ATE266025T1 - Thrombin-rezeptor antagonisten - Google Patents

Thrombin-rezeptor antagonisten

Info

Publication number
ATE266025T1
ATE266025T1 AT98958039T AT98958039T ATE266025T1 AT E266025 T1 ATE266025 T1 AT E266025T1 AT 98958039 T AT98958039 T AT 98958039T AT 98958039 T AT98958039 T AT 98958039T AT E266025 T1 ATE266025 T1 AT E266025T1
Authority
AT
Austria
Prior art keywords
receptor antagonists
thrombin receptor
thrombin
antagonists
receptor
Prior art date
Application number
AT98958039T
Other languages
English (en)
Inventor
Samuel Chackalamannil
Theodros Asberom
Yan Xia
Dario Doller
Martin C Clasby
Michael F Czarniecki
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE266025T1 publication Critical patent/ATE266025T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
AT98958039T 1997-11-25 1998-11-23 Thrombin-rezeptor antagonisten ATE266025T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97797997A 1997-11-25 1997-11-25
PCT/US1998/024523 WO1999026943A1 (en) 1997-11-25 1998-11-23 Thrombin receptor antagonists

Publications (1)

Publication Number Publication Date
ATE266025T1 true ATE266025T1 (de) 2004-05-15

Family

ID=25525702

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98958039T ATE266025T1 (de) 1997-11-25 1998-11-23 Thrombin-rezeptor antagonisten

Country Status (30)

