TR200401185T4 - Yeni piridazin endotelin antagonistleri - Google Patents
Yeni piridazin endotelin antagonistleriInfo
- Publication number
- TR200401185T4 TR200401185T4 TR2004/01185T TR200401185T TR200401185T4 TR 200401185 T4 TR200401185 T4 TR 200401185T4 TR 2004/01185 T TR2004/01185 T TR 2004/01185T TR 200401185 T TR200401185 T TR 200401185T TR 200401185 T4 TR200401185 T4 TR 200401185T4
- Authority
- TR
- Turkey
- Prior art keywords
- endothelin antagonists
- new pyridazine
- endothelin
- pyridazine
- new
- Prior art date
Links
- 102000002045 Endothelin Human genes 0.000 title abstract 2
- 108050009340 Endothelin Proteins 0.000 title abstract 2
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 title 1
- 102000010180 Endothelin receptor Human genes 0.000 abstract 1
- 108050001739 Endothelin receptor Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
Abstract
Endotelin reseptörlerine yakinlik gösteren formül (I) bilesikleri, ETa için ETb'den fazla seçicidirler ve endotelinin aracilik ettigi durumlarin tedavisinde potansiyel olarak kullanilirlar. Formül (I)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0023074.8A GB0023074D0 (en) | 2000-09-20 | 2000-09-20 | Pyridazines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200401185T4 true TR200401185T4 (tr) | 2004-06-21 |
Family
ID=9899818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2004/01185T TR200401185T4 (tr) | 2000-09-20 | 2001-09-05 | Yeni piridazin endotelin antagonistleri |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1191026B1 (tr) |
| JP (1) | JP3545735B2 (tr) |
| AT (1) | ATE267193T1 (tr) |
| BR (1) | BR0104141A (tr) |
| CA (1) | CA2357687C (tr) |
| DE (1) | DE60103342T2 (tr) |
| DK (1) | DK1191026T3 (tr) |
| ES (1) | ES2220677T3 (tr) |
| GB (1) | GB0023074D0 (tr) |
| MX (1) | MXPA01009174A (tr) |
| PT (1) | PT1191026E (tr) |
| TR (1) | TR200401185T4 (tr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7323465B2 (en) * | 2002-01-02 | 2008-01-29 | Actelion Pharmaceuticals Ltd. | Alkansulfonamides as endothelin antagonists |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0096657B1 (de) * | 1982-06-08 | 1989-04-05 | Ciba-Geigy Ag | 2-Phenyl-, 2-Naphthyl- und 2-Heterocyclylpyrimidine als Gegenmittel zum Schützen von Kulturpflanzen vor durch Herbizide verursachte phytotoxische Schäden |
| US5707966A (en) * | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
| DE19537548A1 (de) * | 1995-10-09 | 1997-04-10 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
| WO1997022595A1 (en) * | 1995-12-20 | 1997-06-26 | Yamanouchi Pharmaceutical Co., Ltd. | Arylethenesulfonamide derivatives and drug composition containing the same |
-
2000
- 2000-09-20 GB GBGB0023074.8A patent/GB0023074D0/en not_active Ceased
-
2001
- 2001-09-05 AT AT01307528T patent/ATE267193T1/de not_active IP Right Cessation
- 2001-09-05 ES ES01307528T patent/ES2220677T3/es not_active Expired - Lifetime
- 2001-09-05 PT PT01307528T patent/PT1191026E/pt unknown
- 2001-09-05 DK DK01307528T patent/DK1191026T3/da active
- 2001-09-05 EP EP01307528A patent/EP1191026B1/en not_active Expired - Lifetime
- 2001-09-05 DE DE60103342T patent/DE60103342T2/de not_active Expired - Fee Related
- 2001-09-05 TR TR2004/01185T patent/TR200401185T4/tr unknown
- 2001-09-11 MX MXPA01009174A patent/MXPA01009174A/es active IP Right Grant
- 2001-09-18 CA CA002357687A patent/CA2357687C/en not_active Expired - Fee Related
- 2001-09-19 BR BR0104141-0A patent/BR0104141A/pt not_active IP Right Cessation
- 2001-09-19 JP JP2001285183A patent/JP3545735B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002128780A (ja) | 2002-05-09 |
| ATE267193T1 (de) | 2004-06-15 |
| PT1191026E (pt) | 2004-10-29 |
| ES2220677T3 (es) | 2004-12-16 |
| BR0104141A (pt) | 2002-07-09 |
| MXPA01009174A (es) | 2004-10-15 |
| JP3545735B2 (ja) | 2004-07-21 |
| DK1191026T3 (da) | 2004-06-28 |
| GB0023074D0 (en) | 2000-11-01 |
| EP1191026A1 (en) | 2002-03-27 |
| EP1191026B1 (en) | 2004-05-19 |
| DE60103342T2 (de) | 2004-09-23 |
| CA2357687A1 (en) | 2002-03-20 |
| DE60103342D1 (de) | 2004-06-24 |
| CA2357687C (en) | 2006-03-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE314371T1 (de) | Spiro-indole als y5-rezeptor antagonisten | |
| EA200201119A1 (ru) | Лиганды меланокортиновых рецепторов | |
| ATE470662T1 (de) | Piperazinylpyrazinverbindungen als agonisten oder antagonisten am serotonin-5ht-2-rezeptor | |
| DE60126785D1 (de) | Nicht-imidazol aryloxypiperidine als h3 rezeptor liganden | |
| ATE268324T1 (de) | 4-amino substituierte -2-subsituierte-1,2,3,4- tetrahydrochinoline als cetp inhibitoren | |
| BRPI0413022A (pt) | derivados de 3-amino cromado e 2-amino tetralina | |
| DE60020595D1 (de) | 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p38-kinase-inhibitoren | |
| DE602005012634D1 (en) | Arylsulfonylnaphthalinderivate als 5ht2a-antagonisten | |
| MXPA02012076A (es) | Compuestos quimicos. | |
| MXPA03002911A (es) | Compuestos quimicos. | |
| MXPA02012659A (es) | Derivados de pirazindiona condensados. | |
| DE50208918D1 (de) | 6-aminomorphinanderivate, herstellungsverfahren dafür und deren verwendung | |
| ATE297903T1 (de) | Substituierte phenyluracile | |
| DE60015599D1 (de) | 3,4-DIHYDRO-(1H)CHINAZOLIN-2-ON-VERBINDUNGEN ALS CSBP/p38-KINASE-INHIBITOREN | |
| BRPI0408117A (pt) | compostos heterocìclicos bifuncionais e métodos de produção e uso dos mesmos | |
| DE60121048D1 (de) | PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE | |
| DK1204659T3 (da) | Serotonerge benzofuraner | |
| NO20031033D0 (no) | Reseptor i EDb-fibronectindomene | |
| BR9713176A (pt) | Benzotiofenos amorfos,métodos de preparação e métodos de uso | |
| MXPA02012400A (es) | Heterociclos hetaril-substituidos. | |
| BR0102150A (pt) | Isoxazol-sulfonamidas antagonistas de endotelina | |
| BR0316544A (pt) | Compostos calcilìticos | |
| ATE401388T1 (de) | Protomikroemulsion, diese enthaltendes reinigungsgerät und verwendung von diesen | |
| DE10108995A1 (de) | Substituierte Pyrimidinon-Derivate als Liganden von Integrinrezeptoren | |
| ATE267193T1 (de) | Neue pyridazine als endothelin-antagonisten |