ATE267584T1 - Thermosensitive biologisch abbaubare polymere auf basis von poly(ester-ester)blockcopolymeren - Google Patents

Thermosensitive biologisch abbaubare polymere auf basis von poly(ester-ester)blockcopolymeren

Info

Publication number
ATE267584T1
ATE267584T1 AT96937727T AT96937727T ATE267584T1 AT E267584 T1 ATE267584 T1 AT E267584T1 AT 96937727 T AT96937727 T AT 96937727T AT 96937727 T AT96937727 T AT 96937727T AT E267584 T1 ATE267584 T1 AT E267584T1
Authority
AT
Austria
Prior art keywords
ester
poly
block copolymers
biodegradable polymers
polymers based
Prior art date
Application number
AT96937727T
Other languages
English (en)
Inventor
Younsik Cha
Young Kweon Choi
You Han Bae
Original Assignee
Macromed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macromed Inc filed Critical Macromed Inc
Application granted granted Critical
Publication of ATE267584T1 publication Critical patent/ATE267584T1/de

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1858Platelet-derived growth factor [PDGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/2013IL-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/225Calcitonin gene related peptide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT96937727T 1995-10-25 1996-10-25 Thermosensitive biologisch abbaubare polymere auf basis von poly(ester-ester)blockcopolymeren ATE267584T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/548,185 US5702717A (en) 1995-10-25 1995-10-25 Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
PCT/US1996/017023 WO1997015287A1 (en) 1995-10-25 1996-10-25 Thermosensitive biodegradable polymers based on poly(ether-ester) block copolymers

Publications (1)

Publication Number Publication Date
ATE267584T1 true ATE267584T1 (de) 2004-06-15

Family

ID=24187770

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96937727T ATE267584T1 (de) 1995-10-25 1996-10-25 Thermosensitive biologisch abbaubare polymere auf basis von poly(ester-ester)blockcopolymeren

Country Status (10)

Country Link
US (1) US5702717A (de)
EP (1) EP0863745B1 (de)
JP (1) JP4187789B2 (de)
KR (1) KR100447244B1 (de)
AR (1) AR004522A1 (de)
AT (1) ATE267584T1 (de)
AU (1) AU7520096A (de)
DE (1) DE69632593D1 (de)
WO (1) WO1997015287A1 (de)
ZA (1) ZA968944B (de)

Families Citing this family (268)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
IL110787A0 (en) * 1993-08-27 1994-11-11 Sandoz Ag Biodegradable polymer, its preparation and pharmaceutical composition containing it
US5817327A (en) * 1994-07-27 1998-10-06 The Trustees Of The University Of Pennsylvania Incorporation of biologically active molecules into bioactive glasses
WO1997005185A2 (en) 1995-07-28 1997-02-13 Focal, Inc. Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatment agents
KR0180334B1 (ko) 1995-09-21 1999-03-20 김윤 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법
US6600029B1 (en) 1995-12-19 2003-07-29 Regents Of The University Of Minnesota Metabolic engineering of polyhydroxyalkanoate monomer synthases
DE69734060T2 (de) * 1996-05-24 2006-06-29 Angiotech Pharmaceuticals, Inc., Vancouver Zubereitungen und verfahren zur behandlung oder prävention von krankheiten der körperpassagewege
US8728536B2 (en) 1996-10-16 2014-05-20 Etex Corporation Chemotherapeutic composition using nanocrystalline calcium phosphate paste
JP4642946B2 (ja) * 1996-12-20 2011-03-02 アルザ コーポレイション ゲル組成物および方法
EP0986402A2 (de) 1997-06-06 2000-03-22 Battelle Memorial Institute Reversibles gelbindendes copolymer und verfahren
EP1034207B1 (de) * 1997-10-03 2005-03-02 Macromed Inc. Biologisch abbaubare triblock-poly(lactide-co-glycolide)-polyethylenglycol-copolymere mit umgekehrter thermischer gelierung
US6201072B1 (en) * 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6117949A (en) * 1998-10-01 2000-09-12 Macromed, Inc. Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US20020164374A1 (en) * 1997-10-29 2002-11-07 John Jackson Polymeric systems for drug delivery and uses thereof
AU1819499A (en) * 1997-12-12 1999-06-28 Samyang Corporation Positively-charged poly{alpha-(omega-aminoalkyl)glycolic acid} for the delivery of a bioactive agent via tissue and cellular uptake
US6733767B2 (en) 1998-03-19 2004-05-11 Merck & Co., Inc. Liquid polymeric compositions for controlled release of bioactive substances
US7087244B2 (en) * 2000-09-28 2006-08-08 Battelle Memorial Institute Thermogelling oligopeptide polymers
US20040228794A1 (en) * 1998-04-10 2004-11-18 Battelle Memorial Institute Therapeutic agent carrier compositions
US6841617B2 (en) * 2000-09-28 2005-01-11 Battelle Memorial Institute Thermogelling biodegradable aqueous polymer solution