Country Link
EP (1) EP1036072B1 (de)
JP (2) JP3449620B2 (de)
KR (1) KR100393492B1 (de)
CN (2) CN1290265A (de)
AR (1) AR017189A1 (de)
AT (1) ATE266025T1 (de)
AU (1) AU747204B2 (de)
BR (1) BR9812793A (de)
CA (1) CA2309352C (de)
CO (1) CO4990946A1 (de)
CZ (1) CZ298578B6 (de)
DE (1) DE69823694T2 (de)
DK (1) DK1036072T3 (de)
ES (1) ES2219919T3 (de)
HU (1) HUP0100607A3 (de)
ID (1) ID24726A (de)
IL (1) IL135797A (de)
MY (1) MY140887A (de)
NO (1) NO322022B1 (de)
NZ (1) NZ504218A (de)
PE (1) PE133799A1 (de)
PL (1) PL195027B1 (de)
PT (1) PT1036072E (de)
RU (1) RU2204557C2 (de)
SA (1) SA99190972B1 (de)
SK (1) SK285153B6 (de)
TR (1) TR200001480T2 (de)
TW (1) TWI236476B (de)
WO (1) WO1999026943A1 (de)
ZA (1) ZA9810685B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000229961A (ja) * 1998-12-11 2000-08-22 Sagami Chem Res Center ヒドロナフト［２，３−ｃ］フラン誘導体およびその製造方法
AU6731100A (en) 1999-09-02 2001-04-10 Shionogi & Co., Ltd. Integrase inhibitors containing aromatic heterocycle derivatives
ES2291323T3 (es) * 2000-06-15 2008-03-01 Schering Corporation Antagonistas de receptores de trombina.
US7488742B2 (en) * 2000-06-15 2009-02-10 Schering Corporation Thrombin receptor antagonists
EP1764366A3 (de) * 2000-06-15 2007-10-03 Schering Corporation Thrombinrezeptorantagonisten
US7304078B2 (en) * 2002-04-16 2007-12-04 Schering Corporation Thrombin receptor antagonists
US7235567B2 (en) * 2000-06-15 2007-06-26 Schering Corporation Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
NZ528820A (en) 2001-04-19 2007-01-26 Eisai Co Ltd 2-iminopyrrolidine derivatives
BR0213967A (pt) * 2001-10-18 2005-08-30 Schering Corp Análogos de himbacina como antagonistas do receptor de trombina
ES2211315B1 (es) * 2002-11-12 2005-10-16 Almirall Prodesfarma, S.A. Nuevos compuestos triciclicos.
EP2444393A1 (de) 2003-02-19 2012-04-25 Eisai R&D Management Co., Ltd. Verfahren zur Herstellung von zyklischen Benzamidinderivaten
JPWO2005108370A1 (ja) * 2004-04-16 2008-03-21 味の素株式会社 ベンゼン化合物
MXPA06013903A (es) * 2004-05-28 2007-01-26 Schering Corp Analogos restringidos de himbacina como antagonistas del receptor de trombina.
WO2006041872A2 (en) * 2004-10-08 2006-04-20 Schering Corporation Thrombin receptor antagonists
JP4681617B2 (ja) * 2005-01-14 2011-05-11 シェーリング コーポレイション ヒンバシンアナログの合成
JP4775971B2 (ja) * 2005-01-14 2011-09-21 シェーリング コーポレイション ヒンバシンアナログのエキソ−選択的合成
ATE530516T1 (de) 2005-01-14 2011-11-15 Schering Corp Exo- und diastereoselektive synthese von himbacin-analoga
TWI367112B (en) * 2006-06-30 2012-07-01 Schering Corp Immediate-release tablet formulations of a thrombin receptor antagonist
CN101541782A (zh) * 2006-10-04 2009-09-23 先灵公司 作为凝血酶受体拮抗剂的二环和三环衍生物
PL2558462T3 (pl) 2010-04-16 2015-03-31 Sanofi Sa Pirydylo-winylo-pirazolo-chinoliny jako inhibitory PAR1
ES2532902T3 (es) 2010-04-16 2015-04-01 Sanofi Piridil-vinil-pirroles tricíclicos como inhibidores de PAR1
CN108658910B (zh) * 2017-03-29 2020-11-03 北京新领先医药科技发展有限公司 一种沃拉帕沙中间体1-α的制备方法
CN113387947B (zh) * 2021-07-12 2022-07-01 中国科学院成都生物研究所 调节雌激素受体合成活性的吡唑并吡啶衍生物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773792A (en) 1968-03-08 1973-11-20 Itt Rayonier Inc Acetates of plicatic acid and processes for the preparation thereof
US4486445A (en) 1983-01-12 1984-12-04 E. I. Du Pont De Nemours And Company Justicidin insecticidal and antiviral compounds
CA2008116C (en) * 1989-02-23 2001-11-20 Thomas Weller Glycine derivatives
IL106197A (en) * 1992-07-30 1999-11-30 Cor Therapeutics Inc Agagonists for the rhombin receptors and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
WO1999026943A1 (en) 1999-06-03
CZ20001856A3 (cs) 2000-10-11
DK1036072T3 (da) 2004-09-06
NZ504218A (en) 2002-04-26
HK1031726A1 (en) 2001-06-22
JP2001524479A (ja) 2001-12-04
CA2309352C (en) 2005-01-25
ID24726A (id) 2000-08-03
SA99190972B1 (ar) 2006-07-30
CN101274929A (zh) 2008-10-01
IL135797A0 (en) 2001-05-20
CZ298578B6 (cs) 2007-11-14
IL135797A (en) 2003-09-17
CN1290265A (zh) 2001-04-04
CO4990946A1 (es) 2000-12-26
KR100393492B1 (ko) 2003-08-02
NO322022B1 (no) 2006-08-07
TR200001480T2 (tr) 2000-09-21
PE133799A1 (es) 2000-01-10
DE69823694T2 (de) 2005-04-21
CA2309352A1 (en) 1999-06-03
ZA9810685B (en) 1999-12-23
BR9812793A (pt) 2000-10-17
PL341114A1 (en) 2001-03-26
EP1036072A1 (de) 2000-09-20
RU2204557C2 (ru) 2003-05-20
JP3449620B2 (ja) 2003-09-22
PL195027B1 (pl) 2007-08-31
SK285153B6 (sk) 2006-07-07
ES2219919T3 (es) 2004-12-01
AU1415899A (en) 1999-06-15
TWI236476B (en) 2005-07-21
AU747204B2 (en) 2002-05-09
KR20010032439A (ko) 2001-04-25
DE69823694D1 (de) 2004-06-09
HUP0100607A2 (hu) 2002-05-29
PT1036072E (pt) 2004-08-31
MY140887A (en) 2010-01-29
NO20002659D0 (no) 2000-05-24
NO20002659L (no) 2000-07-24
AR017189A1 (es) 2001-08-22
JP2003128670A (ja) 2003-05-08
HUP0100607A3 (en) 2002-06-28
EP1036072B1 (de) 2004-05-06
SK7592000A3 (en) 2001-02-12

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