ATE266622T1 - Industrielles verfahren zur herstellung von l- carnitin - Google Patents

Industrielles verfahren zur herstellung von l- carnitin

Info

Publication number: ATE266622T1
Authority: AT; Austria
Prior art keywords: carnitine; chloro; reduction; producing; substrate
Prior art date: 1998-11-16

Application number

AT99956324T

Other languages

English (en)

Inventor

Maria Ornella Tinti

Oreste Piccolo

Fausto Bonifacio

Cristina Crescenzi

Sergio Penco

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-16

Filing date

1999-11-12

Publication date

2004-05-15

1999-11-12 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

2004-05-15 Application granted granted Critical

2004-05-15 Publication of ATE266622T1 publication Critical patent/ATE266622T1/de

Links

PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title abstract 4
238000004519 manufacturing process Methods 0.000 title 1
238000006722 reduction reaction Methods 0.000 abstract 3
239000003054 catalyst Substances 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
239000000758 substrate Substances 0.000 abstract 2
GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 abstract 2
VCPNLOMAQUZMBY-UHFFFAOYSA-N 4-chloro-3-oxobutanamide Chemical compound NC(=O)CC(=O)CCl VCPNLOMAQUZMBY-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 abstract 1
-1 alkyl 4-chloro-3-oxobutyrate Chemical compound 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
238000009776 industrial production Methods 0.000 abstract 1
229910052707 ruthenium Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
General Factory Administration (AREA)
Automobile Manufacture Line, Endless Track Vehicle, Trailer (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Catalysts (AREA)

AT99956324T 1998-11-16 1999-11-12 Industrielles verfahren zur herstellung von l- carnitin ATE266622T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1998MI002477A IT1303757B1 (it)	1998-11-16	1998-11-16	Processo industriale per la produzione di l-carnitina.
PCT/IT1999/000365 WO2000029370A1 (en)	1998-11-16	1999-11-12	Industrial process for the production of l-carnitine

Publications (1)

Publication Number	Publication Date
ATE266622T1 true ATE266622T1 (de)	2004-05-15

Family

ID=11381066

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99956324T ATE266622T1 (de)	1998-11-16	1999-11-12	Industrielles verfahren zur herstellung von l- carnitin

Country Status (14)

Country	Link
US (1)	US6566552B2 (de)
EP (1)	EP1131279B1 (de)
JP (1)	JP2002529528A (de)
KR (1)	KR100575605B1 (de)
CN (1)	CN1255375C (de)
AT (1)	ATE266622T1 (de)
AU (1)	AU1295300A (de)
CA (1)	CA2349536A1 (de)
DE (1)	DE69917318T2 (de)
DK (1)	DK1131279T3 (de)
ES (1)	ES2220128T3 (de)
IT (1)	IT1303757B1 (de)
PT (1)	PT1131279E (de)
WO (1)	WO2000029370A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100449750B1 (ko) *	2001-12-13	2004-09-22	화일약품주식회사	라세믹 알킬 4-클로로-3-히드록시부티레이트의 제조방법
GB0211716D0 (en) *	2002-05-22	2002-07-03	Phoenix Chemicals Ltd	Process
US7629470B2 (en)	2004-07-08	2009-12-08	Merck & Co., Inc.	Formation of tetra-substituted enamides and stereoselective reduction thereof
US7422653B2 (en) *	2004-07-13	2008-09-09	Applied Materials, Inc.	Single-sided inflatable vertical slit valve
CN100348573C (zh) *	2004-07-28	2007-11-14	香港理工大学	一种制备l－肉碱的方法
US7927346B2 (en) *	2004-09-10	2011-04-19	Stryker Corporation	Diversion device to increase cerebral blood flow
CN1312118C (zh) *	2004-11-10	2007-04-25	浙江大学	肉碱的合成工艺
KR101097006B1 (ko)	2006-11-09	2011-12-20	미츠비시 레이온 가부시키가이샤	베타인의 제조 방법
TWI400223B (zh) *	2007-11-16	2013-07-01	Lonza Ag	製備甜菜鹼的方法
JP2010119357A (ja) *	2008-11-21	2010-06-03	Mitsubishi Rayon Co Ltd	光学活性４−ハロ−３−ヒドロキシブチルアミド及び光学活性カルニチンアミドの製造方法
EP2386536A1 (de)	2010-05-11	2011-11-16	Lonza Ltd.	Prozess zur Hydrogenierung von Ketoestern
CN101875616B (zh) *	2010-06-12	2012-11-21	胡建荣	一种左卡尼汀化合物及其制法
KR20160037031A (ko)	2014-09-26	2016-04-05	엔자이텍 주식회사	라세믹 또는 광학적으로 활성이 있는 D 또는 L-α-글리세로포스포릴콜린 고체의 제조방법
CN108912022A (zh) *	2018-07-26	2018-11-30	湖北吉和昌化工科技有限公司	一种聚二硫二丙烷磺酸钠的提纯方法
CN111592466B (zh)	2020-06-05	2022-08-19	复旦大学	一种左卡尼汀的微反应连续流合成方法
CN116655481B (zh) *	2023-06-14	2023-11-28	海南卓科制药有限公司	一种工业化合成左卡尼汀的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0699367B2 (ja) *	1987-06-11	1994-12-07	高砂香料工業株式会社	光学活性アルコ−ルの製法
JPH0678277B2 (ja) *	1988-02-19	1994-10-05	高砂香料工業株式会社	光学活性アルコールおよびその誘導体の製造方法
JPH0641445B2 (ja) *	1988-12-22	1994-06-01	高砂香料工業株式会社	光学活性カルニチンエステルの製法
FR2693190B1 (fr) *	1992-07-02	1994-09-23	Elf Aquitaine	Procédé d'hydrogénation énantiosélectif de la double liaison C=O OXO.
DE4330730A1 (de) *	1993-09-10	1995-03-16	Bayer Ag	Neue Bisphosphine für asymmetrische Hydrierkatalysatoren
IT1270082B (it) *	1994-07-12	1997-04-28	Univ Degli Studi Milano	Difosfine eteroaromatiche come leganti chirali, complessi tra dette difosfine e metalli di transizione ed impiego di detti complessi come catalizzatori chirali
JP3652394B2 (ja) *	1995-01-27	2005-05-25	高砂香料工業株式会社	Ｎ−置換−７−アミノ−５−ヒドロキシ−３−オキソヘプタン酸誘導体およびその製造法
US5614031A (en)	1995-05-11	1997-03-25	Cushing; Ernest W.	Method and apparatus for washing a fibrous mat
IT1299068B1 (it) *	1998-04-10	2000-02-07	Chemi Spa	Legandi fosforati chirali e loro complessi organometallici, utili come catalizzatori in sintesi stereoselettive