US6296831B1 (en) * 1998-04-10 2001-10-02 Battelle Memorial Institute Stimulus sensitive gel with radioisotope and methods of making
US6265202B1 (en) 1998-06-26 2001-07-24 Regents Of The University Of Minnesota DNA encoding methymycin and pikromycin
US6541033B1 (en) * 1998-06-30 2003-04-01 Amgen Inc. Thermosensitive biodegradable hydrogels for sustained delivery of leptin
WO2000000222A1 (en) * 1998-06-30 2000-01-06 Amgen Inc. Thermosensitive biodegradable hydrogels for sustained delivery of biologically active agents
EP1109563A4 (de) 1998-08-04 2009-07-22 Madash Llp Am ende modifizierte hydrogele mit temperaturabhängigen eigenschaften
US6514534B1 (en) * 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
KR100274842B1 (ko) * 1998-10-01 2001-03-02 김효근 미립구를 이용한 레티노익산의 서방형 약물방출 시스템
BR9915548A (pt) * 1998-10-16 2001-08-14 Biogen Inc Proteìnas de fusão de interferon-beta e usos
HU229888B1 (en) 1998-10-16 2014-11-28 Biogen Idec Ma Inc Cambridge Polymer conjugates of interferon betha-1a and uses
US6451346B1 (en) * 1998-12-23 2002-09-17 Amgen Inc Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
US6245740B1 (en) * 1998-12-23 2001-06-12 Amgen Inc. Polyol:oil suspensions for the sustained release of proteins
KR100288103B1 (ko) 1998-12-26 2001-05-02 윤덕용 폴리에테르가 그라프트된 생분해성 지방족 폴리에스테르 및 그의 제조방법
US6241918B1 (en) 1998-12-28 2001-06-05 Johnson & Johnson Vision Care, Inc. Process of manufacturing contact lenses in ambient environment
US6958212B1 (en) 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
DK1181323T3 (da) 1999-02-01 2011-10-17 Eidgenoess Tech Hochschule Biomaterialer dannet med nukleofil additionsreaktion med konjugerede uimættede grupper
DE19908753C2 (de) 1999-02-20 2003-10-02 Jenapharm Gmbh Bioabbaubare, injizierbare Oligomer-Polymer-Zusammensetzung
AU3867400A (en) 1999-03-19 2000-10-09 Duke University Methods of using bioelastomers
US6287588B1 (en) * 1999-04-29 2001-09-11 Macromed, Inc. Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof
US6521431B1 (en) * 1999-06-22 2003-02-18 Access Pharmaceuticals, Inc. Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments
US6541020B1 (en) * 1999-07-09 2003-04-01 Trimeris, Inc. Methods and compositions for administration of therapeutic reagents
US7425581B2 (en) * 1999-07-30 2008-09-16 Universiteit Utrecht Temperature sensitive polymers
WO2001010482A1 (en) 1999-08-05 2001-02-15 Biocardia, Inc. A system and method for delivering thermally sensitive and reverse-thermal gelation matrials
KR100360827B1 (ko) * 1999-08-14 2002-11-18 주식회사 삼양사 난용성 약물을 가용화하기 위한 고분자 조성물 및 그의 제조방법
US20020055708A1 (en) * 1999-09-24 2002-05-09 Peterson Kenneth R. Coupling syringe system and methods for obtaining a mixed composition
US8226598B2 (en) * 1999-09-24 2012-07-24 Tolmar Therapeutics, Inc. Coupling syringe system and methods for obtaining a mixed composition
AU1792601A (en) * 1999-12-07 2001-06-18 Amgen, Inc. Thermosensitive biodegradable hydrogels based on low molecular weight pluronics
KR100416242B1 (ko) * 1999-12-22 2004-01-31 주식회사 삼양사 약물전달체용 생분해성 블록 공중합체의 액체 조성물 및이의 제조방법
US7097855B1 (en) 2000-01-31 2006-08-29 Massachusetts Institute Of Technology Transdermal thermal polymerization
KR100358027B1 (ko) * 2000-02-14 2002-10-25 한국과학기술연구원 의료용 생분해성 삼중블록 공중합체 및 그의 제조 방법
CA2427543A1 (en) * 2000-03-15 2004-11-02 Yu-Ling Cheng Thermally reversible implant and filler
US20030211974A1 (en) * 2000-03-21 2003-11-13 Brodbeck Kevin J. Gel composition and methods
KR100434439B1 (ko) * 2000-04-11 2004-06-04 이재민 폴리 블록 코폴리머로 안정화한 물/오일/물 다중 에멀젼의제조 방법
EP2213743A1 (de) 2000-04-12 2010-08-04 Human Genome Sciences, Inc. Albuminfusionsproteine
US6589549B2 (en) 2000-04-27 2003-07-08 Macromed, Incorporated Bioactive agent delivering system comprised of microparticles within a biodegradable to improve release profiles
US7018645B1 (en) * 2000-04-27 2006-03-28 Macromed, Inc. Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties
CA2408548C (en) * 2000-05-12 2008-03-11 Samyang Corporation Method for the preparation of polymeric micelle via phase separation of block copolymer
US6723814B2 (en) * 2000-05-16 2004-04-20 Biocure, Inc. Amphiphilic copolymer planar membranes
US7217770B2 (en) * 2000-05-17 2007-05-15 Samyang Corporation Stable polymeric micelle-type drug composition and method for the preparation thereof
JP2001329183A (ja) * 2000-05-22 2001-11-27 Yuichi Mori ゲル化性組成物
US7291673B2 (en) * 2000-06-02 2007-11-06 Eidgenossiche Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
MXPA02011891A (es) * 2000-06-02 2004-04-02 Eidgenoess Tech Hochschule Reacciones de adicion conjugadas para la entrega controlada de compuestos farmaceuticamente activos.
