surgical element and method for selective tissue regeneration
US4990336A (en) * 1989-02-08 1991-02-05 Biosearch, Inc. Sustained release dosage form
US5126147A (en) * 1990-02-08 1992-06-30 Biosearch, Inc. Sustained release dosage form
GB9107628D0 (en) 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
US5993805A (en) * 1991-04-10 1999-11-30 Quadrant Healthcare (Uk) Limited Spray-dried microparticles and their use as therapeutic vehicles
GB9204918D0 (en) * 1992-03-06 1992-04-22 Nycomed As Chemical compounds
FR2712892B1 (fr) * 1993-11-24 1995-12-22 Rhone Poulenc Chimie Procédé de préparation de polyimides ou de leurs hydrolysats biodégradables.
EP0659875B1 (de) * 1993-11-24 2001-08-08 Rhodia Chimie Verfahren zur Herstellung von Polyimiden oder ihren biologisch abbaubauren polypeptidischen Hydrolysaten
US5904935A (en) * 1995-06-07 1999-05-18 Alza Corporation Peptide/protein suspending formulations
DE19545678A1 (de) * 1995-12-07 1997-06-12 Goldschmidt Ag Th Copolymere Polyaminosäureester
US6231888B1 (en) 1996-01-18 2001-05-15 Perio Products Ltd. Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps
US6441025B2 (en) * 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
AU5546698A (en) * 1997-01-13 1998-08-03 Universite Laval Membrane-permeable derivatives converted intracellularly into active peptides
US6517869B1 (en) * 1997-12-12 2003-02-11 Expression Genetics, Inc. Positively charged poly(alpha-(omega-aminoalkyl)lycolic acid) for the delivery of a bioactive agent via tissue and cellular uptake
DE19822600C2 (de) * 1998-05-20 2003-08-21 Goldschmidt Ag Th Copolymere, hydrophob modifizierte Polyasparaginsäureester mit erhöhter Molekularmasse
DE19822599C2 (de) * 1998-05-20 2003-02-06 Goldschmidt Ag Th Copolymere hydrophob modifizierte Polyasparaginsäureesteramide und ihre Verwendung
US6531152B1 (en) 1998-09-30 2003-03-11 Dexcel Pharma Technologies Ltd. Immediate release gastrointestinal drug delivery system
US6632451B2 (en) 1999-06-04 2003-10-14 Dexcel Pharma Technologies Ltd. Delayed total release two pulse gastrointestinal drug delivery system
CA2401327C (en) * 2000-03-03 2014-05-06 Valentis, Inc. Nucleic acid formulations comprising poly-amino acids for gene delivery and methods of use
US7109167B2 (en) 2000-06-02 2006-09-19 Bracco International B.V. Compounds for targeting endothelial cells, compositions containing the same and methods for their use
AU2002253454A1 (en) * 2001-04-06 2002-10-21 Bracco Research S.A. Method for improved measurement of local physical parameters in afluid-filled cavity
AUPR610501A0 (en) * 2001-07-04 2001-07-26 Smart Drug Systems Inc Treatment of parasitic disease
US20030109432A1 (en) * 2001-12-10 2003-06-12 Zuo William W. Anticancer polypeptide-metal complexes and compositions, methods of making, and methods of using same
EP2277551B1 (de) 2002-09-06 2013-05-08 Cerulean Pharma Inc. Polymere auf basis von cyclodextrin zur verabreichung von an diese kovalent gebundene arzneimittel
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
WO2004069284A2 (en) 2003-02-04 2004-08-19 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
JP5513708B2 (ja) * 2003-12-22 2014-06-04 ブラッコ・シュイス・ソシエテ・アノニム 造影イメージング用の気体封入マイクロベシクル・アセンブリー
US20060067972A1 (en) * 2004-06-23 2006-03-30 Flowmedica, Inc. Devices for renal-based heart failure treatment
US9248204B2 (en) 2004-08-18 2016-02-02 Bracco Suisse S.A. Gas-filled microvesicles composition for contrast imaging
EP1714642A1 (de) 2005-04-18 2006-10-25 Bracco Research S.A. Pharmazeutische Formulierung mit gasgefüllten Mikrokapseln zur ultraschallgesteuerten Freisetzung
US20090155279A1 (en) 2005-10-28 2009-06-18 Jiro Tanaka Pseudomonas Aeruginosa Outer Membrane Protein PA5158
EP2077290B1 (de) * 2005-12-05 2010-04-21 Nitto Denko Corporation Polyglutamat-Aminosäure-Konjugate und Verfahren
JPWO2007114340A1 (ja) 2006-03-30 2009-08-20 明治製菓株式会社 緑膿菌の外膜タンパク質ｐａ０４２７
US20080176958A1 (en) 2007-01-24 2008-07-24 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
US20080181852A1 (en) * 2007-01-29 2008-07-31 Nitto Denko Corporation Multi-functional Drug Carriers
JP2010526159A (ja) * 2007-04-10 2010-07-29 日東電工株式会社 多機能性ポリグルタミン酸塩薬物担体
EP2155253A2 (de) * 2007-05-09 2010-02-24 Nitto Denko Corporation Polyglutamatkonjugate und polyglutamat-aminosäure-konjugate mit mehreren wirkstoffen
ES2430380T3 (es) * 2007-05-09 2013-11-20 Nitto Denko Corporation Composiciones que incluyen un compuesto hidrófobo y un conjugado de poliaminoácido
CN101730549B (zh) * 2007-05-09 2015-12-09 日东电工株式会社 与铂类药物结合的聚合物
WO2009005040A1 (ja) * 2007-06-29 2009-01-08 Meiji Seika Kaisha Ltd. 緑膿菌の外膜タンパク質pa4710
WO2009081955A1 (ja) 2007-12-25 2009-07-02 Meiji Seika Kaisha, Ltd. 緑膿菌のiii型分泌装置構成タンパク質pa1698
WO2009111271A1 (en) * 2008-03-06 2009-09-11 Nitto Denko Corporation Polymer paclitaxel conjugates and methods for treating cancer
SG179101A1 (en) 2009-09-15 2012-05-30 Alomone Preclinical Ltd Novel peptides isolated from spider venom, and uses thereof
EP2503888A4 (de) * 2009-11-23 2015-07-29 Cerulean Pharma Inc Polymere auf cyclodextrinbasis zur therapeutischen verabreichung
WO2011119995A2 (en) 2010-03-26 2011-09-29 Cerulean Pharma Inc. Formulations and methods of use
CA2830415A1 (en) 2011-03-16 2012-12-13 Regents Of The University Of Minnesota Compositions and methods for inducing immune responses against bacteria in the genus staphylococcus
WO2013168965A2 (ko) 2012-05-07 2013-11-14 목암생명공학연구소 포도상구균 감염 예방용 백신 조성물
US20140094432A1 (en) 2012-10-02 2014-04-03 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
WO2019195766A1 (en) * 2018-04-06 2019-10-10 AMMA Therapeutics, Inc. Composition for controlled release of therapeutic agents
EP4308288A1 (de) * 2021-03-18 2024-01-24 Agfa-Gevaert Nv Kapseln auf poly(aminosäure)-basis
WO2025132906A1 (en) 2023-12-22 2025-06-26 Bracco Suisse Sa Focused ultrasound thermal ablation with thermal enhancers