1998
- 1998-11-16 IT IT1998MI002477A patent/IT1303757B1/it active
1999
- 1999-11-12 PT PT99956324T patent/PT1131279E/pt unknown
- 1999-11-12 AT AT99956324T patent/ATE266622T1/de not_active IP Right Cessation
- 1999-11-12 KR KR1020017005577A patent/KR100575605B1/ko not_active Expired - Fee Related
- 1999-11-12 CA CA002349536A patent/CA2349536A1/en not_active Abandoned
- 1999-11-12 WO PCT/IT1999/000365 patent/WO2000029370A1/en not_active Ceased
- 1999-11-12 CN CNB998133655A patent/CN1255375C/zh not_active Expired - Fee Related
- 1999-11-12 DK DK99956324T patent/DK1131279T3/da active
- 1999-11-12 DE DE69917318T patent/DE69917318T2/de not_active Expired - Fee Related
- 1999-11-12 EP EP99956324A patent/EP1131279B1/de not_active Expired - Lifetime
- 1999-11-12 ES ES99956324T patent/ES2220128T3/es not_active Expired - Lifetime
- 1999-11-12 AU AU12953/00A patent/AU1295300A/en not_active Abandoned
- 1999-11-12 JP JP2000582358A patent/JP2002529528A/ja active Pending
2001
- 2001-05-07 US US09/849,363 patent/US6566552B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1131279B1 (de)	2004-05-12
CN1326435A (zh)	2001-12-12
US6566552B2 (en)	2003-05-20
ES2220128T3 (es)	2004-12-01
US20020165408A1 (en)	2002-11-07
KR100575605B1 (ko)	2006-05-02
AU1295300A (en)	2000-06-05
DE69917318T2 (de)	2005-06-02
CN1255375C (zh)	2006-05-10
CA2349536A1 (en)	2000-05-25
JP2002529528A (ja)	2002-09-10
EP1131279A1 (de)	2001-09-12
DE69917318D1 (de)	2004-06-17
DK1131279T3 (da)	2004-09-20
ITMI982477A1 (it)	2000-05-16
WO2000029370A1 (en)	2000-05-25
KR20010080380A (ko)	2001-08-22
PT1131279E (pt)	2004-09-30
IT1303757B1 (it)	2001-02-23

Legal Events

Date

Code

Title

Description

2004-12-15

UEP

Publication of translation of european patent specification

Ref document number: 1131279

Country of ref document: EP

2009-08-15

REN

Ceased due to non-payment of the annual fee

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