US7767197B2 (en) 2000-06-22 2010-08-03 Endo Pharmaceuticals Colorado LLC Delivery vehicle composition and methods for delivering antigens and other drugs
BR0111948A (pt) 2000-06-26 2004-08-24 Rxkinetix Inc Composição para entrega de fator de crescimento hematopoiético
US6338859B1 (en) * 2000-06-29 2002-01-15 Labopharm Inc. Polymeric micelle compositions
US6669959B1 (en) 2000-07-18 2003-12-30 Aeropharm Technology Incorporated Modulated release particles for lung delivery
JP2004520088A (ja) 2000-08-15 2004-07-08 サーモディックス,インコーポレイティド 薬剤混和マトリックス
WO2002055185A2 (en) * 2000-10-19 2002-07-18 Eidgenoess Tech Hochschule Block copolymers for multifunctional self-assembled systems
AU2002216650A1 (en) * 2000-10-31 2002-05-15 Lynn Bonham Triazine derivatives as lpaat-b inhibitors and uses thereof
KR100446101B1 (ko) * 2000-12-07 2004-08-30 주식회사 삼양사 수난용성 약물의 서방성 제형 조성물
DK1355566T3 (da) 2000-12-18 2013-03-04 Univ Texas Lokal regional kemoterapi og radioterapi ved anvendelse af hydrogel in situ
US6565530B2 (en) 2001-02-28 2003-05-20 Scimed Life Systems, Inc. Immobilizing objects in the body
KR100354828B1 (ko) * 2001-03-12 2002-10-05 주식회사 씨엠리서치 생분해성 폴리에스테르의 제조방법 및 그에 의해 제조된생분해성 폴리에스테르
EP1372573B1 (de) * 2001-03-21 2009-10-07 Madash LLC Thermisch reversible wasser-in-öl-in-wasser-emulsionen
US20030194784A1 (en) * 2001-04-17 2003-10-16 Sherman David H. DNA encoding methymycin and pikromycin
US7094810B2 (en) * 2001-06-08 2006-08-22 Labopharm, Inc. pH-sensitive block copolymers for pharmaceutical compositions
US6939564B2 (en) 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
US6730772B2 (en) 2001-06-22 2004-05-04 Venkatram P. Shastri Degradable polymers from derivatized ring-opened epoxides
CN1253220C (zh) 2001-06-29 2006-04-26 贝克顿迪肯森公司 通过微管在真皮内输入疫苗和基因治疗剂
US20030082235A1 (en) * 2001-08-13 2003-05-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Novel reverse thermo-sensitive block copolymers
US6863859B2 (en) * 2001-08-16 2005-03-08 Objet Geometries Ltd. Reverse thermal gels and the use thereof for rapid prototyping
US6747121B2 (en) * 2001-09-05 2004-06-08 Synthes (Usa) Poly(L-lactide-co-glycolide) copolymers, methods for making and using same, and devices containing same
US6592899B2 (en) 2001-10-03 2003-07-15 Macromed Incorporated PLA/PLGA oligomers combined with block copolymers for enhancing solubility of a drug in water
MXPA04003640A (es) * 2001-10-16 2005-04-11 Rxkinetix Inc Formulaciones de proteina de alta concentracion y metodo de fabricacion.
WO2003037346A1 (en) * 2001-10-31 2003-05-08 Cell Therapeutics, Inc. 6-phenyl-n-phenyl-(1,3,5) -triazine-2,4-diamine derivatives and related compounds with lysophphosphatidic acid acyltransferase beta (lpaat-beta) inhibitory activity for use in the treatment of cancer
AU2002364586A1 (en) 2001-12-21 2003-07-30 Delta Biotechnology Limited Albumin fusion proteins
WO2005003296A2 (en) 2003-01-22 2005-01-13 Human Genome Sciences, Inc. Albumin fusion proteins
PT3025726T (pt) * 2002-01-18 2020-01-09 Biogen Ma Inc Compostos do polímero polialquileno e utilizações dos mesmos
WO2003080629A2 (en) 2002-02-25 2003-10-02 Guilford Pharmaceuticals, Inc. Phosphorus-containing compounds with polymeric chains, and methods of making and using the same
KR100906547B1 (ko) 2002-03-12 2009-07-07 에띠빠흠 생활성 물질의 지속적 전달을 위한 겔화 특성을 갖는 조성물
EP1485066B1 (de) 2002-03-12 2016-09-21 Ethypharm Zusammensetzung mit gelierenden eigenschaften zur verlängerten freigabe bioaktiver substanzen
WO2003078947A2 (en) * 2002-03-15 2003-09-25 The Penn State Research Foundation Method for control of temperature-sensitivity of polymers in solution
US7649023B2 (en) * 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
US20030228366A1 (en) * 2002-06-11 2003-12-11 Chung Shih Reconstitutable compositions of biodegradable block copolymers
US7160551B2 (en) * 2002-07-09 2007-01-09 The Board Of Trustees Of The University Of Illinois Injectable system for controlled drug delivery
ES2601143T3 (es) * 2002-07-19 2017-02-14 Omeros Corporation Copolímeros tribloque biodegradables, métodos de síntesis de los mismos, e hidrogeles y biomateriales preparados a partir de los mismos
