ATE266027T1 - Optisch aktives pyridyl-4h-1,2,4-oxadiazinderivat und seine verwendung zur behandlung von gefässkrankheiten - Google Patents

Optisch aktives pyridyl-4h-1,2,4-oxadiazinderivat und seine verwendung zur behandlung von gefässkrankheiten

Info

Publication number
ATE266027T1
ATE266027T1 AT99961225T AT99961225T ATE266027T1 AT E266027 T1 ATE266027 T1 AT E266027T1 AT 99961225 T AT99961225 T AT 99961225T AT 99961225 T AT99961225 T AT 99961225T AT E266027 T1 ATE266027 T1 AT E266027T1
Authority
AT
Austria
Prior art keywords
treatment
optically active
vascular diseases
oxadiazine derivative
pyridyl
Prior art date
Application number
AT99961225T
Other languages
English (en)
Inventor
Andrea Jednakovits
Laszlo Ueroegdi
Laszlou Denes
Istvan Kurucz
Ede Marvanyos
Mihaly Barabas
Erno Bacsy
Zsuzsanna Korom
Zoltan Nagy
Laszlo Uerge
Jeno Szilbereky
Karoly Acsai
Peter Krajcsi
Zita Csakai
Magdolna Toeroek
Original Assignee
Biorex Kutato Fejlesztoe Kft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biorex Kutato Fejlesztoe Kft filed Critical Biorex Kutato Fejlesztoe Kft
Application granted granted Critical
Publication of ATE266027T1 publication Critical patent/ATE266027T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT99961225T 1998-12-14 1999-12-07 Optisch aktives pyridyl-4h-1,2,4-oxadiazinderivat und seine verwendung zur behandlung von gefässkrankheiten ATE266027T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9802897A HU226617B1 (en) 1998-12-14 1998-12-14 Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient
PCT/HU1999/000095 WO2000035914A1 (en) 1998-12-14 1999-12-07 Optically active pyridyl-4h-1,2,4-oxadiazine derivative and its use in the treatment of vascular diseases

Publications (1)

Publication Number Publication Date
ATE266027T1 true ATE266027T1 (de) 2004-05-15

Family

ID=10991166

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99961225T ATE266027T1 (de) 1998-12-14 1999-12-07 Optisch aktives pyridyl-4h-1,2,4-oxadiazinderivat und seine verwendung zur behandlung von gefässkrankheiten

Country Status (27)

