NO20002659L - Trombinreseptorantagonister - Google Patents

Trombinreseptorantagonister

Info

Publication number
NO20002659L
NO20002659L NO20002659A NO20002659A NO20002659L NO 20002659 L NO20002659 L NO 20002659L NO 20002659 A NO20002659 A NO 20002659A NO 20002659 A NO20002659 A NO 20002659A NO 20002659 L NO20002659 L NO 20002659L
Authority
NO
Norway
Prior art keywords
thrombin
Prior art date
Application number
NO20002659A
Other languages
English (en)
Other versions
NO20002659D0 (no
NO322022B1 (no
Inventor
Samuel Chackalamannil
Theodros Asberom
Yan Xia
Dario Doller
Martin C Clasby
Michael F Czarniecki
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO20002659D0 publication Critical patent/NO20002659D0/no
Publication of NO20002659L publication Critical patent/NO20002659L/no
Publication of NO322022B1 publication Critical patent/NO322022B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
NO20002659A 1997-11-25 2000-05-24 Trombinreseptorantagonister, farmasoytisk preparat og anvendelse av disse for fremstilling av medisin NO322022B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97797997A 1997-11-25 1997-11-25
PCT/US1998/024523 WO1999026943A1 (en) 1997-11-25 1998-11-23 Thrombin receptor antagonists

Publications (3)

Publication Number Publication Date
NO20002659D0 NO20002659D0 (no) 2000-05-24
NO20002659L true NO20002659L (no) 2000-07-24
NO322022B1 NO322022B1 (no) 2006-08-07

Family

ID=25525702

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20002659A NO322022B1 (no) 1997-11-25 2000-05-24 Trombinreseptorantagonister, farmasoytisk preparat og anvendelse av disse for fremstilling av medisin

Country Status (30)