KR100502840B1 (ko) * 2002-09-04 2005-07-21 학교법인 포항공과대학교 약물 담지능력이 우수한 블록 공중합체 미셀 조성물
KR100552954B1 (ko) * 2002-09-04 2006-02-20 주식회사 바이오레인 열감응성 유착방지용 조성물, 용액, 필름, 스폰지 및 분말
US7419984B2 (en) * 2002-10-17 2008-09-02 Cell Therapeutics, Inc. Pyrimidines and uses thereof
US6800663B2 (en) * 2002-10-18 2004-10-05 Alkermes Controlled Therapeutics Inc. Ii, Crosslinked hydrogel copolymers
US20040122065A1 (en) * 2002-11-12 2004-06-24 Lerner E. Itzhak Pharmaceutical compositions and dosage forms for buccal and sublingual delivery of tizanidine and methods of administering tizanidine sublingually or buccally
WO2004078147A2 (en) * 2003-03-05 2004-09-16 Pr Pharmaceuticals Oxytocin controlled release formulations and methods of using same
US6875781B2 (en) * 2003-04-04 2005-04-05 Cell Therapeutics, Inc. Pyridines and uses thereof
CA2521623C (en) 2003-04-11 2015-03-17 Etex Corporation Osteoinductive bone material
CA2523484A1 (en) * 2003-05-02 2004-11-11 Rimon Therapeutics Ltd. Thermally reversible implant
WO2004096309A1 (en) * 2003-05-02 2004-11-11 Rimon Therapeutics Ltd. Thermally reversible implant
US7588774B2 (en) * 2003-05-12 2009-09-15 Becton, Dickinson And Company Molecules enhancing dermal delivery of influenza vaccines
US20050123550A1 (en) * 2003-05-12 2005-06-09 Laurent Philippe E. Molecules enhancing dermal delivery of influenza vaccines
WO2004103342A2 (en) * 2003-05-16 2004-12-02 Alkermes Controlled Therapeutics, Inc. Injectable sustained release compositions
US7051654B2 (en) * 2003-05-30 2006-05-30 Clemson University Ink-jet printing of viable cells
NL1023720C2 (nl) * 2003-06-23 2004-12-28 Univ Eindhoven Tech Werkwijze voor het wijzigen van de transporteigenschappen van een materiaal, werkwijze voor het vrijmaken van een werkstof uit een implantaat, evenals implantaat met werkstof.
US20050118206A1 (en) * 2003-11-14 2005-06-02 Luk Andrew S. Surfactant-based gel as an injectable, sustained drug delivery vehicle
JP2007516968A (ja) * 2003-12-05 2007-06-28 ベクトン・ディキンソン・アンド・カンパニー 皮内コンパートメントにおける免疫応答を増強する方法、およびそれらの方法で有用な化合物
US8052669B2 (en) 2004-02-25 2011-11-08 Femasys Inc. Methods and devices for delivery of compositions to conduits
US9238127B2 (en) 2004-02-25 2016-01-19 Femasys Inc. Methods and devices for delivering to conduit
US8048086B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US8048101B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US8043631B2 (en) * 2004-04-02 2011-10-25 Au Jessie L S Tumor targeting drug-loaded particles
WO2005100429A1 (en) * 2004-04-15 2005-10-27 The University Of Utah Research Foundation Bioresponsive polymer system for delivery of microbicides
JP2007533376A (ja) 2004-04-15 2007-11-22 エテックス コーポレーション 遅延凝固リン酸カルシウムペースト
US20060018872A1 (en) * 2004-06-16 2006-01-26 Tew Gregory N Poly(lactic acid) copolymer hydrogels and related methods of drug delivery
US8980300B2 (en) 2004-08-05 2015-03-17 Advanced Cardiovascular Systems, Inc. Plasticizers for coating compositions
US20060034889A1 (en) 2004-08-16 2006-02-16 Macromed, Inc. Biodegradable diblock copolymers having reverse thermal gelation properties and methods of use thereof
FR2878533B1 (fr) * 2004-11-26 2007-04-27 Univ Cergy Pontoise Biomateriau capable d'effectuer successivement une transition solution/gel puis une transition gel/solution
US20060121055A1 (en) * 2004-12-06 2006-06-08 Becton, Dickinson And Company, Inc. Compositions with enhanced immunogenicity
US8128952B2 (en) * 2005-01-12 2012-03-06 Clemson University Research Foundation Ligand-mediated controlled drug delivery
CA2600085A1 (en) * 2005-03-09 2006-09-14 Toray Industries, Inc. Microparticle and pharmaceutical preparation
KR20070122522A (ko) * 2005-03-31 2007-12-31 에이피 파마, 인코포레이티드 Peg-폴리(오르토 에스테르) 그라프트 공중합체 및 약학조성물
WO2006105123A2 (en) * 2005-03-31 2006-10-05 Ap Pharma, Inc. Peg-polyacetal diblock and triblock copolymers and pharmaceutical compositions
US20060224095A1 (en) * 2005-04-05 2006-10-05 University Of New Hampshire Biocompatible polymeric vesicles self assembled from triblock copolymers
KR100665672B1 (ko) 2005-04-13 2007-01-09 성균관대학교산학협력단 새로운 온도 및 pH 민감성 블록 공중합체 및 이를 이용한고분자 하이드로겔
WO2007008300A2 (en) * 2005-05-31 2007-01-18 ECOLE POLYTECHNIQUE FéDéRALE DE LAUSANNE Triblock copolymers for cytoplasmic delivery of gene-based drugs
