ATE267193T1 - Neue pyridazine als endothelin-antagonisten - Google Patents

Neue pyridazine als endothelin-antagonisten

Info

Publication number: ATE267193T1
Authority: AT; Austria
Prior art keywords: endothelin antagonists; new pyridazine; endothelin; pyridazine; new
Prior art date: 2000-09-20

Application number

AT01307528T

Other languages

English (en)

Inventor

Bernard Joseph Banks

Nathan Anthony Logan Chubb

Douglas James Critcher

James John Eshelby

Darren John Schulz

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-09-20

Filing date

2001-09-05

Publication date

2004-06-15

2001-09-05 Application filed by Pfizer filed Critical Pfizer

2004-06-15 Application granted granted Critical

2004-06-15 Publication of ATE267193T1 publication Critical patent/ATE267193T1/de

Links

102000002045 Endothelin Human genes 0.000 title abstract 2
108050009340 Endothelin Proteins 0.000 title abstract 2
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title abstract 2
239000005557 antagonist Substances 0.000 title 1
PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 title 1
102000010180 Endothelin receptor Human genes 0.000 abstract 1
108050001739 Endothelin receptor Proteins 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Gynecology & Obstetrics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Diaphragms For Electromechanical Transducers (AREA)

AT01307528T 2000-09-20 2001-09-05 Neue pyridazine als endothelin-antagonisten ATE267193T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0023074.8A GB0023074D0 (en)	2000-09-20	2000-09-20	Pyridazines

Publications (1)

Publication Number	Publication Date
ATE267193T1 true ATE267193T1 (de)	2004-06-15

Family

ID=9899818

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01307528T ATE267193T1 (de)	2000-09-20	2001-09-05	Neue pyridazine als endothelin-antagonisten

Country Status (12)

Country	Link
EP (1)	EP1191026B1 (de)
JP (1)	JP3545735B2 (de)
AT (1)	ATE267193T1 (de)
BR (1)	BR0104141A (de)
CA (1)	CA2357687C (de)
DE (1)	DE60103342T2 (de)
DK (1)	DK1191026T3 (de)
ES (1)	ES2220677T3 (de)
GB (1)	GB0023074D0 (de)
MX (1)	MXPA01009174A (de)
PT (1)	PT1191026E (de)
TR (1)	TR200401185T4 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2471220C (en)	2002-01-02	2010-11-16	Actelion Pharmaceuticals Ltd	Novel alkansulfonamides as endothelin antagonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3379544D1 (en) *	1982-06-08	1989-05-11	Ciba Geigy Ag	2-phenyl-2-naphthyl and 2-heterocyclic pyrimidines as antidotes for protecting cultured plants before phytotoxic damages caused by herbicides
US5707966A (en) *	1994-03-04	1998-01-13	Eli Lilly And Company	Antithrombotic agents
DE19537548A1 (de) *	1995-10-09	1997-04-10	Merck Patent Gmbh	Endothelin-Rezeptor-Antagonisten
JP3087968B2 (ja) *	1995-12-20	2000-09-18	山之内製薬株式会社	アリールエテンスルホンアミド誘導体及びその医薬組成物

2000
- 2000-09-20 GB GBGB0023074.8A patent/GB0023074D0/en not_active Ceased
2001
- 2001-09-05 PT PT01307528T patent/PT1191026E/pt unknown
- 2001-09-05 AT AT01307528T patent/ATE267193T1/de not_active IP Right Cessation
- 2001-09-05 ES ES01307528T patent/ES2220677T3/es not_active Expired - Lifetime
- 2001-09-05 DK DK01307528T patent/DK1191026T3/da active
- 2001-09-05 EP EP01307528A patent/EP1191026B1/de not_active Expired - Lifetime
- 2001-09-05 TR TR2004/01185T patent/TR200401185T4/xx unknown
- 2001-09-05 DE DE60103342T patent/DE60103342T2/de not_active Expired - Fee Related
- 2001-09-11 MX MXPA01009174A patent/MXPA01009174A/es active IP Right Grant
- 2001-09-18 CA CA002357687A patent/CA2357687C/en not_active Expired - Fee Related
- 2001-09-19 JP JP2001285183A patent/JP3545735B2/ja not_active Expired - Fee Related
- 2001-09-19 BR BR0104141-0A patent/BR0104141A/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT1191026E (pt)	2004-10-29
EP1191026A1 (de)	2002-03-27
DE60103342T2 (de)	2004-09-23
JP3545735B2 (ja)	2004-07-21
BR0104141A (pt)	2002-07-09
MXPA01009174A (es)	2004-10-15
CA2357687C (en)	2006-03-14
DE60103342D1 (de)	2004-06-24
CA2357687A1 (en)	2002-03-20
JP2002128780A (ja)	2002-05-09
ES2220677T3 (es)	2004-12-16
GB0023074D0 (en)	2000-11-01
DK1191026T3 (da)	2004-06-28
EP1191026B1 (de)	2004-05-19
TR200401185T4 (tr)	2004-06-21

Legal Events

Date

Code

Title

Description

2005-11-15

UEP

Publication of translation of european patent specification

Ref document number: 1191026

Country of ref document: EP

2008-06-15

REN

Ceased due to non-payment of the annual fee

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