UA70340C2 - Optically active 5,6-dihydro-5-[(1-piperidinyl)-meoptically active 5,6-dihydro-5-[(1-piperidinyl)-methyl-3-(3-pyridyl)-4h-1,2,4-oxadiazine, a method fthyl-3-(3-pyridyl)-4h-1,2,4-oxadiazine, a method for the treatment and prevention of vascular diseasor the treatment and prevention of vascular diseases and a pharmaceutical composition es and a pharmaceutical composition - Google Patents

Optically active 5,6-dihydro-5-[(1-piperidinyl)-meoptically active 5,6-dihydro-5-[(1-piperidinyl)-methyl-3-(3-pyridyl)-4h-1,2,4-oxadiazine, a method fthyl-3-(3-pyridyl)-4h-1,2,4-oxadiazine, a method for the treatment and prevention of vascular diseasor the treatment and prevention of vascular diseases and a pharmaceutical composition es and a pharmaceutical composition Download PDF

Info

Publication number: UA70340C2
Authority: UA; Ukraine
Prior art keywords: piperidinyl; pyridyl; oxadiazine; dihydro; methyl
Prior art date: 1998-12-14

Application number

UA2001063850A

Other languages

English (en)

Ukrainian (uk)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-14

Filing date

1999-07-12

Publication date

2004-10-15

1999-07-12 Application filed filed Critical

2004-10-15 Publication of UA70340C2 publication Critical patent/UA70340C2/uk

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Heart & Thoracic Surgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

UA2001063850A 1998-12-14 1999-07-12 Optically active 5,6-dihydro-5-[(1-piperidinyl)-meoptically active 5,6-dihydro-5-[(1-piperidinyl)-methyl-3-(3-pyridyl)-4h-1,2,4-oxadiazine, a method fthyl-3-(3-pyridyl)-4h-1,2,4-oxadiazine, a method for the treatment and prevention of vascular diseasor the treatment and prevention of vascular diseases and a pharmaceutical composition es and a pharmaceutical composition UA70340C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU9802897A HU226617B1 (en)	1998-12-14	1998-12-14	Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient
PCT/HU1999/000095 WO2000035914A1 (en)	1998-12-14	1999-12-07	Optically active pyridyl-4h-1,2,4-oxadiazine derivative and its use in the treatment of vascular diseases

Publications (1)

Publication Number	Publication Date
UA70340C2 true UA70340C2 (en)	2004-10-15

Family

ID=10991166

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA2001063850A UA70340C2 (en)	1998-12-14	1999-07-12	Optically active 5,6-dihydro-5-[(1-piperidinyl)-meoptically active 5,6-dihydro-5-[(1-piperidinyl)-methyl-3-(3-pyridyl)-4h-1,2,4-oxadiazine, a method fthyl-3-(3-pyridyl)-4h-1,2,4-oxadiazine, a method for the treatment and prevention of vascular diseasor the treatment and prevention of vascular diseases and a pharmaceutical composition es and a pharmaceutical composition

Country Status (27)