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
US20070224164A1 (en) * 2005-11-14 2007-09-27 Maciej Radosz Degradable nanogel for drug delivery
US8080028B2 (en) * 2005-12-05 2011-12-20 Novartis Ag Surgical device includes an anti-microbial coating
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
WO2007067624A2 (en) 2005-12-06 2007-06-14 Tyco Healthcare Group Lp Bioabsorbable compounds and compositions containing them
EP2633834A1 (de) 2005-12-06 2013-09-04 Covidien LP Bioabsorbierbare chirurgische Zusammensetzung
US20070142287A1 (en) * 2005-12-20 2007-06-21 Biomed Solutions, Llc Compositions And Methods For Treatment Of Cancer
WO2007073486A2 (en) 2005-12-20 2007-06-28 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
US20130172274A1 (en) 2005-12-20 2013-07-04 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
US8841255B2 (en) 2005-12-20 2014-09-23 Duke University Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
US7709227B2 (en) * 2006-01-04 2010-05-04 Phasebio Pharmaceuticals, Inc. Multimeric ELP fusion constructs
US8048419B2 (en) 2006-02-02 2011-11-01 Innovative Biotherapies, Inc. Extracorporeal cell-based therapeutic device and delivery system
US20100119529A1 (en) * 2006-05-12 2010-05-13 Furgeson Darin Y Elastin-like polymer delivery vehicles
US8197499B2 (en) * 2006-06-21 2012-06-12 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for joining non-conjoined lumens
US8608760B2 (en) * 2006-06-21 2013-12-17 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for joining non-conjoined lumens
CA2656179A1 (en) * 2006-06-21 2007-12-27 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for joining non-conjoined lumens
US8974542B2 (en) 2006-06-27 2015-03-10 University of Pittsburgh—of the Commonwealth System of Higher Education Biodegradable elastomeric patch for treating cardiac or cardiovascular conditions
FR2903599B1 (fr) * 2006-07-13 2012-08-31 Oreal Composition cosmetique a phase continue aqueuse comprenant au moins un polymere thermogelifiant, au moins un solvant organique volatil miscible dans l'eau et au moins un agent absorbant les radiations uv.
US7846361B2 (en) 2006-07-20 2010-12-07 Orbusneich Medical, Inc. Bioabsorbable polymeric composition for a medical device
KR100795214B1 (ko) * 2006-08-22 2008-01-21 이화여자대학교 산학협력단 온도 민감성 졸-젤 전이 폴리(에틸렌글리콜)/폴리(카보네이트) 블록 공중합체 및 이의 제조방법
WO2008035229A2 (en) * 2006-09-22 2008-03-27 Labopharm, Inc. Compositions and methods for ph targeted drug delivery
WO2008045904A2 (en) * 2006-10-10 2008-04-17 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Thermoresponsive, biodegradable, elastomeric material
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
EP2073754A4 (de) 2006-10-20 2012-09-26 Orbusneich Medical Inc Bioresorbierbare polymerzusammensetzung und hintergrund für eine medizinische vorrichtung
WO2008067127A2 (en) * 2006-11-09 2008-06-05 Alcon Research, Ltd. Water insoluble polymer matrix for drug delivery
US7757057B2 (en) * 2006-11-27 2010-07-13 Lsi Corporation Optimized rollback of copy-on-write snapshot volumes
US20080140106A1 (en) * 2006-12-12 2008-06-12 Kimberly-Clark Worldwide, Inc. Enhanced cuff sealing for endotracheal tubes
WO2008134828A2 (en) 2007-05-04 2008-11-13 Katholieke Universiteit Leuven Tissue degeneration protection
US20090004243A1 (en) 2007-06-29 2009-01-01 Pacetti Stephen D Biodegradable triblock copolymers for implantable devices
EP2042538A1 (de) * 2007-09-18 2009-04-01 Nirvana's Tree House Amphiphile Copolymere und Zusammensetzungen mit solchen Polymeren
WO2009055312A1 (en) * 2007-10-22 2009-04-30 Dfb Pharmaceuticals, Inc. Process for producing a poloxamer gel
US8642062B2 (en) 2007-10-31 2014-02-04 Abbott Cardiovascular Systems Inc. Implantable device having a slow dissolving polymer
EP2219620B1 (de) * 2007-11-13 2017-07-19 Surmodics, Inc. Viskose terpolymere als arzneiabgabe-plattform
WO2009086206A2 (en) * 2007-12-20 2009-07-09 Synvascular, Inc. Compositions and methods for joining non-conjoined lumens
TWI388591B (zh) * 2008-03-28 2013-03-11 Ind Tech Res Inst 溫度敏感性材料
