ATE266001T1 - Zur herstellung von sulfurierten oligonukleotidanaloga - Google Patents

Zur herstellung von sulfurierten oligonukleotidanaloga

Info

Publication number
ATE266001T1
ATE266001T1 AT98908882T AT98908882T ATE266001T1 AT E266001 T1 ATE266001 T1 AT E266001T1 AT 98908882 T AT98908882 T AT 98908882T AT 98908882 T AT98908882 T AT 98908882T AT E266001 T1 ATE266001 T1 AT E266001T1
Authority
AT
Austria
Prior art keywords
sulfurated
production
oligonucleotide analogs
oligonucleotide analog
oligonucleotide
Prior art date
Application number
AT98908882T
Other languages
English (en)
Inventor
Zacharia S Cheruvallath
Daniel C Capaldi
Vasulinga T Ravikumar
Douglas L Cole
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE266001T1 publication Critical patent/ATE266001T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
    • C07C329/12—Dithiocarbonic acids; Derivatives thereof
    • C07C329/14—Esters of dithiocarbonic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT98908882T 1997-03-03 1998-03-03 Zur herstellung von sulfurierten oligonukleotidanaloga ATE266001T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/811,233 US5902881A (en) 1997-03-03 1997-03-03 Reagent useful for synthesizing sulfurized oligonucleotide analogs
PCT/US1998/004111 WO1998039290A1 (en) 1997-03-03 1998-03-03 Reagent useful for synthesizing sulfurized oligonucleotide analogs

Publications (1)

Publication Number Publication Date
ATE266001T1 true ATE266001T1 (de) 2004-05-15

Family

ID=25205965

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98908882T ATE266001T1 (de) 1997-03-03 1998-03-03 Zur herstellung von sulfurierten oligonukleotidanaloga

Country Status (7)

Country Link
US (3) US5902881A (de)
EP (1) EP0983233B1 (de)
JP (1) JP2000510872A (de)
AT (1) ATE266001T1 (de)
AU (1) AU6680498A (de)
DE (1) DE69823657T2 (de)
WO (1) WO1998039290A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5902881A (en) * 1997-03-03 1999-05-11 Isis Pharmaceuticals, Inc. Reagent useful for synthesizing sulfurized oligonucleotide analogs
US6242591B1 (en) * 1997-10-15 2001-06-05 Isis Pharmaceuticals, Inc. Synthesis of sulfurized 2'-substituted oligonucleotides
US6124484A (en) 1998-07-17 2000-09-26 Isis Pharmaceuticals, Inc. Recovery of triarylmethyl halide protecting groups cleaved during oligonucleotide synthesis
US6069243A (en) * 1998-10-06 2000-05-30 Isis Pharmaceuticals, Inc. Process for oligonucleotide synthesis
WO2002081476A1 (en) * 2001-04-06 2002-10-17 Micrologix Biotech, Inc. Thiophosphate nucleic acid-based compounds
US20040241665A1 (en) * 2003-05-30 2004-12-02 Bass Jay K. Methods and devices for identifying a fluid on a substrate surface
JP2007531794A (ja) 2004-04-05 2007-11-08 アルニラム ファーマスーティカルズ インコーポレイテッド オリゴヌクレオチドの合成および精製に使用する方法および反応試薬
WO2012059510A1 (en) 2010-11-02 2012-05-10 Girindus America, Inc. Back pressure control during solid-phase synthesis on polymeric supports
CA3033867A1 (en) 2016-08-17 2018-02-22 Solstice Biologics, Ltd. Polynucleotide constructs
US11597744B2 (en) 2017-06-30 2023-03-07 Sirius Therapeutics, Inc. Chiral phosphoramidite auxiliaries and methods of their use
CN119751529A (zh) * 2024-12-27 2025-04-04 北京炫景瑞医药科技有限公司 核苷酸二聚体及其制备方法和用途

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Also Published As

Publication number Publication date
US6399831B1 (en) 2002-06-04
EP0983233B1 (de) 2004-05-06
WO1998039290A1 (en) 1998-09-11
AU6680498A (en) 1998-09-22
EP0983233A4 (de) 2002-03-20
DE69823657T2 (de) 2005-04-07
US6040438A (en) 2000-03-21
EP0983233A1 (de) 2000-03-08
DE69823657D1 (de) 2004-06-09
US5902881A (en) 1999-05-11
JP2000510872A (ja) 2000-08-22

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