Country Link
EP (1) EP1036072B1 (no)
JP (2) JP3449620B2 (no)
KR (1) KR100393492B1 (no)
CN (2) CN101274929A (no)
AR (1) AR017189A1 (no)
AT (1) ATE266025T1 (no)
AU (1) AU747204B2 (no)
BR (1) BR9812793A (no)
CA (1) CA2309352C (no)
CO (1) CO4990946A1 (no)
CZ (1) CZ298578B6 (no)
DE (1) DE69823694T2 (no)
DK (1) DK1036072T3 (no)
ES (1) ES2219919T3 (no)
HU (1) HUP0100607A3 (no)
ID (1) ID24726A (no)
IL (1) IL135797A (no)
MY (1) MY140887A (no)
NO (1) NO322022B1 (no)
NZ (1) NZ504218A (no)
PE (1) PE133799A1 (no)
PL (1) PL195027B1 (no)
PT (1) PT1036072E (no)
RU (1) RU2204557C2 (no)
SA (1) SA99190972B1 (no)
SK (1) SK285153B6 (no)
TR (1) TR200001480T2 (no)
TW (1) TWI236476B (no)
WO (1) WO1999026943A1 (no)
ZA (1) ZA9810685B (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000229961A (ja) * 1998-12-11 2000-08-22 Sagami Chem Res Center ヒドロナフト[2,3−c]フラン誘導体およびその製造方法
JP4577751B2 (ja) * 1999-09-02 2010-11-10 塩野義製薬株式会社 芳香族ヘテロ環誘導体を含有するインテグラーゼ阻害剤
EP1764366A3 (en) * 2000-06-15 2007-10-03 Schering Corporation Thrombin receptor antagonists
US7488742B2 (en) * 2000-06-15 2009-02-10 Schering Corporation Thrombin receptor antagonists
US7235567B2 (en) 2000-06-15 2007-06-26 Schering Corporation Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
US6645987B2 (en) * 2000-06-15 2003-11-11 Schering Corporation Nor-seco himbacine derivatives useful as thrombin receptor antagonists
DE60233043D1 (de) 2001-04-19 2009-09-03 Eisai R&D Man Co Ltd 2-iminoimidazolderivate
WO2003033501A1 (en) * 2001-10-18 2003-04-24 Schering Corporation Himbacine analogues as thrombin receptor antagonists
DE60335679D1 (de) * 2002-04-16 2011-02-17 Schering Corp Tricyclischer Thrombinrezeptorantagonist
ES2211315B1 (es) * 2002-11-12 2005-10-16 Almirall Prodesfarma, S.A. Nuevos compuestos triciclicos.
AU2004218187C1 (en) 2003-02-19 2011-04-07 Eisai R&D Management Co., Ltd. Methods for producing cyclic benzamidine derivatives
WO2005108370A1 (ja) * 2004-04-16 2005-11-17 Ajinomoto Co., Inc. ベンゼン化合物
MY143987A (en) * 2004-05-28 2011-07-29 Schering Corp Constrained himbacine analogs as thrombin receptor antagonists
CN101072772A (zh) * 2004-10-08 2007-11-14 先灵公司 凝血酶受体拮抗剂
AR052870A1 (es) * 2005-01-14 2007-04-11 Schering Corp Sintesis de analogos de himbacina
CA2594807A1 (en) * 2005-01-14 2006-07-20 Schering Corporation An exo-selective synthesis of himbacine analogs
RS51315B (sr) * 2005-01-14 2010-12-31 Schering Corporation EGZO-i DIASTEREO-SELEKTIVNA SINTEZA ANALOGA HIMBACINA
TWI367112B (en) * 2006-06-30 2012-07-01 Schering Corp Immediate-release tablet formulations of a thrombin receptor antagonist
CA2667082A1 (en) * 2006-10-04 2008-04-10 Schering Corporation Bicyclic and tricyclic derivatives as thrombin receptor antagonists
PL2558465T3 (pl) 2010-04-16 2015-05-29 Sanofi Sa Trycykliczne pirydylo-winylo-pirole jako inhibitory receptora aktywowanego proteazą 1 (PAR1)
ES2527535T3 (es) 2010-04-16 2015-01-26 Sanofi Piridil-vinil-pirazolo-quinolinas como inhibidores de PAR1
CN108658910B (zh) * 2017-03-29 2020-11-03 北京新领先医药科技发展有限公司 一种沃拉帕沙中间体1-α的制备方法
CN113387947B (zh) * 2021-07-12 2022-07-01 中国科学院成都生物研究所 调节雌激素受体合成活性的吡唑并吡啶衍生物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773792A (en) 1968-03-08 1973-11-20 Itt Rayonier Inc Acetates of plicatic acid and processes for the preparation thereof
US4486445A (en) 1983-01-12 1984-12-04 E. I. Du Pont De Nemours And Company Justicidin insecticidal and antiviral compounds
CA2008116C (en) * 1989-02-23 2001-11-20 Thomas Weller Glycine derivatives
IL106197A (en) * 1992-07-30 1999-11-30 Cor Therapeutics Inc Agagonists for the rhombin receptors and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
JP2003128670A (ja) 2003-05-08
KR20010032439A (ko) 2001-04-25
JP3449620B2 (ja) 2003-09-22
CZ20001856A3 (cs) 2000-10-11
ID24726A (id) 2000-08-03
CA2309352C (en) 2005-01-25
DE69823694D1 (de) 2004-06-09
HUP0100607A3 (en) 2002-06-28
PE133799A1 (es) 2000-01-10
ZA9810685B (en) 1999-12-23
PL341114A1 (en) 2001-03-26
NO20002659D0 (no) 2000-05-24
EP1036072A1 (en) 2000-09-20
CZ298578B6 (cs) 2007-11-14
IL135797A0 (en) 2001-05-20
AU747204B2 (en) 2002-05-09
ES2219919T3 (es) 2004-12-01
IL135797A (en) 2003-09-17
HUP0100607A2 (hu) 2002-05-29
RU2204557C2 (ru) 2003-05-20
MY140887A (en) 2010-01-29
PL195027B1 (pl) 2007-08-31
CO4990946A1 (es) 2000-12-26
SK285153B6 (sk) 2006-07-07
PT1036072E (pt) 2004-08-31
NZ504218A (en) 2002-04-26
AU1415899A (en) 1999-06-15
EP1036072B1 (en) 2004-05-06
HK1031726A1 (en) 2001-06-22
JP2001524479A (ja) 2001-12-04
KR100393492B1 (ko) 2003-08-02
NO322022B1 (no) 2006-08-07
AR017189A1 (es) 2001-08-22
DE69823694T2 (de) 2005-04-21
TR200001480T2 (tr) 2000-09-21
CN1290265A (zh) 2001-04-04
TWI236476B (en) 2005-07-21
CA2309352A1 (en) 1999-06-03
WO1999026943A1 (en) 1999-06-03
SA99190972B1 (ar) 2006-07-30
ATE266025T1 (de) 2004-05-15
CN101274929A (zh) 2008-10-01
SK7592000A3 (en) 2001-02-12
DK1036072T3 (da) 2004-09-06
BR9812793A (pt) 2000-10-17

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