US20090263489A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Analgesic and anti-inflammatory compositions and methods for reducing, preventing or treating pain and inflammation
US8916188B2 (en) * 2008-04-18 2014-12-23 Abbott Cardiovascular Systems Inc. Block copolymer comprising at least one polyester block and a poly (ethylene glycol) block
FR2932070B1 (fr) 2008-06-10 2012-08-17 Oreal Ensemble de maquillage et/ou de soin des cils
AU2009327485A1 (en) 2008-06-18 2010-06-24 Cytopherx, Inc. Methods for propagation of renal precursor cells
CN102131516B (zh) * 2008-06-27 2016-03-16 杜克大学 包含弹性蛋白样肽的治疗剂
BRPI0916761A2 (pt) 2008-07-17 2018-02-14 Ap Pharma formulações analgésicas injetáveis de ação prolongada para animais
US20100081622A1 (en) * 2008-09-29 2010-04-01 Sanos Bioscience A/S Reduction of parathyroid hormone levels
US12171463B2 (en) 2008-10-03 2024-12-24 Femasys Inc. Contrast agent generation and injection system for sonographic imaging
US9554826B2 (en) 2008-10-03 2017-01-31 Femasys, Inc. Contrast agent injection system for sonographic imaging
US10070888B2 (en) 2008-10-03 2018-09-11 Femasys, Inc. Methods and devices for sonographic imaging
CA2737763C (en) * 2008-10-11 2019-04-09 Rutgers, The State University Of New Jersey Phase-separated biocompatible polymer compositions for medical uses
US9271929B2 (en) 2008-11-25 2016-03-01 École Polytechnique Fédérale De Lausanne (Epfl) Block copolymers and uses thereof
US8951546B2 (en) * 2008-12-23 2015-02-10 Surmodics Pharmaceuticals, Inc. Flexible implantable composites and implants comprising same
US9415197B2 (en) * 2008-12-23 2016-08-16 Surmodics, Inc. Implantable suction cup composites and implants comprising same
US9480643B2 (en) 2008-12-23 2016-11-01 Surmodics Pharmaceuticals, Inc. Implantable composites and implants comprising same
US8974808B2 (en) 2008-12-23 2015-03-10 Surmodics, Inc. Elastic implantable composites and implants comprising same
TWI374903B (en) 2008-12-31 2012-10-21 Ind Tech Res Inst Biodegradable copolymer hydrogel materials
MX2011007532A (es) * 2009-01-15 2011-11-04 Univ Texas Estructuras porosas con cinetica de biodegradacion modificada.
EP2210584A1 (de) 2009-01-27 2010-07-28 Bayer Schering Pharma Aktiengesellschaft Stabile Polymerzusammensetzung mit einem Epothilon und einem amphiphilischen Blockpolymer
US8563037B2 (en) * 2009-02-06 2013-10-22 Tautona Group, L.P. Compositions and methods for joining non-conjoined lumens
JP5956337B2 (ja) 2009-07-31 2016-07-27 ラトガース,ザ ステート ユニバーシティ オブ ニュー ジャージー 天然代謝産物のモノマー類似体から合成された生体吸収性ポリマー
US9029505B2 (en) 2009-08-14 2015-05-12 Phasebio Pharmaceuticals, Inc. Modified vasoactive intestinal peptides
US8753621B2 (en) * 2009-09-18 2014-06-17 Protherics Salt Lake City, Inc. BAB triblock polymers having improved release characteristics
WO2011035261A1 (en) * 2009-09-18 2011-03-24 Protherics Salt Lake City, Inc. Reconstitutable reverse thermal gelling polymers
WO2011035264A1 (en) 2009-09-18 2011-03-24 Protherics Salt Lake City, Inc. Bab triblock polymers having improved release characteristics
US9155722B2 (en) * 2009-09-18 2015-10-13 Protherics Salt Lake City, Inc. Reconstitutable reverse thermal gelling polymers
WO2011044567A1 (en) 2009-10-11 2011-04-14 Rutgers, The State University Of New Jersey Biocompatible polymers for medial devices
US9993441B2 (en) 2009-12-30 2018-06-12 Surmodics, Inc. Controlled release matrix barrier structure for subcutaneous medical devices
EP2343046A1 (de) 2010-01-08 2011-07-13 Nirvana's Tree House B.V. Funktionalisierte Triblockcopolymere und Zusammensetzungen, die solche Polymere enthalten
EP2382966A1 (de) 2010-03-12 2011-11-02 DSM IP Assets B.V. Mizellenzusammensetzungen und Herstellungsverfahren dafür
US8551531B2 (en) 2010-04-12 2013-10-08 The Curators Of The University Of Missouri Pentablock polymers
US8471335B2 (en) * 2010-06-21 2013-06-25 Stmicroelectronics S.R.L. Semiconductor structure with alignment control mask
US9421307B2 (en) 2010-08-17 2016-08-23 University of Pittsburgh—of the Commonwealth System of Higher Education Biohybrid composite scaffold
EP2611868B1 (de) * 2010-08-30 2020-01-08 Surmodics Pharmaceuticals, Inc. Biologisch abbaubare terpolymere und terpolymermischungen als haftkleber