Country	Link
US (1)	US6384029B1 (de)
EP (1)	EP1147105B1 (de)
JP (2)	JP2002532498A (de)
KR (1)	KR100661774B1 (de)
AT (1)	ATE266027T1 (de)
AU (1)	AU765336B2 (de)
BG (1)	BG65179B1 (de)
BR (1)	BR9913982A (de)
CA (1)	CA2340734C (de)
CZ (1)	CZ300764B6 (de)
DE (1)	DE69917074T2 (de)
DK (1)	DK1147105T3 (de)
EE (1)	EE04551B1 (de)
ES (1)	ES2219091T3 (de)
HR (1)	HRP20010133B1 (de)
HU (1)	HU226617B1 (de)
IL (1)	IL141515A (de)
NO (1)	NO317649B1 (de)
PL (1)	PL196584B1 (de)
PT (1)	PT1147105E (de)
RS (1)	RS50129B (de)
RU (1)	RU2222538C2 (de)
SI (1)	SI1147105T1 (de)
SK (1)	SK285582B6 (de)
UA (1)	UA70340C2 (de)
WO (1)	WO2000035914A1 (de)
ZA (1)	ZA200101182B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
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RU2320330C2 (ru)	2002-01-11	2008-03-27	СиУайТиАрЭкс КОРПОРЕЙШН	Производные карбоксамидина и их использование при лечении заболеваний сосудов
KR100678577B1 (ko) *	2006-09-11	2007-02-06	조만규	가정용 분전함
DK3578195T5 (da)	2008-06-26	2024-06-10	Zevra Denmark As	Anvendelse af Hsp70 som regulator af enzymatisk aktivitet
EP2356988A4 (de)	2008-11-18	2012-05-09	Santen Pharmaceutical Co Ltd	Therapeutikum für chorioretinale degeneration mit pyridin-3-carbaldehyd o-(piperidin-1-yl-propyl)-oxim-derivat als wirkstoff
WO2012072082A1 (en)	2010-11-30	2012-06-07	Orphazyme Aps	Methods for increasing intracellular activity of hsp70
HUP1100534A2 (en)	2011-09-26	2013-04-29	Balazs Dr Hazay	Pharmaceutical composition for the treatment of muscle atrophy
HUE054957T2 (hu)	2014-09-15	2021-10-28	Orphazyme As	Arimoklomol készítése
WO2017178029A1 (en)	2016-04-13	2017-10-19	Orphazyme Aps	Heat shock proteins and cholesterol homeostasis
CA3287846A1 (en)	2016-04-29	2025-11-29	Zevra Denmark A/S	Arimoclomol for treating glucocerebrosidase associated disorders
BR112019024667A2 (pt)	2017-05-24	2020-06-16	Orphazyme A/S	Uso de um agente bioativo, e, de uma composição
BR112020024182A2 (pt)	2018-05-28	2021-03-30	Orphazyme A/S	Métodos para detectar proteína de choque térmico 70, para diagnosticar uma doença apresentando um nível reduzido de proteína de choque térmico 70, para selecionar um paciente tendo uma doença apresentando um nível reduzido de hsp70, para monitorar progressão de doença em um indivíduo, para monitorar a eficácia de uma terapia para tratamento de uma doença, e, para ajustar a dosagem de um derivado de hidroxilamina de molécula pequena.
KR20230128462A (ko)	2020-11-19	2023-09-05	제브라 덴마크 에이/에스	아리모클로몰 시트레이트 및 이의 중간체를 제조하기 위한 공정

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT395853B (de) *	1991-01-31	1993-03-25	Chem Pharm Forsch Gmbh	Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung
HU222994B1 (hu) *	1995-11-02	2004-01-28	BIOREX Kutató és Fejlesztő Rt.	Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
EP0858413B1 (de) *	1995-11-03	2003-05-21	Summit Packaging Systems Limited	Vorrichtung zum abgeben und füllen von beuteln an einem kassenplatz eines supermarkts
UA64716C2 (en) *	1996-08-09	2004-03-15		Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells