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3230274A (en) * 1960-12-30 1966-01-18 Merck & Co Inc Preparation of linear polypeptides
US3371069A (en) * 1963-03-20 1968-02-27 Ajinomoto Kk Filaments and surgical sutures of polyl-glutamic acid partly esterified with lower alkanols and process therefor
JPS5031905B1 (de) * 1971-07-05 1975-10-16
US4351337A (en) * 1973-05-17 1982-09-28 Arthur D. Little, Inc. Biodegradable, implantable drug delivery device, and process for preparing and using the same
CA1045977A (en) * 1973-05-17 1979-01-09 Arthur D. Little Biodegradable, implantable drug delivery device, and process for preparing and using the same
US4356166A (en) * 1978-12-08 1982-10-26 University Of Utah Time-release chemical delivery system

Also Published As

Publication number Publication date
DE3463211D1 (en) 1987-05-21
EP0130935A1 (de) 1985-01-09
DK88385D0 (da) 1985-02-27
AU2698684A (en) 1985-02-07
US4675381A (en) 1987-06-23
FI850835A0 (fi) 1985-02-28
WO1985000372A1 (fr) 1985-01-31
CA1241322A (fr) 1988-08-30
EP0130935B1 (de) 1987-04-15
DK88385A (da) 1985-02-27
FI73448B (fi) 1987-06-30
FI850835L (fi) 1985-02-28
EP0150184A1 (de) 1985-08-07
JPS60501759A (ja) 1985-10-17
FI73448C (fi) 1987-10-09
NO850771L (no) 1985-02-26

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