US8642502B2 (en) 2010-10-11 2014-02-04 TRGel, LLC Reversible gel-forming compositions for controlled delivery of bioactive substances
US20140066439A1 (en) 2010-11-10 2014-03-06 Katholieke Universiteit Leuen, K.U.Leuven R&D Osteoclast activity
US9648874B2 (en) 2010-12-07 2017-05-16 Kimberly-Clark Worldwide, Inc. Natural, multiple use and re-use, user saturated wipes
US9832993B2 (en) 2010-12-07 2017-12-05 Kimberly-Clark Worldwide, Inc. Melt processed antimicrobial composition
US10821085B2 (en) 2010-12-07 2020-11-03 Kimberly-Clark Worldwide, Inc. Wipe coated with a botanical composition having antimicrobial properties
US9149045B2 (en) 2010-12-07 2015-10-06 Kimberly-Clark Worldwide, Inc. Wipe coated with a botanical emulsion having antimicrobial properties
US8524264B2 (en) 2010-12-07 2013-09-03 Kimberly-Clark Worldwide, Inc. Protein stabilized antimicrobial composition formed by melt processing
US8445032B2 (en) 2010-12-07 2013-05-21 Kimberly-Clark Worldwide, Inc. Melt-blended protein composition
RU2578467C2 (ru) * 2010-12-20 2016-03-27 Торэй Индастриз, Инк. Биоразлагаемые частицы для медицинского лечения и материал для эмболизации сосудов
WO2012106317A1 (en) 2011-01-31 2012-08-09 Northwestern University Injectable thermoresponsive polyelectrolytes
DK2691079T3 (da) 2011-03-31 2020-09-28 Ingell Tech Holding B V Bionedbrydelige sammensætninger, der er egnet til kontrolleret udløsning
CA2831471C (en) * 2011-03-31 2020-02-25 Ingell Technologies Holding B.V. Biodegradable compositions suitable for controlled release
TW201247225A (en) * 2011-05-17 2012-12-01 Univ Nat Chiao Tung Drug carrier with thermal sensitivity, manufacturing method thereof, and use of the same as NMR contrast agent
CA2873553C (en) 2011-06-06 2020-01-28 Phasebio Pharmaceuticals, Inc. Use of modified vasoactive intestinal peptides in the treatment of hypertension
ES2685638T3 (es) 2011-07-26 2018-10-10 The Curators Of The University Of Missouri Carne comestible producida artificialmente
US20130072575A1 (en) * 2011-09-19 2013-03-21 Johnson & Johnson Consumer Companies, Inc. Method and Composition for Treating Pain
US20130101547A1 (en) 2011-10-19 2013-04-25 Allergan, Inc. Thermoresponsive compositions for dermatological use and methods thereof
KR101466893B1 (ko) * 2011-12-16 2014-12-05 주식회사 삼양바이오팜 안정성이 향상된 다중블록 공중합체의 수용액 조성물
US8574628B2 (en) 2011-12-19 2013-11-05 Kimberly-Clark Worldwide, Inc. Natural, multiple release and re-use compositions
US11472918B2 (en) 2012-02-03 2022-10-18 Rutgers, The State University Of New Jersey Polymeric biomaterials derived from phenolic monomers and their medical uses
CA3069030C (en) 2012-02-03 2021-11-16 Rutgers, The State University Of New Jersey Polymeric biomaterials derived from phenolic monomers and their medical uses
US9040034B2 (en) * 2013-04-09 2015-05-26 International Business Machines Corporation Vitamin functionalized gel-forming block copolymers for biomedical applications
WO2014179615A2 (en) * 2013-05-01 2014-11-06 Dae Won Park Biodegradable copolymers, systems including the copolymers, and methods of forming and using same
US9611353B2 (en) * 2013-05-16 2017-04-04 The Curators Of The University Of Missouri Drug loading pentablock polymers
WO2015013510A1 (en) 2013-07-25 2015-01-29 Ecole Polytechnique Federale De Lausanne Epfl High aspect ratio nanofibril materials
EP2842583A1 (de) 2013-08-29 2015-03-04 Ella-CS, s.r.o. Biologisch abbaubare und biologisch erodierbare Polyurethane, Verfahren zu ihrer Herstellung und Verwendung
WO2015038988A1 (en) 2013-09-13 2015-03-19 Modern Meadow, Inc. Edible and animal-product-free microcarriers for engineered meat
US9757330B2 (en) 2013-10-18 2017-09-12 Industrial Technology Research Institute Recipe for in-situ gel, and implant, drug delivery system formed thereby
AU2014354793B2 (en) * 2013-11-26 2018-04-05 Avent, Inc. Foams for oxygen delivery to wounds
JP2017505138A (ja) 2014-02-05 2017-02-16 モダン メドー インコーポレイテッド 培養筋細胞から形成される乾燥食品
US11052132B2 (en) 2014-05-08 2021-07-06 Phasebio Pharmaceuticals, Inc. Methods and compositions for treating cystic fibrosis
MX379365B (es) 2014-06-30 2025-03-11 Tarveda Therapeutics Inc Conjugados y partículas direccionados y formulaciones de estos.