1998
- 1998-12-14 HU HU9802897A patent/HU226617B1/hu not_active IP Right Cessation
1999
- 1999-07-12 UA UA2001063850A patent/UA70340C2/uk unknown
- 1999-12-07 AT AT99961225T patent/ATE266027T1/de active
- 1999-12-07 BR BR9913982-0A patent/BR9913982A/pt not_active Application Discontinuation
- 1999-12-07 DK DK99961225T patent/DK1147105T3/da active
- 1999-12-07 US US09/762,949 patent/US6384029B1/en not_active Expired - Lifetime
- 1999-12-07 AU AU17906/00A patent/AU765336B2/en not_active Expired
- 1999-12-07 SI SI9930566T patent/SI1147105T1/xx unknown
- 1999-12-07 ES ES99961225T patent/ES2219091T3/es not_active Expired - Lifetime
- 1999-12-07 KR KR1020017002870A patent/KR100661774B1/ko not_active Expired - Fee Related
- 1999-12-07 DE DE69917074T patent/DE69917074T2/de not_active Expired - Lifetime
- 1999-12-07 CZ CZ20011550A patent/CZ300764B6/cs not_active IP Right Cessation
- 1999-12-07 EP EP99961225A patent/EP1147105B1/de not_active Expired - Lifetime
- 1999-12-07 PT PT99961225T patent/PT1147105E/pt unknown
- 1999-12-07 HR HR20010133A patent/HRP20010133B1/xx not_active IP Right Cessation
- 1999-12-07 SK SK234-2001A patent/SK285582B6/sk not_active IP Right Cessation
- 1999-12-07 RS YUP-250/01A patent/RS50129B/sr unknown
- 1999-12-07 JP JP2000588174A patent/JP2002532498A/ja not_active Withdrawn
- 1999-12-07 RU RU2001118854/04A patent/RU2222538C2/ru not_active IP Right Cessation
- 1999-12-07 PL PL346767A patent/PL196584B1/pl not_active IP Right Cessation
- 1999-12-07 WO PCT/HU1999/000095 patent/WO2000035914A1/en not_active Ceased
- 1999-12-07 EE EEP200100188A patent/EE04551B1/xx not_active IP Right Cessation
- 1999-12-07 CA CA002340734A patent/CA2340734C/en not_active Expired - Lifetime
- 1999-12-07 IL IL14151599A patent/IL141515A/xx not_active IP Right Cessation
2001
- 2001-02-12 ZA ZA200101182A patent/ZA200101182B/en unknown
- 2001-03-14 BG BG105342A patent/BG65179B1/bg unknown
- 2001-05-10 NO NO20012310A patent/NO317649B1/no not_active IP Right Cessation
2011
- 2011-06-08 JP JP2011128516A patent/JP5620340B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IL141515A (en)	2005-09-25
AU1790600A (en)	2000-07-03
CZ300764B6 (cs)	2009-08-05
YU25001A (sh)	2004-07-15
EP1147105B1 (de)	2004-05-06
ZA200101182B (en)	2002-02-12
EE04551B1 (et)	2005-10-17
NO317649B1 (no)	2004-11-29
RS50129B (sr)	2009-03-25
JP2002532498A (ja)	2002-10-02
NO20012310L (no)	2001-05-10
PT1147105E (pt)	2004-07-30
AU765336B2 (en)	2003-09-18
US6384029B1 (en)	2002-05-07
PL346767A1 (en)	2002-02-25
KR100661774B1 (ko)	2006-12-28
HU226617B1 (en)	2009-04-28
DE69917074D1 (de)	2004-06-09
SK2342001A3 (en)	2001-08-06
BG65179B1 (bg)	2007-05-31
CA2340734C (en)	2008-10-21
CA2340734A1 (en)	2000-06-22
SK285582B6 (sk)	2007-04-05
HRP20010133B1 (en)	2005-02-28
BG105342A (en)	2001-12-29
RU2222538C2 (ru)	2004-01-27
SI1147105T1 (en)	2004-08-31
PL196584B1 (pl)	2008-01-31
ATE266027T1 (de)	2004-05-15
NO20012310D0 (no)	2001-05-10
HRP20010133A2 (en)	2002-02-28
JP5620340B2 (ja)	2014-11-05
DE69917074T2 (de)	2005-05-12
IL141515A0 (en)	2002-03-10
DK1147105T3 (da)	2004-06-01
JP2011201916A (ja)	2011-10-13
HUP9802897A2 (hu)	2000-11-28
CZ20011550A3 (cs)	2001-08-15
EP1147105A1 (de)	2001-10-24
ES2219091T3 (es)	2004-11-16
EE200100188A (et)	2002-08-15
HU9802897D0 (en)	1999-02-01
HUP9802897A3 (en)	2001-08-28
KR20010073129A (ko)	2001-07-31
WO2000035914A1 (en)	2000-06-22
BR9913982A (pt)	2001-06-12

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JP2011201916A5 (de)	2012-08-02
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US11427542B2 (en)	2022-08-30	Compounds for treatment of cardiac arrhythmias and heart failure
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