Country Link
US (1) US6384029B1 (de)
EP (1) EP1147105B1 (de)
JP (2) JP2002532498A (de)
KR (1) KR100661774B1 (de)
AT (1) ATE266027T1 (de)
AU (1) AU765336B2 (de)
BG (1) BG65179B1 (de)
BR (1) BR9913982A (de)
CA (1) CA2340734C (de)
CZ (1) CZ300764B6 (de)
DE (1) DE69917074T2 (de)
DK (1) DK1147105T3 (de)
EE (1) EE04551B1 (de)
ES (1) ES2219091T3 (de)
HR (1) HRP20010133B1 (de)
HU (1) HU226617B1 (de)
IL (1) IL141515A (de)
NO (1) NO317649B1 (de)
PL (1) PL196584B1 (de)
PT (1) PT1147105E (de)
RS (1) RS50129B (de)
RU (1) RU2222538C2 (de)
SI (1) SI1147105T1 (de)
SK (1) SK285582B6 (de)
UA (1) UA70340C2 (de)
WO (1) WO2000035914A1 (de)
ZA (1) ZA200101182B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2471752A1 (en) 2002-01-11 2003-07-17 Biorex Kutato Es Fejlesztoe Rt. Carboxamidine derivatives and their use in the treatment of vascular diseases
KR100678577B1 (ko) * 2006-09-11 2007-02-06 조만규 가정용 분전함
EP2484371B1 (de) 2008-06-26 2014-12-17 Orphazyme APS Verwendung von HSP70 als Regler der enzymatischen Aktivität
KR20110084514A (ko) 2008-11-18 2011-07-25 산텐 세이야꾸 가부시키가이샤 피리딘-3-카르발데히드 ｏ-(피페리딘-1-일-프로필)-옥심 유도체를 유효 성분으로서 함유하는 망맥락막 변성 질환의 치료제
RU2013125923A (ru) 2010-11-30 2015-01-10 Орфазиме Апс СПОСОБЫ УВЕЛИЧЕНИЯ ВНУТРИКЛЕТОЧНОЙ АКТИВНОСТИ Hsp70
HUP1100534A2 (en) 2011-09-26 2013-04-29 Balazs Dr Hazay Pharmaceutical composition for the treatment of muscle atrophy
US10709700B2 (en) 2014-09-15 2020-07-14 Orphazyme A/S Arimoclomol formulation
EP3442530A1 (de) 2016-04-13 2019-02-20 Orphazyme A/S Hitzeschockproteinen und cholesterinhomöostase
SI3448382T1 (sl) 2016-04-29 2021-03-31 Orphazyme A/S, c/o COBIS A/S Arimoclomol za zdravljenje motenj, povezanih z glukocerebrozidazo
JP2020520947A (ja) 2017-05-24 2020-07-16 オーファザイム エー／エス 熱ショックタンパク質誘導因子および前頭側頭障害
US20210164997A1 (en) 2018-05-28 2021-06-03 Orphazyme A/S Hsp70 protein levels in pbmc samples as biomarker for disease
WO2022106614A1 (en) 2020-11-19 2022-05-27 Orphazyme A/S Processes for preparing arimoclomol citrate and intermediates thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT395853B (de) * 1991-01-31 1993-03-25 Chem Pharm Forsch Gmbh Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung
HU222994B1 (hu) * 1995-11-02 2004-01-28 BIOREX Kutató és Fejlesztő Rt. Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
WO1997016349A1 (en) * 1995-11-03 1997-05-09 Global Trading Uk Limited Apparatus for dispensing and filling bags at a checkout counter of a supermarket
UA64716C2 (en) * 1996-08-09 2004-03-15 Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells

Also Published As

Publication number Publication date
BG65179B1 (bg) 2007-05-31
US6384029B1 (en) 2002-05-07
CA2340734C (en) 2008-10-21
AU765336B2 (en) 2003-09-18
SK2342001A3 (en) 2001-08-06
RS50129B (sr) 2009-03-25
JP2002532498A (ja) 2002-10-02
CZ300764B6 (cs) 2009-08-05
HU226617B1 (en) 2009-04-28
HRP20010133A2 (en) 2002-02-28
HUP9802897A2 (hu) 2000-11-28
DE69917074T2 (de) 2005-05-12
KR100661774B1 (ko) 2006-12-28
AU1790600A (en) 2000-07-03
EP1147105A1 (de) 2001-10-24
JP2011201916A (ja) 2011-10-13
EE04551B1 (et) 2005-10-17
NO20012310D0 (no) 2001-05-10
EE200100188A (et) 2002-08-15
IL141515A (en) 2005-09-25
EP1147105B1 (de) 2004-05-06
YU25001A (sh) 2004-07-15
JP5620340B2 (ja) 2014-11-05
KR20010073129A (ko) 2001-07-31
NO20012310L (no) 2001-05-10
RU2222538C2 (ru) 2004-01-27
SI1147105T1 (en) 2004-08-31
ES2219091T3 (es) 2004-11-16
CA2340734A1 (en) 2000-06-22
HU9802897D0 (en) 1999-02-01
HUP9802897A3 (en) 2001-08-28
BR9913982A (pt) 2001-06-12
NO317649B1 (no) 2004-11-29
PL196584B1 (pl) 2008-01-31
IL141515A0 (en) 2002-03-10
HRP20010133B1 (en) 2005-02-28
DK1147105T3 (da) 2004-06-01
ZA200101182B (en) 2002-02-12
UA70340C2 (en) 2004-10-15
CZ20011550A3 (cs) 2001-08-15
DE69917074D1 (de) 2004-06-09
SK285582B6 (sk) 2007-04-05
PT1147105E (pt) 2004-07-30
PL346767A1 (en) 2002-02-25
BG105342A (en) 2001-12-29
WO2000035914A1 (en) 2000-06-22

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