WO2016020547A1 (en) 2014-08-08 2016-02-11 Dsm Ip Assets B.V. Amphiphilic blockcopolymers comprising reduction sensitive biodegradable polyesteramides
US10618998B2 (en) * 2014-11-12 2020-04-14 Purdue Research Foundation Poly(alkylene carbonate)-based amphiphilic block copolymers and methods of use thereof
WO2016094594A1 (en) 2014-12-09 2016-06-16 Sweetwater Energy, Inc. Rapid pretreatment
AU2015370426B2 (en) 2014-12-23 2019-09-12 Rutgers, The State University Of New Jersey Biocompatible iodinated diphenol monomers and polymers
US10774030B2 (en) 2014-12-23 2020-09-15 Rutgers, The State University Of New Jersey Polymeric biomaterials derived from phenolic monomers and their medical uses
US9750785B2 (en) 2015-01-30 2017-09-05 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9925233B2 (en) 2015-01-30 2018-03-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9937223B2 (en) 2015-01-30 2018-04-10 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744239B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744209B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9687526B2 (en) 2015-01-30 2017-06-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
CN114652817B (zh) 2015-02-09 2026-04-17 费斯生物制药公司 用于治疗肌肉疾病和病症的方法和组合物
ES2809537T3 (es) * 2015-03-12 2021-03-04 Kuros Biosciences B V Materiales compuestos biocompatibles anhidros
JP6354905B2 (ja) * 2015-07-28 2018-07-11 株式会社島津製作所 ゲル組成物、およびゲル組成物の製造方法
JP6886402B2 (ja) * 2015-08-24 2021-06-16 株式会社スリー・ディー・マトリックス 生分解性インジェクタブルゲル
EP3337923B2 (de) 2015-09-21 2023-01-04 Modern Meadow, Inc. Faserverstärkte gewebeverbundwerkstoffe
US11160871B2 (en) 2015-10-28 2021-11-02 Tarveda Therapeutics, Inc. SSTR-targeted conjugates and particles and formulations thereof
US20170136144A1 (en) 2015-11-12 2017-05-18 John C. Herr Compositions and methods for vas-occlusive contraception
JP7109882B2 (ja) 2016-02-15 2022-08-01 モダン メドウ,インコーポレイテッド コラーゲンフィブリルを含むバイオファブリケーテッド材料を作製するための方法
EP3448361A4 (de) 2016-04-29 2019-11-20 I-Novion, Inc. Flüssige pentablock-copolymer-formulierungen zur anhaltenden freisetzung von therapeutika
US20180028715A1 (en) 2016-07-27 2018-02-01 Contraline, Inc. Carbon-based compositions useful for occlusive medical devices and methods of making and using them
DE102016119102A1 (de) 2016-10-07 2018-04-12 Forschungszentrum Jülich GmbH Translokation von synthetischen Polymeren durch Lipidmembrane
DK3541442T3 (da) 2016-11-16 2022-03-14 Persica Pharmaceuticals Ltd Antibiotiske formuleringer mod lændesmerter
US12383421B2 (en) 2017-01-05 2025-08-12 Contraline, Inc. Contraceptive devices
EP4400166A3 (de) 2017-01-05 2025-01-22 Contraline, Inc. Verfahren zum implantieren und umkehren von stimulierend wirkenden implantaten
US11821047B2 (en) 2017-02-16 2023-11-21 Apalta Patent OÜ High pressure zone formation for pretreatment
AU2018253595A1 (en) 2017-11-13 2019-05-30 Modern Meadow, Inc. Biofabricated leather articles having zonal properties
DK3709970T3 (da) 2017-11-16 2025-07-07 Persica Pharmaceuticals Ltd Linezolidformuleringer
JP7582939B2 (ja) 2018-11-13 2024-11-13 コントラライン,インコーポレイテッド 生体材料を送達するためのシステムおよび方法
AU2020209847B2 (en) 2019-01-17 2024-10-17 Modern Meadow, Inc. Layered collagen materials and methods of making the same
BR112022012348A2 (pt) 2019-12-22 2022-09-13 Sweetwater Energy Inc Métodos de fazer lignina especializada e produtos de lignina da biomassa
EP4143258A4 (de) 2020-05-01 2024-05-22 Modern Meadow, Inc. Proteinpolyurethanlegierungen und schichtmaterialien damit
EP4014963A1 (de) * 2020-12-16 2022-06-22 Medincell Pharmazeutische zusammensetzung
CN113024783B (zh) * 2021-03-12 2023-01-13 山东谷雨春生物科技有限公司 一种可降解嵌段共聚物水凝胶的合成方法
GB202103785D0 (en) * 2021-03-18 2021-05-05 UCB Biopharma SRL Formulations
CN114634632B (zh) * 2022-03-21 2023-11-28 复旦大学 一种温敏性嵌段共聚物水凝胶及其制备方法与应用
WO2024249565A2 (en) * 2023-05-30 2024-12-05 Lung Therapeutics, Llc Modified caveolin-1 peptide formulations and methods of manufacturing and use thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0092918B1 (de) * 1982-04-22 1988-10-19 Imperial Chemical Industries Plc Mittel mit verzögerter Freigabe
US4438253A (en) * 1982-11-12 1984-03-20 American Cyanamid Company Poly(glycolic acid)/poly(alkylene glycol) block copolymers and method of manufacturing the same
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
GB8416234D0 (en) * 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
ES2058081T3 (es) * 1986-09-05 1994-11-01 American Cyanamid Co Poliesteres que contienen bloques de oxido de alquileno como sistemas de administracion de medicamentos.
JP2670680B2 (ja) * 1988-02-24 1997-10-29 株式会社ビーエムジー 生理活性物質含有ポリ乳酸系微小球およびその製造法
JPH064540B2 (ja) * 1988-09-14 1994-01-19 多木化学株式会社 医用組成物
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5324519A (en) * 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5165713A (en) * 1991-07-03 1992-11-24 5Th Boot Industries Inc. Fifth wheel cover
US5330768A (en) * 1991-07-05 1994-07-19 Massachusetts Institute Of Technology Controlled drug delivery using polymer/pluronic blends

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